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Role Played by Paraoxonase-2 Enzyme in Cell Viability, Proliferation and Sensitivity to Chemotherapy of Oral Squamous Cell Carcinoma Cell Lines. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010338"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0140-6736(19)31282-6","article-title":"Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: An open-label, randomised controlled trial","volume":"394","author":"Easterling","year":"2019","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fcvm.2018.00050","article-title":"Use of Antihypertensive Drugs During Preeclampsia","volume":"5","author":"Odigboegwu","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sammar, M., Drobnjak, T., Mandala, M., Gizurarson, S., Huppertz, B., and Meiri, H. (2019). Galectin 13 (PP13) Facilitates Remodeling and Structural Stabilization of Maternal Vessels during Pregnancy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133192"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.csbj.2017.09.002","article-title":"Personalized Therapy against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients with Impaired PP13 Molecule or Function","volume":"15","author":"Meiri","year":"2017","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jri.2014.11.003","article-title":"Maternal-fetal interactions, predictive markers for preeclampsia, and programming","volume":"108","author":"Huppertz","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sousa, S.O., Santos, M.R.D., Teixeira, S.C., Ferro, E.A.V., and Oliani, S.M. (2022). 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