{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:00:04Z","timestamp":1791979204437,"version":"4.4.0"},"reference-count":115,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic postsurgical pain (CPSP) following total knee arthroplasty (TKA) and total hip arthroplasty (THA) is a prevalent complication of joint replacement surgery which has the potential to decrease patient satisfaction, increase financial burden, and lead to long-term disability. The identification of risk factors for CPSP following TKA and THA is challenging but essential for targeted preventative therapy. Recent meta-analyses and individual studies highlight associations between elevated state anxiety, depression scores, preoperative pain, diabetes, sleep disturbances, and various other factors with an increased risk of CPSP, with differences observed in prevalence between TKA and THA. While the etiology of CPSP is not fully understood, several factors such as chronic inflammation and preoperative central sensitization have been identified. Other potential mechanisms include genetic factors (e.g., catechol-O-methyltransferase (COMT) and potassium inwardly rectifying channel subfamily J member 6 (KCNJ6) genes), lipid markers, and psychological risk factors (anxiety and depression). With regards to therapeutics and prevention, multimodal pharmacological analgesia, emphasizing nonopioid analgesics like acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs), has gained prominence over epidural analgesia. Nerve blocks and local infiltrative anesthesia have shown mixed results in preventing CPSP. Ketamine, an N-methyl-D-aspartate (NMDA)-receptor antagonist, exhibits antihyperalgesic properties, but its efficacy in reducing CPSP is inconclusive. Lidocaine, an amide-type local anesthetic, shows tentative positive effects on CPSP. Selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) have mixed results, while gabapentinoids, like gabapentin and pregabalin, present hopeful data but require further research, especially in the context of TKA and THA, to justify their use for CPSP prevention.<\/jats:p>","DOI":"10.3390\/ijms25094722","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:18:27Z","timestamp":1714119507000},"page":"4722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Mechanisms and Preventative Strategies for Persistent Pain following Knee and Hip Joint Replacement Surgery: A Narrative Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Jasper","family":"Murphy","sequence":"first","affiliation":[{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sery","family":"Pak","sequence":"additional","affiliation":[{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Shteynman","sequence":"additional","affiliation":[{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Winkeler","sequence":"additional","affiliation":[{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2495-7048","authenticated-orcid":false,"given":"Zhaosheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kaczocha","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio D.","family":"Bergese","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.15585\/mmwr.mm7241a1","article-title":"Prevalence of Diagnosed Arthritis\u2014United States, 2019\u20132021","volume":"72","author":"Fallon","year":"2023","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S245","DOI":"10.21037\/atm.2019.06.68","article-title":"Non-Operative Treatment Options for Knee Osteoarthritis","volume":"7","author":"DeRogatis","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s10067-019-04811-y","article-title":"Total Joint Replacement Improves Pain, Functional Quality of Life, and Health Utilities in Patients with Late-Stage Knee and Hip Osteoarthritis for up to 5 Years","volume":"39","author":"Neuprez","year":"2020","journal-title":"Clin. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e22.00112","DOI":"10.2106\/JBJS.OA.22.00112","article-title":"Projections and Epidemiology of Primary Hip and Knee Arthroplasty in Medicare Patients to 2040\u20132060","volume":"8","author":"Shichman","year":"2023","journal-title":"JBJS Open Access"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2106\/JBJS.N.01141","article-title":"Prevalence of Total Hip and Knee Replacement in the United States","volume":"97","author":"Kremers","year":"2015","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.joca.2017.07.022","article-title":"Projected Increase in Total Knee Arthroplasty in the United States\u2014An Alternative Projection Model","volume":"25","author":"Inacio","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2174\/1874325001105010080","article-title":"Epidemiology of Knee and Hip Arthroplasty: A Systematic Review","volume":"5","author":"Singh","year":"2011","journal-title":"Open Orthop. