{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:43:38Z","timestamp":1791434618895,"version":"4.3.3"},"reference-count":67,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["950050"],"award-info":[{"award-number":["950050"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Distinguished Scientist Fellowship Program of King Saud University, Riyadh, Saudi Arabia","award":["950050"],"award-info":[{"award-number":["950050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Milk holds a high nutritional value and is associated with diverse health benefits. The understanding of its composition of (poly)phenolic metabolites is limited, which necessitates a comprehensive evaluation of the subject. This study aimed at analyzing the (poly)phenolic profile of commercial milk samples from cows and goats and investigating their sterilization treatments, fat content, and lactose content. Fingerprinting of phenolic metabolites was achieved by using ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry (UHPLC-QqQ-MS\/MS). Two hundred and three potential microbial and phase II metabolites of the main dietary (poly)phenols were targeted. Twenty-five metabolites were identified, revealing a diverse array of phenolic metabolites in milk, including isoflavones and their microbial catabolites equol and O-desmethylangolensin, phenyl-\u03b3-valerolactones (flavan-3-ol microbial catabolites), enterolignans, urolithins (ellagitannin microbial catabolites), benzene diols, and hippuric acid derivates. Goat\u2019s milk contained higher concentrations of these metabolites than cow\u2019s milk, while the sterilization process and milk composition (fat and lactose content) had minimal impact on the metabolite profiles. Thus, the consumption of goat\u2019s milk might serve as a potential means to supplement bioactive phenolic metabolites, especially in individuals with limited production capacity. However, further research is needed to elucidate the potential health effects of milk-derived phenolics.<\/jats:p>","DOI":"10.3390\/ijms25084536","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:44:09Z","timestamp":1713771849000},"page":"4536","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Using Targeted Metabolomics to Unravel Phenolic Metabolites of Plant Origin in Animal Milk"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6846-6072","authenticated-orcid":false,"given":"Vicente","family":"Agull\u00f3","sequence":"first","affiliation":[{"name":"Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0669-2223","authenticated-orcid":false,"given":"Claudia","family":"Favari","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Pilla","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-4987","authenticated-orcid":false,"given":"Letizia","family":"Bresciani","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-1739","authenticated-orcid":false,"given":"Francisco A.","family":"Tom\u00e1s-Barber\u00e1n","sequence":"additional","affiliation":[{"name":"Quality, Safety, and Bioactivity of Plant Foods Research Group, Laboratory of Food & Health, CEBAS\u2013CSIC, Espinardo P.O. Box 164, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Crozier","sequence":"additional","affiliation":[{"name":"Department of Chemistry, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-1259","authenticated-orcid":false,"given":"Daniele","family":"Del Rio","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy"},{"name":"Microbiome Research Hub, University of Parma, 43125 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2150-2977","authenticated-orcid":false,"given":"Pedro","family":"Mena","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, Department of Food & Drug, University of Parma, 43125 Parma, Italy"},{"name":"Microbiome Research Hub, University of Parma, 43125 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109279","DOI":"10.1016\/j.foodres.2020.109279","article-title":"Milk metabolomics based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to discriminate different cows feeding regimens","volume":"134","author":"Rocchetti","year":"2020","journal-title":"Food Res. 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