{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:41:46Z","timestamp":1790818906822,"version":"4.1.0"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant Agency of the Ministry of the Education, Science, Research, and Sport of the Slovak Republic","award":["VEGA 1\/0617\/22"],"award-info":[{"award-number":["VEGA 1\/0617\/22"]}]},{"name":"Grant Agency of the Ministry of the Education, Science, Research, and Sport of the Slovak Republic","award":["VVGS-2023-2747"],"award-info":[{"award-number":["VVGS-2023-2747"]}]},{"name":"Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice","award":["VEGA 1\/0617\/22"],"award-info":[{"award-number":["VEGA 1\/0617\/22"]}]},{"name":"Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice","award":["VVGS-2023-2747"],"award-info":[{"award-number":["VVGS-2023-2747"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The signaling lymphocytic activation molecule (SLAM) receptor family (SLAMF) consists of nine glycoproteins that belong to the CD2 superfamily of immunoglobulin (Ig) domain-containing molecules. SLAMF receptors modulate the differentiation and activation of a wide range of immune cells. Individual SLAMF receptors are expressed on the surface of hematopoietic stem cells, hematopoietic progenitor cells, B cells, T cells, NK cells, NKT cells, monocytes, macrophages, dendritic cells, neutrophils, and platelets. The expression of SLAMF receptors was studied during normal B cell maturation. Several SLAMF receptors were also detected in cancer cell lines of B-lymphoid origin and in pathological B cells from patients with B cell chronic lymphoproliferative disorders (B-CLPD), the most frequent hematological malignancies in adults. This review summarizes current knowledge on the expression of SLAMF receptors and their adaptor proteins SAP and EAT-2 in B-CLPD. Several SLAMF receptors could be regarded as potential diagnostic and differential diagnostic markers, prognostic factors, and targets for the development of novel drugs for patients with B-CLPD.<\/jats:p>","DOI":"10.3390\/ijms25074014","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T06:57:34Z","timestamp":1712213854000},"page":"4014","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["SLAM Family Receptors in B Cell Chronic Lymphoproliferative Disorders"],"prefix":"10.3390","volume":"25","author":[{"given":"Dominik","family":"K\u013eoc","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-0336","authenticated-orcid":false,"given":"Slavom\u00edr","family":"Kurhajec","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Pharmacognosy, and Botany, University of Veterinary Medicine and Pharmacy, Komensk\u00e9ho 73, 04181 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykhailo","family":"Huniadi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1n","family":"S\u00fdkora","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncohaematology, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice and Louis Pasteur University Hospital Ko\u0161ice, Trieda SNP 1, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Guman","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncohaematology, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice and Louis Pasteur University Hospital Ko\u0161ice, Trieda SNP 1, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"\u0160ari\u0161sk\u00fd","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1146\/annurev-immunol-030409-101302","article-title":"SLAM Family Receptors and SAP Adaptors in Immunity","volume":"29","author":"Cannons","year":"2011","journal-title":"Annu. 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