{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T03:29:34Z","timestamp":1769225374253,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Entrepreneurship Leadership Project in Guangzhou Development Zone of China","award":["2020-L037"],"award-info":[{"award-number":["2020-L037"]}]},{"name":"National Key Research and Development Entrepreneurship Leadership Project in Guangzhou Development Zone of China","award":["2022B1111020003"],"award-info":[{"award-number":["2022B1111020003"]}]},{"name":"National Key Research and Development Entrepreneurship Leadership Project in Guangzhou Development Zone of China","award":["YWH(2022)3398"],"award-info":[{"award-number":["YWH(2022)3398"]}]},{"name":"National Key Research and Development Entrepreneurship Leadership Project in Guangzhou Development Zone of China","award":["A2024089"],"award-info":[{"award-number":["A2024089"]}]},{"name":"Guangdong Key Research and Development Program","award":["2020-L037"],"award-info":[{"award-number":["2020-L037"]}]},{"name":"Guangdong Key Research and Development Program","award":["2022B1111020003"],"award-info":[{"award-number":["2022B1111020003"]}]},{"name":"Guangdong Key Research and Development Program","award":["YWH(2022)3398"],"award-info":[{"award-number":["YWH(2022)3398"]}]},{"name":"Guangdong Key Research and Development Program","award":["A2024089"],"award-info":[{"award-number":["A2024089"]}]},{"name":"Guangzhou Municipal Health Commission","award":["2020-L037"],"award-info":[{"award-number":["2020-L037"]}]},{"name":"Guangzhou Municipal Health Commission","award":["2022B1111020003"],"award-info":[{"award-number":["2022B1111020003"]}]},{"name":"Guangzhou Municipal Health Commission","award":["YWH(2022)3398"],"award-info":[{"award-number":["YWH(2022)3398"]}]},{"name":"Guangzhou Municipal Health Commission","award":["A2024089"],"award-info":[{"award-number":["A2024089"]}]},{"name":"Guangdong Provincial Medical Research Fund Project","award":["2020-L037"],"award-info":[{"award-number":["2020-L037"]}]},{"name":"Guangdong Provincial Medical Research Fund Project","award":["2022B1111020003"],"award-info":[{"award-number":["2022B1111020003"]}]},{"name":"Guangdong Provincial Medical Research Fund Project","award":["YWH(2022)3398"],"award-info":[{"award-number":["YWH(2022)3398"]}]},{"name":"Guangdong Provincial Medical Research Fund Project","award":["A2024089"],"award-info":[{"award-number":["A2024089"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The exacerbation of pneumonia in children with human adenovirus type 3 (HAdV-3E) is secondary to a Staphylococcus aureus (S. aureus) infection. The influence of host\u2013pathogen interactions on disease progression remains unclear. It is important to note that S. aureus infections following an HAdV-3E infection are frequently observed in clinical settings, yet the underlying susceptibility mechanisms are not fully understood. This study utilized an A549 cell model to investigate secondary infection with S. aureus following an HAdV-3E infection. The findings suggest that HAdV-3E exacerbates the S. aureus infection by intensifying lung epithelial cell damage. The results highlight the role of HAdV-3E in enhancing the interferon signaling pathway through RIG-I (DDX58), resulting in the increased expression of interferon-stimulating factors like MX1, RSAD2, and USP18. The increase in interferon-stimulating factors inhibits the NF-\u03baB and MAPK\/P38 pro-inflammatory signaling pathways. These findings reveal new mechanisms of action for HAdV-3E and S. aureus in secondary infections, enhancing our comprehension of pathogenesis.<\/jats:p>","DOI":"10.3390\/ijms25084178","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:07:46Z","timestamp":1712729266000},"page":"4178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Activation of the RIG-I\/MAVS Signaling Pathway during Human Adenovirus Type 3 Infection Impairs the Pro-Inflammatory Response Induced by Secondary Infection with Staphylococcus aureus"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8802-7061","authenticated-orcid":false,"given":"Jiehan","family":"Chen","sequence":"first","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4897-2235","authenticated-orcid":false,"given":"Qiaowen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biying","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8253-4301","authenticated-orcid":false,"given":"Huiying","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingjun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chen, M., Zhu, Z., Huang, F., Liu, D., Zhang, T., Ying, D., Wu, J., and Xu, W. 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