{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:19:53Z","timestamp":1792804793969,"version":"4.5.0"},"reference-count":416,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre, Poland","doi-asserted-by":"publisher","award":["OPUS 22 2021\/43\/B\/NZ7\/00230"],"award-info":[{"award-number":["OPUS 22 2021\/43\/B\/NZ7\/00230"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maj Institute of Pharmacology Polish Academy of Sciences","award":["OPUS 22 2021\/43\/B\/NZ7\/00230"],"award-info":[{"award-number":["OPUS 22 2021\/43\/B\/NZ7\/00230"]}],"id":[{"id":"https:\/\/ror.org\/01dr6c206","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite significant progress in modern medicine and pharmacology, damage to the nervous system with various etiologies still poses a challenge to doctors and scientists. Injuries lead to neuroimmunological changes in the central nervous system (CNS), which may result in both secondary damage and the development of tactile and thermal hypersensitivity. In our review, based on the analysis of many experimental and clinical studies, we indicate that the mechanisms occurring both at the level of the brain after direct damage and at the level of the spinal cord after peripheral nerve damage have a common immunological basis. This suggests that there are opportunities for similar pharmacological therapeutic interventions in the damage of various etiologies. Experimental data indicate that after CNS\/PNS damage, the levels of 16 among the 28 CC-family chemokines, i.e., CCL1, CCL2, CCL3, CCL4, CCL5, CCL6, CCL7, CCL8, CCL9, CCL11, CCL12, CCL17, CCL19, CCL20, CCL21, and CCL22, increase in the brain and\/or spinal cord and have strong proinflammatory and\/or pronociceptive effects. According to the available literature data, further investigation is still needed for understanding the role of the remaining chemokines, especially six of them which were found in humans but not in mice\/rats, i.e., CCL13, CCL14, CCL15, CCL16, CCL18, and CCL23. Over the past several years, the results of studies in which available pharmacological tools were used indicated that blocking individual receptors, e.g., CCR1 (J113863 and BX513), CCR2 (RS504393, CCX872, INCB3344, and AZ889), CCR3 (SB328437), CCR4 (C021 and AZD-2098), and CCR5 (maraviroc, AZD-5672, and TAK-220), has beneficial effects after damage to both the CNS and PNS. Recently, experimental data have proved that blockades exerted by double antagonists CCR1\/3 (UCB 35625) and CCR2\/5 (cenicriviroc) have very good anti-inflammatory and antinociceptive effects. In addition, both single (J113863, RS504393, SB328437, C021, and maraviroc) and dual (cenicriviroc) chemokine receptor antagonists enhanced the analgesic effect of opioid drugs. This review will display the evidence that a multidirectional strategy based on the modulation of neuronal\u2013glial\u2013immune interactions can significantly improve the health of patients after CNS and PNS damage by changing the activity of chemokines belonging to the CC family. Moreover, in the case of pain, the combined administration of such antagonists with opioid drugs could reduce therapeutic doses and minimize the risk of complications.<\/jats:p>","DOI":"10.3390\/ijms25073788","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T12:52:12Z","timestamp":1711630332000},"page":"3788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["CC Chemokine Family Members\u2019 Modulation as a Novel Approach for Treating Central Nervous System and Peripheral Nervous System Injury\u2014A Review of Clinical and Experimental Findings"],"prefix":"10.3390","volume":"25","author":[{"given":"Agata","family":"Ciechanowska","sequence":"first","affiliation":[{"name":"Department of Pain Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Str., 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-7205","authenticated-orcid":false,"given":"Joanna","family":"Mika","sequence":"additional","affiliation":[{"name":"Department of Pain Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Str., 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1474-4422(18)30415-0","article-title":"Global, Regional, and National Burden of Traumatic Brain Injury and Spinal Cord Injury, 1990-2016: A Systematic Analysis for the Global Burden of Disease Study 2016","volume":"18","author":"James","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3171\/2017.10.JNS17352","article-title":"Estimating the Global Incidence of Traumatic Brain Injury","volume":"130","author":"Dewan","year":"2019","journal-title":"J. Neurosurg."},{"key":"ref_3","unstructured":"NIH (National Institutes of Health) (2023, November 16). Traumatic Brain Injury Information, Available online: https:\/\/www.nih.gov\/about-nih\/what-we-do\/nih-turning-discovery-into-health\/healthy-mind\/traumatic-brain-injury-tbi."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"995044","DOI":"10.3389\/fmed.2022.995044","article-title":"Immune Modulation after Traumatic Brain Injury","volume":"9","author":"Bouras","year":"2022","journal-title":"Front. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"740939","DOI":"10.3389\/fphys.2021.740939","article-title":"Traumatic Brain Injury: Mechanisms of Glial Response","volume":"12","author":"Mira","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1750-3639.2011.00513.x","article-title":"Widespread Tau and Amyloid-Beta Pathology Many Years after a Single Traumatic Brain Injury in Humans","volume":"22","author":"Johnson","year":"2012","journal-title":"Brain Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-3940(93)90398-5","article-title":"\u03b2-Amyloid Precursor Protein (\u0392APP) as a Marker for Axonal Injury after Head Injury","volume":"160","author":"Gentleman","year":"1993","journal-title":"Neurosci. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/jnnp-2017-317557","article-title":"Understanding Neurodegeneration after Traumatic Brain Injury: From Mechanisms to Clinical Trials in Dementia","volume":"90","author":"Graham","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1001\/archneur.63.3.418","article-title":"Cognitive Sequelae of Diffuse Axonal Injury","volume":"63","author":"Scheid","year":"2006","journal-title":"Arch. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1371\/journal.pmed.1002103","article-title":"Long-Term Outcomes Associated with Traumatic Brain Injury in Childhood and Adolescence: A Nationwide Swedish Cohort Study of a Wide Range of Medical and Social Outcomes","volume":"13","author":"Sariaslan","year":"2016","journal-title":"PLoS Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Li, Y., Li, Y., Li, X., Zhang, S., Zhao, J., Zhu, X., and Tian, G. (2017). Head Injury as a Risk Factor for Dementia and Alzheimer\u2019s Disease: A Systematic Review and Meta-Analysis of 32 Observational Studies. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169650"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Nordstr\u00f6m, A., and Nordstr\u00f6m, P. (2018). Traumatic Brain Injury and the Risk of Dementia Diagnosis: A Nationwide Cohort Study. PLoS Med., 15.","DOI":"10.1371\/journal.pmed.1002496"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S2215-0366(18)30065-8","article-title":"Long-Term Risk of Dementia among People with Traumatic Brain Injury in Denmark: A Population-Based Observational Cohort Study","volume":"5","author":"Fann","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/pm\/pnx153","article-title":"Chronic Pain after Traumatic Brain Injury: Pathophysiology and Pain Mechanisms","volume":"19","author":"Irvine","year":"2018","journal-title":"Pain Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/0269905021000030823","article-title":"Presence of Post-Concussion Syndrome Symptoms in Patients with Chronic Pain vs Mild Traumatic Brain Injury","volume":"17","author":"Fow","year":"2003","journal-title":"Brain Inj."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1526-4637.2009.00721.x","article-title":"Systematic Review of the Literature on Pain in Patients with Polytrauma Including Traumatic Brain Injury","volume":"10","author":"Dobscha","year":"2009","journal-title":"Pain Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11916-015-0520-1","article-title":"Posttraumatic Headache: Clinical Characterization and Management","volume":"19","author":"Lucas","year":"2015","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1089\/neu.2012.2740","article-title":"Effects of Acute Intrathecal Baclofen in an Animal Model of Tbi-Induced Spasticity, Cognitive, and Balance Disabilities","volume":"30","author":"Bose","year":"2013","journal-title":"J. Neurotrauma"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.pain.2007.06.015","article-title":"The Characteristics of Chronic Central Pain after Traumatic Brain Injury","volume":"131","author":"Ofek","year":"2007","journal-title":"Pain"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/cns.12366","article-title":"Ethyl Pyruvate Protects against Blood-Brain Barrier Damage and Improves Long-Term Neurological Outcomes in a Rat Model of Traumatic Brain Injury","volume":"21","author":"Shi","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/TA.0000000000000445","article-title":"Altering Leukocyte Recruitment Following Traumatic Brain Injury with Ghrelin Therapy","volume":"77","author":"Lee","year":"2014","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00005373-199807000-00025","article-title":"Analysis of Upper and Lower Extremity Peripheral Nerve Injuries in a Population of Patients with Multiple Injuries","volume":"45","author":"Noble","year":"1998","journal-title":"J. Trauma-Inj. Infect. Crit. Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.clinph.2008.03.018","article-title":"Evaluation and Management of Peripheral Nerve Injury","volume":"119","author":"Campbell","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3171\/jns.2001.94.6.0905","article-title":"Evaluation of Iatrogenic Lesions in 722 Surgically Treated Cases of Peripheral Nerve Trauma","volume":"94","author":"Kretschmer","year":"2001","journal-title":"J. Neurosurg."},{"key":"ref_25","unstructured":"Althagafi, A., and Nadi, M. (2023). Acute Nerve Injury, StatPearls Publishing."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1445-2197.1982.tb06081.x","article-title":"Trauma to the Central and Peripheral Nervous Systems. Part II: A Statistical Profile of Surgical Treatment New South Wales 1977","volume":"52","author":"Selecki","year":"1982","journal-title":"Aust. N. Z. J. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00003086-198808000-00017","article-title":"Peripheral Nerve Injuries in the Adult with Traumatic Brain Injury","volume":"233","author":"Stone","year":"1988","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_28","unstructured":"Wordliczek, J., and Dobrogowski, J. (2007). Leczenie B\u00f3lu, PZWL."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J. Pain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic Pain: From Mechanisms to Treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12974-017-0944-0","article-title":"Prophylactic Inhibition of Neutrophil Elastase Prevents the Development of Chronic Neuropathic Pain in Osteoarthritic Mice","volume":"14","author":"Muley","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1523\/JNEUROSCI.2233-16.2017","article-title":"Neuroimmune\u2013Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia","volume":"37","author":"Silva","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1097\/j.pain.0000000000000959","article-title":"IKK\/NF-B-Dependent Satellite Glia Activation Induces Spinal Cord Microglia Activation and Neuropathic Pain after Nerve Injury","volume":"158","author":"Lim","year":"2017","journal-title":"Pain"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2147\/JPR.S21751","article-title":"High TNF-Alpha Plasma Levels and Macrophages INOS and TNF-Alpha Expression as Risk Factors for Painful Diabetic Neuropathy","volume":"4","author":"Purwata","year":"2011","journal-title":"J. Pain Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1016\/j.celrep.2018.02.068","article-title":"TAFA4 Reverses Mechanical Allodynia through Activation of GABAergic Transmission and Microglial Process Retraction","volume":"22","author":"Kambrun","year":"2018","journal-title":"Cell Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"20151","DOI":"10.1073\/pnas.0709250104","article-title":"Chemokines and the Pathophysiology of Neuropathic Pain","volume":"104","author":"White","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.pharep.2018.01.006","article-title":"The Importance of Chemokines in Neuropathic Pain Development and Opioid Analgesic Potency","volume":"70","author":"Kwiatkowski","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.nurt.2007.07.004","article-title":"Chemokines and Chemokine Receptors in Neurological Disease: Raise, Retain, or Reduce?","volume":"4","author":"Ransohoff","year":"2007","journal-title":"Neurotherapeutics"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A Guide to Chemokines and Their Receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1058204","DOI":"10.3389\/fimmu.2022.1058204","article-title":"New Insights into the Analgesic Properties of the XCL1\/XCR1 and XCL1\/ITGA9 Axes Modulation under Neuropathic Pain Conditions-Evidence from Animal Studies","volume":"13","author":"Ciechanowska","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fimmu.2018.00494","article-title":"Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine","volume":"9","author":"Rojewska","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1161\/ATVBAHA.108.169417","article-title":"Platelet Chemokines in Vascular Disease","volume":"28","author":"Gleissner","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2014.00277","article-title":"Biased and g Protein-Independent Signaling of Chemokine Receptors","volume":"5","author":"Steen","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41385-022-00538-3","article-title":"Critical Roles of G Protein-Coupled Receptors in Regulating Intestinal Homeostasis and Inflammatory Bowel Disease","volume":"15","author":"Feng","year":"2022","journal-title":"Mucosal Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2741\/4860","article-title":"Molecular Insights into Kinase Mediated Signaling Pathways of Chemokines and Their Cognate G Protein Coupled Receptors","volume":"25","author":"Tripathi","year":"2020","journal-title":"Front. Biosci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Henrot, P., Prevel, R., Berger, P., and Dupin, I. (2019). Chemokines in COPD: From Implication to Therapeutic Use. