{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:17:18Z","timestamp":1791980238973,"version":"4.4.0"},"reference-count":86,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Dental tissue stem cells (DTSCs) are well known for their multipotent capacity and regenerative potential. They also play an important role in the immune response of inflammatory processes derived from caries lesions, periodontitis, and gingivitis. These oral diseases are triggered by toxins known as lipopolysaccharides (LPS) produced by gram-negative bacteria. LPS present molecular patterns associated with pathogens and are recognized by Toll-like receptors (TLRs) in dental stem cells. In this review, we describe the effect of LPS on the biological behavior of DTSCs. We also focus on the molecular sensors, signaling pathways, and emerging players participating in the interaction of DTSCs with lipopolysaccharides. Although the scientific advances generated provide an understanding of the immunomodulatory potential of DTSCs, there are still new reflections to explore with regard to their clinical application in the treatment of oral inflammatory diseases.<\/jats:p>","DOI":"10.3390\/ijms25084338","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:24:26Z","timestamp":1713176666000},"page":"4338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dental Stem Cells and Lipopolysaccharides: A Concise Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Beatriz A.","family":"Rodas-Junco","sequence":"first","affiliation":[{"name":"CONAHCYT\u2013Facultad de Ingenier\u00eda Qu\u00edmica, Campus de Ciencias Exactas e Ingenier\u00edas, Universidad Aut\u00f3noma de Yucat\u00e1n, Perif\u00e9rico Norte Kil\u00f3metro 33.5, Tablaje Catastral 13615 Chuburn\u00e1 de Hidalgo Inn, M\u00e9rida CP 97203, Yucat\u00e1n, Mexico"},{"name":"Laboratorio Traslacional de C\u00e9lulas Troncales de la Cavidad Bucal, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Yucat\u00e1n, Calle 61-A #492-A X Av. Itzaes Costado Sur \u201cParque de la Paz\u201d, Col. Centro, M\u00e9rida CP 97000, Yucat\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-7510","authenticated-orcid":false,"given":"Sandra E.","family":"Hern\u00e1ndez-Sol\u00eds","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Oral y Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Yucat\u00e1n, Calle 61-A #492-A X Av. Itzaes Costado Sur \u201cParque de la Paz\u201d, Col. Centro, M\u00e9rida CP 97000, Yucat\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica A.","family":"Serralta-Interian","sequence":"additional","affiliation":[{"name":"Laboratorio Traslacional de C\u00e9lulas Troncales de la Cavidad Bucal, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Yucat\u00e1n, Calle 61-A #492-A X Av. Itzaes Costado Sur \u201cParque de la Paz\u201d, Col. Centro, M\u00e9rida CP 97000, Yucat\u00e1n, Mexico"},{"name":"Facultad de Ingenier\u00eda Qu\u00edmica, Campus de Ciencias Exactas e Ingenier\u00edas, Universidad Aut\u00f3noma de Yucat\u00e1n, Perif\u00e9rico Norte Kil\u00f3metro 33.5, Tablaje Catastral 13615 Chuburn\u00e1 de Hidalgo Inn, M\u00e9rida CP 97203, Yucat\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-6555","authenticated-orcid":false,"given":"Florencio","family":"Rueda-Gordillo","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Oral y Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Yucat\u00e1n, Calle 61-A #492-A X Av. Itzaes Costado Sur \u201cParque de la Paz\u201d, Col. Centro, M\u00e9rida CP 97000, Yucat\u00e1n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2012.11.006","article-title":"The oral microbiome in health and disease","volume":"69","author":"Wade","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.csbj.2021.02.010","article-title":"The oralome and its dysbiosis: New insights into oral microbiome-host interactions","volume":"19","author":"Radaic","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Li, X., Liu, Y., Yang, X., Li, C., and Song, Z. (2022). The oral microbiota: Community composition, influencing factors, pathogenesis, and interventions. Front. 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