{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:55Z","timestamp":1792022455784,"version":"4.4.0"},"reference-count":55,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key project of Natural Science Foundation of Xinjiang Uygur Autonomous Region in China","award":["2021D01D14"],"award-info":[{"award-number":["2021D01D14"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study aimed to investigate the preventive effects of the total polyphenols from Nymphaea candida (NCTP) on LPS-induced septic acute lung injury (ALI) in mice and its mechanisms. NCTP could significantly ameliorate LPS-induced lung tissue pathological injury in mice as well as lung wet\/dry ratio and MPO activities (p &lt; 0.05). NCTP could significantly decrease the blood leukocyte, neutrophil, monocyte, basophil, and eosinophil amounts and LPS contents in ALI mice compared with the model group (p &lt; 0.05), improving lymphocyte amounts (p &lt; 0.05). Moreover, compared with the model group, NCTP could decrease lung tissue TNF-\u03b1, IL-6, and IL-1\u03b2 levels (p &lt; 0.05) and downregulate the protein expression of TLR4, MyD88, TRAF6, IKK\u03b2, I\u03baB-\u03b1, p-I\u03baB-\u03b1, NF-\u03baB p65, p-NF-\u03baB p65, NLRP3, ASC, and Caspase1 in lung tissues (p &lt; 0.05). Furthermore, NCTP could inhibit ileum histopathological injuries, restoring the ileum tight junctions by increasing the expression of ZO-1 and occludin. Simultaneously, NCTP could reverse the gut microbiota disorder, restore the diversity of gut microbiota, increase the relative abundance of Clostridiales and Lachnospiraceae, and enhance the content of SCFAs (acetic acid, propionic acid, and butyric acid) in feces. These results suggested that NCTP has preventive effects on septic ALI, and its mechanism is related to the regulation of gut microbiota, SCFA metabolism, and the TLR-4\/NF-\u03baB and NLRP3 pathways.<\/jats:p>","DOI":"10.3390\/ijms25084276","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:28:06Z","timestamp":1712914086000},"page":"4276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Preventive Effect of the Total Polyphenols from Nymphaea candida on Sepsis-Induced Acute Lung Injury in Mice via Gut Microbiota and NLRP3, TLR-4\/NF-\u03baB Pathway"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9984-0541","authenticated-orcid":false,"given":"Chenyang","family":"Li","sequence":"first","affiliation":[{"name":"School of Public Health, Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-6289","authenticated-orcid":false,"given":"Xinxin","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi 830004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi 830004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Yao","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi 830004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-4582","authenticated-orcid":false,"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, Xinjiang Medical University, Urumqi 830011, China"},{"name":"Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi 830004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.intimp.2019.02.020","article-title":"Protective effect of sophocarpine on lipopolysaccharide-induced acute lung injury in mice","volume":"70","author":"Lu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100777","DOI":"10.1016\/j.cpsurg.2020.100777","article-title":"Acute lung injury","volume":"57","author":"Mowery","year":"2020","journal-title":"Curr. Probl. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s12272-019-01200-6","article-title":"Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4\u2013MyD88\u2013NF-\u03baB signaling pathway","volume":"42","author":"Wang","year":"2019","journal-title":"Arch. Pharmacal Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ctm2.16","article-title":"Acute lung injury in patients with COVID-19 infection","volume":"10","author":"Li","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"ref_5","first-page":"1","article-title":"Diagnostic value of miR-155 for acute lung injury\/acute respiratory distress syndrome in patients with sepsis","volume":"48","author":"Wang","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.2017.21907","article-title":"Acute Respiratory Distress Syndrome","volume":"319","author":"Fan","year":"2018","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.biopha.2018.10.197","article-title":"The protective effect of the flavonoid fraction of Abutilon theophrasti Medic. leaves on LPS-induced acute lung injury in mice via the NF-\u03baB and MAPK signalling pathways","volume":"109","author":"Tian","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_8","first-page":"2213","article-title":"Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-\u03baB signaling in an Nrf2-dependent manner","volume":"44","author":"Huang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wu, X., Lin, L., and Wu, H. (2020). Ferulic acid alleviates lipopolysaccharide-induced acute lung injury through inhibiting TLR4\/NF-\u03baB signaling pathway. J. Biochem. Mol. Toxicol., 35.","DOI":"10.1002\/jbt.22664"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41385-019-0160-6","article-title":"Microbes, metabolites, and the gut\u2013lung axis","volume":"12","author":"Dang","year":"2019","journal-title":"Mucosal Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.ijbiomac.2021.05.066","article-title":"Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation","volume":"183","author":"Gao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107272","DOI":"10.1016\/j.intimp.2020.107272","article-title":"Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4\/NF-kB signaling pathway","volume":"91","author":"Tang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1021\/acs.jafc.8b06359","article-title":"Sodium Butyrate Inhibits the Inflammation of Lipopolysaccharide-Induced Acute Lung Injury in Mice by Regulating the Toll-Like Receptor 4\/Nuclear Factor \u03baB Signaling Pathway","volume":"67","author":"Liu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.biopha.2018.08.048","article-title":"Sinomenine protects against E. coli-induced acute lung injury in mice through Nrf2-NF-\u03baB pathway","volume":"107","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_15","unstructured":"Hu, X.M. (1999). Chinese Materia Medica\u2014Uyghur Medicine Volume, Shanghai Scientific & Technical Publishers."