{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:46:45Z","timestamp":1791892005839,"version":"4.3.4"},"reference-count":255,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers \u2018Digital Biodesign and Personalized Healthcare\u2019","award":["75-15-2020-913"],"award-info":[{"award-number":["75-15-2020-913"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The persisting presence of opportunistic pathogens like Pseudomonas aeruginosa poses a significant threat to many immunocompromised cancer patients with pulmonary infections. This review highlights the complexity of interactions in the host\u2019s defensive eicosanoid signaling network and its hijacking by pathogenic bacteria to their own advantage. Human lipoxygenases (ALOXs) and their mouse counterparts are integral elements of the innate immune system, mostly operating in the pro-inflammatory mode. Taking into account the indispensable role of inflammation in carcinogenesis, lipoxygenases have counteracting roles in this process. In addition to describing the structure-function of lipoxygenases in this review, we discuss their roles in such critical processes as cancer cell signaling, metastases, death of cancer and immune cells through ferroptosis, as well as the roles of ALOXs in carcinogenesis promoted by pathogenic infections. Finally, we discuss perspectives of novel oncotherapeutic approaches to harness lipoxygenase signaling in tumors.<\/jats:p>","DOI":"10.3390\/ijms25073961","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:58:38Z","timestamp":1712105918000},"page":"3961","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Lipoxygenases at the Intersection of Infection and Carcinogenesis"],"prefix":"10.3390","volume":"25","author":[{"given":"Abdul-Saleem","family":"Amoah","sequence":"first","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow 119121, Russia"},{"name":"Laboratory of Molecular Oncology, Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay B.","family":"Pestov","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow 119121, Russia"},{"name":"Group of Cross-Linking Enzymes, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia"},{"name":"Laboratory of Tick-Borne Encephalitis and Other Viral Encephalitides, Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Moscow 108819, Russia"},{"name":"Vavilov Institute of General Genetics, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana V.","family":"Korneenko","sequence":"additional","affiliation":[{"name":"Group of Cross-Linking Enzymes, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor A.","family":"Prokhorenko","sequence":"additional","affiliation":[{"name":"Group of Cross-Linking Enzymes, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-8264","authenticated-orcid":false,"given":"Georgy F.","family":"Kurakin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Pirogov Russian National Research Medical University, Moscow 117513, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-2446","authenticated-orcid":false,"given":"Nickolai A.","family":"Barlev","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Chemistry, Moscow 119121, Russia"},{"name":"Laboratory of Tick-Borne Encephalitis and Other Viral Encephalitides, Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Moscow 108819, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1128\/JB.00119-09","article-title":"Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung","volume":"191","author":"Starkey","year":"2009","journal-title":"J. Bacteriol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1172\/JCI99490","article-title":"Pseudomonas aeruginosa Utilizes Host Polyunsaturated Phosphatidylethanolamines to Trigger Theft-Ferroptosis in Bronchial Epithelium","volume":"128","author":"Dar","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbalip.2017.11.005","article-title":"Specific Oxygenation of Plasma Membrane Phospholipids by Pseudomonas aeruginosa Lipoxygenase Induces Structural and Functional Alterations in Mammalian Cells","volume":"1863","author":"Aldrovandi","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.abb.2015.09.003","article-title":"Secreted Lipoxygenase from Pseudomonas aeruginosa Exhibits Biomembrane Oxygenase Activity and Induces Hemolysis in Human Red Blood Cells","volume":"584","author":"Banthiya","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid Storm in Infection and Inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_6","unstructured":"Singh, R.B., Watanabe, S., and Isaza, A.A. (2022). Functional Foods and Nutraceuticals in Metabolic and Non-Communicable Diseases, Academic Press."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3390\/molecules19011273","article-title":"Oxidized Fatty Acids as Inter-Kingdom Signaling Molecules","volume":"19","author":"Pohl","year":"2014","journal-title":"Molecules"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1021\/cr200246d","article-title":"Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease","volume":"111","author":"Funk","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.abb.2010.08.016","article-title":"Molecular Enzymology of Lipoxygenases","volume":"503","author":"Ivanov","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Singh, P., Arif, Y., Miszczuk, E., Bajguz, A., and Hayat, S. (2022). Specific Roles of Lipoxygenases in Development and Responses to Stress in Plants. Plants, 11.","DOI":"10.3390\/plants11070979"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12374-020-09241-x","article-title":"Plant Lipoxygenases and Their Role in Plant Physiology","volume":"63","author":"Viswanath","year":"2020","journal-title":"J. Plant Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9234","DOI":"10.1021\/bi800638v","article-title":"Structural Properties of Plant and Mammalian Lipoxygenases. Temperature-Dependent Conformational Alterations and Membrane Binding Ability","volume":"47","author":"Mei","year":"2008","journal-title":"Biochemistry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bbalip.2014.10.002","article-title":"Mammalian Lipoxygenases and Their Biological Relevance","volume":"1851","author":"Kuhn","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1096\/fj.13-235952","article-title":"Structure and Interaction with Phospholipids of a Prokaryotic Lipoxygenase from Pseudomonas aeruginosa","volume":"27","author":"Garreta","year":"2013","journal-title":"FASEB J."},{"key":"ref_15","first-page":"57","article-title":"Python: A Programming Language for Software Integration and Development","volume":"17","author":"Sanner","year":"1999","journal-title":"J. Mol. Graph. Model."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014A Visualization System for Exploratory Research and Analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chrisnasari, R., Hennebelle, M., Vincken, J.-P., van Berkel, W.J.H., and Ewing, T.A. (2022). Bacterial Lipoxygenases: Biochemical Characteristics, Molecular Structure and Potential Applications. Biotechnol. Adv., 61.","DOI":"10.1016\/j.biotechadv.2022.108046"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kim, S.-E., Lee, J., An, J.-U., Kim, T.-H., Oh, C.-W., Ko, Y.-J., Krishnan, M., Choi, J., Yoon, D.-Y., and Kim, Y. (2022). Regioselectivity of an Arachidonate 9S-Lipoxygenase from Sphingopyxis macrogoltabida That Biosynthesizes 9S,15S- and 11S,17S-Dihydroxy Fatty Acids from C20 and C22 Polyunsaturated Fatty Acids. Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids, 1867.","DOI":"10.1016\/j.bbalip.2021.159091"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Erba, F., Mei, G., Minicozzi, V., Sabatucci, A., Di Venere, A., and Maccarrone, M. (2024). Conformational Dynamics of Lipoxygenases and Their Interaction with Biological Membranes. