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project","award":["2022-36-Z06-01"],"award-info":[{"award-number":["2022-36-Z06-01"]}]},{"name":"Guangxi Major science and technology Innovation base construction project","award":["Guike ZY23055011"],"award-info":[{"award-number":["Guike ZY23055011"]}]},{"name":"Central Guidance Fund for Local Scientific and Technological Development Project","award":["32060216"],"award-info":[{"award-number":["32060216"]}]},{"name":"Central Guidance Fund for Local Scientific and Technological Development Project","award":["GuiKe AA20297007"],"award-info":[{"award-number":["GuiKe AA20297007"]}]},{"name":"Central Guidance Fund for Local Scientific and Technological Development Project","award":["20223038"],"award-info":[{"award-number":["20223038"]}]},{"name":"Central Guidance Fund for Local Scientific and Technological Development Project","award":["2022-36-Z06-01"],"award-info":[{"award-number":["2022-36-Z06-01"]}]},{"name":"Central Guidance Fund for Local Scientific and Technological Development Project","award":["Guike ZY23055011"],"award-info":[{"award-number":["Guike ZY23055011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The expression of polysialic acid (polySia) on the neuronal cell adhesion molecule (NCAM) is called NCAM-polysialylation, which is strongly related to the migration and invasion of tumor cells and aggressive clinical status. Thus, it is important to select a proper drug to block tumor cell migration during clinical treatment. In this study, we proposed that lactoferrin (LFcinB11) may be a better candidate for inhibiting NCAM polysialylation when compared with CMP and low-molecular-weight heparin (LMWH), which were determined based on our NMR studies. Furthermore, neutrophil extracellular traps (NETs) represent the most dramatic stage in the cell death process, and the release of NETs is related to the pathogenesis of autoimmune and inflammatory disorders, with proposed involvement in glomerulonephritis, chronic lung disease, sepsis, and vascular disorders. In this study, the molecular mechanisms involved in the inhibition of NET release using LFcinB11 as an inhibitor were also determined. Based on these results, LFcinB11 is proposed as being a bifunctional inhibitor for inhibiting both NCAM polysialylation and the release of NETs.<\/jats:p>","DOI":"10.3390\/ijms25094641","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:18:36Z","timestamp":1713953916000},"page":"4641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Bifunctional Effects of Lactoferrin (LFcinB11) in Inhibiting Neural Cell Adhesive Molecule (NCAM) Polysialylation and the Release of Neutrophil Extracellular Traps (NETs)"],"prefix":"10.3390","volume":"25","author":[{"given":"Bo","family":"Lu","sequence":"first","affiliation":[{"name":"National Key Laboratory of Non-Food Biomass Energy Technology, National Engineering Research Center for Non-Food Biorefinery, Institute of Biological Science and Technology, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ming","family":"Liao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Non-Food Biomass Energy Technology, National Engineering Research Center for Non-Food Biorefinery, Institute of Biological Science and Technology, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Liang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Non-Food Biomass Energy Technology, National Engineering Research Center for Non-Food Biorefinery, Institute of Biological Science and Technology, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Xin","family":"Peng","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Non-Food Biomass Energy Technology, National Engineering Research Center for Non-Food Biorefinery, Institute of Biological Science and Technology, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-9712","authenticated-orcid":false,"given":"Jian-Xiu","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Non-Food Biomass Energy Technology, National Engineering Research Center for Non-Food Biorefinery, Institute of Biological Science and Technology, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ri-Bo","family":"Huang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Non-Food Biomass Energy Technology, National Engineering Research Center for Non-Food Biorefinery, Institute of Biological Science and Technology, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China"},{"name":"Rocky Mount Life Sciences Institute, Rocky Mount, NC 27804, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-2481","authenticated-orcid":false,"given":"Guo-Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Non-Food Biomass Energy Technology, National Engineering Research Center for Non-Food Biorefinery, Institute of Biological Science and Technology, Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China"},{"name":"Rocky Mount Life Sciences Institute, Rocky Mount, NC 27804, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lepers, A.H., Petit, D., Mollicone, R., Delannoy, P., Petit, J.M., and Oriol, R. 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