{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:43:59Z","timestamp":1789087439210,"version":"build-2803163510"},"reference-count":115,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["2SC3GM116669"],"award-info":[{"award-number":["2SC3GM116669"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In response to cellular metabolic and signaling cues, the mitochondrial network employs distinct sets of membrane-shaping factors to dynamically modulate organellar structures through a balance of fission and fusion. While these organellar dynamics mediate mitochondrial structure\/function homeostasis, they also directly impact critical cell-wide signaling pathways such as apoptosis, autophagy, and the integrated stress response (ISR). Mitochondrial fission is driven by the recruitment of the cytosolic dynamin-related protein-1 (DRP1), while fusion is carried out by mitofusins 1 and 2 (in the outer membrane) and optic atrophy-1 (OPA1) in the inner membrane. This dynamic balance is highly sensitive to cellular stress; when the transmembrane potential across the inner membrane (\u0394\u03c8m) is lost, fusion-active OPA1 is cleaved by the overlapping activity with m-AAA protease-1 (OMA1 metalloprotease, disrupting mitochondrial fusion and leaving dynamin-related protein-1 (DRP1)-mediated fission unopposed, thus causing the collapse of the mitochondrial network to a fragmented state. OMA1 is a unique regulator of stress-sensitive homeostatic mitochondrial balance, acting as a key upstream sensor capable of priming the cell for apoptosis, autophagy, or ISR signaling cascades. Recent evidence indicates that higher-order macromolecular associations within the mitochondrial inner membrane allow these specialized domains to mediate crucial organellar functionalities.<\/jats:p>","DOI":"10.3390\/ijms25084566","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:44:09Z","timestamp":1713771849000},"page":"4566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["OMA1-Mediated Mitochondrial Dynamics Balance Organellar Homeostasis Upstream of Cellular Stress Responses"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-6627","authenticated-orcid":false,"given":"Robert","family":"Gilkerson","sequence":"first","affiliation":[{"name":"School of Integrative Biological & Chemical Sciences, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA"},{"name":"Department of Health & Biomedical Sciences, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4220-1163","authenticated-orcid":false,"given":"Harpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"School of Integrative Biological & Chemical Sciences, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Carrillo","sequence":"additional","affiliation":[{"name":"School of Integrative Biological & Chemical Sciences, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaiah","family":"Ramos","sequence":"additional","affiliation":[{"name":"School of Integrative Biological & Chemical Sciences, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/171030a0","article-title":"Electron microscopy of mitochondria and cytoplasmic double membranes","volume":"171","author":"Sjostrand","year":"1953","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ar.1091140304","article-title":"The fine structure of mitochondria","volume":"114","author":"Palade","year":"1952","journal-title":"Anat. 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