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042241"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"W344","DOI":"10.1093\/nar\/gkw408","article-title":"ConSurf 2016: An Improved Methodology to Estimate and Visualize Evolutionary Conservation in Macromolecules","volume":"44","author":"Ashkenazy","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1074\/jbc.M113.543777","article-title":"The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic","volume":"289","author":"Kobe","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nsb1297-1003","article-title":"The Structure of Mammalian 15-Lipoxygenase Reveals Similarity to the Lipases and the Determinants of Substrate Specificity","volume":"4","author":"Gillmor","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41589-020-0544-7","article-title":"Structural and Mechanistic Insights into 5-Lipoxygenase Inhibition by Natural Products","volume":"16","author":"Gilbert","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.bbalip.2016.08.002","article-title":"Structural and Functional Basis of Phospholipid Oxygenase Activity of Bacterial Lipoxygenase from Pseudomonas aeruginosa","volume":"1861","author":"Banthiya","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj3530345","article-title":"Probing a Novel Potato Lipoxygenase with Dual Positional Specificity Reveals Primary Determinants of Substrate Binding and Requirements for a Surface Hydrophobic Loop and Has Implications for the Role of Lipoxygenases in Tubers","volume":"353","author":"Hughes","year":"2001","journal-title":"Biochem. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1104\/pp.112.207514","article-title":"Defense Activated by 9-Lipoxygenase-Derived Oxylipins Requires Specific Mitochondrial Proteins","volume":"161","author":"Vellosillo","year":"2013","journal-title":"Plant Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1105\/tpc.106.046052","article-title":"Oxylipins Produced by the 9-Lipoxygenase Pathway in Arabidopsis Regulate Lateral Root Development and Defense Responses through a Specific Signaling Cascade","volume":"19","author":"Vellosillo","year":"2007","journal-title":"Plant Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1742-4658.2011.08027.x","article-title":"Oxylipins in Fungi","volume":"278","author":"Brodhun","year":"2011","journal-title":"FEBS J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbrc.2005.08.238","article-title":"Structural Biology of Mammalian Lipoxygenases: Enzymatic Consequences of Targeted Alterations of the Protein Structure","volume":"338","author":"Kuhn","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Oliw, E.H. (2022). Iron and Manganese Lipoxygenases of Plant Pathogenic Fungi and Their Role in Biosynthesis of Jasmonates. Arch. Biochem. Biophys., 722.","DOI":"10.1016\/j.abb.2022.109169"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hashem, C., Stolterfoht, H., Rinnofner, C., Steinberger, S., Winkler, M., and Pichler, H. (2020). Secretion of Pseudomonas aeruginosa Lipoxygenase by Pichia Pastoris upon Glycerol Feed. Biotechnol. J., 15.","DOI":"10.1002\/biot.202000089"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1099\/00221287-147-12-3199","article-title":"Lipoxygenase in Bacteria: A Horizontal Transfer Event?","volume":"147","author":"Porta","year":"2001","journal-title":"Microbiology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1007\/s00253-013-4887-9","article-title":"Bacterial Lipoxygenases, a New Subfamily of Enzymes? A Phylogenetic Approach","volume":"97","author":"Hansen","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.phytochem.2007.02.028","article-title":"Oxylipin Formation in Nostoc punctiforme (PCC73102)","volume":"68","author":"Lang","year":"2007","journal-title":"Phytochemistry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1134\/S0006297923060111","article-title":"Lipoxygenase in a Giant Sulfur Bacterium: An Evolutionary Solution for Size and Complexity?","volume":"88","author":"Kurakin","year":"2023","journal-title":"Biochem. Mosc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1134\/S0006297920090059","article-title":"Bacterial and Protozoan Lipoxygenases Could Be Involved in Cell-to-Cell Signaling and Immune Response Suppression","volume":"85","author":"Kurakin","year":"2020","journal-title":"Biochem. Mosc."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kurakin, G. (2023). Bacterial Lipoxygenases Are Associated with Host-Microbe Interactions and May Provide Cross-Kingdom Host Jumps. bioRxiv, preprint.","DOI":"10.1101\/2022.06.21.497025"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1128\/JCM.41.10.4812-4814.2003","article-title":"Cellular Fatty Acid Profile Distinguishes Burkholderia pseudomallei from Avirulent Burkholderia thailandensis","volume":"41","author":"Inglis","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.biotechadv.2012.04.004","article-title":"Lipoxygenases: Potential Starting Biocatalysts for the Synthesis of Signaling Compounds","volume":"30","author":"Joo","year":"2012","journal-title":"Biotechnol. Adv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1007\/s00253-014-6353-8","article-title":"Characterization of an Omega-6 Linoleate Lipoxygenase from Burkholderia thailandensis and Its Application in the Production of 13-Hydroxyoctadecadienoic Acid","volume":"99","author":"An","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1021\/ja068503d","article-title":"Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme","volume":"129","author":"Neidig","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1021\/acs.biochem.6b00338","article-title":"Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase","volume":"55","author":"Deschamps","year":"2016","journal-title":"Biochemistry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0005-2760(93)90085-N","article-title":"Overexpression, Purification and Characterization of Human Recombinant 15-Lipoxygenase","volume":"1169","author":"Barnett","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.1021\/bi800550n","article-title":"Substrate Specificity Changes for Human Reticulocyte and Epithelial 15-Lipoxygenases Reveal Allosteric Product Regulation","volume":"47","author":"Wecksler","year":"2008","journal-title":"Biochemistry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1021\/bi802332j","article-title":"Mechanistic Investigations of Human Reticulocyte 15- and Platelet 12-Lipoxygenases with Arachidonic Acid","volume":"48","author":"Wecksler","year":"2009","journal-title":"Biochemistry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"25412","DOI":"10.1074\/jbc.271.41.25412","article-title":"Defining the Arachidonic Acid Binding Site of Human 15-Lipoxygenase. Molecular Modeling and Mutagenesis","volume":"271","author":"Gan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"19413","DOI":"10.1074\/jbc.M116.741454","article-title":"Membrane-Dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS","volume":"291","author":"Bender","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1021\/bi4010649","article-title":"Kinetic and Structural Investigations into the Allosteric and pH Effect on the Substrate Specificity of Human Epithelial 15-Lipoxygenase-2","volume":"52","author":"Joshi","year":"2013","journal-title":"Biochemistry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s00253-013-5039-y","article-title":"Enhanced Thermal Stability of Pseudomonas aeruginosa Lipoxygenase through Modification of Two Highly Flexible Regions","volume":"98","author":"Lu","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1007\/s00253-012-4457-6","article-title":"Overproduction, Purification, and Characterization of Extracellular Lipoxygenase of Pseudomonas aeruginosa in Escherichia Coli","volume":"97","author":"Lu","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1021\/bi401621d","article-title":"ATP Allosterically Activates the Human 5-Lipoxygenase Molecular Mechanism of Arachidonic Acid and 5(S)-Hydroperoxy-6(E),8(Z),11(Z),14(Z)-Eicosatetraenoic Acid","volume":"53","author":"Smyrniotis","year":"2014","journal-title":"Biochemistry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1016\/j.bmcl.2016.06.025","article-title":"Kinetic Investigation of Human 5-Lipoxygenase with Arachidonic Acid","volume":"26","author":"Mittal","year":"2016","journal-title":"Bioorg Med. Chem. Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1016\/S0021-9258(20)81957-7","article-title":"Arachidonate 5-Lipoxygenase of Guinea Pig Peritoneal Polymorphonuclear Leukocytes. Activation by Adenosine 5\u2032-Triphosphate","volume":"258","author":"Ochi","year":"1983","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7982","DOI":"10.1016\/S0021-9258(19)57499-3","article-title":"Purification of Arachidonate 5-Lipoxygenase from Porcine Leukocytes and Its Reactivity with Hydroperoxyeicosatetraenoic Acids","volume":"261","author":"Ueda","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1073\/pnas.0307308101","article-title":"The Opportunistic Pathogen Pseudomonas aeruginosa Carries a Secretable Arachidonate 15-Lipoxygenase","volume":"101","author":"Vance","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/j.1440-1843.2010.01819.x","article-title":"Pseudomonas aeruginosa: Host Defence in Lung Diseases","volume":"15","author":"Williams","year":"2010","journal-title":"Respirology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrmicro2199","article-title":"The Type III Secretion System of Pseudomonas aeruginosa: Infection by Injection","volume":"7","author":"Hauser","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Morello, E., P\u00e9rez-Berezo, T., Boisseau, C., Baranek, T., Guillon, A., Br\u00e9a, D., Lanotte, P., Carpena, X., Pietrancosta, N., and Herv\u00e9, V. (2019). Pseudomonas aeruginosa Lipoxygenase LoxA Contributes to Lung Infection by Altering the Host Immune Lipid Signaling. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01826"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1073\/pnas.1610242114","article-title":"Pseudomonas aeruginosa Sabotages the Generation of Host Proresolving Lipid Mediators","volume":"114","author":"Flitter","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ijmm.2010.08.005","article-title":"Protein Secretion Systems in Pseudomonas aeruginosa: A Wealth of Pathogenic Weapons","volume":"300","author":"Bleves","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.4049\/jimmunol.1201922","article-title":"Hepoxilin A(3) Facilitates Neutrophilic Breach of Lipoxygenase-Expressing Airway Epithelial Barriers","volume":"189","author":"Tamang","year":"2012","journal-title":"J. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12967-017-1193-9","article-title":"Cystic Fibrosis: Current Therapeutic Targets and Future Approaches","volume":"15","author":"Rafeeq","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Farinha, C.M., and Callebaut, I. (2022). Molecular Mechanisms of Cystic Fibrosis\u2014How Mutations Lead to Misfunction and Guide Therapy. Biosci. Rep., 42.","DOI":"10.1042\/BSR20212006"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00018-016-2387-7","article-title":"From the Endoplasmic Reticulum to the Plasma Membrane: Mechanisms of CFTR Folding and Trafficking","volume":"74","author":"Farinha","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ramalho, S.S., Silva, I.A.L., Amaral, M.D., and Farinha, C.M. (2021). Rare Trafficking CFTR Mutations Involve Distinct Cellular Retention Machineries and Require Different Rescuing Strategies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010024"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cell.2017.02.024","article-title":"Molecular Structure of the Human CFTR Ion Channel","volume":"169","author":"Liu","year":"2017","journal-title":"Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0090-6980(02)00047-3","article-title":"Lipoxins and Aspirin-Triggered 15-Epi-Lipoxin Biosynthesis: An Update and Role in Anti-Inflammation and pro-Resolution","volume":"68\u201369","author":"Serhan","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1084\/jem.20031325","article-title":"Exogenous Pathogen and Plant 15-Lipoxygenase Initiate Endogenous Lipoxin A4 Biosynthesis","volume":"199","author":"Bannenberg","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"L150","DOI":"10.1152\/ajplung.00383.2017","article-title":"An Epoxide Hydrolase Secreted by Pseudomonas aeruginosa Decreases Mucociliary Transport and Hinders Bacterial Clearance from the Lung","volume":"314","author":"Hvorecny","year":"2018","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Harwood, J.L. (2023). Polyunsaturated Fatty Acids: Conversion to Lipid Mediators, Roles in Inflammatory Diseases and Dietary Sources. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108838"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0090-6980(02)00036-9","article-title":"Lipoxygenase Genes and Their Targeted Disruption","volume":"68\u201369","author":"Funk","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"C243","DOI":"10.1152\/ajpcell.1994.266.1.C243","article-title":"Epidermis Contains Platelet-Type 12-Lipoxygenase That Is Overexpressed in Germinal Layer Keratinocytes in Psoriasis","volume":"266","author":"Hussain","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1073\/pnas.95.6.3100","article-title":"Increased Platelet Sensitivity to ADP in Mice Lacking Platelet-Type 12-Lipoxygenase","volume":"95","author":"Johnson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1046\/j.1523-1747.1999.00595.x","article-title":"Basal Transepidermal Water Loss Is Increased in Platelet-Type 12-Lipoxygenase Deficient Mice","volume":"112","author":"Johnson","year":"1999","journal-title":"J. Investig. Dermatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1073\/pnas.95.12.6744","article-title":"A 12R-Lipoxygenase in Human Skin: Mechanistic Evidence, Molecular Cloning, and Expression","volume":"95","author":"Boeglin","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"33540","DOI":"10.1074\/jbc.273.50.33540","article-title":"Human 12(R)-Lipoxygenase and the Mouse Ortholog. Molecular Cloning, Expression, and Gene Chromosomal Assignment","volume":"273","author":"Sun","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"15579","DOI":"10.1073\/pnas.0406727101","article-title":"A Single Active Site Residue Directs Oxygenation Stereospecificity in Lipoxygenases: Stereocontrol Is Linked to the Position of Oxygenation","volume":"101","author":"Coffa","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"24046","DOI":"10.1074\/jbc.M111.251496","article-title":"Lipoxygenases Mediate the Effect of Essential Fatty Acid in Skin Barrier Formation: A Proposed Role in Releasing Omega-Hydroxyceramide for Construction of the Corneocyte Lipid Envelope","volume":"286","author":"Zheng","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/geno.1999.5816","article-title":"cDNA Cloning, Genomic Structure, and Chromosomal Localization of a Novel Murine Epidermis-Type Lipoxygenase","volume":"58","author":"Kinzig","year":"1999","journal-title":"Genomics"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"9162","DOI":"10.1073\/pnas.1633612100","article-title":"The Lipoxygenase Gene ALOXE3 Implicated in Skin Differentiation Encodes a Hydroperoxide Isomerase","volume":"100","author":"Yu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.abb.2006.09.002","article-title":"Human and Mouse eLOX3 Have Distinct Substrate Specificities: Implications for Their Linkage with Lipoxygenases in Skin","volume":"455","author":"Yu","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/jid.2008.409","article-title":"Molecular Analysis of 250 Patients with Autosomal Recessive Congenital Ichthyosis: Evidence for Mutation Hotspots in ALOXE3 and Allelic Heterogeneity in ALOX12B","volume":"129","author":"Eckl","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Hotz, A., Kopp, J., Bourrat, E., Oji, V., Komlosi, K., Giehl, K., Bouadjar, B., Bygum, A., Tantcheva-Poor, I., and Hellstr\u00f6m Pigg, M. (2021). Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients. Genes, 12.","DOI":"10.3390\/genes12010080"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1042420","DOI":"10.3389\/fphar.2022.1042420","article-title":"Arachidonate 15-Lipoxygenase Type B: Regulation, Function, and Its Role in Pathophysiology","volume":"13","author":"Benatzy","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.plipres.2018.09.002","article-title":"The Evolutionary Hypothesis of Reaction Specificity of Mammalian ALOX15 Orthologs","volume":"72","author":"Kuhn","year":"2018","journal-title":"Prog. Lipid Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.07.073","article-title":"Structural and Functional Biology of Arachidonic Acid 15-Lipoxygenase-1 (ALOX15)","volume":"573","author":"Ivanov","year":"2015","journal-title":"Gene"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12944-021-01599-2","article-title":"15-Lipoxygenase and Its Metabolites in the Pathogenesis of Breast Cancer: A Double-Edged Sword","volume":"20","author":"Vaezi","year":"2021","journal-title":"Lipids Health Dis."