{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:59:50Z","timestamp":1788325190908,"version":"build-2803163510"},"reference-count":27,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["NRF-2022R1C1C1002705"],"award-info":[{"award-number":["NRF-2022R1C1C1002705"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Soonchunhyang University Research Fund","award":["NRF-2022R1C1C1002705"],"award-info":[{"award-number":["NRF-2022R1C1C1002705"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Visceral adiposity is known to be related to poor prognosis in patients with cholangiocarcinoma; however, the prognostic significance of the qualitative features of adipose tissue in cholangiocarcinoma has yet to be well defined. This study investigated the prognostic impact of adipose tissue imaging parameters reflecting the quantity and qualitative characteristics of subcutaneous (SAT) and visceral (VAT) adipose tissue on recurrence-free survival (RFS) and overall survival (OS) in 94 patients undergoing resection of cholangiocarcinoma. The area, mean computed tomography (CT) attenuation, and mean 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake of SAT and VAT on positron emission tomography (PET)\/CT for staging work-up were measured, and the relationship of these adipose tissue imaging parameters with clinicopathological factors and survival was assessed. TNM stage, histologic grade, lymphovascular invasion, and the size of cholangiocarcinoma showed positive correlations with adipose tissue imaging parameters. Multivariate survival analysis demonstrated that the visceral-to-subcutaneous adipose tissue area ratio (VSR) (p = 0.024; hazard ratio, 1.718) and mean FDG uptake of VAT (p = 0.033; hazard ratio, 9.781) were significant predictors for RFS, but all of the adipose tissue imaging parameters failed to show statistical significance for predicting OS. In addition to visceral adiposity, FDG uptake of VAT might be a promising prognostic parameter for predicting RFS in patients with cholangiocarcinoma.<\/jats:p>","DOI":"10.3390\/ijms25073939","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T07:18:28Z","timestamp":1711955908000},"page":"3939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prognostic Impact of Visceral Adipose Tissue Imaging Parameters in Patients with Cholangiocarcinoma after Surgical Resection"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-3578","authenticated-orcid":false,"given":"Jeong Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-2375","authenticated-orcid":false,"given":"Ik Dong","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-pyo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beodeul","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Kil","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ho","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-6830","authenticated-orcid":false,"given":"Su Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-3807","authenticated-orcid":false,"given":"Sang Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/liv.14093","article-title":"Anatomical, histomorphological and molecular classification of cholangiocarcinoma","volume":"39","author":"Kendall","year":"2019","journal-title":"Liver Int."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Qurashi, M., Vithayathil, M., and Khan, S.A. (2023). Epidemiology of cholangiocarcinoma. Eur. J. Surg. Oncol., 107064.","DOI":"10.1016\/j.ejso.2023.107064"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hau, H.M., Devantier, M., Jahn, N., Sucher, E., Rademacher, S., Seehofer, D., and Sucher, R. (2021). Impact of body mass index on tumor recurrence in patients undergoing liver resection for perihilar cholangiocarcinoma (pCCA). Cancers, 13.","DOI":"10.3390\/cancers13194772"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.ejso.2019.03.004","article-title":"Impact of body mass index on tumor recurrence among patients undergoing curative-intent resection of intrahepatic cholangiocarcinoma- a multi-institutional international analysis","volume":"45","author":"Merath","year":"2019","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1245\/s10434-022-11463-x","article-title":"Systematic review and meta-analysis of prognostic factors for early recurrence in intrahepatic cholangiocarcinoma after curative-intent resection","volume":"29","author":"Choi","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102223","DOI":"10.1016\/j.clinre.2023.102223","article-title":"New epidemiologic trends in cholangiocarcinoma","volume":"47","author":"Pascale","year":"2023","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1245\/s10434-016-5668-3","article-title":"Impact of skeletal muscle mass, muscle quality, and visceral adiposity on outcomes following resection of intrahepatic cholangiocarcinoma","volume":"24","author":"Okumura","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/01635581.2022.2117387","article-title":"High Visceral fat is associated with a worse survival after liver resection for intrahepatic cholangiocarcinoma","volume":"75","author":"Lacaze","year":"2023","journal-title":"Nutr. