{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:36:12Z","timestamp":1787063772560,"version":"build-2736575974"},"reference-count":144,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To date, the SARS-CoV-2 pandemic still represents a great clinical challenge worldwide, and effective anti-COVID-19 drugs are limited. For this reason, nutritional supplements have been investigated as adjuvant therapeutic approaches in disease management. Among such supplements, vitamin D has gained great interest, due to its immunomodulatory and anti-inflammatory actions both in adult and pediatric populations. Even if there is conflicting evidence about its prevention and\/or mitigation effectiveness in SARS-CoV-2 infection, several studies demonstrated a strict correlation between hypovitaminosis D and disease severity in acute COVID-19 and MIS-C (multisystem inflammatory syndrome in children). This narrative review offers a resume of the state of the art about vitamin D\u2019s role in immunity and its clinical use in the context of the current pandemic, specially focusing on pediatric manifestations and MIS-C. It seems biologically reasonable that interventions aimed at normalizing circulating vitamin D levels could be beneficial. To help clinicians in establishing the correct prophylaxis and\/or supportive therapy with vitamin D, well-designed and adequately statistically powered clinical trials involving both adult and pediatric populations are needed. Moreover, this review will also discuss the few other nutraceuticals evaluated in this context.<\/jats:p>","DOI":"10.3390\/ijms25073712","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:39:56Z","timestamp":1711546796000},"page":"3712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D Supplementation in Neonatal and Infant MIS-C Following COVID-19 Infection"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6174-7111","authenticated-orcid":false,"given":"Manuela","family":"Rizzi","sequence":"first","affiliation":[{"name":"Department of Health Sciences (DiSS), Universit\u00e0 del Piemonte Orientale (UPO), 28100 Novara, Italy"},{"name":"IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Universit\u00e0 del Piemonte Orientale (UPO), 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Avellis","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Turin, 10124 Turin, Italy"},{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6868-036X","authenticated-orcid":false,"given":"Alessandro","family":"Messina","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Turin, 10124 Turin, Italy"},{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-3803","authenticated-orcid":false,"given":"Chiara","family":"Germano","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of 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