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Sch\u00e4fer, M., Kakularam, K.R., Reisch, F., Rothe, M., Stehling, S., Heydeck, D., P\u00fcschel, G.P., and Kuhn, H. (2022). Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging. Biomedicines, 10.","DOI":"10.3390\/biomedicines10061379"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1074\/jbc.M109.057802","article-title":"Applicability of the Triad Concept for the Positional Specificity of Mammalian Lipoxygenases","volume":"285","author":"Vogel","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Kakularam, K.R., Canyelles-Ni\u00f1o, M., Chen, X., Lluch, J.M., Gonz\u00e1lez-Lafont, \u00c0., and Kuhn, H. (2023). Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210046"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0014-5793(96)01517-7","article-title":"Murine Epidermal Lipoxygenase (Aloxe) Encodes a 12-Lipoxygenase Isoform","volume":"402","author":"Kinzig","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/bj3550097","article-title":"Enzymic Characterization of Epidermis-Derived 12-Lipoxygenase Isoenzymes","volume":"355","author":"Siebert","year":"2001","journal-title":"Biochem. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.jid.2016.05.088","article-title":"Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation","volume":"136","author":"Miyai","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1002\/cam4.4066","article-title":"ALOX5-5-HETE Promotes Gastric Cancer Growth and Alleviates Chemotherapy Toxicity via MEK\/ERK Activation","volume":"10","author":"Tang","year":"2021","journal-title":"Cancer Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/jcb.24069","article-title":"Arachidonate 5 Lipoxygenase Expression in Papillary Thyroid Carcinoma Promotes Invasion via MMP-9 Induction","volume":"113","author":"Kummer","year":"2012","journal-title":"J. Cell Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3892\/or.2014.3650","article-title":"Inhibition of 5-Lipoxygenase Triggers Apoptosis in Pancreatic Cancer Cells","volume":"33","author":"Zhou","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ejmech.2019.06.060","article-title":"Discovery of a Novel 2,5-Dihydroxycinnamic Acid-Based 5-Lipoxygenase Inhibitor That Induces Apoptosis and May Impair Autophagic Flux in RCC4 Renal Cancer Cells","volume":"179","author":"Selka","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41419-023-06333-7","article-title":"ALOX5 Deficiency Contributes to Bladder Cancer Progression by Mediating Ferroptosis Escape","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/S0021-9258(19)40034-3","article-title":"MK886, a Potent and Specific Leukotriene Biosynthesis Inhibitor Blocks and Reverses the Membrane Association of 5-Lipoxygenase in Ionophore-Challenged Leukocytes","volume":"265","author":"Rouzer","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/343282a0","article-title":"Requirement of a 5-Lipoxygenase-Activating Protein for Leukotriene Synthesis","volume":"343","author":"Dixon","year":"1990","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1084\/jem.185.6.1065","article-title":"Role of the 5-Lipoxygenase-Activating Protein (FLAP) in Murine Acute Inflammatory Responses","volume":"185","author":"Byrum","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1046\/j.1432-1327.1999.00818.x","article-title":"Differential Characteristics of Human 15-Lipoxygenase Isozymes and a Novel Splice Variant of 15S-Lipoxygenase","volume":"266","author":"Kilty","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1021\/acs.biochem.5b01339","article-title":"Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential","volume":"55","author":"Green","year":"2016","journal-title":"Biochemistry"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"16340","DOI":"10.1016\/S0021-9258(18)66571-8","article-title":"Lipoxin A. Stereochemistry and Biosynthesis","volume":"261","author":"Serhan","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1183\/09031936.00106013","article-title":"Reduced 15-Lipoxygenase 2 and Lipoxin A4\/Leukotriene B4 Ratio in Children with Cystic Fibrosis","volume":"44","author":"Ringholz","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.4161\/cc.28757","article-title":"Tumor-Suppressive Functions of 15-Lipoxygenase-2 and RB1CC1 in Prostate Cancer","volume":"13","author":"Suraneni","year":"2014","journal-title":"Cell Cycle"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/1097-0142(20010215)91:4<737::AID-CNCR1059>3.0.CO;2-F","article-title":"Lipoxygenase-5 Is Overexpressed in Prostate Adenocarcinoma","volume":"91","author":"Gupta","year":"2001","journal-title":"Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.plipres.2014.11.001","article-title":"Evolutionary Aspects of Lipoxygenases and Genetic Diversity of Human Leukotriene Signaling","volume":"57","author":"Horn","year":"2015","journal-title":"Prog. Lipid Res."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Tan, R., Yan, B., Wang, C., and Zhang, L. (2022). The Role of 12\/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses. Biomed. Res. Int., 2022.","DOI":"10.1155\/2022\/4589191"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory Responses and Inflammation-Associated Diseases in Organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2013.10.006","article-title":"Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases","volume":"19","author":"Spite","year":"2014","journal-title":"Cell Metab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbalip.2014.08.012","article-title":"5-Lipoxygenase, a Key Enzyme for Leukotriene Biosynthesis in Health and Disease","volume":"1851","author":"Werz","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/286264a0","article-title":"Leukotriene B, a Potent Chemokinetic and Aggregating Substance Released from Polymorphonuclear Leukocytes","volume":"286","author":"Bray","year":"1980","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/ijc.22153","article-title":"What Are Cyclooxygenases and Lipoxygenases Doing in the Driver\u2019s Seat of Carcinogenesis?","volume":"119","author":"Krieg","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_116","first-page":"60","article-title":"Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through \u03922 Integrins","volume":"4","author":"Filep","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3389\/fphar.2019.00719","article-title":"Regulation and Functions of 15-Lipoxygenases in Human Macrophages","volume":"10","author":"Snodgrass","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1586\/14737140.3.4.525","article-title":"Lipoxygenase Inhibitors for the Treatment of Pancreatic Cancer","volume":"3","author":"Kennedy","year":"2003","journal-title":"Expert. Rev. Anticancer. Ther."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1038\/s41467-022-30392-7","article-title":"Rapid Acceleration of KRAS-Mutant Pancreatic Carcinogenesis via Remodeling of Tumor Immune Microenvironment by PPAR\u03b4","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1038\/onc.2010.197","article-title":"Transgenic Expression of 15-Lipoxygenase 2 (15-LOX2) in Mouse Prostate Leads to Hyperplasia and Cell Senescence","volume":"29","author":"Suraneni","year":"2010","journal-title":"Oncogene"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0092-8674(02)00738-9","article-title":"Suppression of Myc-Induced Apoptosis in Beta Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression","volume":"109","author":"Pelengaris","year":"2002","journal-title":"Cell"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1158\/1940-6207.CAPR-09-0110","article-title":"Profiling Lipoxygenase Metabolism in Specific Steps of Colorectal Tumorigenesis","volume":"3","author":"Shureiqi","year":"2010","journal-title":"Cancer Prev. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.humpath.2004.04.001","article-title":"15-Lipoxygenase-2 Expression in Benign and Neoplastic Lung: An Immunohistochemical Study and Correlation with Tumor Grade and Proliferation","volume":"35","author":"Gonzalez","year":"2004","journal-title":"Hum. Pathol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.prostaglandins.2011.08.004","article-title":"Regulation of Inflammation in Cancer by Eicosanoids","volume":"96","author":"Greene","year":"2011","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Chen, H.-C., Chang, W.-C., Chuang, J.-Y., Chang, K.-Y., Liou, J.-P., and Hsu, T.-I. (2023). The Complex Role of Eicosanoids in the Brain: Implications for Brain Tumor Development and Therapeutic Opportunities. Biochim. Biophys. Acta Rev. Cancer, 1878.","DOI":"10.1016\/j.bbcan.2023.188957"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1593\/neo.07565","article-title":"15-Lipoxygenase-1 Production Is Lost in Pancreatic Cancer and Overexpression of the Gene Inhibits Tumor Cell Growth","volume":"9","author":"Hennig","year":"2007","journal-title":"Neoplasia"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s13277-012-0544-7","article-title":"Induction of Apoptosis by Trichostatin A in Human Breast Cancer Cell Lines: Involvement of 15-Lox-1","volume":"34","author":"Salimi","year":"2013","journal-title":"Tumour Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e530s","DOI":"10.6061\/clinics\/2018\/e530s","article-title":"Eicosanoids and Cancer","volume":"73","author":"Gomes","year":"2018","journal-title":"Clinics"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Finetti, F., Travelli, C., Ercoli, J., Colombo, G., Buoso, E., and Trabalzini, L. (2020). Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity. Biology, 9.","DOI":"10.3390\/biology9120434"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1158\/1541-7786.MCR-06-0221","article-title":"Genetic and Epigenetic Regulation of the Human Prostacyclin Synthase Promoter in Lung Cancer Cell Lines","volume":"5","author":"Stearman","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jcmgh.2016.12.001","article-title":"The Clinical Evidence Linking Helicobacter Pylori to Gastric Cancer","volume":"3","author":"Moss","year":"2017","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/epirev\/mxx006","article-title":"Periodontal Disease, Tooth Loss, and Cancer Risk","volume":"39","author":"Michaud","year":"2017","journal-title":"Epidemiol. Rev."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3389\/fonc.2018.00601","article-title":"Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants","volume":"8","author":"Shao","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chom.2013.07.007","article-title":"Fusobacterium Nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment","volume":"14","author":"Kostic","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1038\/s41467-020-16967-2","article-title":"Breast Cancer Colonization by Fusobacterium Nucleatum Accelerates Tumor Growth and Metastatic Progression","volume":"11","author":"Parhi","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"212","DOI":"10.21147\/j.issn.1000-9604.2019.01.16","article-title":"Colorectal Cancer, Radiotherapy and Gut Microbiota","volume":"31","author":"Zhang","year":"2019","journal-title":"Chin. J. Cancer Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"9968","DOI":"10.1073\/pnas.1631086100","article-title":"The 15-Lipoxygenase-1 Product 13-S-Hydroxyoctadecadienoic Acid down-Regulates PPAR-Delta to Induce Apoptosis in Colorectal Cancer Cells","volume":"100","author":"Shureiqi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"13182","DOI":"10.1073\/pnas.95.22.13182","article-title":"Inhibition of Arachidonate 5-Lipoxygenase Triggers Massive Apoptosis in Human Prostate Cancer Cells","volume":"95","author":"Ghosh","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"G1137","DOI":"10.1152\/ajpgi.00197.2005","article-title":"Extracellular Matrix Stimulates Reactive Oxygen Species Production and Increases Pancreatic Cancer Cell Survival through 5-Lipoxygenase and NADPH Oxidase","volume":"289","author":"Edderkaoui","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Nosaka, T., Murata, Y., Takahashi, K., Naito, T., Ofuji, K., Matsuda, H., Ohtani, M., Hiramatsu, K., Imamura, Y., and Goi, T. (2023). Hepatocellular Carcinoma Progression Promoted by 5-Lipoxygenase Activity in CD163(+) Tumor-Associated Macrophages. Biomed. Pharmacother., 162.","DOI":"10.1016\/j.biopha.2023.114592"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1227\/01.NEU.0000195096.43258.94","article-title":"Increased Expression of 5-Lipoxygenase in High-Grade Astrocytomas","volume":"58","author":"Nathoo","year":"2006","journal-title":"Neurosurgery"},{"key":"ref_142","first-page":"1195","article-title":"5-Lipoxygenase Contributes to the Progression of Hepatocellular Carcinoma","volume":"4","author":"Xu","year":"2011","journal-title":"Mol. Med. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.plefa.2006.01.009","article-title":"Reduction of Isoforms of 15-Lipoxygenase (15-LOX)-1 and 15-LOX-2 in Human Breast Cancer","volume":"74","author":"Jiang","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"16189","DOI":"10.1074\/jbc.M111936200","article-title":"Evidence That Arachidonate 15-Lipoxygenase 2 Is a Negative Cell Cycle Regulator in Normal Prostate Epithelial Cells","volume":"277","author":"Tang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/ijc.24118","article-title":"Downregulation of Vascular Endothelial Growth Factor and Induction of Tumor Dormancy by 15-Lipoxygenase-2 in Prostate Cancer","volume":"124","author":"Tang","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"8721","DOI":"10.1021\/bi9009242","article-title":"Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-Lipoxygenase-2","volume":"48","author":"Wecksler","year":"2009","journal-title":"Biochemistry"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12944-019-1089-1","article-title":"Up-Regulation of 15-Lipoxygenase Enzymes and Products in Functional and Non-Functional Pituitary Adenomas","volume":"18","author":"Barooni","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/cpr.12267","article-title":"Interplay between 15-Lipoxygenase-1 and Metastasis-Associated Antigen 1 in the Metastatic Potential of Colorectal Cancer","volume":"49","author":"Konu","year":"2016","journal-title":"Cell Prolif."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/jnci\/djs187","article-title":"Effects of Gut-Targeted 15-LOX-1 Transgene Expression on Colonic Tumorigenesis in Mice","volume":"104","author":"Zuo","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_150","first-page":"360","article-title":"Expression of 15-Lipoxygenase-1 in Human Colorectal Cancer","volume":"59","author":"Ikawa","year":"1999","journal-title":"Cancer Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/01.sla.0000164177.95620.c1","article-title":"Tumor-Associated down-Regulation of 15-Lipoxygenase-1 Is Reversed by Celecoxib in Colorectal Cancer","volume":"241","author":"Heslin","year":"2005","journal-title":"Ann. Surg."