{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:15:27Z","timestamp":1773814527528,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Iron deficiency (IDA) and chronic disease (ACD) anemia are complications of inflammatory bowel diseases (IBDs). Therapeutic modalities in remission and active IBD depend on the type of anemia. This study evaluated the link between hepcidin-25, proinflammatory cytokines, and platelet activation markers as biomarkers of anemia and inflammation in active IBD and remission. This prospective observational study included 62 patients with IBD (49 with ulcerative colitis and 13 with Crohn\u2019s) and anemia. Patients were divided into Group I (no or minimal endoscopic signs of disease activity and IDA), Group II (moderate and major endoscopic signs of disease activity and mild ACD), and Control group (10 patients with IBD in remission, without anemia). We assessed the difference among groups in the levels of CRP, hemoglobin (Hgb), serum iron, ferritin, hepcidin-25, interleukins, TNF\u2013\u03b1, IFN-\u03b3, soluble CD40 ligand, and sP-selectin. Hepcidin-25 levels were significantly higher in Group II versus Group I (11.93 vs. 4.48 ng\/mL, p &lt; 0.001). Ferritin and CRP values showed similar patterns in IBD patients: significantly higher levels were observed in Group II (47.5 ng\/mL and 13.68 mg\/L) than in Group I (11.0 ng\/mL and 3.39 mg\/L) (p &lt; 0.001). In Group II, hepcidin-25 was positively correlated with ferritin (\u03c1 = 0.725, p &lt; 0.001) and CRP (\u03c1 = 0.502, p = 0.003). Ferritin was an independent variable influencing hepcidin-25 concentration in IBD patients, regardless of disease activity and severity of anemia. IBD hepcidin-25 best correlates with ferritin, and both parameters reflected inflammation extent and IBD activity.<\/jats:p>","DOI":"10.3390\/ijms25073564","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T05:10:53Z","timestamp":1711084253000},"page":"3564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Prospective Observational Study Analyzing the Diagnostic Value of Hepcidin-25 for Anemia in Patients with Inflammatory Bowel Diseases"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3848-6993","authenticated-orcid":false,"given":"Stanko","family":"Petrovi\u0107","sequence":"first","affiliation":[{"name":"Medical Faculty of the Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dino","family":"Tarabar","sequence":"additional","affiliation":[{"name":"Clinic for Gastroenterology, University Hospital Center \u201cDr. Dragi\u0161a Mi\u0161ovi\u0107\u201d, 11 050 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-3850","authenticated-orcid":false,"given":"Danica","family":"\u0106uji\u0107","sequence":"additional","affiliation":[{"name":"Institute for Application of Nuclear Energy, University of Belgrade, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-1966","authenticated-orcid":false,"given":"Dusica","family":"Stamenkovic","sequence":"additional","affiliation":[{"name":"Medical Faculty of the Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"},{"name":"Department of Anesthesiology and Intensive Care, Military Medical Academy, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Petrovi\u0107","sequence":"additional","affiliation":[{"name":"Medical Faculty of the Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"},{"name":"Clinic for Nephrology, Military Medical Academy, 11 050 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-8094","authenticated-orcid":false,"given":"Nemanja","family":"Ran\u010di\u0107","sequence":"additional","affiliation":[{"name":"Centre for Clinical Pharmacology, Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Subota","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry, Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nenad","family":"Peri\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Medical Faculty of the Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1938-8298","authenticated-orcid":false,"given":"Mihailo","family":"Bezmarevi\u0107","sequence":"additional","affiliation":[{"name":"Medical Faculty of the Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia"},{"name":"Unit for Perioperative Nutrition, Department of Hepatobiliary and Pancreatic Surgery, Clinic for General Surgery, Military Medical Academy, University of Defence, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fmed.2014.00058","article-title":"Anemia in inflammatory bowel disease: An under-estimated problem?","volume":"1","author":"Rogler","year":"2015","journal-title":"Front. 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