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40634-021-00436-w","article-title":"Recovery Patterns in Patients Undergoing Revision Surgery of the Primary Knee Prosthesis","volume":"8","author":"Liu","year":"2021","journal-title":"J. Exp. Orthop."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"van der Wees, P.J., Wammes, J.J.G., Akkermans, R.P., Koetsenruijter, J., Westert, G.P., van Kampen, A., Hannink, G., de Waal-Malefijt, M., and Schreurs, B.W. (2017). Patient-Reported Health Outcomes after Total Hip and Knee Surgery in a Dutch University Hospital Setting: Results of Twenty Years Clinical Registry. BMC Musculoskelet. Disord., 18.","DOI":"10.1186\/s12891-017-1455-y"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.arth.2023.04.055","article-title":"Predictors of Chronic Pain in Elderly Patients Undergoing Total Knee and Hip Arthroplasty: A Prospective Observational Study","volume":"38","author":"Tang","year":"2023","journal-title":"J. Arthroplast."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bja\/aeu012","article-title":"I. Defining Persistent Post-Surgical Pain: Is an Update Required?","volume":"113","author":"Werner","year":"2014","journal-title":"Br. J. Anaesth."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/aas.12377","article-title":"A Systematic Review and Meta-Analysis of Ketamine for the Prevention of Persistent Post-Surgical Pain","volume":"58","author":"McNicol","year":"2014","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.knee.2012.10.015","article-title":"Inflammatory Predictors of Ongoing Pain 2 Years Following Knee Replacement Surgery","volume":"20","author":"Gandhi","year":"2013","journal-title":"Knee"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1302\/2058-5241.3.180004","article-title":"Chronic Pain after Total Knee Arthroplasty","volume":"3","author":"Wylde","year":"2018","journal-title":"EFORT Open Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e1052","DOI":"10.1097\/PR9.0000000000001052","article-title":"Factors Associated with Persistent Postsurgical Pain after Total Knee or Hip Joint Replacement: A Systematic Review and Meta-Analysis","volume":"8","author":"Ghoshal","year":"2023","journal-title":"Pain Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/17453674.2015.1044389","article-title":"Diabetes Is Associated with Persistent Pain after Hip and Knee Replacement","volume":"86","author":"Puolakka","year":"2015","journal-title":"Acta Orthop."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/bja\/aeu441","article-title":"Predictors of Persistent Pain after Total Knee Arthroplasty: A Systematic Review and Meta-Analysis","volume":"114","author":"Lewis","year":"2015","journal-title":"Br. J. Anaesth."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101630","DOI":"10.1016\/j.smrv.2022.101630","article-title":"Sleep Disturbances and Sleep Disorders as Risk Factors for Chronic Postsurgical Pain: A Systematic Review and Meta-Analysis","volume":"63","author":"Varallo","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1399-6576.2006.00976.x","article-title":"Chronic Pain Following Total Hip Arthroplasty: A Nationwide Questionnaire Study","volume":"50","author":"Nikolajsen","year":"2006","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.2147\/JPR.S137892","article-title":"Clinical Relevance of Persistent Postoperative Pain after Total Hip Replacement\u2014A Prospective Observational Cohort Study","volume":"10","author":"Erlenwein","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e000435","DOI":"10.1136\/bmjopen-2011-000435","article-title":"What Proportion of Patients Report Long-Term Pain after Total Hip or Knee Replacement for Osteoarthritis? A Systematic Review of Prospective Studies in Unselected Patients","volume":"2","author":"Beswick","year":"2012","journal-title":"BMJ Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/EJA.0b013e328335b31c","article-title":"Persistent Pain Following Knee Arthroplasty","volume":"27","author":"Puolakka","year":"2010","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_23","first-page":"E729","article-title":"Predictive Factors of Chronic Post-Surgical Pain At6 Months Following Knee Replacement: Influenceof Postoperative Pain Trajectory and Genetics","volume":"5","year":"2016","journal-title":"Pain Physician"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.2147\/JPR.S345496","article-title":"Prevalence and Predictors of Chronic Pain with Two-Year Follow-Up after Knee Arthroplasty","volume":"15","author":"Tian","year":"2022","journal-title":"J. Pain Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s11999-013-3389-5","article-title":"Pain Trajectories Identify Patients at Risk of Persistent Pain after Knee Arthroplasty: An Observational Study","volume":"472","author":"Grosu","year":"2014","journal-title":"Clin. Orthop."