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(Spain)","award":["CB16\/12\/00390"],"award-info":[{"award-number":["CB16\/12\/00390"]}]},{"name":"Principado de Asturias (Spain)","award":["IDI\/2021\/000079"],"award-info":[{"award-number":["IDI\/2021\/000079"]}]},{"name":"FICYT","award":["PI22\/00167"],"award-info":[{"award-number":["PI22\/00167"]}]},{"name":"FICYT","award":["CB16\/12\/00390"],"award-info":[{"award-number":["CB16\/12\/00390"]}]},{"name":"FICYT","award":["IDI\/2021\/000079"],"award-info":[{"award-number":["IDI\/2021\/000079"]}]},{"name":"FEDER Funding Program from the European Union","award":["PI22\/00167"],"award-info":[{"award-number":["PI22\/00167"]}]},{"name":"FEDER Funding Program from the European Union","award":["CB16\/12\/00390"],"award-info":[{"award-number":["CB16\/12\/00390"]}]},{"name":"FEDER Funding Program from the European Union","award":["IDI\/2021\/000079"],"award-info":[{"award-number":["IDI\/2021\/000079"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer. The incidence of metastasis for cSCC is estimated to be around 1.2\u20135%. Ribosomal protein S6 (p-S6) and the p21 protein (p21) are two proteins that play central roles in other cancers. These proteins may be equally important in cSCC, and together, these could constitute a good candidate for metastasis risk assessment of these patients. We investigate the relationship of p-S6 and p21 expression with the impact on the prognosis of head and neck cSCC (cSCCHN). p-S6 and p21 expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 116 patients with cSCCHN and associations sought with clinical characteristics. Kaplan\u2013Meier estimators and Cox proportional hazard regression models were also used. The expression of p-S6 was significantly inversely associated with tumor thickness, tumor size, desmoplastic growth, pathological stage, perineural invasion and tumor buds. p21 expression was significantly inversely correlated with &gt;6 mm tumor thickness, desmoplastic growth, and perineural invasion. p-S6-negative expression significantly predicted an increased risk of nodal metastasis (HR = 2.63, 95% CI 1.51\u20134.54; p &lt; 0.001). p21 expression was not found to be a significant risk factor for nodal metastasis. These findings demonstrate that p-S6-negative expression is an independent predictor of nodal metastasis. The immunohistochemical expression of p-S6 might aid in better risk stratification and management of patients with cSCCHN.<\/jats:p>","DOI":"10.3390\/ijms25084304","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:24:26Z","timestamp":1713176666000},"page":"4304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low-Level Expression of p-S6 Is Associated with Nodal Metastasis in Patients with Head and Neck Cutaneous Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-4210","authenticated-orcid":false,"given":"Celia","family":"G\u00f3mez-de Castro","sequence":"first","affiliation":[{"name":"Grider, Grupo de Investigaci\u00f3n en Dermatolog\u00eda, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Dermatology Division, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Santos-Juanes","sequence":"additional","affiliation":[{"name":"Dermatology Area, Department of Medicine, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Nu\u00f1ez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Dermatology Area, Department of Medicine, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-6493","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Fern\u00e1ndez-Vega","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Central de Asturias, Biobank of the Principality of Asturias (BioPA), 33011 Oviedo, Spain"},{"name":"Department of Pathology, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Vivanco","sequence":"additional","affiliation":[{"name":"Grider, Grupo de Investigaci\u00f3n en Dermatolog\u00eda, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Department of Pathology, Hospital Universitario Central de Asturias, Biobank of the Principality of Asturias (BioPA), 33011 Oviedo, Spain"},{"name":"Department of Pathology, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-8614","authenticated-orcid":false,"given":"Adela","family":"Fern\u00e1ndez-Velasco","sequence":"additional","affiliation":[{"name":"Grider, Grupo de Investigaci\u00f3n en Dermatolog\u00eda, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Department of Pathology, Hospital Universitario Central de Asturias, Biobank of the Principality of Asturias (BioPA), 33011 Oviedo, Spain"},{"name":"Department of Pathology, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-4817","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Reyes-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Dermatology Division, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimena","family":"Carrero-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Dermatology Division, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5891-9488","authenticated-orcid":false,"given":"Juana M.","family":"Garc\u00eda-Pedrero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0890","authenticated-orcid":false,"given":"Juan P.","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Carmen","family":"Gonz\u00e1lez-Vela","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Marqu\u00e9s de Valdecilla, 39008 Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-3522","authenticated-orcid":false,"given":"Jorge","family":"Santos-Juanes","sequence":"additional","affiliation":[{"name":"Grider, Grupo de Investigaci\u00f3n en Dermatolog\u00eda, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Dermatology Division, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Dermatology Area, Department of Medicine, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias, University of Oviedo, 33006 Oviedo, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-2863","authenticated-orcid":false,"given":"Cristina","family":"Galache","sequence":"additional","affiliation":[{"name":"Grider, Grupo de Investigaci\u00f3n en Dermatolog\u00eda, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Dermatology Division, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias, University of Oviedo, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1080\/07357907.2022.2116454","article-title":"Real-World Evidence Shows 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