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They are characterized by the absence of hormonal hypersecretion syndrome, and patients present with compressive symptoms, such as a headache and visual field defects. Immunohistochemically, most CNFPAs are of gonadotrope differentiation, with only a few of them being truly null cell adenomas. Although these tumors express receptors for one or more hypothalamic releasing hormones, to what extent this has an impact on the biological and clinical behavior of these neoplasms remains to be defined. In this research, we evaluated the basal and hypothalamic secretagogue-stimulated intracellular calcium mobilization in 13 CNFPAs, trying to correlate this response to the phenotypic features of the patients. Our results indicate that the recurrence of a CNFPA correlates positively with cellular responsiveness, as measured by spontaneous intracellular calcium activity and the ability to respond to multiple hypothalamic secretagogues. We conclude that this finding may be a useful tool for predicting the clinicopathologic behavior of CNFPAs, by testing the variation of cellular responsiveness to hypothalamic secretagogues.<\/jats:p>","DOI":"10.3390\/ijms25073968","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:58:38Z","timestamp":1712105918000},"page":"3968","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between Intracellular Calcium Signaling and Tumor Recurrence in Human Non-Functioning Pituitary Adenomas"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-7746","authenticated-orcid":false,"given":"Yorgui","family":"Santiago-Andres","sequence":"first","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda Comparada, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico"},{"name":"Posgrado en Ciencias Biol\u00f3gicas, Unidad de Posgrado, Edificio D, 1\u00b0 Piso, Circuito de Posgrados, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-0308","authenticated-orcid":false,"given":"Ana","family":"Aquiles","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Campus Juriquilla, Quer\u00e9taro 76230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Taniguchi-Ponciano","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latife","family":"Salame","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7018-4093","authenticated-orcid":false,"given":"Gerardo","family":"Guinto","sequence":"additional","affiliation":[{"name":"Centro Neurol\u00f3gico, Centro M\u00e9dico ABC, Ciudad de M\u00e9xico 05370, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Mercado","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de Mexico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-1476","authenticated-orcid":false,"given":"Tatiana","family":"Fiordelisio","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda Comparada, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1093\/neuonc\/not151","article-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006\u20132010","volume":"15","author":"Ostrom","year":"2013","journal-title":"Neuro. 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