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Hence, there is a significant focus on studying the role of mitochondria in cancer, ageing, neurodegenerative diseases, and the field of developmental biology. Mitochondria could exist as discrete organelles in the cell; however, they have the ability to fuse, resulting in the formation of interconnected reticular structures. The dynamic changes between these forms correlate with mitochondrial function and mitochondrial health, and consequently, there is a significant scientific interest in uncovering the specific molecular constituents that govern these transitions. Moreover, the specialized mitochondria display a wide array of variable morphologies in their cristae formations. These inner mitochondrial structures are closely associated with the specific functions performed by the mitochondria. In multiple cases, the presence of mitochondrial dysfunction has been linked to male sterility, as it has been observed to cause a range of abnormal spermatogenesis and sperm phenotypes in different species. This review aims to elucidate the dynamic alterations and functions of mitochondria in germ cell development during the spermatogenesis of Drosophila melanogaster.<\/jats:p>","DOI":"10.3390\/ijms25073980","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T03:37:21Z","timestamp":1712115441000},"page":"3980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mitochondrial Differentiation during Spermatogenesis: Lessons from Drosophila melanogaster"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-8226","authenticated-orcid":false,"given":"Viktor","family":"Vedelek","sequence":"first","affiliation":[{"name":"Department of Genetics, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-4472","authenticated-orcid":false,"given":"Ferenc","family":"Jankovics","sequence":"additional","affiliation":[{"name":"Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Department of Medical Biology, Albert Szent-Gy\u00f6rgyi Medical Centre, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Z\u00e1dori","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine, Albert Szent-Gy\u00f6rgyi Medical Centre, University of Szeged, 6723 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-4184","authenticated-orcid":false,"given":"Rita","family":"Sinka","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1567-7249(01)00038-1","article-title":"Lamellar and Tubular Associations of the Mitochondrial Cristae: Unique Forms of the Cristae Present in Steroid-Producing Cells","volume":"1","author":"Prince","year":"2002","journal-title":"Mitochondrion"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/humupd\/dmp016","article-title":"Mitochondrial Functionality in Reproduction: From Gonads and Gametes to Embryos and Embryonic Stem Cells","volume":"15","author":"Varum","year":"2009","journal-title":"Hum. 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