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1080\/14786419.2019.1622105","article-title":"Hepatoprotective activity of isostrictiniin from Nymphaea candida on Con A-induced acute liver injury in mice","volume":"35","author":"Zhao","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/13880209.2019.1675716","article-title":"The analgesic and anti-inflammatory effects of zukamu granules, a traditional Chinese medical formulation","volume":"57","author":"Yin","year":"2019","journal-title":"Pharm. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117831","DOI":"10.1016\/j.jep.2024.117831","article-title":"A novel mechanism for regulating lung immune homeostasis: Zukamu granules alleviated acute lung injury in mice by inhibiting NLRP3 inflammasome activation and regulating Th17\/Treg cytokine balance","volume":"324","author":"Yu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"115568","DOI":"10.1016\/j.jep.2022.115568","article-title":"A novel therapeutic approach for IPF: Based on the \u201cAutophagy-Apoptosis\u201d balance regulation of Zukamu Granules in alveolar macrophages","volume":"297","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhao, J., Zhang, S., You, S., Liu, T., Xu, F., Ji, T., and Gu, Z. (2017). Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A-Induced and D-Galactosamine-Induced Liver Injury in Mice. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18030587"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1080\/14786419.2022.2065673","article-title":"Preventive effect of isostrictiniin from Nymphaea candida on carbon tetrachloride-induced hepatic fibrosis in mice","volume":"37","author":"Dong","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"117789","DOI":"10.1016\/j.jep.2024.117789","article-title":"Anti-inflammatory, analgesic, antitussive and antipyretic activities of polyphenol-enriched fraction from Nymphaea candida","volume":"324","author":"Sun","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ijbiomac.2019.10.010","article-title":"Protective effect of Ganoderma atrum polysaccharides in acute lung injury rats and its metabolomics","volume":"142","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.redox.2018.05.006","article-title":"Olive oil polyphenols reduce oxysterols -induced redox imbalance and pro-inflammatory response in intestinal cells","volume":"17","author":"Serra","year":"2018","journal-title":"Redox Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/1040841X.2016.1176988","article-title":"Gut\u2013lung axis: The microbial contributions and clinical implications","volume":"43","author":"He","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"115957","DOI":"10.1016\/j.carbpol.2020.115957","article-title":"Cultured Cordyceps sinensis polysaccharides modulate intestinal mucosal immunity and gut microbiota in cyclophosphamide-treated mice","volume":"235","author":"Ying","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"104465","DOI":"10.1016\/j.jff.2021.104465","article-title":"Long-chain polyunsaturated fatty acids improve airway pathological features and gut microbial imbalances in BALB\/c mice with ovalbumin-induced asthma","volume":"81","author":"Jiang","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12931-021-01872-z","article-title":"Gut microbiota dysbiosis contributes to the development of chronic obstructive pulmonary disease","volume":"22","author":"Li","year":"2021","journal-title":"Respir. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhou, X., and Liao, Y. (2021). Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.779620"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lyu, M., Wang, Y.-F., Fan, G.-W., Wang, X.-Y., Xu, S.-Y., and Zhu, Y. (2017). Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.02146"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"104424","DOI":"10.1016\/j.jff.2021.104424","article-title":"Probiotic-fermented Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] juice modulates the intestinal mucosal barrier and increases the abundance of Akkermansia in the gut in association with polyphenols","volume":"80","author":"Guo","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-0039-1683996","article-title":"Pathogenesis of Acute Respiratory Distress Syndrome","volume":"40","author":"Huppert","year":"2019","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_33","first-page":"4483","article-title":"Downregulation of miR-155 attenuates sepsis-induced acute lung injury by targeting SIRT1","volume":"11","author":"Tuerdi","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e12070","DOI":"10.1002\/pul2.12070","article-title":"Topotecan reduces sepsis-induced acute lung injury and decreases the inflammatory response via the inhibition of the NF-kappaB signaling pathway","volume":"12","author":"Wang","year":"2022","journal-title":"Pulm. Circ."