{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:00:41Z","timestamp":1760144441234,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We are pleased to present this Special Issue of the International Journal of Molecular Sciences, entitled \u201cPhysiology and Pathophysiology of Placenta 2 [...]<\/jats:p>","DOI":"10.3390\/ijms25094586","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T05:28:06Z","timestamp":1713850086000},"page":"4586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Special Issue \u201cPhysiology and Pathophysiology of Placenta 2.0\u201d"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-1230","authenticated-orcid":false,"given":"Giovanni","family":"Tossetta","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tossetta, G., Fantone, S., Piani, F., Crescimanno, C., Ciavattini, A., Giannubilo, S.R., and Marzioni, D. (2023). Modulation of NRF2\/KEAP1 Signaling in Preeclampsia. Cells, 12.","DOI":"10.3390\/cells12111545"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4081\/1623","article-title":"Hyaluronate and CD44 expression patterns in the human placenta throughout pregnancy","volume":"45","author":"Marzioni","year":"2001","journal-title":"Eur. J. Histochem."},{"key":"ref_3","first-page":"2724","article-title":"High temperature requirement A1 and fibronectin: Two possible players in placental tissue remodelling","volume":"60","author":"Tossetta","year":"2016","journal-title":"Eur. J. Histochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1210\/jc.2004-1512","article-title":"Placental expression of substance P and vasoactive intestinal peptide: Evidence for a local effect on hormone release","volume":"90","author":"Marzioni","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s004410050625","article-title":"Codistribution of basic fibroblast growth factor and heparan sulfate proteoglycan in the growth zones of the human placenta","volume":"285","author":"Muhlhauser","year":"1996","journal-title":"Cell Tissue Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101549","DOI":"10.1016\/j.tice.2021.101549","article-title":"HTRA family proteins in pregnancy outcome","volume":"72","author":"Fantone","year":"2021","journal-title":"Tissue Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"639342","DOI":"10.1155\/2012\/639342","article-title":"Macrophage migration inhibitory factor in fetoplacental tissues from preeclamptic pregnancies with or without fetal growth restriction","volume":"2012","author":"Cardaropoli","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"ref_8","first-page":"1213","article-title":"Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases","volume":"24","author":"Marzioni","year":"2009","journal-title":"Histol. Histopathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.14715\/cmb\/2017.63.3.10","article-title":"Molecular analysis of endometrial inflammation in preterm birth","volume":"63","author":"Cecati","year":"2017","journal-title":"Cell Mol. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tossetta, G., Fantone, S., Gesuita, R., Di Renzo, G.C., Meyyazhagan, A., Tersigni, C., Scambia, G., Di Simone, N., and Marzioni, D. (2022). HtrA1 in Gestational Diabetes Mellitus: A Possible Biomarker?. Diagnostics, 12.","DOI":"10.3390\/diagnostics12112705"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tem.2020.12.005","article-title":"Roles of TGF-beta Superfamily Proteins in Extravillous Trophoblast Invasion","volume":"32","author":"Li","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_12","first-page":"5947859","article-title":"Akt\/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy","volume":"2017","author":"Silva","year":"2017","journal-title":"J. Diabetes Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12016-016-8596-x","article-title":"Tumor Necrosis Factor-Alpha and Pregnancy: Focus on Biologics. An Updated and Comprehensive Review","volume":"53","author":"Llurba","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_14","first-page":"759","article-title":"Analysis of cell-cell junctions in human amnion and chorionic plate affected by chorioamnionitis","volume":"31","author":"Licini","year":"2016","journal-title":"Histol. Histopathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1097\/HJH.0000000000003213","article-title":"Preeclampsia and severe acute respiratory syndrome coronavirus 2 infection: A systematic review","volume":"40","author":"Tossetta","year":"2022","journal-title":"J. Hypertens."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mateuszuk, L., Campagna, R., Kutryb-Zajac, B., Kus, K., Slominska, E.M., Smolenski, R.T., and Chlopicki, S. (2020). Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside. Biochem. Pharmacol., 178.","DOI":"10.1016\/j.bcp.2020.114019"},{"key":"ref_17","first-page":"4678252","article-title":"Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium","volume":"2020","author":"Stojak","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Campagna, R., Mateuszuk, L., Wojnar-Lason, K., Kaczara, P., Tworzydlo, A., Kij, A., Bujok, R., Mlynarski, J., Wang, Y., and Sartini, D. (2021). Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury. Biochim. Biophys. Acta Mol. Cell Res., 1868.","DOI":"10.1016\/j.bbamcr.2021.119082"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/tra.12700","article-title":"Actin-spectrin scaffold supports open fenestrae in liver sinusoidal endothelial cells","volume":"20","author":"Zapotoczny","year":"2019","journal-title":"Traffic"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tossetta, G., Piani, F., Borghi, C., and Marzioni, D. (2023). Role of CD93 in Health and Disease. Cells, 12.","DOI":"10.3390\/cells12131778"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Campagna, R., and Vignini, A. (2023). NAD(+) Homeostasis and NAD(+)-Consuming Enzymes: Implications for Vascular Health. Antioxidants, 12.","DOI":"10.3390\/antiox12020376"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Togni, L., Mascitti, M., Sartini, D., Campagna, R., Pozzi, V., Salvolini, E., Offidani, A., Santarelli, A., and Emanuelli, M. (2021). Nicotinamide N-Methyltransferase in Head and Neck Tumors: A Comprehensive Review. Biomolecules, 11.","DOI":"10.3390\/biom11111594"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Campagna, R., Pozzi, V., Spinelli, G., Sartini, D., Milanese, G., Galosi, A.B., and Emanuelli, M. (2021). The Utility of Nicotinamide N-Methyltransferase as a Potential Biomarker to Predict the Oncological Outcomes for Urological Cancers: An Update. Biomolecules, 11.","DOI":"10.3390\/biom11081214"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s13577-021-00581-5","article-title":"Differential immunohistochemical expression of paraoxonase-2 in actinic keratosis and squamous cell carcinoma","volume":"34","author":"Sartini","year":"2021","journal-title":"Hum. Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.preghy.2019.08.005","article-title":"Association between first trimester plasma htra1 level and subsequent preeclampsia: A possible early marker?","volume":"18","author":"Gesuita","year":"2019","journal-title":"Pregnancy Hypertens."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1080\/14767058.2020.1732345","article-title":"First trimester HtrA1 maternal plasma level and spontaneous preterm birth","volume":"35","author":"Giannubilo","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/HJH.0000000000003472","article-title":"Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes","volume":"41","author":"Piani","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s40292-023-00608-y","article-title":"First Trimester CD93 as a Novel Marker of Preeclampsia and Its Complications: A Pilot Study","volume":"30","author":"Piani","year":"2023","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Bacchetti, T., Campagna, R., Sartini, D., Cecati, M., Morresi, C., Bellachioma, L., Martinelli, E., Rocchetti, G., Lucini, L., and Ferretti, G. (2022). C. spinosa L. subsp. rupestris Phytochemical Profile and Effect on Oxidative Stress in Normal and Cancer Cells. Molecules, 27.","DOI":"10.3390\/molecules27196488"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Tossetta, G., Fantone, S., Giannubilo, S.R., and Marzioni, D. (2021). The Multifaced Actions of Curcumin in Pregnancy Outcome. Antioxidants, 10.","DOI":"10.3390\/antiox10010126"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/9\/4586\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:32:30Z","timestamp":1760106750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/9\/4586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["ijms25094586"],"URL":"https:\/\/doi.org\/10.3390\/ijms25094586","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}