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1365-2559.2007.02799.x","article-title":"Reversal of Expression of 15-Lipoxygenase-1 to Cyclooxygenase-2 Is Associated with Development of Colonic Cancer","volume":"51","author":"Yuri","year":"2007","journal-title":"Histopathology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.plefa.2003.06.001","article-title":"15-Lipoxygenase-1 Has Anti-Tumorigenic Effects in Colorectal Cancer","volume":"70","author":"Nixon","year":"2004","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biochi.2016.12.012","article-title":"Control of Adipogenesis by Oxylipins, GPCRs and PPARs","volume":"136","author":"Barquissau","year":"2017","journal-title":"Biochimie"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/hep.28000","article-title":"Stimulation of Nuclear Receptor Peroxisome Proliferator-Activated Receptor-\u03b3 Limits NF-\u03baB-Dependent Inflammation in Mouse Cystic Fibrosis Biliary Epithelium","volume":"62","author":"Scirpo","year":"2015","journal-title":"Hepatology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejphar.2015.11.004","article-title":"Fatty Acids, Eicosanoids and PPAR Gamma","volume":"785","author":"Savoye","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fimmu.2014.00075","article-title":"Polyunsaturated Fatty Acid-Derived Lipid Mediators and T Cell Function","volume":"5","author":"Nicolaou","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_158","first-page":"599","article-title":"Regulation of 15-Lipoxygenase Expression by Cytokines","volume":"400B","author":"Brinckmann","year":"1997","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.yexcr.2011.10.017","article-title":"Epigenetic and Transcriptional Control of the 15-Lipoxygenase-1 Gene in a Hodgkin Lymphoma Cell Line","volume":"318","author":"Liu","year":"2012","journal-title":"Exp. Cell Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1007\/s10753-017-0637-y","article-title":"1,6-O,O-Diacetylbritannilactone Inhibits Eotaxin-1 and ALOX15 Expression Through Inactivation of STAT6 in A549 Cells","volume":"40","author":"Chen","year":"2017","journal-title":"Inflammation"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"27631","DOI":"10.1016\/S0021-9258(18)47031-7","article-title":"Induction of 15-Lipoxygenase by Interleukin-13 in Human Blood Monocytes","volume":"269","author":"Nassar","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"32023","DOI":"10.1074\/jbc.273.48.32023","article-title":"Induction of 15-Lipoxygenase Expression by IL-13 Requires Tyrosine Phosphorylation of Jak2 and Tyk2 in Human Monocytes","volume":"273","author":"Roy","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1172\/JCI116738","article-title":"Human Alveolar Macrophages Have 15-Lipoxygenase and Generate 15(S)-Hydroxy-5,8,11-Cis-13-Trans-Eicosatetraenoic Acid and Lipoxins","volume":"92","author":"Levy","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"844142","DOI":"10.3389\/fimmu.2022.844142","article-title":"Immunotherapy: Reshape the Tumor Immune Microenvironment","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.plipres.2018.11.001","article-title":"Emerging Role of 12\/15-Lipoxygenase (ALOX15) in Human Pathologies","volume":"73","author":"Singh","year":"2019","journal-title":"Prog. Lipid Res."},{"key":"ref_166","first-page":"1865","article-title":"Hydroxyeicosatetraenoic Acids in Patients with Pancreatic Cancer: A Preliminary Report","volume":"8","author":"Bodnarczuk","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/cam4.227","article-title":"Enzyme 15-Lipoxygenase 1 Promotes Hypoxia-Inducible Factor 1\u03b1 Turnover and Reduces Vascular Endothelial Growth Factor Expression: Implications for Angiogenesis","volume":"3","author":"Zhong","year":"2014","journal-title":"Cancer Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1158\/0008-5472.CAN-04-4090","article-title":"5-Lipoxygenase, a Marker for Early Pancreatic Intraepithelial Neoplastic Lesions","volume":"65","author":"Hennig","year":"2005","journal-title":"Cancer Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0002-9440(10)64198-3","article-title":"5-Lipoxygenase and Leukotriene B(4) Receptor Are Expressed in Human Pancreatic Cancers but Not in Pancreatic Ducts in Normal Tissue","volume":"161","author":"Hennig","year":"2002","journal-title":"Am. J. Pathol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Nie, J.Z., Wang, M.-T., and Nie, D. (2023). Regulations of Tumor Microenvironment by Prostaglandins. Cancers, 15.","DOI":"10.3390\/cancers15123090"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s41418-023-01153-w","article-title":"Apoptotic Cell Death in Disease-Current Understanding of the NCCD 2023","volume":"30","author":"Vitale","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular Mechanisms and Health Implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"8810785","DOI":"10.1155\/2020\/8810785","article-title":"The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors","volume":"2020","author":"Zhu","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2020.02.005","article-title":"Autophagy-Dependent Ferroptosis: Machinery and Regulation","volume":"27","author":"Liu","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1080\/15548627.2020.1739447","article-title":"Mitochondrial DNA Stress Triggers Autophagy-Dependent Ferroptotic Death","volume":"17","author":"Li","year":"2021","journal-title":"Autophagy"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the Ferroptosis Regulator Gpx4 Triggers Acute Renal Failure in Mice","volume":"16","author":"Schneider","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of Polyunsaturated Fatty Acids by Lipoxygenases Drives Ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-Stress-Mediated AMPK Activation Inhibits Ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Wang, M., Zeng, G., Xiong, B., Zhu, X., Guo, J., Chen, D., Zhang, S., Luo, M., Guo, L., and Cai, L. (2023). ALOX5 Promotes Autophagy-Dependent Ferroptosis by Activating the AMPK\/mTOR Pathway in Melanoma. Biochem. Pharmacol., 212.","DOI":"10.1016\/j.bcp.2023.115554"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"17835","DOI":"10.1021\/jacs.8b09913","article-title":"Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE","volume":"140","author":"Anthonymuthu","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"32433","DOI":"10.1073\/pnas.2006828117","article-title":"Polyunsaturated Fatty Acid Biosynthesis Pathway Determines Ferroptosis Sensitivity in Gastric Cancer","volume":"117","author":"Lee","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cell.2017.09.044","article-title":"PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals","volume":"171","author":"Wenzel","year":"2017","journal-title":"Cell"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"672904","DOI":"10.3389\/fgene.2021.672904","article-title":"Ferroptosis-Related Genes in Lung Adenocarcinoma: Prognostic Signature and Immune, Drug Resistance, Mutation Analysis","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Genet."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.4155\/fmc-2023-0125","article-title":"Exploring ACSL4\/LPCAT3\/ALOX15 and SLC7A11\/GPX4\/NFE2L2 as Potential Targets in Ferroptosis-Based Cancer Therapy","volume":"15","author":"Gupta","year":"2023","journal-title":"Future Med. Chem."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1111\/cas.13380","article-title":"Lipoxygenase-Mediated Generation of Lipid Peroxides Enhances Ferroptosis Induced by Erastin and RSL3","volume":"108","author":"Shintoku","year":"2017","journal-title":"Cancer Sci."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Anthonymuthu, T.S., Tyurina, Y.Y., Sun, W.