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112785"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rizeq, B., and Malki, M.I. (2020). The Role of CCL21\/CCR7 Chemokine Axis in Breast Cancer Progression. Cancers, 12.","DOI":"10.3390\/cancers12041036"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s11481-017-9729-6","article-title":"The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats","volume":"12","author":"Kwiatkowski","year":"2017","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.270.5243.1811","article-title":"Identification of RANTES, MIP-1 Alpha, and MIP-1 Beta as the Major HIV-Suppressive Factors Produced by CD8+ T Cells","volume":"270","author":"Cocchi","year":"1995","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1359-6101(02)00045-X","article-title":"Macrophage Inflammatory Protein-1","volume":"13","author":"Menten","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Baba, N., Wang, F., Iizuka, M., Shen, Y., Yamashita, T., Takaishi, K., Tsuru, E., Matsushima, S., Miyamura, M., and Fujieda, M. (2019). Induction of Regional Chemokine Expression in Response to Human Umbilical Cord Blood Cell Infusion in the Neonatal Mouse Ischemia-Reperfusion Brain Injury Model. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221111"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/jphp.13235","article-title":"Gadolinium Causes M1 and M2 Microglial Apoptosis after Intracerebral Haemorrhage and Exerts Acute Neuroprotective Effects","volume":"72","author":"Ohnishi","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e679","DOI":"10.1038\/cddis.2013.198","article-title":"CCL-1 in the Spinal Cord Contributes to Neuropathic Pain Induced by Nerve Injury","volume":"4","author":"Akimoto","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1007\/s43440-020-00137-8","article-title":"Metamizole Relieves Pain by Influencing Cytokine Levels in Dorsal Root Ganglia in a Rat Model of Neuropathic Pain","volume":"72","author":"Zajaczkowska","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"101671","DOI":"10.1016\/j.mcp.2020.101671","article-title":"The CCL2\/CCL7\/CCL12\/CCR2 Pathway Is Substantially and Persistently Upregulated in Mice after Traumatic Brain Injury, and CCL2 Modulates the Complement System in Microglia","volume":"54","author":"Ciechanowska","year":"2020","journal-title":"Mol. Cell. Probes"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.jfma.2019.01.008","article-title":"Modulation of Parietal Cytokine and Chemokine Gene Profiles by Mesenchymal Stem Cell as a Basis for Neurotrauma Recovery","volume":"118","author":"Lin","year":"2019","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/jcbfm.2009.262","article-title":"Role of CCL2 (MCP-1) in Traumatic Brain Injury (TBI): Evidence from Severe TBI Patients and CCL2\u2212\/\u2212 Mice","volume":"30","author":"Semple","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1089\/neu.2018.5636","article-title":"Acute Inflammatory Biomarker Responses to Diffuse Traumatic Brain Injury in the Rat Monitored by a Novel Microdialysis Technique","volume":"36","author":"Clausen","year":"2019","journal-title":"J. Neurotrauma"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Geng, H., Chen, L., Tang, J., Chen, Y., and Wang, L. (2022). The Role of CCL2\/CCR2 Axis in Cerebral Ischemia-Reperfusion Injury and Treatment: From Animal Experiments to Clinical Trials. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073485"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"114773","DOI":"10.1016\/j.jep.2021.114773","article-title":"Identification of Potential Regulating Effect of Baicalin on NF\u03baB\/CCL2\/CCR2 Signaling Pathway in Rats with Cerebral Ischemia by Antibody-Based Array and Bioinformatics Analysis","volume":"284","author":"Xu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.expneurol.2017.10.024","article-title":"Inhibition of MicroRNA-210 Suppresses pro-Inflammatory Response and Reduces Acute Brain Injury of Ischemic Stroke in Mice","volume":"300","author":"Huang","year":"2018","journal-title":"Exp. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/glia.22323","article-title":"The CCL2-CCR2 System Affects the Progression and Clearance of Intracerebral Hemorrhage","volume":"60","author":"Yao","year":"2012","journal-title":"Glia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/jnr.22820","article-title":"Expression of Inflammatory Cytokines Following Acute Spinal Cord Injury in a Rodent Model","volume":"90","author":"Stammers","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1007\/s12035-022-03184-9","article-title":"Spinal MCP-1 Contributes to Central Post-Stroke Pain by Inducing Central Sensitization in Rats","volume":"60","author":"Yang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Pawlik, K., Ciapa\u0142a, K., Ciechanowska, A., Kwiatkowski, K., and Mika, J. (2023). Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2\/7\/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain. Cells, 12.","DOI":"10.3390\/cells12010098"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/imm.13172","article-title":"The Blockade of CC Chemokine Receptor Type 1 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in a Rat Model of Neuropathic Pain","volume":"159","author":"Pawlik","year":"2020","journal-title":"Immunology"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ciapa\u0142a, K., Rojewska, E., Pawlik, K., Ciechanowska, A., and Mika, J. (2023). Analgesic Effects of Fisetin, Peimine, Astaxanthin, Artemisinin, Bardoxolone Methyl and 740 Y-P and Their Influence on Opioid Analgesia in a Mouse Model of Neuropathic Pain. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24109000"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Ciechanowska, A., Popiolek-Barczyk, K., Pawlik, K., Ciapa\u0142a, K., Oggioni, M., Mercurio, D., De Simoni, M.G., and Mika, J. (2020). Changes in Macrophage Inflammatory Protein-1 (MIP-1) Family Members Expression Induced by Traumatic Brain Injury in Mice. Immunobiology, 225.","DOI":"10.1016\/j.imbio.2020.151911"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1089\/neu.2017.5593","article-title":"Neuroinflammation after Traumatic Brain Injury Is Enhanced in Activating Transcription Factor 3 Mutant Mice","volume":"35","author":"Rehman","year":"2018","journal-title":"J. Neurotrauma"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"615327","DOI":"10.3389\/fimmu.2020.615327","article-title":"Bidirectional Action of Cenicriviroc, a CCR2\/CCR5 Antagonist, Results in Alleviation of Pain-Related Behaviors and Potentiation of Opioid Analgesia in Rats With Peripheral Neuropathy","volume":"11","author":"Kwiatkowski","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pnpbp.2015.07.005","article-title":"Beneficial Properties of Maraviroc on Neuropathic Pain Development and Opioid Effectiveness in Rats","volume":"64","author":"Kwiatkowski","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Ciechanowska, A., Pawlik, K., Ciapa\u0142a, K., and Mika, J. (2023). Pharmacological Modulation of the MIP-1 Family and Their Receptors Reduces Neuropathic Pain Symptoms and Influences Morphine Analgesia: Evidence from a Mouse Model. Brain Sci., 13.","DOI":"10.3390\/brainsci13040579"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2010.07.085","article-title":"CC-Chemokine MIP-1\u03b1 in the Spinal Cord Contributes to Nerve Injury-Induced Neuropathic Pain","volume":"484","author":"Kiguchi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jneuroim.2004.06.003","article-title":"Complement C3 and C5 Play Critical Roles in Traumatic Brain Cryoinjury: Blocking Effects on Neutrophil Extravasation by C5a Receptor Antagonist","volume":"155","author":"Sewell","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12967-023-04044-3","article-title":"CCL5\/CCR5-Mediated Peripheral Inflammation Exacerbates Blood\u2013brain Barrier Disruption after Intracerebral Hemorrhage in Mice","volume":"21","author":"Lin","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/sj.jcbfm.9600217","article-title":"Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System","volume":"26","author":"Offner","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Yin, Q., Fan, Q., Zhao, Y., Cheng, M.-Y., Liu, H., Li, J., Lu, F.-F., Jia, J.-T., Cheng, W., and Yan, C.-D. (2015). Spinal NF-\u039aB and Chemokine Ligand 5 Expression during Spinal Glial Cell Activation in a Neuropathic Pain Model. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0115120"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Piotrowska, A., Ciapa\u0142a, K., Pawlik, K., Kwiatkowski, K., Rojewska, E., and Mika, J. (2021). Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model\u2014In Vivo and In Vitro Study. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011074"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/brain\/aws330","article-title":"Epigenetic Transcriptional Activation of Monocyte Chemotactic Protein 3 Contributes to Long-Lasting Neuropathic Pain","volume":"136","author":"Imai","year":"2013","journal-title":"Brain"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"781310","DOI":"10.3389\/fimmu.2021.781310","article-title":"Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain","volume":"12","author":"Pawlik","year":"2021","journal-title":"Front. Immunol"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"42260","DOI":"10.1038\/srep42260","article-title":"Interleukin-1\u03b2 Pre-Treated Bone Marrow Stromal Cells Alleviate Neuropathic Pain through CCL7-Mediated Inhibition of Microglial Activation in the Spinal Cord","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Bogacka, J., Pawlik, K., Ciapa\u0142a, K., Ciechanowska, A., and Mika, J. (2022). CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415638"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13287-017-0474-9","article-title":"CCL11 Promotes Migration and Proliferation of Mouse Neural Progenitor Cells","volume":"8","author":"Wang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.14336\/AD.2019.1229","article-title":"Age-Related CCL12 Aggravates Intracerebral Hemorrhage-Induced Brain Injury via Recruitment of Macrophages and T Lymphocytes","volume":"11","author":"Huang","year":"2020","journal-title":"Aging Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"106540","DOI":"10.1016\/j.intimp.2020.106540","article-title":"Comparison of the Beneficial Effects of RS504393, Maraviroc and Cenicriviroc on Neuropathic Pain-Related Symptoms in Rodents: Behavioral and Biochemical Analyses","volume":"84","author":"Kwiatkowski","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cyto.2019.03.007","article-title":"Chemokines CCL2 and CCL7, but Not CCL12, Play a Significant Role in the Development of Pain-Related Behavior and Opioid-Induced Analgesia","volume":"119","author":"Kwiatkowski","year":"2019","journal-title":"Cytokine"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12974-017-0867-9","article-title":"Exercise Attenuates Neurological Deficits by Stimulating a Critical HSP70\/NF-\u039aB\/IL-6\/Synapsin I Axis in Traumatic Brain Injury Rats","volume":"14","author":"Chio","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1089\/neu.2017.5102","article-title":"Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome","volume":"35","author":"Zhao","year":"2018","journal-title":"J. Neurotrauma"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12974-021-02112-3","article-title":"Recombinant CCL17-Dependent CCR4 Activation Alleviates Neuroinflammation and Neuronal Apoptosis through the PI3K\/AKT\/Foxo1 Signaling Pathway after ICH in Mice","volume":"18","author":"Deng","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1007\/s13311-020-00908-4","article-title":"Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4\/ERK\/Nrf2\/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice","volume":"17","author":"Deng","year":"2020","journal-title":"Neurotherapeutics"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1091498","DOI":"10.3389\/fnmol.2022.1091498","article-title":"The Roles of Chemokines Following Intracerebral Hemorrhage in Animal Models and Humans","volume":"15","author":"Wang","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"173166","DOI":"10.1016\/j.ejphar.2020.173166","article-title":"CCR4 Antagonist (C021) Influences the Level of Nociceptive Factors and Enhances the Analgesic Potency of Morphine in a Rat Model of Neuropathic Pain","volume":"880","author":"Bogacka","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12974-019-1499-z","article-title":"CCL20-CCR6 Axis Modulated Traumatic Brain Injury-Induced Visual Pathologies","volume":"16","author":"Das","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnmol.2012.00006","article-title":"The Cytokine Temporal Profile in Rat Cortex after Controlled Cortical Impact","volume":"5","author":"Dalgard","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12975-012-0203-8","article-title":"CCL20 Is Associated with Neurodegeneration Following Experimental Traumatic Brain Injury and Promotes Cellular Toxicity In Vitro","volume":"3","author":"Leonardo","year":"2012","journal-title":"Transl. Stroke Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"102247","DOI":"10.1016\/j.nano.2020.102247","article-title":"Treatment with ShCCL20-CCR6 Nanodendriplexes and Human Mesenchymal Stem Cell Therapy Improves Pathology in Mice with Repeated Traumatic Brain Injury","volume":"29","author":"Mayilsamy","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"114561","DOI":"10.1016\/j.expneurol.2023.114561","article-title":"Microglia-Derived CCL20 Deteriorates Neurogenesis Following Intraventricular Hemorrhage","volume":"370","author":"Yao","year":"2023","journal-title":"Exp. Neurol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neures.2009.01.017","article-title":"Macrophage Inflammatory Protein-3alpha Plays a Key Role in the Inflammatory Cascade in Rat Focal Cerebral Ischemia","volume":"64","author":"Terao","year":"2009","journal-title":"Neurosci. