{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:00:57Z","timestamp":1781586057450,"version":"3.54.5"},"reference-count":112,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Garnett Passe and Rodney Williams Memorial Foundation"},{"name":"IMPACT Philanthropy Application"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The prevalence of diseases characterised by eosinophilia is on the rise, emphasising the importance of understanding the role of eosinophils in these conditions. Eosinophils are a subset of granulocytes that contribute to the body\u2019s defence against bacterial, viral, and parasitic infections, but they are also implicated in haemostatic processes, including immunoregulation and allergic reactions. They contain cytoplasmic granules which can be selectively mobilised and secrete specific proteins, including chemokines, cytokines, enzymes, extracellular matrix, and growth factors. There are multiple biological and emerging functions of these specialised immune cells, including cancer surveillance, tissue remodelling and development. Several oral diseases, including oral cancer, are associated with either tissue or blood eosinophilia; however, their exact mechanism of action in the pathogenesis of these diseases remains unclear. This review presents a comprehensive synopsis of the most recent literature for both clinicians and scientists in relation to eosinophils and oral diseases and reveals a significant knowledge gap in this area of research.<\/jats:p>","DOI":"10.3390\/ijms25084373","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T04:21:59Z","timestamp":1713241319000},"page":"4373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Eosinophils in Oral Disease: A Narrative Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Huda Moutaz Asmael","family":"Al-Azzawi","sequence":"first","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-4723","authenticated-orcid":false,"given":"Rita","family":"Paolini","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-1323","authenticated-orcid":false,"given":"Nicola","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7134-6496","authenticated-orcid":false,"given":"Lorraine Ann","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia"},{"name":"Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-5426","authenticated-orcid":false,"given":"Ilaria","family":"Mormile","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Moore","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-1114","authenticated-orcid":false,"given":"Tami","family":"Yap","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-2511","authenticated-orcid":false,"given":"Antonio","family":"Celentano","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"ref_1","unstructured":"Ehrlich, P. 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