-Y., Mikulska-Ruminska, K., Shrivastava, I.H., Tyurin, V.A., Cinemre, F.B., Dar, H.H., VanDemark, A.P., and Holman, T.R. (2021). Resolving the Paradox of Ferroptotic Cell Death: Ferrostatin-1 Binds to 15LOX\/PEBP1 Complex, Suppresses Generation of Peroxidized ETE-PE, and Protects against Ferroptosis. Redox Biol., 38.","DOI":"10.1016\/j.redox.2020.101744"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1038\/s41467-021-24604-9","article-title":"Tumor-Killing Nanoreactors Fueled by Tumor Debris Can Enhance Radiofrequency Ablation Therapy and Boost Antitumor Immune Responses","volume":"12","author":"Yang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez Borrero, L.J., and El-Deiry, W.S. (2021). Tumor Suppressor P53: Biology, Signaling Pathways, and Therapeutic Targeting. Biochim. Biophys. Acta Rev. Cancer, 1876.","DOI":"10.1016\/j.bbcan.2021.188556"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/cdd.2009.73","article-title":"The microRNA and P53 Families Join Forces against Cancer","volume":"17","author":"Barlev","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/s41388-018-0566-8","article-title":"Orphan Receptor NR4A3 Is a Novel Target of P53 That Contributes to Apoptosis","volume":"38","author":"Fedorova","year":"2019","journal-title":"Oncogene"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1038\/s41375-020-0949-z","article-title":"MDM2 Inhibition: An Important Step Forward in Cancer Therapy","volume":"34","author":"Konopleva","year":"2020","journal-title":"Leukemia"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Rozenberg, J.M., Zvereva, S., Dalina, A., Blatov, I., Zubarev, I., Luppov, D., Bessmertnyi, A., Romanishin, A., Alsoulaiman, L., and Kumeiko, V. (2021). The P53 Family Member P73 in the Regulation of Cell Stress Response. Biol. Direct, 16.","DOI":"10.1186\/s13062-021-00307-5"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41420-018-0120-z","article-title":"Isatin-Schiff Base-Copper (II) Complex Induces Cell Death in P53-Positive Tumors","volume":"4","author":"Bulatov","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"114334","DOI":"10.1016\/j.ejmech.2022.114334","article-title":"Small-Molecule MDM2 Inhibitors in Clinical Trials for Cancer Therapy","volume":"236","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1021\/acsmedchemlett.5b00011","article-title":"Discovery of Novel Isatin-Based P53 Inducers","volume":"6","author":"Davidovich","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","article-title":"P53 in Ferroptosis Regulation: The New Weapon for the Old Guardian","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"908772","DOI":"10.3389\/fphar.2022.908772","article-title":"Post-Translational Modifications of P53 in Ferroptosis: Novel Pharmacological Targets for Cancer Therapy","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.bbagrm.2015.06.004","article-title":"5-Lipoxygenase Is a Direct P53 Target Gene in Humans","volume":"1849","author":"Gilbert","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1096\/fj.04-2258fje","article-title":"5-Lipoxygenase Antagonizes Genotoxic Stress-Induced Apoptosis by Altering P53 Nuclear Trafficking","volume":"18","author":"Catalano","year":"2004","journal-title":"FASEB J."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/sj.emboj.7600502","article-title":"5-Lipoxygenase Regulates Senescence-like Growth Arrest by Promoting ROS-Dependent P53 Activation","volume":"24","author":"Catalano","year":"2005","journal-title":"EMBO J."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"100058","DOI":"10.1016\/j.labinv.2022.100058","article-title":"P53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells","volume":"103","author":"Li","year":"2023","journal-title":"Lab. Investig."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41419-020-03327-7","article-title":"Interplay between P53 and Non-Coding RNAs in the Regulation of EMT in Breast Cancer","volume":"12","author":"Parfenyev","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/j.apsb.2023.03.025","article-title":"The Suppression of Cervical Cancer Ferroptosis by Macrophages: The Attenuation of ALOX15 in Cancer Cells by Macrophages-Derived Exosomes","volume":"13","author":"Luo","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1767609","article-title":"MicroRNA-125b Is a Novel Negative Regulator of P53","volume":"23","author":"Le","year":"2009","journal-title":"Genes. Dev."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.4251\/wjgo.v13.i12.2114","article-title":"Propofol Induces Ferroptosis and Inhibits Malignant Phenotypes of Gastric Cancer Cells by Regulating miR-125b-5p\/STAT3 Axis","volume":"13","author":"Liu","year":"2021","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 Is Required for P53-Mediated Tumour Suppression through a Distinct Ferroptosis Pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13046-022-02589-7","article-title":"S1PR1\/S1PR3-YAP Signaling and S1P-ALOX15 Signaling Contribute to an Aggressive Behavior in Obesity-Lymphoma","volume":"42","author":"Wang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biochi.2020.09.005","article-title":"Fatty Acid Binding Protein 7 Mediates Linoleic Acid-Induced Cell Death in Triple Negative Breast Cancer Cells by Modulating 13-HODE","volume":"179","author":"Kwong","year":"2020","journal-title":"Biochimie"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3892\/or.2012.1924","article-title":"Human 5-, 12- and 15-Lipoxygenase-1 Coexist in Kidney but Show Opposite Trends and Their Balance Changes in Cancer","volume":"28","author":"Gohara","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1593\/neo.06202","article-title":"Conditional Expression of Human 15-Lipoxygenase-1 in Mouse Prostate Induces Prostatic Intraepithelial Neoplasia: The FLiMP Mouse Model","volume":"8","author":"Kelavkar","year":"2006","journal-title":"Neoplasia"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"e155884","DOI":"10.1172\/JCI155884","article-title":"The Role of 15 Lipoxygenase 1 in Asthma Comes into Focus","volume":"132","author":"Boyce","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00109-012-0954-4","article-title":"12\/15-Lipoxygenase during the Regulation of Inflammation, Immunity, and Self-Tolerance","volume":"90","author":"Uderhardt","year":"2012","journal-title":"J. Mol. Med."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00011-023-01770-8","article-title":"Transgenic Mice Overexpressing Human ALOX15 under the Control of the aP2 Promoter Are Partly Protected in the Complete Freund\u2019s Adjuvant-Induced Paw Inflammation Model","volume":"72","author":"Heydeck","year":"2023","journal-title":"Inflamm. Res."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1073\/pnas.1018075108","article-title":"15-Lipoxygenase 1 Interacts with Phosphatidylethanolamine-Binding Protein to Regulate MAPK Signaling in Human Airway Epithelial Cells","volume":"108","author":"Zhao","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s11888-012-0146-1","article-title":"Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention","volume":"8","author":"Rao","year":"2012","journal-title":"Curr. Colorectal Cancer Rep."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41417-022-00531-9","article-title":"Knock-out of 5-Lipoxygenase in Overexpressing Tumor Cells-Consequences on Gene Expression and Cellular Function","volume":"30","author":"Weisser","year":"2023","journal-title":"Cancer Gene Ther."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/imm.12746","article-title":"Loss of Natural Killer T Cells Promotes Pancreatic Cancer in LSL-KrasG12D\/+ Mice","volume":"152","author":"Janakiram","year":"2017","journal-title":"Immunology"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"102269","DOI":"10.1016\/j.plefa.2021.102269","article-title":"Oxylipin Patterns in Human Colon Adenomas","volume":"167","author":"Gottschall","year":"2021","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10555-011-9311-2","article-title":"Role of Lipoxins, Resolvins, and Other Bioactive Lipids in Colon and Pancreatic Cancer","volume":"30","author":"Janakiram","year":"2011","journal-title":"Cancer Metastasis Rev."