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12974-016-0630-7","article-title":"C-C Motif Chemokine Ligand 20 Regulates Neuroinflammation Following Spinal Cord Injury via Th17 Cell Recruitment","volume":"13","author":"Hu","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1016\/j.bbadis.2018.07.032","article-title":"Pharmacological Blockade of CXCR3 by (\u00b1)-NBI-74330 Reduces Neuropathic Pain and Enhances Opioid Effectiveness-Evidence from in Vivo and in Vitro Studies","volume":"1864","author":"Piotrowska","year":"2018","journal-title":"BBA-Mol. Basis Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/emboj.2011.89","article-title":"Neuronal CCL21 Up-Regulates Microglia P2X4 Expression and Initiates Neuropathic Pain Development","volume":"30","author":"Biber","year":"2011","journal-title":"EMBO J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3389\/fneur.2018.00964","article-title":"Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type","volume":"9","author":"Madathil","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.2147\/JIR.S361072","article-title":"Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke","volume":"15","author":"Pu","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"607370","DOI":"10.3389\/fneur.2021.607370","article-title":"Inhibition of Colony Stimulating Factor 1 Receptor Suppresses Neuroinflammation and Neonatal Hypoxic-Ischemic Brain Injury","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1182\/blood.V95.10.3032","article-title":"Chemokine Receptors and Their Role in Inflammation and Infectious Diseases","volume":"95","author":"Murdoch","year":"2000","journal-title":"Blood"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1074\/jbc.273.12.7118","article-title":"Secondary Lymphoid-Tissue Chemokine Is a Functional Ligand for the CC Chemokine Receptor CCR7","volume":"273","author":"Yoshida","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"23214","DOI":"10.1074\/jbc.M402125200","article-title":"Differential Desensitization, Receptor Phosphorylation, Beta-Arrestin Recruitment, and ERK1\/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7","volume":"279","author":"Kohout","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Scheu, S., Ali, S., Ruland, C., Arolt, V., and Alferink, J. (2017). The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112306"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M601192200","article-title":"Aryl Hydrocarbon Receptor- and Calcium-Dependent Induction of the Chemokine CCL1 by the Environmental Contaminant Benzo[a]Pyrene","volume":"281","author":"Corre","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"14495","DOI":"10.1073\/pnas.94.26.14495","article-title":"Chemotaxis in a Lymphocyte Cell Line Transfected with C-C Chemokine Receptor 2B: Evidence That Directed Migration Is Mediated by \u0392\u03b3 Dimers Released by Activation of G\u03b1i-Coupled\u2009Receptors","volume":"94","author":"Arai","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"14489","DOI":"10.1073\/pnas.94.26.14489","article-title":"Receptors Induce Chemotaxis by Releasing the Betagamma Subunit of Gi, Not by Activating Gq or Gs","volume":"94","author":"Neptune","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.287.5455.1049","article-title":"Central Role for G Protein-Coupled Phosphoinositide 3-Kinase Gamma in Inflammation","volume":"287","author":"Hirsch","year":"2000","journal-title":"Science"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1023\/B:NERE.0000021246.96864.89","article-title":"Chemokines and Glial Cells: A Complex Network in the Central Nervous System","volume":"29","author":"Ambrosini","year":"2004","journal-title":"Neurochem. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clim.2016.09.010","article-title":"An Emerging Role for Eotaxins in Neurodegenerative Disease","volume":"189","author":"Huber","year":"2018","journal-title":"Clin. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.2174\/0929867323666160607120124","article-title":"Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain","volume":"23","author":"Mika","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.intimp.2013.06.034","article-title":"Neutrophil Cell Surface Receptors and Their Intracellular Signal Transduction Pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_117","first-page":"251","article-title":"Chemokiny Jako Wa\u017cne Mediatory Stanu Zapalnego","volume":"7","author":"Henc","year":"2013","journal-title":"Forum Med. Rodz."},{"key":"ref_118","first-page":"31","article-title":"Consider the Chemokines: A Review of the Interplay between Chemokines and T Cell Subset Function","volume":"24","author":"Strazza","year":"2017","journal-title":"Discov. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/hs0302.103740","article-title":"Hypoxic-Ischemic Injury Induces Macrophage Inflammatory Protein-1alpha Expression in Immature Rat Brain","volume":"33","author":"Cowell","year":"2002","journal-title":"Stroke"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1007\/s13311-019-00821-5","article-title":"CCR1 Activation Promotes Neuroinflammation Through CCR1\/TPR1\/ERK1\/2 Signaling Pathway After Intracerebral Hemorrhage in Mice","volume":"17","author":"Yan","year":"2020","journal-title":"Neurotherapeutics"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/ana.10733","article-title":"CCR1 Is an Early and Specific Marker of Alzheimer\u2019s Disease","volume":"54","author":"Schroeder","year":"2003","journal-title":"Ann. Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1750-3639.2003.tb00490.x","article-title":"Differential Expression of the Chemokine Receptors CX3CR1 and CCR1 by Microglia and Macrophages in Myelin-Oligodendrocyte-Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis","volume":"13","author":"Sunnemark","year":"2003","journal-title":"Brain Pathol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41434-021-00285-3","article-title":"CCR1 Enhances SUMOylation of DGCR8 by Up-Regulating ERK Phosphorylation to Promote Spinal Nerve Ligation-Induced Neuropathic Pain","volume":"29","author":"Shi","year":"2021","journal-title":"Gene Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1186\/1742-2094-5-28","article-title":"Suppression of Acute Proinflammatory Cytokine and Chemokine Upregulation by Post-Injury Administration of a Novel Small Molecule Improves Long-Term Neurologic Outcome in a Mouse Model of Traumatic Brain Injury","volume":"5","author":"Lloyd","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1089\/neu.2008.0562","article-title":"Distinct Cellular Patterns of Upregulated Chemokine Expression Supporting a Prominent Inflammatory Role in Traumatic Brain Injury","volume":"25","author":"Israelsson","year":"2008","journal-title":"J. Neurotrauma"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejpain.2008.04.017","article-title":"CCL2 Is a Key Mediator of Microglia Activation in Neuropathic Pain States","volume":"13","author":"Thacker","year":"2009","journal-title":"Eur. J. Pain"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"15934","DOI":"10.1523\/JNEUROSCI.1924-15.2015","article-title":"CCL2 Mediates Neuron\u2013Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury","volume":"35","author":"Kwon","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cyto.2013.09.019","article-title":"Epigenetic Upregulation of CCL2 and CCL3 via Histone Modifications in Infiltrating Macrophages after Peripheral Nerve Injury","volume":"64","author":"Kiguchi","year":"2013","journal-title":"Cytokine"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1093\/rheumatology\/keab064","article-title":"CCL2 Produced by CD68+\/CD163+ Macrophages as a Promising Clinical Biomarker of Microscopic Polyangiitis-Interstitial Lung Disease","volume":"60","author":"Matsuda","year":"2021","journal-title":"Rheumatology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.smim.2016.04.003","article-title":"Neutrophil-Derived Chemokines on the Road to Immunity","volume":"28","author":"Tecchio","year":"2016","journal-title":"Semin. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12987-022-00365-5","article-title":"Microglia-Derived CCL2 Has a Prime Role in Neocortex Neuroinflammation","volume":"19","author":"Errede","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1523\/JNEUROSCI.3623-08.2009","article-title":"JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain","volume":"29","author":"Gao","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jlb.63.1.108","article-title":"Endogenous Monocyte Chemoattractant Protein-1 Recruits Monocytes in the Zymosan Peritonitis Model","volume":"63","author":"Ajuebor","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"113776","DOI":"10.1016\/j.celrep.2024.113776","article-title":"Modulation of Central Synapse Remodeling after Remote Peripheral Injuries by the CCL2-CCR2 Axis and Microglia","volume":"43","author":"Rotterman","year":"2024","journal-title":"Cell Rep."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12974-016-0500-3","article-title":"Inflammatory Cytokine and Chemokine Profiles Are Associated with Patient Outcome and the Hyperadrenergic State Following Acute Brain Injury","volume":"13","author":"Rhind","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/glia.10156","article-title":"LPS-Induced Expression of a Novel Chemokine Receptor (L-CCR) in Mouse Glial Cells in Vitro and in Vivo","volume":"41","author":"Zuurman","year":"2003","journal-title":"Glia"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"E106","DOI":"10.1097\/j.pain.0000000000002321","article-title":"Sympathectomy Decreases Pain Behaviors and Nerve Regeneration by Downregulating Monocyte Chemokine CCL2 in Dorsal Root Ganglia in the Rat Tibial Nerve Crush Model","volume":"163","author":"Zhu","year":"2022","journal-title":"Pain"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1742-2094-7-67","article-title":"CCL2 Modulates Cytokine Production in Cultured Mouse Astrocytes","volume":"7","author":"Semple","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e2118238119","DOI":"10.1073\/pnas.2118238119","article-title":"Skin-Resident Dendritic Cells Mediate Postoperative Pain via CCR4 on Sensory Neurons","volume":"119","author":"Silva","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.3389\/fimmu.2019.02198","article-title":"Pharmacological Blockade of Spinal CXCL3\/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury","volume":"10","author":"Piotrowska","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"750182","DOI":"10.1155\/2015\/750182","article-title":"The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy","volume":"2015","author":"Zychowska","year":"2015","journal-title":"J. Diabetes Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI81950","article-title":"CXCL13 Drives Spinal Astrocyte Activation and Neuropathic Pain via CXCR5","volume":"126","author":"Jiang","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.pharep.2018.10.002","article-title":"Kynurenic Acid and Zaprinast Diminished CXCL17-Evoked Pain-Related Behaviour and Enhanced Morphine Analgesia in a Mouse Neuropathic Pain Model","volume":"71","author":"Rojewska","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/ALN.0000000000001219","article-title":"Microglial Inhibition Influences XCL1\/XCR1 Expression and Causes Analgesic Effects in a Mouse Model of Diabetic Neuropathy","volume":"125","author":"Zychowska","year":"2016","journal-title":"Anesthesiology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1471-4159.2010.06837.x","article-title":"Reduced Inflammatory and Neuropathic Pain and Decreased Spinal Microglial Response in Fractalkine Receptor (CX3CR1) Knockout Mice","volume":"114","author":"Staniland","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.2147\/CCID.S394398","article-title":"ITGA9 Inhibits Proliferation and Migration of Dermal Microvascular Endothelial Cells in Psoriasis","volume":"15","author":"Hou","year":"2022","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7555\/JBR.32.20170057","article-title":"Atypical Chemokine Receptor CCRL2 Is Overexpressed in Prostate Cancer Cells","volume":"33","author":"Reyes","year":"2019","journal-title":"J. Biomed. