{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:09:54Z","timestamp":1782155394499,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-65\/2024-03\/200124"],"award-info":[{"award-number":["451-03-65\/2024-03\/200124"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-66\/2024-03\/200124"],"award-info":[{"award-number":["451-03-66\/2024-03\/200124"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-65\/2024-03\/200113"],"award-info":[{"award-number":["451-03-65\/2024-03\/200113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Marrubiin is a diterpene with a long history of a wide range of biological activities. In this study, the anti-inflammatory effects of marrubiin were investigated using several in vitro and in vivo assays. Marrubiin inhibited carrageenan-induced peritoneal inflammation by preventing inflammatory cell infiltration and peritoneal mast cell degranulation. The anti-inflammatory activity was further demonstrated by monitoring a set of biochemical parameters, showing that the peritoneal fluid of animals treated with marrubiin had lower levels of proteins and lower myeloperoxidase activity compared with the fluid of animals that were not treated. Marrubiin exerted the most pronounced cytotoxic activity towards peripheral mononuclear cells, being the main contributors to peritoneal inflammation. Additionally, a moderate lipoxygenase inhibition activity of marrubiin was observed.<\/jats:p>","DOI":"10.3390\/ijms25084496","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T10:53:17Z","timestamp":1713523997000},"page":"4496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Marrubiin Inhibits Peritoneal Inflammatory Response Induced by Carrageenan Application in C57 Mice"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-7567","authenticated-orcid":false,"given":"Niko S.","family":"Radulovi\u0107","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Mathematics, University of Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miljana R.","family":"\u0110or\u0111evi\u0107 Zlatkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Mathematics, University of Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0124-3501","authenticated-orcid":false,"given":"Nikola M.","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan S.","family":"Ne\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Mathematics, University of Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan B.","family":"Zlatkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Mathematics, University of Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-8296","authenticated-orcid":false,"given":"Milena S.","family":"Poti\u0107 Floranovi\u0107","sequence":"additional","affiliation":[{"name":"Scientific Research Centre for Biomedicine, Faculty of Medicine, University of Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana S.","family":"Tri\u010dkovi\u0107 Vuki\u0107","sequence":"additional","affiliation":[{"name":"Scientific Research Centre for Biomedicine, Faculty of Medicine, University of Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4569-1787","authenticated-orcid":false,"given":"Pavle J.","family":"Randjelovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Ni\u0161, 18000 Ni\u0161, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9049","DOI":"10.3390\/molecules18089049","article-title":"Marrubiin","volume":"18","author":"Popoola","year":"2013","journal-title":"Molecules"},{"key":"ref_2","first-page":"585","article-title":"The Diterpenoids of the Genus Marrubium (Lamiaceae)","volume":"1","author":"Piozzi","year":"2006","journal-title":"Nat. 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