{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:43:38Z","timestamp":1783453418887,"version":"3.55.0"},"reference-count":86,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"U.S. Army Engineer Research and Development Center\u2013Environmental Laboratory (ERDC-EL)","award":["W912HZ-23-2-0024"],"award-info":[{"award-number":["W912HZ-23-2-0024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Quantum dots (QDs) are a novel type of nanomaterial that has unique optical and physical characteristics. As such, QDs are highly desired because of their potential to be used in both biomedical and industrial applications. However, the mass adoption of QDs usage has raised concerns among the scientific community regarding QDs\u2019 toxicity. Although many papers have reported the negative impact of QDs on a cellular level, the exact mechanism of the QDs\u2019 toxicity is still unclear. In this investigation, we study the adverse effects of QDs by focusing on one of the most important cellular processes: actin polymerization and depolymerization. Our results showed that QDs act in a biphasic manner where lower concentrations of QDs stimulate the polymerization of actin, while high concentrations of QDs inhibit actin polymerization. Furthermore, we found that QDs can bind to filamentous actin (F-actin) and cause bundling of the filament while also promoting actin depolymerization. Through this study, we found a novel mechanism in which QDs negatively influence cellular processes and exert toxicity.<\/jats:p>","DOI":"10.3390\/ijms25084179","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:07:46Z","timestamp":1712729266000},"page":"4179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CdSe\/ZnS Quantum Dots\u2019 Impact on In Vitro Actin Dynamics"],"prefix":"10.3390","volume":"25","author":[{"given":"Abhishu","family":"Chand","sequence":"first","affiliation":[{"name":"Department of Biology, Missouri State University, 901 S National, Springfield, MO 65897, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhi","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Biology, Missouri State University, 901 S National, Springfield, MO 65897, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0896-9572","authenticated-orcid":false,"given":"Kyoungtae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biology, Missouri State University, 901 S National, Springfield, MO 65897, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nair, A., Haponiuk, J.T., Thomas, S., and Gopi, S. 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