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fnagi.2017.00148","article-title":"Del Role of Atypical Chemokine Receptors in Microglial Activation and Polarization","volume":"9","author":"Salvi","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ni.1675","article-title":"The Duffy Antigen Receptor for Chemokines Transports Chemokines and Supports Their Promigratory Activity","volume":"10","author":"Pruenster","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/icb.2014.90","article-title":"The Atypical Chemokine Receptor ACKR2 Suppresses Th17 Responses to Protein Autoantigens","volume":"93","author":"Hansell","year":"2015","journal-title":"Immunol. Cell Biol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11481-015-9616-y","article-title":"Pattern of CXCR7 Gene Expression in Mouse Brain Under Normal and Inflammatory Conditions","volume":"11","author":"Banisadr","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"110334","DOI":"10.1016\/j.celrep.2022.110334","article-title":"Mechanosensitive ACKR4 Scavenges CCR7 Chemokines to Facilitate T Cell De-Adhesion and Passive Transport by Flow in Inflamed Afferent Lymphatics","volume":"38","author":"Friess","year":"2022","journal-title":"Cell Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.intimp.2017.09.021","article-title":"Spinal CCL1\/CCR8 Signaling Interplay as a Potential Therapeutic Target\u2013Evidence from a Mouse Diabetic Neuropathy Model","volume":"52","author":"Zychowska","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s10787-019-00592-7","article-title":"Neuroprotective and Anti-Inflammatory Effects of Isoliquiritigenin in Kainic Acid-Induced Epileptic Rats via the TLR4\/MYD88 Signaling Pathway","volume":"27","author":"Zhu","year":"2019","journal-title":"Inflammopharmacology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"304","DOI":"10.21307\/ane-2017-029","article-title":"Upregulation of CCL3\/MIP-1alpha Regulated by MAPKs and NF-KappaB Mediates Microglial Inflammatory Response in LPS-Induced Brain Injury","volume":"76","author":"Zhu","year":"2016","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3171\/JNS\/2008\/108\/5\/0958","article-title":"Chemokine Detection in the Cerebral Tissue of Patients with Posttraumatic Brain Contusions","volume":"108","author":"Stefini","year":"2008","journal-title":"J. Neurosurg."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/jlb.62.5.681","article-title":"MIP-1alpha and MCP-1 Differentially Regulate Acute and Relapsing Autoimmune Encephalomyelitis as Well as Th1\/Th2 Lymphocyte Differentiation","volume":"62","author":"Karpus","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.4049\/jimmunol.155.10.5003","article-title":"An Important Role for the Chemokine Macrophage Inflammatory Protein-1 Alpha in the Pathogenesis of the T Cell-Mediated Autoimmune Disease, Experimental Autoimmune Encephalomyelitis","volume":"155","author":"Karpus","year":"1995","journal-title":"J. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0165-5728(98)00187-8","article-title":"Acute and Relapsing Experimental Autoimmune Encephalomyelitis Are Regulated by Differential Expression of the CC Chemokines Macrophage Inflammatory Protein-1\u03b1 and Monocyte Chemotactic Protein-1","volume":"92","author":"Kennedy","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12035-007-0036-8","article-title":"Neuronal Chemokines: Versatile Messengers in Central Nervous System Cell Interaction","volume":"36","author":"Boddeke","year":"2007","journal-title":"Mol. Neurobiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a Source and Target of Cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1167\/iovs.12-10602","article-title":"Regulation of T-Lymphocyte CCL3 and CCL4 Production by Retinal Pigment Epithelial Cells","volume":"54","author":"Wallace","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1753425911423270","article-title":"Chemokine Release by Neutrophils in Chronic Obstructive Pulmonary Disease","volume":"18","author":"Blidberg","year":"2012","journal-title":"Innate Immun."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/ALN.0000000000000190","article-title":"Chemokine (C-C Motif) Receptor 5 Is an Important Pathological Regulator in the Development and Maintenance of Neuropathic Pain","volume":"120","author":"Matsushita","year":"2014","journal-title":"Anesthesiology"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"15862","DOI":"10.1038\/srep15862","article-title":"The Chemokine MIP-1\u03b1\/CCL3 Impairs Mouse Hippocampal Synaptic Transmission, Plasticity and Memory","volume":"5","author":"Marciniak","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"14500","DOI":"10.1073\/pnas.95.24.14500","article-title":"Chemokines Regulate Hippocampal Neuronal Signaling and Gp120 Neurotoxicity","volume":"95","author":"Meucci","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_167","first-page":"8342","article-title":"Neuroinflammation in Alzheimer\u2019s Disease: Chemokines Produced by Astrocytes and Chemokine Receptors","volume":"7","author":"Liu","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0002-9440(10)65542-3","article-title":"Immunohistochemical Study of the Beta-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer\u2019s Disease Brains","volume":"153","author":"Xia","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/brain\/awv308","article-title":"MTHFSD and DDX58 Are Novel RNA-Binding Proteins Abnormally Regulated in Amyotrophic Lateral Sclerosis","volume":"139","author":"MacNair","year":"2016","journal-title":"Brain"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.4049\/jimmunol.171.11.6052","article-title":"Cross-Talk in the Innate Immune System: Neutrophils Instruct Recruitment and Activation of Dendritic Cells during Microbial Infection","volume":"171","author":"Bennouna","year":"2003","journal-title":"J. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Charmoy, M., Brunner-Agten, S., Aebischer, D., Auderset, F., Launois, P., Milon, G., Proudfoot, A.E.I., and Tacchini-Cottier, F. (2010). Neutrophil-Derived CCL3 Is Essential for the Rapid Recruitment of Dendritic Cells to the Site of Leishmania Major Inoculation in Resistant Mice. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000755"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/(SICI)1097-4547(19961215)46:6<727::AID-JNR9>3.0.CO;2-H","article-title":"Chemokine Expression in Rat Stab Wound Brain Injury","volume":"46","author":"Ghirnikar","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Makker, P.G.S., Duffy, S.S., Lees, J.G., Perera, C.J., Tonkin, R.S., Butovsky, O., Park, S.B., Goldstein, D., and Moalem-Taylor, G. (2017). Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170814"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"9998","DOI":"10.1038\/s41598-017-10201-8","article-title":"Metabotropic Glutamate Receptor 5 Deficiency Inhibits Neutrophil Infiltration after Traumatic Brain Injury in Mice","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/clin.1995.1157","article-title":"Macrophage Inflammatory Protein-I\u03b2: A C-C Chemokine in Osteoarthritis","volume":"77","author":"Koch","year":"1995","journal-title":"Clin. Immunol. Immunopathol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1464-5491.2005.01743.x","article-title":"Altered Chemokine Levels in Individuals at Risk of Type 1 Diabetes Mellitus","volume":"23","author":"Kappler","year":"2006","journal-title":"Diabet. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1034\/j.1399-3003.1999.14a27.x","article-title":"Increased MCP-1 and MIP-1\u03b2 in Bronchoalveolar Lavage Fluid of Chronic Bronchitics","volume":"14","author":"Capelli","year":"1999","journal-title":"Eur. Respir. J."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4049\/jimmunol.166.1.552","article-title":"The Chemokine RANTES Is a Crucial Mediator of the Progression from Acute to Chronic Colitis in the Rat","volume":"166","author":"Ajuebor","year":"2001","journal-title":"J. Immunol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/347669a0","article-title":"Selective Attraction of Monocytes and T Lymphocytes of the Memory Phenotype by Cytokine RANTES","volume":"347","author":"Schall","year":"1990","journal-title":"Nature"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neulet.2004.07.032","article-title":"Differential Expression of Cytokines and Chemokines during Secondary Neuron Death Following Brain Injury in Old and Young Mice","volume":"369","author":"Sandhir","year":"2004","journal-title":"Neurosci. Lett."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/jcbfm.2010.142","article-title":"The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production","volume":"31","author":"Helmy","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/TA.0b013e318160df9b","article-title":"Plasma Levels of the Beta Chemokine Regulated upon Activation, Normal T Cell Expressed, and Secreted (RANTES) Correlate with Severe Brain Injury","volume":"64","author":"Lumpkins","year":"2008","journal-title":"J. Trauma-Inj. Infect. Crit. Care"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1038\/s41380-021-01103-3","article-title":"CCL5 Promotion of Bioenergy Metabolism Is Crucial for Hippocampal Synapse Complex and Memory Formation","volume":"26","author":"Ajoy","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainres.2013.04.022","article-title":"RANTES Has a Potential to Play a Neuroprotective Role in an Autocrine\/Paracrine Manner after Ischemic Stroke","volume":"1517","author":"Tokami","year":"2013","journal-title":"Brain Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpain.2012.09.015","article-title":"Peritoneal Administration of Met-RANTES Attenuates Inflammatory and Nociceptive Responses in a Murine Neuropathic Pain Model","volume":"14","author":"Liou","year":"2013","journal-title":"J. Pain"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1523\/JNEUROSCI.21-14-05027.2001","article-title":"Chemokines and Glycoprotein 120 Produce Pain Hypersensitivity by Directly Exciting Primary Nociceptive Neurons","volume":"21","author":"Oh","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.pain.2012.03.008","article-title":"Absence of C-C Motif Chemokine Ligand 5 in Mice Leads to Decreased Local Macrophage Recruitment and Behavioral Hypersensitivity in a Murine Neuropathic Pain Model","volume":"153","author":"Liou","year":"2012","journal-title":"Pain"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jneuroim.2016.05.003","article-title":"Calcitonin Gene-Related Peptide Contributes to Peripheral Nerve Injury-Induced Mechanical Hypersensitivity through CCL5 and P38 Pathways","volume":"297","author":"Malon","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/bcpt.12099","article-title":"Involvement of Spinal CC Chemokine Ligand 5 in the Development of Bone Cancer Pain in Rats","volume":"113","author":"Hang","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1126\/sciadv.abb5943","article-title":"Eosinophilic Inflammation Promotes CCL6-Dependent Metastatic Tumor Growth","volume":"7","author":"Li","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jneuroim.2005.06.028","article-title":"Functional Expression of CCL6 by Rat Microglia: A Possible Role of CCL6 in Cell\u2013Cell Communication","volume":"167","author":"Kanno","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41392-021-00482-x","article-title":"Eosinophil-Derived Chemokine (HCCL15\/23, MCCL6) Interacts with CCR1 to Promote Eosinophilic Airway Inflammation","volume":"6","author":"Du","year":"2021","journal-title":"Signal Transduct. Target. Ther. 2021 61"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0014-5793(96)01024-1","article-title":"Structural Characterization of a Monomeric Chemokine: Monocyte Chemoattractant Protein-3","volume":"395","author":"Kim","year":"1996","journal-title":"FEBS Lett."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s13365-010-0017-y","article-title":"MCP-3\/CCL7 Production by Astrocytes: Implications for SIV Neuroinvasion and AIDS Encephalitis","volume":"17","author":"Renner","year":"2011","journal-title":"J. Neurovirol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2009.06.081","article-title":"Inflammatory Cytokines Stimulate the Chemokines CCL2\/MCP-1 and CCL7\/MCP-7 through NF\u03baB and MAPK Dependent Pathways in Rat Astrocytes","volume":"1287","author":"Thompson","year":"2009","journal-title":"Brain Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jneuroim.2003.12.025","article-title":"The Scope and Activation Mechanisms of Chemokine Gene Expression in Primary Astrocytes Following Infection with Theiler\u2019s Virus","volume":"149","author":"Palma","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cyto.2014.06.007","article-title":"The Role of CXCL12 and CCL7 Chemokines in Immune Regulation, Embryonic Development, and Tissue Regeneration","volume":"69","author":"Cheng","year":"2014","journal-title":"Cytokine"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/WNR.0000000000000625","article-title":"Neuronal-Derived Ccl7 Drives Neuropathic Pain by Promoting Astrocyte Proliferation","volume":"27","author":"Ke","year":"2016","journal-title":"Neuroreport"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1006\/bbrc.1994.1729","article-title":"Mouse Macrophage Derived Monocyte Chemotactic Protein-3: CDNA Cloning and Identification as MARC\/FIC","volume":"201","author":"Thirion","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"107975","DOI":"10.1016\/j.intimp.2021.107975","article-title":"Astrocyte-Derived CCL7 Promotes Microglia-Mediated Inflammation Following Traumatic Brain Injury","volume":"99","author":"Xue","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.4049\/jimmunol.175.2.1257","article-title":"A Non-Glycosaminoglycan-Binding Variant of CC Chemokine Ligand 7 (Monocyte Chemoattractant Protein-3) Antagonizes Chemokine-Mediated Inflammation","volume":"175","author":"Ali","year":"2005","journal-title":"J. Immunol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1189\/jlb.1A0314-170R","article-title":"The Chemotaxis of M1 and M2 Macrophages Is Regulated by Different Chemokines","volume":"97","author":"Xuan","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12974-016-0547-1","article-title":"Age Exacerbates the CCR2\/5-Mediated Neuroinflammatory Response to Traumatic Brain Injury","volume":"13","author":"Morganti","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Chou, A., Krukowski, K., Morganti, J.M., Riparip, L.K., and Rosi, S. (2018). Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061616"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/neu.2013.3029","article-title":"Temporal Course of Changes in Gene Expression Suggests a Cytokine-Related Mechanism for Long-Term Hippocampal Alteration after Controlled Cortical Impact","volume":"31","author":"Li","year":"2014","journal-title":"J. Neurotrauma"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1089\/neu.2018.6320","article-title":"Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care","volume":"36","author":"Dyhrfort","year":"2019","journal-title":"J. Neurotrauma"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.brainresbull.2017.10.009","article-title":"Chemokine CCL8 and Its Receptor CCR5 in the Spinal Cord Are Involved in Visceral Pain Induced by Experimental Colitis in Mice","volume":"135","author":"Lu","year":"2017","journal-title":"Brain Res. Bull."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1186\/s12935-021-02350-8","article-title":"Correlation of CCL8 Expression with Immune Cell Infiltration of Skin Cutaneous Melanoma: Potential as a Prognostic Indicator and Therapeutic Pathway","volume":"21","author":"Yang","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1097\/j.pain.0000000000001061","article-title":"High Levels of Cerebrospinal Fluid Chemokines Point to the Presence of Neuroinflammation in Peripheral Neuropathic Pain: A Cross-Sectional Study of 2 Cohorts of Patients Compared with Healthy Controls","volume":"158","author":"Lind","year":"2017","journal-title":"Pain"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.it.2011.06.008","article-title":"Neutrophils Cascading Their Way to Inflammation","volume":"32","author":"Sadik","year":"2011","journal-title":"Trends Immunol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/joim.12738","article-title":"CCL23: A New CC Chemokine Involved in Human Brain Damage","volume":"283","author":"Simats","year":"2018","journal-title":"J. Intern. Med."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/joim.12742","article-title":"CCL23 Is a Promising Biomarker of Injury in Patients with Ischaemic Stroke","volume":"283","author":"Bonaventura","year":"2018","journal-title":"J. Intern. Med."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cca.2022.10.012","article-title":"Serum CCL23 Emerges as a Biomarker for Poor Prognosis in Patients with Intracerebral Hemorrhage","volume":"537","author":"Lin","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1002\/1521-4141(2000)30:8<2372::AID-IMMU2372>3.0.CO;2-D","article-title":"Leukocyte Recruitment during Onset of Experimental Allergic Encephalomyelitis Is CCR1 Dependent","volume":"30","author":"Rottman","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.mcn.2015.12.013","article-title":"Blockade of IL-18 Signaling Diminished Neuropathic Pain and Enhanced the Efficacy of Morphine and Buprenorphine","volume":"71","author":"Pilat","year":"2016","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejphar.2015.05.058","article-title":"IL-1 Receptor Antagonist Improves Morphine and Buprenorphine Efficacy in a Rat Neuropathic Pain Model","volume":"764","author":"Pilat","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2013.01.072","article-title":"Importance of Glial Activation in Neuropathic Pain","volume":"716","author":"Mika","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_218","first-page":"10","article-title":"Zastosowanie Lek\u00f3w Opioidowych w Leczeniu B\u00f3lu","volume":"114","author":"Wordliczek","year":"2013","journal-title":"Wszech\u015bwiat"},{"key":"ref_219","first-page":"8","article-title":"Diagnosis and Management of Neuropathic Pain: Review of Literature and Recommendations of the Polish Society for the Study of Pain and the Neurological Society-Part One","volume":"15","author":"Szczudlik","year":"2014","journal-title":"B\u00f3l"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.2174\/156802610791561237","article-title":"CCR1 Antagonists: What Have We Learned from Clinical Trials","volume":"10","author":"Gladue","year":"2010","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/aogs.13105","article-title":"Efficacy, Safety and Tolerability of the CCR1 Antagonist BAY 86-5047 for the Treatment of Endometriosis-Associated Pelvic Pain: A Randomized Controlled Trial","volume":"96","author":"Trummer","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s12031-013-0091-8","article-title":"Chemokine CCL2 Induces Apoptosis in Cortex Following Traumatic Brain Injury","volume":"51","author":"Liu","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbr.2017.05.066","article-title":"Astrocyte-Derived CCL2 Participates in Surgery-Induced Cognitive Dysfunction and Neuroinflammation via Evoking Microglia Activation","volume":"332","author":"Xu","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneuroim.2016.04.017","article-title":"Direct and Indirect Pharmacological Modulation of CCL2\/CCR2 Pathway Results in Attenuation of Neuropathic Pain-In Vivo and in Vitro Evidence","volume":"297","author":"Piotrowska","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1742-2094-9-136","article-title":"Chemokine CCL2 and Its Receptor CCR2 in the Medullary Dorsal Horn Are Involved in Trigeminal Neuropathic Pain","volume":"9","author":"Zhang","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1523\/JNEUROSCI.2405-14.2015","article-title":"CCR2 Antagonism Alters Brain Macrophage Polarization and Ameliorates Cognitive Dysfunction Induced by Traumatic Brain Injury","volume":"35","author":"Morganti","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1161\/STROKEAHA.115.009426","article-title":"Evidence That Ly6C(Hi) Monocytes Are Protective in Acute Ischemic Stroke by Promoting M2 Macrophage Polarization","volume":"46","author":"Chu","year":"2015","journal-title":"Stroke"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1523\/JNEUROSCI.5986-10.2011","article-title":"CCL2 Released from Neuronal Synaptic Vesicles in the Spinal Cord Is a Major Mediator of Local Inflammation and Pain after Peripheral Nerve Injury","volume":"31","author":"Goazigo","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1186\/1744-8069-6-90","article-title":"Blocking Spinal CCR2 with AZ889 Reversed Hyperalgesia in a Model of Neuropathic Pain","volume":"6","author":"Serrano","year":"2010","journal-title":"Mol. Pain"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3389\/fimmu.2020.01241","article-title":"CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain","volume":"11","author":"Bogacka","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/svn-2022-001659","article-title":"CCL17 Exerts Neuroprotection through Activation of CCR4\/MTORC2 Axis in Microglia after Subarachnoid Haemorrhage in Rats","volume":"8","author":"Zhang","year":"2022","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/1673-5374.344829","article-title":"Maraviroc Promotes Recovery from Traumatic Brain Injury in Mice by Suppression of Neuroinflammation and Activation of Neurotoxic Reactive Astrocytes","volume":"18","author":"Liu","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"113604","DOI":"10.1016\/j.expneurol.2021.113604","article-title":"Pharmacological Blockers of CCR5 and CXCR4 Improve Recovery after Traumatic Brain Injury","volume":"338","author":"Shemesh","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1038\/s41401-023-01100-y","article-title":"A Novel Small-Molecular CCR5 Antagonist Promotes Neural Repair after Stroke","volume":"44","author":"Wu","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"108755","DOI":"10.1016\/j.intimp.2022.108755","article-title":"Maraviroc, an Inhibitor of Chemokine Receptor Type 5, Alleviates Neuroinflammatory Response after Cerebral Ischemia\/Reperfusion Injury via Regulating MAPK\/NF-\u039aB Signaling","volume":"108","author":"Chen","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"110855","DOI":"10.1016\/j.intimp.2023.110855","article-title":"Inflammatory Regulation by Restraining M2 Microglial Polarization: Neurodestructive Effects of Kallikrein-Related Peptidase 8 Activation in Intracerebral Hemorrhage","volume":"124","author":"Tang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuropharm.2016.04.024","article-title":"Maraviroc Reduces Neuropathic Pain through Polarization of Microglia and Astroglia\u2014Evidence from in Vivo and in Vitro Studies","volume":"108","author":"Piotrowska","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/00004647-200207000-00003","article-title":"TAK-779, a Nonpeptide CC Chemokine Receptor Antagonist, Protects the Brain against Focal Cerebral Ischemia in Mice","volume":"22","author":"Takami","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte Chemoattractant Protein-1 (MCP-1): An Overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interf. Cytokine Res."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1074\/jbc.271.20.11603","article-title":"Cloning and Functional Expression of MCCR2, a Murine Receptor for the C-C Chemokines JE and FIC","volume":"271","author":"Kurihara","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1523\/JNEUROSCI.0485-09.2009","article-title":"Visualization of Chemokine Receptor Activation in Transgenic Mice Reveals Peripheral Activation of CCR2 Receptors in States of Neuropathic Pain","volume":"29","author":"Jung","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1523\/JNEUROSCI.3016-07.2007","article-title":"Expression of CCR2 in Both Resident and Bone Marrow-Derived Microglia Plays a Critical Role in Neuropathic Pain","volume":"27","author":"Zhang","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4049\/jimmunol.1100421","article-title":"The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood","volume":"188","author":"Mizutani","year":"2012","journal-title":"J. Immunol."},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Saederup, N., Cardona, A.E., Croft, K., Mizutani, M., Cotleur, A.C., Tsou, C.L., Ransohoff, R.M., and Charo, I.F. (2010). Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-in Mice. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013693"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2010.01.002","article-title":"Chemokines, Neuronal-Glial Interactions, and Central Processing of Neuropathic Pain","volume":"126","author":"Gao","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Pawlik, K., and Mika, J. (2023). Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain. Molecules, 28.","DOI":"10.3390\/molecules28155766"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1182\/blood-2012-01-403386","article-title":"CCR2 Recruits an Inflammatory Macrophage Subpopulation Critical for Angiogenesis in Tissue Repair","volume":"120","author":"Willenborg","year":"2012","journal-title":"Blood"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1242\/dmm.003186","article-title":"Multiple Roles for CCR2 during Fracture Healing","volume":"3","author":"Xing","year":"2010","journal-title":"DMM Dis. Model. Mech."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nm1555","article-title":"Ccr2 Deficiency Impairs Microglial Accumulation and Accelerates Progression of Alzheimer-like Disease","volume":"13","author":"Toft","year":"2007","journal-title":"Nat. Med."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1523\/JNEUROSCI.0299-11.2011","article-title":"CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer\u2019s Disease","volume":"31","author":"Naert","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1002\/eji.201243084","article-title":"Traumatic Brain Injury Induces Macrophage Subsets in the Brain","volume":"43","author":"Hsieh","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1161\/01.STR.0000259709.16654.8f","article-title":"Absence of the Chemokine Receptor CCR2 Protects against Cerebral Ischemia\/Reperfusion Injury in Mice","volume":"38","author":"Dimitrijevic","year":"2007","journal-title":"Stroke"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1044-5323(02)00125-2","article-title":"The Role of MCP-1 (CCL2) and CCR2 in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis (EAE)","volume":"15","author":"Mahad","year":"2003","journal-title":"Semin. Immunol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s00125-022-05860-w","article-title":"CCR2-Positive Monocytes Contribute to the Pathogenesis of Early Diabetic Retinopathy in Mice","volume":"66","author":"Saadane","year":"2023","journal-title":"Diabetologia"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1158\/0008-5472.CAN-12-2989","article-title":"CCR2 Deficiency Prevents Neuronal Dysfunction and Cognitive Impairments Induced by Cranial Irradiation","volume":"73","author":"Belarbi","year":"2013","journal-title":"Cancer Res."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s00109-005-0637-5","article-title":"The Complex Role of the Chemokine Receptor CCR2 in Collagen-Induced Arthritis: Implications for Therapeutic Targeting of CCR2 in Rheumatoid Arthritis","volume":"83","author":"Quinones","year":"2005","journal-title":"J. Mol. Med."