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"17569","DOI":"10.1002\/cam4.6374","article-title":"Body composition is associated with disease aetiology and prognosis in patients undergoing resection of intrahepatic cholangiocarcinoma","volume":"12","author":"Lurje","year":"2023","journal-title":"Cancer Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1200\/JCO.2016.67.4283","article-title":"Obesity and cancer mechanisms: Tumor microenvironment and inflammation","volume":"34","author":"Iyengar","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chang, M.L., Yang, Z., and Yang, S.S. (2020). Roles of adipokines in digestive diseases: Markers of inflammation, metabolic alteration and disease progression. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218308"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10120-019-01001-2","article-title":"Significance of CT attenuation and F-18 fluorodeoxyglucose uptake of visceral adipose tissue for predicting survival in gastric cancer patients after curative surgical resection","volume":"23","author":"Lee","year":"2020","journal-title":"Gastric Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"21109","DOI":"10.1038\/s41598-022-25540-4","article-title":"18F-FDG uptake of visceral adipose tissue on preoperative PET\/CT as a predictive marker for breast cancer recurrence","volume":"12","author":"Kim","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ebadi, M., Moctezuma-Velazquez, C., Meza-Junco, J., Baracos, V.E., DunichandHoedl, A.R., Ghosh, S., Sarlieve, P., Owen, R.J., Kneteman, N., and Montano-Loza, A.J. (2020). Visceral adipose tissue radiodensity is linked to prognosis in hepatocellular carcinoma patients treated with selective internal radiation therapy. Cancers, 12.","DOI":"10.3390\/cancers12020356"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110047","DOI":"10.1016\/j.ejrad.2021.110047","article-title":"Prognostic significance of imaging features of peritumoral adipose tissue in FDG PET\/CT of patients with colorectal cancer","volume":"145","author":"Ahn","year":"2021","journal-title":"Eur. J. Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ahn, H., Song, G.J., Jang, S.H., Son, M.W., Lee, H.J., Lee, M.S., Lee, J.H., Oh, M.H., Jeong, G.C., and Yun, J.H. (2022). Predicting the recurrence of gastric cancer using the textural features of perigastric adipose tissue on [18F]FDG PET\/CT. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911985"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.clnu.2024.01.006","article-title":"Elevated 18F-FDG uptake in subcutaneous adipose tissue correlates negatively with nutritional status and prognostic survival in cachexia patients with gastric cancer","volume":"43","author":"Sun","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Sanhueza, S., Sim\u00f3n, L., Cifuentes, M., and Quest, A.F.G. (2023). The adipocyte-macrophage relationship in cancer: A potential target for antioxidant therapy. Antioxidants, 12.","DOI":"10.3390\/antiox12010126"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e18104","DOI":"10.1111\/jcmm.18104","article-title":"Degradation of AZGP1 suppresses apoptosis and facilitates cholangiocarcinoma tumorigenesis via TRIM25","volume":"28","author":"Yun","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kalezic, A., Udicki, M., Srdic Galic, B., Aleksic, M., Korac, A., Jankovic, A., and Korac, B. (2021). Tissue-specific warburg effect in breast cancer and cancer-associated adipose tissue-relationship between AMPK and glycolysis. Cancers, 13.","DOI":"10.3390\/cancers13112731"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Grigora\u0219, A., and Amalinei, C. (2023). Multi-faceted role of cancer-associated adipocytes in colorectal cancer. Biomedicines, 11.","DOI":"10.3390\/biomedicines11092401"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/gerona\/glt070","article-title":"Adipose tissue density, a novel biomarker predicting mortality risk in older adults","volume":"69","author":"Murphy","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1056.e1","DOI":"10.1016\/j.crad.2018.07.094","article-title":"Prognostic value of CT attenuation and FDG uptake of adipose tissue in patients with pancreatic adenocarcinoma","volume":"73","author":"Lee","year":"2018","journal-title":"Clin. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"786981","DOI":"10.3389\/fonc.2022.786981","article-title":"Fat Attenuation index of renal cell carcinoma reveals biological characteristics and survival outcome","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_25","first-page":"298","article-title":"Leptin stimulates the epithelial-mesenchymal transition and pro-angiogenic capability of cholangiocarcinoma cells through the miR-122\/PKM2 axis","volume":"55","author":"Peng","year":"2019","journal-title":"Int. J. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13045-022-01253-z","article-title":"Immune cell atlas of cholangiocarcinomas reveals distinct tumor microenvironments and associated prognoses","volume":"15","author":"Xia","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1245\/s10434-018-6624-1","article-title":"Marked loss of muscle, visceral fat, or subcutaneous fat after gastrectomy predicts poor survival in advanced gastric cancer: Single-center study from the CLASSIC trial","volume":"25","author":"Park","year":"2018","journal-title":"Ann. Surg. Oncol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/7\/3939\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:22:11Z","timestamp":1760106131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/7\/3939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":27,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["ijms25073939"],"URL":"https:\/\/doi.org\/10.3390\/ijms25073939","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]}}}