},{"key":"ref_35","first-page":"1319","article-title":"Effects of total ginsenosides from Panax ginseng stems and leaves on gut microbiota and short-chain fatty acids metabolism in acute lung injury mice","volume":"48","author":"Ding","year":"2023","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2018.12.003","article-title":"Fraxin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting the NF-kappaB and NLRP3 signalling pathways","volume":"67","author":"Li","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.intimp.2015.05.005","article-title":"Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro","volume":"27","author":"Tao","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"112665","DOI":"10.1016\/j.jep.2020.112665","article-title":"An untargeted metabolomics approach to investigate the wine-processed mechanism of Scutellariae radix in acute lung injury","volume":"253","author":"Hu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Jacobs, M.C., Lankelma, J.M., Wolff, N.S., Hugenholtz, F., de Vos, A.F., van der Poll, T., and Wiersinga, W.J. (2020). Effect of antibiotic gut microbiota disruption on LPS-induced acute lung inflammation. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0241748"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1080\/15384101.2018.1509635","article-title":"MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting in fl ammation and apoptosis through modulating TLR4\/MyD88\/NF-kappaB pathway","volume":"17","author":"Ju","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3892\/ijmm.2020.4610","article-title":"MicroRNA-93 contributes to the suppression of lung inflammatory responses in LPS-induced acute lung injury in mice via the TLR4\/MyD88\/NF-kappaB signaling pathway","volume":"46","author":"Gao","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wang, X., Deng, R., Dong, J., Huang, L., Li, J., and Zhang, B. (2020). Eriodictyol ameliorates lipopolysaccharide-induced acute lung injury by suppressing the inflammatory COX-2\/NLRP3\/NF-kappaB pathway in mice. J. Biochem. Mol. Toxicol., 34.","DOI":"10.1002\/jbt.22434"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4062\/biomolther.2016.234","article-title":"Diosmetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury through Activating the Nrf2 Pathway and Inhibiting the NLRP3 Inflammasome","volume":"26","author":"Liu","year":"2018","journal-title":"Biomol. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.imbio.2018.07.001","article-title":"Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation","volume":"223","author":"Jiang","year":"2018","journal-title":"Immunobiology"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Wang, X., Liu, Z., and Yu, L. (2018). Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR-381. J. Biochem. Mol. Toxicol., 32.","DOI":"10.1002\/jbt.22211"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/SHK.0000000000001244","article-title":"Surfactant Protein D Dampens Lung Injury by Suppressing NLRP3 Inflammasome Activation and NF-kappaB Signaling in Acute Pancreatitis","volume":"51","author":"Yu","year":"2019","journal-title":"Shock"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chioma, O.S., Mallott, E.K., Chapman, A., Van Amburg, J.C., Wu, H., Shah-Gandhi, B., Dey, N., Kirkland, M.E., Blanca Piazuelo, M., and Johnson, J. (2022). Gut microbiota modulates lung fibrosis severity following acute lung injury in mice. Commun. Biol., 5.","DOI":"10.1038\/s42003-022-04357-x"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, Y., Liu, J., Li, F., Ma, S., Zhao, L., Ge, P., Wen, H., Zhang, Y., Liu, X., and Luo, L. (2023). Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK\/NF-kB\/NLRP3 Pathway. Microbiol. Spectr., 11.","DOI":"10.1128\/spectrum.03664-22"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7524","DOI":"10.1002\/jcp.27513","article-title":"Repression of TXNIP-NLRP3 axis restores intestinal barrier function via inhibition of myeloperoxidase activity and oxidative stress in nonalcoholic steatohepatitis","volume":"234","author":"Bai","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"913178","DOI":"10.3389\/fimmu.2022.913178","article-title":"Intestinal Microbiota\u2014An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/jgh.14536","article-title":"Beneficial effect of butyrate-producing Lachnospiraceae on stress-induced visceral hypersensitivity in rats","volume":"34","author":"Zhang","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhang, X., Wang, S., Wu, Y., Liu, X., Wang, J., and Han, D. (2022). Ellagic Acid Alleviates Diquat-Induced Jejunum Oxidative Stress in C57BL\/6 Mice through Activating Nrf2 Mediated Signaling Pathway. Nutrients, 14.","DOI":"10.3390\/nu14051103"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7946","DOI":"10.1039\/C9FO03008E","article-title":"Ellagic acid and urolithin A modulate the immune response in LPS-stimulated U937 monocytic cells and THP-1 differentiated macrophages","volume":"11","author":"Voldvik","year":"2020","journal-title":"Food Funct."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jep.2013.12.003","article-title":"Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L.","volume":"151","author":"Wang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"104759","DOI":"10.1016\/j.phrs.2020.104759","article-title":"Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury: A novel strategy for exploring active components and effective mechanism of TCM formulae","volume":"156","author":"Ding","year":"2020","journal-title":"Pharmacol. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/8\/4276\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:27:10Z","timestamp":1760106430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/8\/4276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":55,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["ijms25084276"],"URL":"https:\/\/doi.org\/10.3390\/ijms25084276","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]}}}