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5604\/1640324x.1108256","article-title":"Chemokines under Neuropathic Pain","volume":"15","author":"Kwiatkowski","year":"2014","journal-title":"B\u00f3l"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1089\/neu.2013.3252","article-title":"CCR2 Deficiency Impairs Macrophage Infiltration and Improves Cognitive Function after Traumatic Brain Injury","volume":"31","author":"Hsieh","year":"2014","journal-title":"J. Neurotrauma"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1073\/pnas.1331358100","article-title":"Impaired Neuropathic Pain Responses in Mice Lacking the Chemokine Receptor CCR2","volume":"100","author":"Abbadie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1073\/pnas.91.7.2752","article-title":"Molecular Cloning and Functional Expression of Two Monocyte Chemoattractant Protein 1 Receptors Reveals Alternative Splicing of the Carboxyl-Terminal Tails","volume":"91","author":"Charo","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1074\/jbc.272.2.1038","article-title":"Organization and Differential Expression of the Human Monocyte Chemoattractant Protein 1 Receptor Gene. Evidence for the Role of the Carboxyl-Terminal Tail in Receptor Trafficking","volume":"272","author":"Wong","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s004010100394","article-title":"CCR2A and CCR2B, the Two Isoforms of the Monocyte Chemoattractant Protein-1 Receptor Are up-Regulated and Expressed by Different Cell Subsets in Idiopathic Inflammatory Myopathies","volume":"102","author":"Bartoli","year":"2001","journal-title":"Acta Neuropathol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1161\/01.ATV.19.9.2085","article-title":"Expression of CCR2 by Endothelial Cells: Implications for MCP-1 Mediated Wound Injury Repair and In Vivo Inflammatory Activation of Endothelium","volume":"19","author":"Weber","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/01.ATV.0000134529.65173.08","article-title":"Rat Aortic MCP-1 and Its Receptor CCR2 Increase with Age and Alter Vascular Smooth Muscle Cell Function","volume":"24","author":"Spinetti","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1242\/jcs.00755","article-title":"Potential Role of MCP-1 in Endothelial Cell Tight Junction \u201cOpening\u201d: Signaling via Rho and Rho Kinase","volume":"116","author":"Stamatovic","year":"2003","journal-title":"J. Cell Sci."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Park, H.K., Na, Y.H., Nguyen, H.T., Nguyen, L.P., Hurh, S., Seong, J.Y., Lee, C.S., Ham, B.J., and Hwang, J.I. (2022). Analysis of CCR2 Splice Variant Expression Patterns and Functional Properties. Cell Biosci., 12.","DOI":"10.1186\/s13578-022-00787-6"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.celrep.2016.04.063","article-title":"Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain","volume":"15","author":"Denk","year":"2016","journal-title":"Cell Rep."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1744-8069-9-57","article-title":"Chemokine Expression in Peripheral Tissues from the Monosodium Iodoacetate Model of Chronic Joint Pain","volume":"9","author":"Dawes","year":"2013","journal-title":"Mol. Pain"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.joca.2016.11.004","article-title":"Role of the C-C Chemokine Receptor-2 in a Murine Model of Injury-Induced Osteoarthritis","volume":"25","author":"Longobardi","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jlb.65.6.744","article-title":"Differential Production of MCP-1 and Cytokine-Induced Neutrophil Chemoattractant in the Ischemic Brain after Transient Focal Ischemia in Rats","volume":"65","author":"Yamagami","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fncel.2017.00270","article-title":"Microglia: An Interface between the Loss of Neuroplasticity and Depression","volume":"11","author":"Singhal","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"109727","DOI":"10.1016\/j.celrep.2021.109727","article-title":"CCR2 Deficiency Alters Activation of Microglia Subsets in Traumatic Brain Injury","volume":"36","author":"Somebang","year":"2021","journal-title":"Cell Rep."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1073\/pnas.1910856117","article-title":"CCR2 Inhibition Reduces Tumor Myeloid Cells and Unmasks a Checkpoint Inhibitor Effect to Slow Progression of Resistant Murine Gliomas","volume":"117","author":"Luo","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jpain.2014.01.492","article-title":"Contribution of Chemokine CCL2\/CCR2 Signaling in the Dorsal Root Ganglion and Spinal Cord to the Maintenance of Neuropathic Pain in a Rat Model of Lumbar Disc Herniation","volume":"15","author":"Zhu","year":"2014","journal-title":"J. Pain"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1523\/JNEUROSCI.1850-04.2004","article-title":"A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine","volume":"24","author":"Johnston","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/MAJ.0b013e31826a82ce","article-title":"Spinal MCP-1 Contributes to the Development of Morphine Antinociceptive Tolerance in Rats","volume":"344","author":"Zhao","year":"2012","journal-title":"Am. J. Med. Sci."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.4049\/jimmunol.165.11.6519","article-title":"Mu-Opioid Induction of Monocyte Chemoattractant Protein-1, RANTES, and IFN-Gamma-Inducible Protein-10 Expression in Human Peripheral Blood Mononuclear Cells","volume":"165","author":"Wetzel","year":"2000","journal-title":"J. Immunol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"10276","DOI":"10.1073\/pnas.102327699","article-title":"Heterologous Desensitization of Opioid Receptors by Chemokines Inhibits Chemotaxis and Enhances the Perception of Pain","volume":"99","author":"Szabo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jneuroim.2004.08.010","article-title":"The Expression of RANTES and Chemokine Receptors in the Brains of Scrapie-Infected Mice","volume":"158","author":"Lee","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cyto.2015.09.012","article-title":"Upregulated Expression of CCR3 in Osteoarthritis and CCR3 Mediated Activation of Fibroblast-like Synoviocytes","volume":"77","author":"Chang","year":"2016","journal-title":"Cytokine"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/exmp.2000.2336","article-title":"Immunohistochemical Analysis of CCR2, CCR3, CCR5, and CXCR4 in the Human Brain: Potential Mechanisms for HIV Dementia","volume":"69","author":"Ulrich","year":"2000","journal-title":"Exp. Mol. Pathol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"ENEURO.0185-16.2016","DOI":"10.1523\/ENEURO.0185-16.2016","article-title":"High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death","volume":"3","author":"Zhang","year":"2016","journal-title":"eNeuro"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bj.2018.01.002","article-title":"Complex Role of Chemokine Mediators in Animal Models of Alzheimer\u2019s Disease","volume":"41","author":"Martin","year":"2018","journal-title":"Biomed. J."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1128\/JVI.73.1.205-213.1999","article-title":"Microglia Express CCR5, CXCR4, and CCR3, but of These, CCR5 Is the Principal Coreceptor for Human Immunodeficiency Virus Type 1 Dementia Isolates","volume":"73","author":"Albright","year":"1999","journal-title":"J. Virol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1398-9995.2006.01253.x","article-title":"T Lymphocytes Expressing CCR3 Are Increased in Allergic Rhinitis Compared with Non-Allergic Controls and Following Allergen Immunotherapy","volume":"62","author":"Francis","year":"2007","journal-title":"Allergy Eur. J. Allergy Clin. Immunol."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0165-5728(03)00009-2","article-title":"Regulation of Chemokine Receptor Expression in Human Microglia and Astrocytes","volume":"136","author":"Flynn","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0002-9440(10)61235-7","article-title":"Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in Bleomycin-Induced Lung Injury and Fibrosis","volume":"167","author":"Huaux","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1073\/pnas.261462598","article-title":"The Murine CCR3 Receptor Regulates Both the Role of Eosinophils and Mast Cells in Allergen-Induced Airway Inflammation and Hyperresponsiveness","volume":"99","author":"Humbles","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1517\/13543784.9.1.43","article-title":"CCR3 Blockade as a New Therapy for Asthma","volume":"9","author":"Bertrand","year":"2000","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"36842","DOI":"10.18632\/oncotarget.9209","article-title":"Crosstalk between CCL7 and CCR3 Promotes Metastasis of Colon Cancer Cells via ERK-JNK Signaling Pathways","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jdermsci.2013.04.011","article-title":"The Chemokine Receptor CCR3 Participates in Tissue Remodeling during Atopic Skin Inflammation","volume":"71","author":"Gaspar","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"Toyoda, H., Honda, Y., Tanaka, S., Miyagawa, T., Honda, M., Honda, K., Tokunaga, K., and Kodama, T. (2017). Narcolepsy Susceptibility Gene CCR3 Modulates Sleep-Wake Patterns in Mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187888"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.1038\/s41598-017-05654-w","article-title":"CCL11, a Novel Mediator of Inflammatory Bone Resorption","volume":"7","author":"Kindstedt","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"174480692311693","DOI":"10.1177\/17448069231169373","article-title":"Chemokine CCL7 Mediates Trigeminal Neuropathic Pain via CCR2\/CCR3-ERK Pathway in the Trigeminal Ganglion of Mice","volume":"19","author":"Zhu","year":"2023","journal-title":"Mol. Pain"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s13760-022-01984-3","article-title":"Eotaxin-1 (CCL11) in Neuroinflammatory Disorders and Possible Role in COVID-19 Neurologic Complications","volume":"122","author":"Nazarinia","year":"2022","journal-title":"Acta Neurol. Belg."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.0212074","article-title":"CCL26\/Eotaxin-3 Is More Effective to Induce the Migration of Eosinophils of Asthmatics than CCL11\/Eotaxin-1 and CCL24\/Eotaxin-2","volume":"94","author":"Provost","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.4049\/jimmunol.169.5.2712","article-title":"Eotaxin (CCL11) and Eotaxin-2 (CCL24) Induce Recruitment of Eosinophils, Basophils, Neutrophils, and Macrophages as Well as Features of Early- and Late-Phase Allergic Reactions Following Cutaneous Injection in Human Atopic and Nonatopic Volunteers","volume":"169","author":"Ying","year":"2002","journal-title":"J. Immunol."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/0004563213506413","article-title":"Altered Profile of Chemokines in Fibromyalgia Patients","volume":"51","author":"Cidoncha","year":"2014","journal-title":"Ann. Clin. Biochem."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/1947603518764280","article-title":"Synovial Fluid Eotaxin-1 Levels May Reflect Disease Progression in Primary Knee Osteoarthritis Among Elderly Han Chinese: A Cross-Sectional Study","volume":"10","author":"Li","year":"2019","journal-title":"Cartilage"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3389\/fimmu.2019.00978","article-title":"Current Clinical Trials in Pemphigus and Pemphigoid","volume":"10","author":"Izumi","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Pelletier, J.P.R., and Mukhtar, F. (2020). Passive Monoclonal and Polyclonal Antibody Therapies. Immunol. Concepts Transfus. Med., 251\u2013348.","DOI":"10.1016\/B978-0-323-67509-3.00016-0"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3389\/fphar.2018.01240","article-title":"Heteromerization Modulates Mu Opioid Receptor Functional Properties in Vivo","volume":"9","author":"Ugur","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fimmu.2020.00094","article-title":"Bidirectional Regulation of Opioid and Chemokine Function","volume":"11","author":"Rogers","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuropharm.2012.10.030","article-title":"Decreased Pain Responses of C-C Chemokine Receptor 5 Knockout Mice to Chemical or Inflammatory Stimuli","volume":"67","author":"Lee","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1165\/rcmb.2020-0425OC","article-title":"Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3","volume":"64","author":"Shah","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41419-020-2306-6","article-title":"Blocking the Autocrine Regulatory Loop of Gankyrin\/STAT3\/CCL24\/CCR3 Impairs the Progression and Pazopanib Resistance of Clear Cell Renal Cell Carcinoma","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/intimm\/dxu079","article-title":"CCR4 and Its Ligands: From Bench to Bedside","volume":"27","author":"Yoshie","year":"2015","journal-title":"Int. Immunol."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.yexcr.2011.01.004","article-title":"Chemokine Oligomerization and Interactions with Receptors and Glycosaminoglycans: The Role of Structural Dynamics in Function","volume":"317","author":"Salanga","year":"2011","journal-title":"Exp. Cell Res."