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"757073","DOI":"10.3389\/fonc.2021.757073","article-title":"Lipoxins and Resolvins in Patients With Pancreatic Cancer: A Preliminary Report","volume":"11","author":"Blogowski","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10555-018-9731-3","article-title":"mPGES-1 and ALOX5\/-15 in Tumor-Associated Macrophages","volume":"37","author":"Weigert","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1476-5586(03)80003-9","article-title":"Reduced 15S-Lipoxygenase-2 Expression in Esophageal Cancer Specimens and Cells and Upregulation in Vitro by the Cyclooxygenase-2 Inhibitor, NS398","volume":"5","author":"Xu","year":"2003","journal-title":"Neoplasia"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"40549","DOI":"10.1074\/jbc.M203522200","article-title":"Opposing Effects of 15-Lipoxygenase-1 and -2 Metabolites on MAPK Signaling in Prostate. Alteration in Peroxisome Proliferator-Activated Receptor Gamma","volume":"277","author":"Hsi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10555-018-9738-9","article-title":"The Importance of 15-Lipoxygenase Inhibitors in Cancer Treatment","volume":"37","author":"Orafaie","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"33290","DOI":"10.18632\/oncotarget.5396","article-title":"Simultaneous Targeting of 5-LOX-COX and EGFR Blocks Progression of Pancreatic Ductal Adenocarcinoma","volume":"6","author":"Rao","year":"2015","journal-title":"Oncotarget"},{"key":"ref_228","first-page":"929","article-title":"Lipoxygenase Inhibitors Attenuate Growth of Human Pancreatic Cancer Xenografts and Induce Apoptosis through the Mitochondrial Pathway","volume":"1","author":"Tong","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1006\/bbrc.1999.1824","article-title":"Lipoxygenase Inhibition Induced Apoptosis, Morphological Changes, and Carbonic Anhydrase Expression in Human Pancreatic Cancer Cells","volume":"266","author":"Ding","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1038\/s41598-020-62845-8","article-title":"Pharmacological and Genetic Targeting of 5-Lipoxygenase Interrupts c-Myc Oncogenic Signaling and Kills Enzalutamide-Resistant Prostate Cancer Cells via Apoptosis","volume":"10","author":"Monga","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"2199166","DOI":"10.1080\/14756366.2023.2199166","article-title":"Triple Targeting of Mutant EGFRL858R\/T790M, COX-2, and 15-LOX: Design and Synthesis of Novel Quinazolinone Tethered Phenyl Urea Derivatives for Anti-Inflammatory and Anticancer Evaluation","volume":"38","author":"Kothayer","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"110505","DOI":"10.1016\/j.intimp.2023.110505","article-title":"The ALOX5 Inhibitor Zileuton Regulates Tumor-Associated Macrophage M2 Polarization by JAK\/STAT and Inhibits Pancreatic Cancer Invasion and Metastasis","volume":"121","author":"Hu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s12253-019-00652-x","article-title":"The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma","volume":"26","author":"Agarwal","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/bbrc.1999.1012","article-title":"Lipoxygenase Inhibitors Abolish Proliferation of Human Pancreatic Cancer Cells","volume":"261","author":"Ding","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.prostaglandins.2010.07.002","article-title":"Inhibition of Arachidonic Acid Metabolism Decreases Tumor Cell Invasion and Matrix Metalloproteinase Expression","volume":"93","author":"Koontongkaew","year":"2010","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.advms.2019.11.006","article-title":"Specific Overexpression of 15-Lipoxygenase in Endothelial Cells Promotes Cancer Cell Death in an in vivo Lewis Lung Carcinoma Mouse Model","volume":"65","author":"Sultan","year":"2020","journal-title":"Adv. Med. Sci."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.canlet.2013.03.012","article-title":"Radiosensitivity of Human Prostate Cancer Cells Can Be Modulated by Inhibition of 12-Lipoxygenase","volume":"335","author":"Nie","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.18632\/aging.203890","article-title":"Senescence-Associated Tumor Growth Is Promoted by 12-Lipoxygenase","volume":"14","author":"Patil","year":"2022","journal-title":"Aging"},{"key":"ref_239","first-page":"653","article-title":"Apoptosis Induced by 13-S-Hydroxyoctadecadienoic Acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231","volume":"16","year":"2013","journal-title":"Iran. J. Basic. Med. Sci."},{"key":"ref_240","unstructured":"(2024, February 23). Doxorubicin Resistance in Breast Cancer Cells Is Mediated by Extracellular Matrix Proteins|BMC Cancer|Full Text. Available online: https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-017-3953-6."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s11064-017-2448-9","article-title":"Expression of DHA-Metabolizing Enzyme Alox15 Is Regulated by Selective Histone Acetylation in Neuroblastoma Cells","volume":"43","author":"Ho","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"e2302070120","DOI":"10.1073\/pnas.2302070120","article-title":"Glucocorticoids Regulate Lipid Mediator Networks by Reciprocal Modulation of 15-Lipoxygenase Isoforms Affecting Inflammation Resolution","volume":"120","author":"Rao","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Souza, F.D.C., Ferreira, M.T., and Colquhoun, A. (2020). Influence of Lipoxygenase Inhibition on Glioblastoma Cell Biology. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218395"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Silva, J.A., and Colquhoun, A. (2023). Effect of Polyunsaturated Fatty Acids on Temozolomide Drug-Sensitive and Drug-Resistant Glioblastoma Cells. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030779"},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Dragnev, K.H., Dragnev, C.P.C., and Lubet, R.A. (2023). Major Hurdles to the Use of Tyrosine Kinase Inhibitors in Clinical Prevention\/Interception Studies: Do Preclinical Studies with EGFR Inhibitors Suggest Approaches to Overcome Some of the Limitations. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1170444"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1158\/1541-7786.MCR-05-0011","article-title":"Overexpression of 15-Lipoxygenase-1 Induces Growth Arrest through Phosphorylation of P53 in Human Colorectal Cancer Cells","volume":"3","author":"Kim","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/mt.2008.44","article-title":"Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer","volume":"16","author":"Wu","year":"2008","journal-title":"Mol. Ther."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.prostaglandins.2006.05.022","article-title":"15-Lipoxygenase 2 (15-LOX2) Is a Functional Tumor Suppressor That Regulates Human Prostate Epithelial Cell Differentiation, Senescence, and Growth (Size)","volume":"82","author":"Tang","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000094761","article-title":"Reduced Expression of 15-Lipoxygenase 2 in Human Head and Neck Carcinomas","volume":"27","author":"Wang","year":"2006","journal-title":"Tumour Biol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/cgt.2008.9","article-title":"Synergistic Effect of 15-Lipoxygenase 2 and Radiation in Killing Head-and-Neck Cancer","volume":"15","author":"Yang","year":"2008","journal-title":"Cancer Gene Ther."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"2192098","DOI":"10.1080\/2162402X.2023.2192098","article-title":"Melanoma-Associated Repair-like Schwann Cells Suppress Anti-Tumor T-Cells via 12\/15-LOX\/COX2-Associated Eicosanoid Production","volume":"12","author":"Kruglov","year":"2023","journal-title":"Oncoimmunology"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pharmthera.2013.05.003","article-title":"Current Status of Local Therapy in Malignant Gliomas\u2014A Clinical Review of Three Selected Approaches","volume":"139","author":"Juratli","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/cgt.2012.76","article-title":"Increased Invasion of Malignant Gliomas after 15-LO-1 and HSV-Tk\/Ganciclovir Combination Gene Therapy","volume":"19","author":"Pacholska","year":"2012","journal-title":"Cancer Gene Ther."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1007\/s00330-019-06189-6","article-title":"Radiofrequency Ablation of Liver Metastasis: Potential Impact on Immune Checkpoint Inhibitor Therapy","volume":"29","author":"Minami","year":"2019","journal-title":"Eur. Radiol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"nwad257","DOI":"10.1093\/nsr\/nwad257","article-title":"Self-Fueling Ferroptosis-Inducing Microreactors Based on pH-Responsive Lipiodol Pickering Emulsions Enable Transarterial Ferro-Embolization Therapy","volume":"11","author":"Wang","year":"2024","journal-title":"Natl. Sci. Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/7\/3961\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:22:38Z","timestamp":1760106158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/7\/3961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":255,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["ijms25073961"],"URL":"https:\/\/doi.org\/10.3390\/ijms25073961","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]}}}