{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:06:15Z","timestamp":1791234375754,"version":"4.1.0"},"reference-count":193,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["R15AI165295-01A1"],"award-info":[{"award-number":["R15AI165295-01A1"]}]},{"name":"National Institutes of Health","award":["R21AI162076"],"award-info":[{"award-number":["R21AI162076"]}]},{"name":"National Institutes of Health","award":["R01HL160229"],"award-info":[{"award-number":["R01HL160229"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite combined antiretroviral therapy (cART) limiting HIV replication to undetectable levels in the blood, people living with HIV continue to experience HIV-associated neurocognitive disorder (HAND). HAND is associated with neurocognitive impairment, including motor impairment, and memory loss. HIV has been detected in the brain within 8 days of estimated exposure and the mechanisms for this early entry are being actively studied. Once having entered into the central nervous system (CNS), HIV degrades the blood\u2013brain barrier through the production of its gp120 and Tat proteins. These proteins are directly toxic to endothelial cells and neurons, and propagate inflammatory cytokines by the activation of immune cells and dysregulation of tight junction proteins. The BBB breakdown is associated with the progression of neurocognitive disease. One of the main hurdles for treatment for HAND is the latent pool of cells, which are insensitive to cART and prolong inflammation by harboring the provirus in long-lived cells that can reactivate, causing damage. Multiple strategies are being studied to combat the latent pool and HAND; however, clinically, these approaches have been insufficient and require further revisions. The goal of this paper is to aggregate the known mechanisms and challenges associated with HAND.<\/jats:p>","DOI":"10.3390\/ijms25094697","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T05:13:41Z","timestamp":1714108421000},"page":"4697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["HIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology"],"prefix":"10.3390","volume":"25","author":[{"given":"Landon John-Patrick","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Genovese","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzi","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera Vir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rochester, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8022-5167","authenticated-orcid":false,"given":"Vir Bahadur","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.10.001","article-title":"Systemic Effects of Inflammation on Health during Chronic HIV Infection","volume":"39","author":"Deeks","year":"2013","journal-title":"Immunity"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(13)61809-7","article-title":"The End of AIDS: HIV Infection as a Chronic Disease","volume":"382","author":"Deeks","year":"2013","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"814362","DOI":"10.3389\/fpsyt.2022.814362","article-title":"Worldwide Occurrence of HIV-Associated Neurocognitive Disorders and Its Associated Factors: A Systematic Review and Meta-Analysis","volume":"13","author":"Zenebe","year":"2022","journal-title":"Front. 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