{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:21:13Z","timestamp":1791814873447,"version":"4.3.4"},"reference-count":28,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The measurement of blood glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) may assist in the management of mild traumatic brain injury (mTBI). This study aims to compare GFAP and UCH-L1 values measured using a handheld device with those measured using a core laboratory platform. We enrolled 230 mTBI patients at intermediate risk of complications. Following French guidelines, a negative S100B value permits the patient to be discharged without a computed tomography scan. Plasma GFAP and UCH-L1 levels were retrospectively measured using i-STAT\u00ae and Alinity\u00ae i analyzers in patients managed within 12 h post-trauma. Our analysis indicates a strong correlation of biomarker measurements between the two analyzers. Cohen\u2019s kappa coefficients and Lin\u2019s concordance coefficients were both \u22650.7, while Spearman\u2019s correlation coefficient was 0.94 for GFAP and 0.90 for UCH-L1. Additionally, the diagnostic performance in identifying an intracranial lesion was not significantly different between the two analyzers, with a sensitivity of 100% and specificity of approximately 30%. GFAP and UCH-L1 levels measured using Abbott\u2019s i-STAT\u00ae and Alinity\u00ae i platform assays are highly correlated both analytically and clinically in a cohort of 230 patients managed for mTBI according to French guidelines.<\/jats:p>","DOI":"10.3390\/ijms25084539","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:44:09Z","timestamp":1713771849000},"page":"4539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of GFAP and UCH-L1 Measurements Using Two Automated Immunoassays (i-STAT\u00ae and Alinity\u00ae) for the Management of Patients with Mild Traumatic Brain Injury: Preliminary Results from a French Single-Center Approach"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7360-4142","authenticated-orcid":false,"given":"Charlotte","family":"Oris","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, University Hospital, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Khatib-Chahidi","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, University Hospital, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-7161","authenticated-orcid":false,"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"Clinical Research and Innovation Department, University Hospital, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Bailly Defrance","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, University Hospital, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2707-4320","authenticated-orcid":false,"given":"Damien","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, University Hospital, 63000 Clermont-Ferrand, France"},{"name":"Institute \u201cGenetic, Reproduction and Development\u201d, UMR INSERM 1103 CNRS 6293, Universit\u00e9 Clermont Auvergne, 63001 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-315X","authenticated-orcid":false,"given":"Vincent","family":"Sapin","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, University Hospital, 63000 Clermont-Ferrand, France"},{"name":"Institute \u201cGenetic, Reproduction and Development\u201d, UMR INSERM 1103 CNRS 6293, Universit\u00e9 Clermont Auvergne, 63001 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Oris, C., Kahouadji, S., Durif, J., Bouvier, D., and Sapin, V. 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