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.injury.2009.09.001","article-title":"Immune Response Deviation and Enhanced Expression of Chemokine Receptor CCR4 in TBI Patients Due to Unknown Serum Factors","volume":"41","author":"Cadosch","year":"2010","journal-title":"Injury"},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Yoshie, O. (2021). CCR4 as a Therapeutic Target for Cancer Immunotherapy. Cancers, 13.","DOI":"10.3390\/cancers13215542"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"876033","DOI":"10.3389\/fimmu.2022.876033","article-title":"CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation","volume":"13","author":"Kim","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10571-019-00669-5","article-title":"CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia\/Macrophage Toward M1 Polarization Through CCR4","volume":"39","author":"Chen","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1111\/cns.14368","article-title":"Monocyte-Related Cytokines\/Chemokines in Cerebral Ischemic Stroke","volume":"29","author":"Bai","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"ref_314","doi-asserted-by":"crossref","unstructured":"Kiguchi, N., Ding, H., Peters, C.M., Kock, N.D., Kishioka, S., Cline, J.M., Wagner, J.D., and Ko, M.C. (2017). Altered Expression of Glial Markers, Chemokines, and Opioid Receptors in the Spinal Cord of Type 2 Diabetic Monkeys. Biochim. Biophys. Acta, 1863.","DOI":"10.1016\/j.bbadis.2016.10.007"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuroscience.2020.06.025","article-title":"Blockade of CCR4 Diminishes Hypersensitivity and Enhances Opioid Analgesia\u2013Evidence from a Mouse Model of Diabetic Neuropathy","volume":"441","author":"Bogacka","year":"2020","journal-title":"Neuroscience"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1440-1843.2006.00822.x","article-title":"Asthma Severity Is Associated with an Increase in Both Blood CXCR3+ and CCR4+ T Cells","volume":"11","author":"Kurashima","year":"2006","journal-title":"Respirology"},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"e12239","DOI":"10.1002\/clt2.12239","article-title":"Association of Asthma Genetic Variants with Asthma-Associated Traits Reveals Molecular Pathways of Eosinophilic Asthma","volume":"13","author":"Vonk","year":"2023","journal-title":"Clin. Transl. Allergy"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1067\/mai.2001.113237","article-title":"Thymus and Activation-Regulated Chemokine in Atopic Dermatitis: Serum Thymus and Activation-Regulated Chemokine Level Is Closely Related with Disease Activity","volume":"107","author":"Kakinuma","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"12362","DOI":"10.1038\/s41598-017-10267-4","article-title":"Up-Regulation of Chemokine Receptor CCR4 Is Associated with Human Hepatocellular Carcinoma Malignant Behavior","volume":"7","author":"Cheng","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1055\/s-0043-113455","article-title":"Ginger Extract Modulates the Expression of Chemokines CCL20 and CCL22 and Their Receptors (CCR6 and CCR4) in the Central Nervous System of Mice with Experimental Autoimmune Encephalomyelitis","volume":"67","author":"Jafarzadeh","year":"2017","journal-title":"Drug Res."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1046\/j.1471-4159.2002.01091.x","article-title":"Characterization of Chemokines and Their Receptors in the Central Nervous System: Physiopathological Implications","volume":"82","author":"Bajetto","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/geno.1996.4552","article-title":"Assignment of the Human CC Chemokine Gene TARC (SCYA17) to Chromosome 16q13","volume":"40","author":"Nomiyama","year":"1997","journal-title":"Genomics"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/glia.23507","article-title":"CCL17 Exerts a Neuroimmune Modulatory Function and Is Expressed in Hippocampal Neurons","volume":"66","author":"Offermann","year":"2018","journal-title":"Glia"},{"key":"ref_324","doi-asserted-by":"crossref","unstructured":"Dai, Y., Wu, Z., Wang, F., Zhang, Z., and Yu, M. (2014). Identification of Chemokines and Growth Factors in Proliferative Diabetic Retinopathy Vitreous. BioMed. Res. Int., 2014.","DOI":"10.1155\/2014\/486386"},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L","article-title":"Dendritic Cells as a Major Source of Macrophage-Derived Chemokine\/CCL22 in Vitro and in Vivo","volume":"31","author":"Vulcano","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1615\/CritRevImmunol.v22.i2.10","article-title":"Regulation of Macrophage-Derived Chemokine (MDC, CCL22) Production","volume":"22","author":"Yamashita","year":"2002","journal-title":"Crit. Rev. Immunol."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1084\/jem.20170277","article-title":"CCL22 Controls Immunity by Promoting Regulatory T Cell Communication with Dendritic Cells in Lymph Nodes","volume":"216","author":"Rapp","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1074\/jbc.273.3.1764","article-title":"Macrophage-Derived Chemokine Is a Functional Ligand for the CC Chemokine Receptor 4","volume":"273","author":"Imai","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/eji.200324429","article-title":"Dominance of CCL22 over CCL17 in Induction of Chemokine Receptor CCR4 Desensitization and Internalization on Human Th2 Cells","volume":"34","author":"Mariani","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3389\/fphar.2019.00579","article-title":"Combination of G-CSF and AMD3100 Improves the Anti-Inflammatory Effect of Mesenchymal Stem Cells on Inducing M2 Polarization of Macrophages through NF-\u039aB-IL1RA Signaling Pathway","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"14746","DOI":"10.1038\/srep14746","article-title":"A Strategy to Discover Decoy Chemokine Ligands with an Anti-Inflammatory Activity","volume":"5","author":"Abboud","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_332","first-page":"3072","article-title":"Chemokine CCL17 Induced by Hypoxia Promotes the Proliferation of Cervical Cancer Cell","volume":"5","author":"Liu","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"ref_333","doi-asserted-by":"crossref","unstructured":"Dogan, R.-N.E., Long, N., Forde, E., Dennis, K., Kohm, A.P., Miller, S.D., and Karpus, W.J. (2011). CCL22 Regulates Experimental Autoimmune Encephalomyelitis by Controlling Inflammatory Macrophage Accumulation and Effector Function. J. Leukoc. Biol., 89.","DOI":"10.1189\/jlb.0810442"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.2174\/15680266106061335","article-title":"Antagonists of CCR4 as Immunomodulatory Agents","volume":"6","author":"Purandare","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.bmcl.2005.02.084","article-title":"Identification of Chemokine Receptor CCR4 Antagonist","volume":"15","author":"Purandare","year":"2005","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_336","doi-asserted-by":"crossref","unstructured":"Cahn, A., Hodgson, S., Wilson, R., Robertson, J., Watson, J., Beerahee, M., Hughes, S.C., Young, G., Graves, R., and Hall, D. (2013). Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2239633, a CC-Chemokine Receptor 4 Antagonist, in Healthy Male Subjects: Results from an Open-Label and from a Randomised Study. BMC Pharmacol. Toxicol., 14.","DOI":"10.1186\/2050-6511-14-14"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1016\/j.bmc.2008.07.062","article-title":"Potent CCR4 Antagonists: Synthesis, Evaluation, and Docking Study of 2,4-Diaminoquinazolines","volume":"16","author":"Yokoyama","year":"2008","journal-title":"Bioorganic Med. Chem."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bmc.2008.11.020","article-title":"Potent and Orally Bioavailable CCR4 Antagonists: Synthesis and Structure-Activity Relationship Study of 2-Aminoquinazolines","volume":"17","author":"Yokoyama","year":"2009","journal-title":"Bioorganic Med. Chem."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1742-2094-11-121","article-title":"Neuronal CCL2 Is Upregulated during Hepatic Encephalopathy and Contributes to Microglia Activation and Neurological Decline","volume":"11","author":"McMillin","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.2217\/imt.14.94","article-title":"Mogamulizumab and the Treatment of CCR4-Positive T-Cell Lymphomas","volume":"6","author":"Remer","year":"2014","journal-title":"Immunotherapy"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1158\/1078-0432.CCR-19-1090","article-title":"A Phase I Study of the Anti-CC Chemokine Receptor 4 Antibody, Mogamulizumab, in Combination with Nivolumab in Patients with Advanced or Metastatic Solid Tumors","volume":"25","author":"Doi","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/sj.cdd.4402006","article-title":"HIV-1 Coreceptors CCR5 and CXCR4 Both Mediate Neuronal Cell Death but CCR5 Paradoxically Can Also Contribute to Protection","volume":"14","author":"Kaul","year":"2007","journal-title":"Cell Death Differ."},{"key":"ref_343","first-page":"1341","article-title":"Cellular Localization of the Chemokine Receptor CCR5: Correlation to Cellular Targets of HIV-1 Infection","volume":"151","author":"Rottman","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"e20985","DOI":"10.7554\/eLife.20985","article-title":"CCR5 Is a Suppressor for Cortical Plasticity and Hippocampal Learning and Memory","volume":"5","author":"Zhou","year":"2016","journal-title":"Elife"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2019.01.044","article-title":"CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury","volume":"176","author":"Joy","year":"2019","journal-title":"Cell"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1523\/JNEUROSCI.5171-04.2005","article-title":"Migration of Perilesional Microglia after Focal Brain Injury and Modulation by CC Chemokine Receptor 5: An in Situ Time-Lapse Confocal Imaging Study","volume":"25","author":"Carbonell","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1523\/JNEUROSCI.4303-03.2004","article-title":"Neurons and Astrocytes Respond to Prion Infection by Inducing Microglia Recruitment","volume":"24","author":"Marella","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"31305","DOI":"10.1074\/jbc.M001269200","article-title":"Morphine Induces Gene Expression of CCR5 in Human CEM X174 Lymphocytes","volume":"275","author":"Miyagi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_349","first-page":"1744","article-title":"Involvement of the Chemokine CCL3 and the Purinoceptor P2\u00d77 in the Spinal Cord in Paclitaxel-Induced Mechanical Allodynia","volume":"10","author":"Nagata","year":"2014","journal-title":"Mol. Pain"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1128\/CDLI.7.5.719-723.2000","article-title":"Detection and Function of Opioid Receptors on Cells from the Immune System","volume":"7","author":"Bidlack","year":"2000","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_351","doi-asserted-by":"crossref","unstructured":"Mika, J., Popiolek-Barczyk, K., Rojewska, E., Makuch, W., Starowicz, K., and Przewlocka, B. (2014). Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104420"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1471-4159.2011.07549.x","article-title":"Modulatory Effects of the CCR5 Antagonist Maraviroc on Microglial Pro-Inflammatory Activation Elicited by Gp120","volume":"120","author":"Lisi","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1517\/13543770802641353","article-title":"Chemokine Receptor Antagonists: Part 2","volume":"19","author":"Pease","year":"2009","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1359-6101(03)00049-2","article-title":"The CC Chemokine CCL20 and Its Receptor CCR6","volume":"14","author":"Schutyser","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3389\/fimmu.2017.01871","article-title":"Expression of Membrane-Bound CC Chemokine Ligand 20 on Follicular T Helper Cells in T-B-Cell Conjugates","volume":"8","author":"Lee","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"14849","DOI":"10.18632\/aging.103548","article-title":"Targeting CCL20 Inhibits Subarachnoid Hemorrhage-Related Neuroinflammation in Mice","volume":"12","author":"Liao","year":"2020","journal-title":"Aging"},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C Chemokine Receptor 6-Regulated Entry of TH-17 Cells into the CNS through the Choroid Plexus Is Required for the Initiation of EAE","volume":"10","author":"Reboldi","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbrc.2022.11.088","article-title":"CCL20\/CCR6 Chemokine Signaling Is Not Essential for Pathogenesis in an Experimental Autoimmune Encephalomyelitis Mouse Model of Multiple Sclerosis","volume":"641","author":"Sachi","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_359","doi-asserted-by":"crossref","unstructured":"Coursey, T.G., Gandhi, N.B., Volpe, E.A., Pflugfelder, S.C., and De Paiva, C.S. (2013). Chemokine Receptors CCR6 and CXCR3 Are Necessary for CD4(+) T Cell Mediated Ocular Surface Disease in Experimental Dry Eye Disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078508"},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1007\/s10753-023-01807-4","article-title":"Identification of CCL20 as a Key Biomarker of Inflammatory Responses in the Pathogenesis of Intracerebral Hemorrhage","volume":"46","author":"Zheng","year":"2023","journal-title":"Inflammation"},{"key":"ref_361","doi-asserted-by":"crossref","unstructured":"L\u00f6tsch, J., Mustonen, L., Harno, H., and Kalso, E. (2022). Machine-Learning Analysis of Serum Proteomics in Neuropathic Pain after Nerve Injury in Breast Cancer Surgery Points at Chemokine Signaling via SIRT2 Regulation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073488"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1515\/sjpain-2021-0195","article-title":"Association between Systemic Inflammation and Experimental Pain Sensitivity in Subjects with Pain and Painless Neuropathy after Traumatic Nerve Injuries","volume":"23","author":"Miclescu","year":"2023","journal-title":"Scand. J. Pain"},{"key":"ref_363","doi-asserted-by":"crossref","unstructured":"Alrumaihi, F. (2022). The Multi-Functional Roles of CCR7 in Human Immunology and as a Promising Therapeutic Target for Cancer Therapeutics. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.834149"},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2010.06.018","article-title":"CCR7 Is Expressed in Astrocytes and Upregulated after an Inflammatory Injury","volume":"227","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1471-4159.2006.04272.x","article-title":"CCR7, CCR8, CCR9 and CCR10 in the Mouse Hippocampal CA1 Area and the Dentate Gyrus during and after Pilocarpine-Induced Status Epilepticus","volume":"100","author":"Liu","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_366","doi-asserted-by":"crossref","unstructured":"J\u00f6nsson, M., Gerdle, B., Ghafouri, B., and B\u00e4ckryd, E. (2021). The Inflammatory Profile of Cerebrospinal Fluid, Plasma, and Saliva from Patients with Severe Neuropathic Pain and Healthy Controls-a Pilot Study. BMC Neurosci., 22.","DOI":"10.1186\/s12868-021-00608-5"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3389\/fneur.2021.540660","article-title":"Nerve Growth Factor Enhances Tooth Mechanical Hyperalgesia Through C-C Chemokine Ligand 19 in Rats","volume":"12","author":"Guo","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"8893","DOI":"10.1523\/JNEUROSCI.2209-07.2007","article-title":"Modulation of Thalamic Nociceptive Processing after Spinal Cord Injury through Remote Activation of Thalamic Microglia by Cysteine\u2013Cysteine Chemokine Ligand 21","volume":"27","author":"Zhao","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1189\/jlb.2MR0815-380R","article-title":"Common and Biased Signaling Pathways of the Chemokine Receptor CCR7 Elicited by Its Ligands CCL19 and CCL21 in Leukocytes","volume":"99","author":"Hauser","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"ref_370","doi-asserted-by":"crossref","unstructured":"Chen, Y., Liang, L., Cao, S., Hou, G., Zhang, Q., Ma, H., and Shi, B. (2020). Serum CCL21 as a Potential Biomarker for Cognitive Impairment in Spinal Cord Injury. BioMed Res. Int., 2020.","DOI":"10.1155\/2020\/6692802"},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.4049\/jimmunol.168.7.3221","article-title":"Secondary Lymphoid Tissue Chemokine (CCL21) Activates CXCR3 to Trigger a Cl\u2212 Current and Chemotaxis in Murine Microglia","volume":"168","author":"Rappert","year":"2002","journal-title":"J. Immunol."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2013.04.011","article-title":"Dichotomy of CCL21 and CXCR3 in Nerve Injury-Evoked and Autoimmunity-Evoked Hyperalgesia","volume":"32","author":"Schmitz","year":"2013","journal-title":"Brain. Behav. Immun."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1006\/geno.1994.1553","article-title":"Cloning of Human and Mouse EBI1, a Lymphoid-Specific G-Protein-Coupled Receptor Encoded on Human Chromosome 17q12-Q21.2","volume":"23","author":"Schweickart","year":"1994","journal-title":"Genomics"},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.cell.2019.07.028","article-title":"Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7","volume":"178","author":"Jaeger","year":"2019","journal-title":"Cell"},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/acs.biochem.9b00893","article-title":"The Inside Story: Crystal Structure of the Chemokine Receptor CCR7 with an Intracellular Allosteric Antagonist","volume":"59","author":"Saha","year":"2020","journal-title":"Biochemistry"},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1177\/2472555218780917","article-title":"Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen","volume":"23","author":"Porter","year":"2018","journal-title":"SLAS Discov. Adv. Life Sci. Drug Discov."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"588","DOI":"10.4049\/jimmunol.170.1.588","article-title":"Antagonist of Secondary Lymphoid-Tissue Chemokine (CCR Ligand 21) Prevents the Development of Chronic Graft-versus-Host Disease in Mice","volume":"170","author":"Sasaki","year":"2003","journal-title":"J. Immunol."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"40276","DOI":"10.1074\/jbc.M405808200","article-title":"Inhibition of Generation of Cytotoxic T Lymphocyte Activity by a CCL19\/Macrophage Inflammatory Protein (MIP)-3beta Antagonist","volume":"279","author":"Pilkington","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_379","doi-asserted-by":"crossref","unstructured":"Salem, A., Alotaibi, M., Mroueh, R., Basheer, H.A., and Afarinkia, K. (2021). CCR7 as a Therapeutic Target in Cancer. Biochim. Biophys. Acta Rev. Cancer, 1875.","DOI":"10.1016\/j.bbcan.2020.188499"},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(00)80059-8","article-title":"CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs","volume":"99","author":"Schubel","year":"1999","journal-title":"Cell"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/eji.201344330","article-title":"CCR7-Mediated Migration in the Thymus Controls \u0393\u03b4 T-Cell Development","volume":"44","author":"Reinhardt","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1084\/jem.20061405","article-title":"CCR7 Is Required for the in Vivo Function of CD4+ CD25+ Regulatory T Cells","volume":"204","author":"Schneider","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1084\/jem.186.1.165","article-title":"Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309","volume":"186","author":"Tiffany","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.4049\/jimmunol.143.9.2907","article-title":"A Novel Polypeptide Secreted by Activated Human T Lymphocytes","volume":"143","author":"Miller","year":"1989","journal-title":"J. Immunol."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1084\/jem.20130240","article-title":"Identification of Human CCR8 as a CCL18 Receptor","volume":"210","author":"Islam","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_386","doi-asserted-by":"crossref","unstructured":"Moser, B. (2022). Chemokine Receptor-Targeted Therapies: Special Case for CCR8. Cancers, 14.","DOI":"10.3390\/cancers14030511"},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.4049\/jimmunol.174.8.5082","article-title":"CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation","volume":"174","author":"Gombert","year":"2005","journal-title":"J. Immunol."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1038\/s41598-019-45653-7","article-title":"CCR8 Leads to Eosinophil Migration and Regulates Neutrophil Migration in Murine Allergic Enteritis","volume":"9","author":"Kato","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/01616412.2023.2257454","article-title":"MiR-184-5p Represses Neuropathic Pain by Regulating CCL1\/CCR8 Signaling Interplay in the Spinal Cord in Diabetic Mice","volume":"46","author":"Wu","year":"2024","journal-title":"Neurol. Res."},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4110\/in.2011.11.4.203","article-title":"Identification of CCL1 as a Gene Differentially Expressed in CD4+ T Cells Expressing TIM-3","volume":"11","author":"Jun","year":"2011","journal-title":"Immune Netw."},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bbrc.2013.05.126","article-title":"Effects of Chemokine (C-C Motif) Ligand 1 on Microglial Function","volume":"436","author":"Akimoto","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"16614","DOI":"10.1002\/jcb.28920","article-title":"MiR-21-5p Inhibits Neuropathic Pain Development via Directly Targeting C-C Motif Ligand 1 and Tissue Inhibitor of Metalloproteinase-3","volume":"120","author":"Zhong","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.4049\/jimmunol.162.10.5671","article-title":"Cutting Edge: Identification of the Orphan Chemokine Receptor GPR-9-6 as CCR9, the Receptor for the Chemokine TECK","volume":"162","author":"Zaballos","year":"1999","journal-title":"J. Immunol."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.intimp.2018.04.049","article-title":"MLN3126, an Antagonist of the Chemokine Receptor CCR9, Ameliorates Inflammation in a T Cell Mediated Mouse Colitis Model","volume":"60","author":"Igaki","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1053\/j.gastro.2011.01.044","article-title":"The Chemokine Receptor CCR9 Is Required for the T-Cell-Mediated Regulation of Chronic Ileitis in Mice","volume":"140","author":"Wermers","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.humpath.2014.02.021","article-title":"Strong Expression of Chemokine Receptor CCR9 in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma Strongly Correlates with Gastrointestinal Involvement","volume":"45","author":"Wu","year":"2014","journal-title":"Hum. Pathol."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13045-016-0236-7","article-title":"CCR9 in Cancer: Oncogenic Role and Therapeutic Targeting","volume":"9","author":"Tu","year":"2016","journal-title":"J. Hematol. Oncol."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.4049\/jimmunol.164.3.1293","article-title":"CCR9A and CCR9B: Two Receptors for the Chemokine CCL25\/TECK\/Ck Beta-15 That Differ in Their Sensitivities to Ligand","volume":"164","author":"Yu","year":"2000","journal-title":"J. Immunol."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1126\/science.7694365","article-title":"Controlling Signal Transduction with Synthetic Ligands","volume":"262","author":"Spencer","year":"1993","journal-title":"Science"},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1124\/jpet.110.169714","article-title":"Characterization of CCX282-B, an Orally Bioavailable Antagonist of the CCR9 Chemokine Receptor, for Treatment of Inflammatory Bowel Disease","volume":"335","author":"Walters","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_401","doi-asserted-by":"crossref","unstructured":"Wu, X., Sun, M., Yang, Z., Lu, C., Wang, Q., Wang, H., Deng, C., Liu, Y., and Yang, Y. (2021). The Roles of CCR9\/CCL25 in Inflammation and Inflammation-Associated Diseases. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.686548"},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11481-019-09854-1","article-title":"Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25\/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis","volume":"14","author":"Zhang","year":"2019","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"e2303402","DOI":"10.1002\/advs.202303402","article-title":"Bone Marrow-Derived GCA+ Immune Cells Drive Alzheimer\u2019s Disease Progression","volume":"10","author":"Zhou","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.18632\/oncotarget.2134","article-title":"Upregulation of Chemokine Receptor CCR10 Is Essential for Glioma Proliferation, Invasion and Patient Survival","volume":"5","author":"Chen","year":"2014","journal-title":"Oncotarget"},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41419-018-0267-9","article-title":"The Chemokine Receptor CCR10 Promotes Inflammation-Driven Hepatocarcinogenesis via PI3K\/Akt Pathway Activation","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nm0202-157","article-title":"CCL27-CCR10 Interactions Regulate T Cell-Mediated Skin Inflammation","volume":"8","author":"Homey","year":"2002","journal-title":"Nat. Med."},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0625.2007.00630.x","article-title":"CCR4 and CCR10 Ligands Play Additive Roles in Mouse Contact Hypersensitivity","volume":"17","author":"Mirshahpanah","year":"2008","journal-title":"Exp. Dermatol."},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"27935","DOI":"10.1074\/jbc.M703255200","article-title":"Small Molecule Receptor Agonists and Antagonists of CCR3 Provide Insight into Mechanisms of Chemokine Receptor Activation","volume":"282","author":"Wise","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1007\/s00018-008-8666-1","article-title":"Modulation of Chemokine Receptor Activity through Dimerization and Crosstalk","volume":"66","author":"Salanga","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1021\/acsmedchemlett.1c00373","article-title":"BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate","volume":"12","author":"Cherney","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.ekir.2018.07.010","article-title":"Effect of PF-04634817, an Oral CCR2\/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy","volume":"3","author":"Gale","year":"2018","journal-title":"Kidney Int. Rep."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/QAD.0000000000000988","article-title":"A 48-Week Randomized Phase 2b Study Evaluating Cenicriviroc versus Efavirenz in Treatment-Naive HIV-Infected Adults with C-C Chemokine Receptor Type 5-Tropic Virus","volume":"30","author":"Thompson","year":"2016","journal-title":"AIDS"},{"key":"ref_413","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1358\/dot.2007.43.11.1131763","article-title":"Maraviroc","volume":"43","author":"Fadel","year":"2007","journal-title":"Drugs Today"},{"key":"ref_414","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1189\/jlb.2MR0815-383R","article-title":"VCCL2\/VMIP-II, the Viral Master KEYmokine","volume":"99","author":"Szpakowska","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1128\/JVI.77.13.7393-7400.2003","article-title":"The Virus-Encoded Chemokine VMIP-II Inhibits Virus-Induced Tc1-Driven Inflammation","volume":"77","author":"Lindow","year":"2003","journal-title":"J. Virol."},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41392-021-00516-4","article-title":"Study on the Promotion of Lymphocytes in Patients with COVID-19 by Broad-Spectrum Chemokine Receptor Inhibitor VMIP-II and Its Mechanism of Signal Transmission in Vitro","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/7\/3788\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:20:13Z","timestamp":1760106013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/7\/3788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":416,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["ijms25073788"],"URL":"https:\/\/doi.org\/10.3390\/ijms25073788","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]}}}