{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:18:02Z","timestamp":1792801082677,"version":"4.5.0"},"reference-count":139,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Until a few years ago, it was believed that the gradual mosaic loss of the Y chromosome (mLOY) was a normal age-related process. However, it is now known that mLOY is associated with a wide variety of pathologies in men, such as cardiovascular diseases, neurodegenerative disorders, and many types of cancer. Nevertheless, the mechanisms that generate mLOY in men have not been studied so far. This task is of great importance because it will allow focusing on possible methods of prophylaxis or therapy for diseases associated with mLOY. On the other hand, it would allow better understanding of mLOY as a possible marker for inferring the age of male samples in cases of human identification. Due to the above, in this work, a comprehensive review of the literature was conducted, presenting the most relevant information on the possible molecular mechanisms by which mLOY is generated, as well as its implications for men\u2019s health and its possible use as a marker to infer age.<\/jats:p>","DOI":"10.3390\/ijms25084230","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T07:09:28Z","timestamp":1712819368000},"page":"4230","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Loss of the Y Chromosome: A Review of Molecular Mechanisms, Age Inference, and Implications for Men\u2019s Health"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6174-0609","authenticated-orcid":false,"given":"Itzae Adonai","family":"Guti\u00e9rrez-Hurtado","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid Desire\u00e9","family":"S\u00e1nchez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Ciencias Morfol\u00f3gico Forenses y Medicina Molecular, Departamento de Morfolog\u00eda, Centro Universitario de Ciencias de la Salud, Guadalajara 44340, Jalisco, Mexico"},{"name":"Doctorado en Gen\u00e9tica Humana, Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-3383","authenticated-orcid":false,"given":"Denisse Stephania","family":"Becerra-Loaiza","sequence":"additional","affiliation":[{"name":"Departamento de Aparatos y Sistemas II, Universidad Aut\u00f3noma de Guadalajara, Zapopan 45129, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2641-8782","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Rangel-Villalobos","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Gen\u00e9tica Molecular, Departamento de Ciencias M\u00e9dicas y de la Vida, Centro Universitario de la Ci\u00e9nega, Universidad de Guadalajara, Ocotl\u00e1n 47820, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Torres-Carrillo","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-1693","authenticated-orcid":false,"given":"Martha Patricia","family":"Gallegos-Arreola","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Gen\u00e9tica, Centro de Investigaci\u00f3n Biom\u00e9dica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-5595","authenticated-orcid":false,"given":"Jos\u00e9 Alonso","family":"Aguilar-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Ciencias Morfol\u00f3gico Forenses y Medicina Molecular, Departamento de Morfolog\u00eda, Centro Universitario de Ciencias de la Salud, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00439-020-02114-w","article-title":"Mosaic Loss of Human Y Chromosome: What, How and Why","volume":"139","author":"Guo","year":"2020","journal-title":"Hum. 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