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The aim was to assess the optimal reaction parameters for the production of a water-insoluble crosslinked gelatin matrix suitable for heat sterilization. Matrices were subjected to enzymatic degradation assessments, and their ability to withstand heat sterilization was evaluated. The impact of different crosslinkers on matrix properties was analyzed. It was found that matrices crosslinked with butanediol diglycidyl ether (BDDE) and poly(ethylene glycol) diglycidyl ether (PEGDE) were resistant to enzymatic degradation and heat sterilization. Additionally, at 1 v\/v % crosslinker concentration, the crosslinked weight was lower than the starting weight, suggesting simultaneous degradation and crosslinking. The crosslinked weight and swelling ratio were optimal in the case of the matrices that were crosslinked with 3% and 5% v\/v BDDE and PEGDE. FTIR analysis confirmed crosslinking, and the reduction of free primary amino groups indicated effective crosslinking even at a 1% v\/v crosslinker concentration. Moreover, stress\u2013strain and compression characteristics of the 5% v\/v BDDE crosslinked matrix were comparable to native gelatin. Based on material science measurements, the crosslinked matrices may be promising candidates for scaffold development, including properties such as resistance to enzymatic degradation and heat sterilization.<\/jats:p>","DOI":"10.3390\/ijms25084336","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:24:26Z","timestamp":1713176666000},"page":"4336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development"],"prefix":"10.3390","volume":"25","author":[{"given":"Vikt\u00f3ria","family":"Varga","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary"},{"name":"Department of Materials Science and Technology, University of Gy\u0151r, 9026 Gy\u0151r, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-3268","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"Smeller","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9031-6724","authenticated-orcid":false,"given":"R\u00f3bert","family":"V\u00e1rdai","sequence":"additional","affiliation":[{"name":"Laboratory of Plastics and Rubber Technology, Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, 1111 Budapest, Hungary"},{"name":"Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, 1111 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4751-5071","authenticated-orcid":false,"given":"Bence","family":"Kocsis","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Technology, University of Gy\u0151r, 9026 Gy\u0151r, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0780-6018","authenticated-orcid":false,"given":"Ibolya","family":"Zsoldos","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Technology, University of Gy\u0151r, 9026 Gy\u0151r, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Cruciani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43\/B, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5957-0062","authenticated-orcid":false,"given":"Renzo","family":"Pala","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43\/B, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-8973","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Horny\u00e1k","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary"},{"name":"Department of Materials Science and Technology, University of Gy\u0151r, 9026 Gy\u0151r, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ten.tea.2018.0138","article-title":"An Overview of the Tissue Engineering Market in the United States from 2011 to 2018","volume":"25","author":"Kim","year":"2019","journal-title":"Tissue Eng. 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Sci., 19.","DOI":"10.3390\/ijms19113433"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1089\/ten.teb.2021.0045","article-title":"Overview of Tissue Engineering Patent Strategies and Patents from 2010 to 2020, Including Outcomes","volume":"28","author":"Hinsenkamp","year":"2022","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hinsenkamp, A., Kardos, D., Lacza, Z., and Horny\u00e1k, I. (2020). A Practical Guide to Class IIa Medical Device Development. Appl. Sci., 10.","DOI":"10.3390\/app10103638"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Hinsenkamp, A., Fulop, A., Hricisak, L., Pal, E., Kun, K., Majer, A., Varga, V., Lacza, Z., and Hornyak, I. (2022). Application of Injectable, Crosslinked, Fibrin-Containing Hyaluronic Acid Scaffolds for In Vivo Remodeling. J. Funct. 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Rheol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bikuna-Izagirre, M., Aldazabal, J., and Paredes, J. (2022). Gelatin Blends Enhance Performance of Electrospun Polymeric Scaffolds in Comparison to Coating Protocols. Polymers, 14.","DOI":"10.3390\/polym14071311"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/term.492","article-title":"Characterization of chitosan-gelatin scaffolds for dermal tissue engineering","volume":"7","author":"Tseng","year":"2013","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Masutani, E.M., Kinoshita, C.K., Tanaka, T.T., Ellison, A.K., and Yoza, B.A. (2014). Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose. Int. J. Biomater., 2014.","DOI":"10.1155\/2014\/979636"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2497","DOI":"10.7717\/peerj.2497","article-title":"Enzymatically crosslinked gelatin hydrogel promotes the proliferation of adipose tissue-derived stromal cells","volume":"4","author":"Yang","year":"2016","journal-title":"PeerJ"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jayachandran, B., Parvin, T.N., Alam, M.M., Chanda, K., and Mm, B. (2022). Insights on Chemical Crosslinking Strategies for Proteins. Molecules, 27.","DOI":"10.3390\/molecules27238124"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1089\/ten.tea.2020.0197","article-title":"Crosslinked Hyaluronic Acid Gels with Blood-Derived Protein Components for Soft Tissue Regeneration","volume":"27","author":"Hinsenkamp","year":"2021","journal-title":"Tissue Eng. Part. 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Sci., 19.","DOI":"10.3390\/ijms19113341"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Skopinska-Wisniewska, J., Tuszynska, M., and Olewnik-Kruszkowska, E. (2021). Comparative Study of Gelatin Hydrogels Modified by Various Cross-Linking Agents. Materials, 14.","DOI":"10.3390\/ma14020396"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.1038\/s41598-021-89358-2","article-title":"Identification of bovine, porcine and fish gelatin signatures using chemometrics fuzzy graph method","volume":"11","author":"Hassan","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/app.1970.070140514","article-title":"Load-compression behavior of brittle foams","volume":"14","author":"Rusch","year":"1970","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jbm.b.33329","article-title":"Hyaluronan dermal fillers via crosslinking with 1,4-butandiol diglycidyl ether: Exploitation of heterogeneous reaction conditions","volume":"104","author":"Papa","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1097-4636(20000915)51:4<541::AID-JBM1>3.0.CO;2-P","article-title":"The kinetics of 1,4-butanediol diglycidyl ether crosslinking of dermal sheep collagen","volume":"51","author":"Zeeman","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1039\/C5TB02564H","article-title":"Modulating In Vivo Degradation Rate of Injectable Extracellular Matrix Hydrogels","volume":"4","author":"Wassenaar","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1524-475x.2000.00005.x","article-title":"Perspective article: The fate of collagen implants in tissue defects","volume":"8","author":"Bailey","year":"2000","journal-title":"Wound Repair. Regen."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Liu, Q., Wang, F., Gu, Z., Ma, Q., and Hu, X. (2018). Exploring the Structural Transformation Mechanism of Chinese and Thailand Silk Fibroin Fibers and Formic-Acid Fabricated Silk Films. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113309"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1042\/bj0610589","article-title":"The amino acid composition of mammalian collagen and gelatin","volume":"61","author":"Eastoe","year":"1955","journal-title":"Biochem. J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kircher, R., Mross, S., Hasse, H., and M\u00fcnnemann, K. (2022). Functionalized Controlled Porous Glasses for Producing Radical-Free Hyperpolarized Liquids by Overhauser DNP. Molecules, 27.","DOI":"10.3390\/molecules27196402"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1021\/ja8094922","article-title":"Amide I\u2019-II\u2019 2D IR spectroscopy provides enhanced protein secondary structural sensitivity","volume":"131","author":"Deflores","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Parker, F.S. (1971). Amides and Amines. Applications of Infrared Spectroscopy in Biochemistry, Biology, and Medicine, Springer.","DOI":"10.1007\/978-1-4684-1872-9"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Derkach, S.R., Kuchina, Y.A., Baryshnikov, A.V., Kolotova, D.S., and Voron\u2019ko, N.G. (2019). Tailoring Cod Gelatin Structure and Physical Properties with Acid and Alkaline Extraction. Polymers, 11.","DOI":"10.3390\/polym11101724"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Stani, C., Vaccari, L., Mitri, E., and Birarda, G. (2020). FTIR investigation of the secondary structure of type I collagen: New insight into the amide III band. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 229.","DOI":"10.1016\/j.saa.2019.118006"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/dsu.12301","article-title":"A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers","volume":"39","author":"Glogau","year":"2013","journal-title":"Dermatol. 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