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"527","DOI":"10.5604\/15093492.1230507","article-title":"Predicting Persistent Unclear Pain Following Primary Total Knee Arthroplasty","volume":"18","year":"2016","journal-title":"Ortop. Traumatol. Rehabil."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s11999-014-3990-2","article-title":"Abnormal Quantitative Sensory Testing Is Associated with Persistent Pain One Year after TKA","volume":"473","author":"Wright","year":"2015","journal-title":"Clin. Orthop."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/AJP.0000000000000146","article-title":"Chronic Postoperative Pain after Primary and Revision Total Knee Arthroplasty","volume":"31","author":"Petersen","year":"2015","journal-title":"Clin. J. Pain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4055\/cios.2017.9.1.50","article-title":"Causes of Aseptic Persistent Pain after Total Knee Arthroplasty","volume":"9","author":"Lim","year":"2017","journal-title":"Clin. Orthop. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.arth.2022.02.060","article-title":"Diagnosis and Detection of Subtle Aseptic Loosening in Total Hip Arthroplasty","volume":"37","author":"Anil","year":"2022","journal-title":"J. Arthroplast."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3892\/etm.2021.10951","article-title":"Outcomes in Revision Total Knee Arthroplasty (Review)","volume":"23","author":"Roman","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00264-010-1144-z","article-title":"Infection in Total Hip Replacement: Meta-Analysis","volume":"35","author":"Senthi","year":"2011","journal-title":"Int. Orthop."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2106\/JBJS.L.01297","article-title":"The Surgical Anatomy of the Infrapatellar Branch of the Saphenous Nerve in Relation to Incisions for Anteromedial Knee Surgery","volume":"95","author":"Kerver","year":"2013","journal-title":"J. Bone Jt. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00000637-200101000-00004","article-title":"Operative Management of Neuromatous Knee Pain: Patient Selection and Outcome","volume":"46","author":"Nahabedian","year":"2001","journal-title":"Ann. Plast. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.knee.2022.09.010","article-title":"Painful Total Knee Arthroplasty: Infrapatellar Branch of the Saphenous Nerve Selective Denervation. A Case Series","volume":"39","author":"Giannetti","year":"2022","journal-title":"Knee"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e19.00160","DOI":"10.5435\/JAAOSGlobal-D-19-00160","article-title":"Incidence of Encountering the Infrapatellar Nerve Branch of the Saphenous Nerve During a Midline Approach for Total Knee Arthroplasty","volume":"3","author":"James","year":"2019","journal-title":"JAAOS Glob. Res. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.arth.2016.09.043","article-title":"Selective Denervation for Persistent Knee Pain after Total Knee Arthroplasty: A Report of 50 Cases","volume":"32","author":"Shi","year":"2017","journal-title":"J. Arthroplast."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s12178-016-9363-6","article-title":"Towards an Understanding of the Painful Total Knee: What Is the Role of Patient Biology?","volume":"9","author":"Preston","year":"2016","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J. Pain Off. J. Am. Pain Soc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/archneur.58.10.1547","article-title":"Neuropathic Central Pain: Epidemiology, Etiology, and Treatment Options","volume":"58","author":"Schwartzman","year":"2001","journal-title":"Arch. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"833104","DOI":"10.3389\/fpain.2022.833104","article-title":"The Path to Discovery of Windup and Central Sensitization","volume":"3","author":"Mendell","year":"2022","journal-title":"Front. Pain Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kim, M.S., Kim, J.J., Kang, K.H., Kim, M.J., and In, Y. (2022). Diagnosis of Central Sensitization and Its Effects on Postoperative Outcomes Following Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. Diagnostics, 12.","DOI":"10.3390\/diagnostics12051248"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pain.0000000000000002","article-title":"Preoperative Widespread Pain Sensitization and Chronic Pain after Hip and Knee Replacement: A Cohort Analysis","volume":"156","author":"Wylde","year":"2015","journal-title":"Pain"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.arth.2020.04.004","article-title":"How Does Preoperative Central Sensitization Affect Quality of Life Following Total Knee Arthroplasty?","volume":"35","author":"Koh","year":"2020","journal-title":"J. Arthroplast."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20220009","DOI":"10.2490\/prm.20220009","article-title":"Central Sensitization and Postoperative Improvement of Quality of Life in Total Knee and Total Hip Arthroplasty: A Prospective Observational Study","volume":"7","author":"Sasaki","year":"2022","journal-title":"Prog. Rehabil. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.arth.2019.03.042","article-title":"Central Sensitization Is a Risk Factor for Persistent Postoperative Pain and Dissatisfaction in Patients Undergoing Revision Total Knee Arthroplasty","volume":"34","author":"Kim","year":"2019","journal-title":"J. Arthroplast."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1186\/s13018-023-04175-9","article-title":"Negative Correlation between Central Sensitization and Forgotten Joint Score-12 after Total Hip Arthroplasty","volume":"18","author":"Imagama","year":"2023","journal-title":"J. Orthop. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.joca.2013.05.008","article-title":"The Association between Pre-Operative Pain Sensitisation and Chronic Pain after Knee Replacement: An Exploratory Study","volume":"21","author":"Wylde","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/ejp.2018","article-title":"Chronic Postoperative Pain after Total Knee Arthroplasty: The Potential Contributions of Synovitis, Pain Sensitization and Pain Catastrophizing\u2014An Explorative Study","volume":"26","author":"Kurien","year":"2022","journal-title":"Eur. J. Pain Lond. Engl."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1090-3801(03)00082-X","article-title":"Pressure Pain Thresholds of Tender Point Sites in Patients with Fibromyalgia and in Healthy Controls","volume":"8","author":"Maquet","year":"2004","journal-title":"Eur. J. Pain Lond. Engl."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"9689","DOI":"10.1523\/JNEUROSCI.5039-14.2015","article-title":"Individual Differences in Temporal Summation of Pain Reflect Pronociceptive and Antinociceptive Brain Structure and Function","volume":"35","author":"Cheng","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e002945","DOI":"10.1136\/rmdopen-2022-002945","article-title":"Associations between Markers of Inflammation and Altered Pain Perception Mechanisms in People with Knee Osteoarthritis: A Systematic Review","volume":"9","author":"Dainese","year":"2023","journal-title":"RMD Open"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/AJP.0000000000000907","article-title":"Patients With High Chronic Postoperative Knee Pain 5 Years After Total Knee Replacement Demonstrate Low-Grad Inflammation, Impairment of Function, and High Levels of Pain Catastrophizing","volume":"37","author":"Skrejborg","year":"2021","journal-title":"Clin. J. Pain"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/rapm-2021-102953","article-title":"Identification of Biological Risk Factors for Persistent Postoperative Pain after Total Knee Arthroplasty","volume":"47","author":"Sideris","year":"2022","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Singh, J.A., Noorbaloochi, S., and Knutson, K.L. (2017). Cytokine and Neuropeptide Levels Are Associated with Pain Relief in Patients with Chronically Painful Total Knee Arthroplasty: A Pilot Study. BMC Musculoskelet. Disord., 18.","DOI":"10.1186\/s12891-016-1375-2"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Gallo, J., Mrazek, F., and Petrek, M. (2009). Variation in Cytokine Genes Can Contribute to Severity of Acetabular Osteolysis and Risk for Revision in Patients with ABG 1 Total Hip Arthroplasty: A Genetic Association Study. BMC Med. Genet., 10.","DOI":"10.1186\/1471-2350-10-109"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1097\/j.pain.0000000000002938","article-title":"Predicting Chronic Postsurgical Pain: Current Evidence and a Novel Program to Develop Predictive Biomarker Signatures","volume":"164","author":"Sluka","year":"2023","journal-title":"Pain"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.pain.2013.08.026","article-title":"Associations between KCNJ6 (GIRK2) Gene Polymorphisms and Pain-Related Phenotypes","volume":"154","author":"Bruehl","year":"2013","journal-title":"Pain"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/jor.24529","article-title":"Metabolomics Signature for Non-Responders to Total Joint Replacement Surgery in Primary Osteoarthritis Patients: The Newfoundland Osteoarthritis Study","volume":"38","author":"Costello","year":"2020","journal-title":"J. Orthop. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.janxdis.2001.04.001","article-title":"The Relationship between Pain and Negative Affect in Older Adults: Anxiety as a Predictor of Pain","volume":"18","author":"Feeney","year":"2004","journal-title":"J. Anxiety Disord."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.semarthrit.2011.07.003","article-title":"Psychological Factors Affecting the Outcome of Total Hip and Knee Arthroplasty: A Systematic Review","volume":"41","author":"Vissers","year":"2012","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jpain.2013.02.013","article-title":"Are Psychological Predictors of Chronic Postsurgical Pain Dependent on the Surgical Model? A Comparison of Total Knee Arthroplasty and Breast Surgery for Cancer","volume":"14","author":"Attal","year":"2013","journal-title":"J. Pain"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00167-013-2409-z","article-title":"The Unhappy Total Knee Arthroplasty (TKA) Patient: Higher WOMAC and Lower KSS in Depressed Patients Prior and after TKA. Knee Surg","volume":"21","author":"Hirschmann","year":"2013","journal-title":"Sports Traumatol. Arthrosc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ejpain.2008.07.015","article-title":"Psychosocial Predictors and Correlates for Chronic Post-Surgical Pain (CPSP)\u2014A Systematic Review","volume":"13","author":"Schulz","year":"2009","journal-title":"Eur. J. Pain"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/j.pain.0000000000001999","article-title":"Psychological and Psychosocial Predictors of Chronic Postsurgical Pain: A Systematic Review and Meta-Analysis","volume":"162","author":"Giusti","year":"2021","journal-title":"Pain"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2106\/JBJS.18.00621","article-title":"Pain Coping Skills Training for Patients Who Catastrophize About Pain Prior to Knee Arthroplasty","volume":"101","author":"Riddle","year":"2019","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1365-2648.2010.05273.x","article-title":"Effectiveness of an Educational Intervention on Levels of Pain, Anxiety and Self-Efficacy for Patients with Musculoskeletal Trauma","volume":"66","author":"Wong","year":"2010","journal-title":"J. Adv. Nurs."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.2147\/JPR.S144066","article-title":"Poorly Controlled Postoperative Pain: Prevalence, Consequences, and Prevention","volume":"10","author":"Gan","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(06)68700-X","article-title":"Persistent Postsurgical Pain: Risk Factors and Prevention","volume":"367","author":"Kehlet","year":"2006","journal-title":"Lancet Lond. Engl."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e1498","DOI":"10.1097\/MD.0000000000001498","article-title":"Subacute Pain as a Predictor of Long-Term Pain Following Orthopedic Surgery","volume":"94","author":"Veal","year":"2015","journal-title":"Medicine"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Soetjahjo, B., Nefihancoro, U.H., Ermawan, R., Saputra, R.D., and Pranandaru, H. (2022). Postoperative Pain after Total Joint Arthroplasty: Pathophysiology and Current Pharmacological Pain Management. Biomol. Health Sci. J., 5.","DOI":"10.4103\/bhsj.bhsj_2_22"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/jamasurg.2017.0898","article-title":"Postoperative Multimodal Analgesia Pain Management with Nonopioid Analgesics and Techniques: A Review","volume":"152","author":"Wick","year":"2017","journal-title":"JAMA Surg."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jor.2020.10.004","article-title":"Perioperative Steroid Administration Improves Knee Function and Reduces Opioid Consumption in Bilateral Total Knee Arthroplasty","volume":"22","author":"Keohane","year":"2020","journal-title":"J. Orthop."},{"key":"ref_74","first-page":"57","article-title":"Regional and Multimodal Analgesia to Reduce Opioid Use after Total Joint Arthroplasty: A Narrative Review","volume":"15","author":"Soffin","year":"2019","journal-title":"HSS J. Musculoskelet. J. Hosp. Spec. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13037-017-0137-x","article-title":"Evaluation of a Multimodal Pain Therapy Concept for Chronic Pain after Total Knee Arthroplasty: A Pilot Study in 21 Patients","volume":"11","author":"Zajonz","year":"2017","journal-title":"Patient Saf. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s42836-019-0011-7","article-title":"The Efficacy of Pre-Emptive Analgesia on Pain Management in Total Knee Arthroplasty: A Mini-Review","volume":"1","author":"Xu","year":"2019","journal-title":"Arthroplasty"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1302\/0301-620X.98B9.36250","article-title":"The Technique of Delivery of Peri-Operative Analgesia Does Not Affect the Rehabilitation or Outcomes Following Total Knee Arthroplasty","volume":"98-B","author":"McDonald","year":"2016","journal-title":"Bone Jt. J."},{"key":"ref_78","first-page":"19","article-title":"Single-Dose Periarticular Steroid Infiltration for Pain Management in Total Knee Arthroplasty: A Prospective, Double-Blind, Randomised Controlled Trial","volume":"52","author":"Sean","year":"2011","journal-title":"Singap. Med. J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00264-016-3357-2","article-title":"Pre-Emptive Injection of Peri-Articular-Multimodal Drug for Post-Operative Pain Management in Total Knee Arthroplasty: A Double-Blind Randomized Clinical Trial","volume":"41","author":"Motififard","year":"2017","journal-title":"Int. Orthop."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3109\/17453674.2014.961399","article-title":"Single Periarticular Local Infiltration Analgesia Reduces Opiate Consumption until 48 Hours after Total Knee Arthroplasty","volume":"85","author":"Kalliovalkama","year":"2014","journal-title":"Acta Orthop."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.arth.2012.07.016","article-title":"Continuous Infusion of Bupivacaine Following Total Knee Arthroplasty: A Randomized Control Trial Pilot Study","volume":"28","author":"Williams","year":"2013","journal-title":"J. Arthroplast."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/j.pain.0000000000000114","article-title":"Effect of Local Anaesthetic Infiltration on Chronic Postsurgical Pain after Total Hip and Knee Replacement: The APEX Randomised Controlled Trials","volume":"156","author":"Wylde","year":"2015","journal-title":"Pain"},{"key":"ref_83","first-page":"CD007105","article-title":"Local Anaesthetics and Regional Anaesthesia versus Conventional Analgesia for Preventing Persistent Postoperative Pain in Adults and Children","volume":"2018","author":"Weinstein","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e028093","DOI":"10.1136\/bmjopen-2018-028093","article-title":"Are Perioperative Interventions Effective in Preventing Chronic Pain after Primary Total Knee Replacement? A Systematic Review","volume":"9","author":"Beswick","year":"2019","journal-title":"BMJ Open"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"569107","DOI":"10.1155\/2014\/569107","article-title":"Continuous Femoral Nerve Block versus Intravenous Patient Controlled Analgesia for Knee Mobility and Long-Term Pain in Patients Receiving Total Knee Replacement: A Randomized Controlled Trial","volume":"2014","author":"Peng","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med. ECAM"},{"key":"ref_86","first-page":"e38552","article-title":"A Comprehensive Review on the Efficacy of Nerve Blocks in Reducing Postoperative Anesthetic and Analgesic Requirements","volume":"15","author":"Jogie","year":"2023","journal-title":"Cureus"},{"key":"ref_87","first-page":"998","article-title":"Impact of Peripheral Nerve Block with Low Dose Local Anesthetics on Analgesia and Functional Outcomes Following Total Knee Arthroplasty: A Retrospective Study. Pain Med","volume":"16","author":"Liu","year":"2015","journal-title":"Malden Mass"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1016\/j.arth.2019.07.029","article-title":"Same-Day Physical Therapy Following Total Knee Arthroplasty Leads to Improved Inpatient Physical Therapy Performance and Decreased Inpatient Opioid Consumption","volume":"34","author":"Sarpong","year":"2019","journal-title":"J. Arthroplast."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/cns.12099","article-title":"Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)","volume":"19","author":"Mion","year":"2013","journal-title":"CNS Neurosci. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s44192-022-00012-3","article-title":"Ketamine Treatment for Depression: A Review","volume":"2","author":"Yavi","year":"2022","journal-title":"Discov. Ment. Health"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4103\/0970-9185.168149","article-title":"Role of Ketamine for Analgesia in Adults and Children","volume":"32","author":"Vadivelu","year":"2016","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/00000542-199704000-00021","article-title":"Multiple Mechanisms of Ketamine Blockade of N-Methyl-D-Aspartate Receptors","volume":"86","author":"Orser","year":"1997","journal-title":"Anesthesiology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1399-6576.1997.tb04854.x","article-title":"Mapping of Punctuate Hyperalgesia around a Surgical Incision Demonstrates That Ketamine Is a Powerful Suppressor of Central Sensitization to Pain Following Surgery","volume":"41","author":"Stubhaug","year":"1997","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1213\/ANE.0b013e3181bdc8a0","article-title":"The Early and Delayed Analgesic Effects of Ketamine after Total Hip Arthroplasty: A Prospective, Randomized, Controlled, Double-Blind Study","volume":"109","author":"Baud","year":"2009","journal-title":"Anesth. Analg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/0310057X0903700202","article-title":"Intraoperative Ketamine May Influence Persistent Pain Following Knee Arthroplasty under Combined General and Spinal Anaesthesia: A Pilot Study","volume":"37","author":"Perrin","year":"2009","journal-title":"Anaesth. Intensive Care"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/AJP.0000000000000033","article-title":"Pain and Recovery After Total Knee Arthroplasty: A 12-Month Follow-up After a Prospective Randomized Study Evaluating Nefopam and Ketamine for Early Rehabilitation","volume":"30","author":"Aveline","year":"2014","journal-title":"Clin. J. Pain"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e19898","DOI":"10.1097\/MD.0000000000019898","article-title":"A Review of the Mechanism of the Central Analgesic Effect of Lidocaine","volume":"99","author":"Yang","year":"2020","journal-title":"Medicine"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.bja.2023.02.041","article-title":"Non-Opioid Analgesics for the Prevention of Chronic Postsurgical Pain: A Systematic Review and Network Meta-Analysis","volume":"130","author":"Doleman","year":"2023","journal-title":"BJA Br. J. Anaesth."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/papr.12442","article-title":"Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials","volume":"17","author":"Chang","year":"2017","journal-title":"Pain Pract. Off. J. World Inst. Pain"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1097\/j.pain.0000000000001273","article-title":"Perioperative Lidocaine Infusions for the Prevention of Chronic Postsurgical Pain: A Systematic Review and Meta-Analysis of Efficacy and Safety","volume":"159","author":"Bailey","year":"2018","journal-title":"Pain"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2174\/157015909790031201","article-title":"Serotonin-Norepinephrine Reuptake Inhibitors for Pain Control: Premise and Promise","volume":"7","author":"Marks","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"110451","DOI":"10.1016\/j.jclinane.2021.110451","article-title":"Efficacy and Adverse Events of Selective Serotonin Noradrenaline Reuptake Inhibitors in the Management of Postoperative Pain: A Systematic Review and Meta-Analysis","volume":"75","author":"Schnabel","year":"2021","journal-title":"J. Clin. Anesth."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e052944","DOI":"10.1136\/bmjopen-2021-052944","article-title":"Effect of Preoperative Duloxetine Treatment on Postoperative Chronic Residual Pain after Total Hip or Knee Arthroplasty: A Randomised Controlled Trial","volume":"11","author":"Rienstra","year":"2021","journal-title":"BMJ Open"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/ALN.0000000000001228","article-title":"Duloxetine and Subacute Pain after Knee Arthroplasty When Added to a Multimodal Analgesic Regimen: A Randomized, Placebo-Controlled, Triple-Blinded Trial","volume":"125","author":"YaDeau","year":"2016","journal-title":"Anesthesiology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bja.2021.08.032","article-title":"Selective Serotonin Reuptake Inhibitors and Serotonin\u2013Norepinephrine Reuptake Inhibitors as Adjuncts for Postoperative Pain Management: Systematic Review and Meta-Analysis of Randomised Controlled Trials","volume":"128","author":"Wang","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/ejp.1915","article-title":"Preventing Persistent Postsurgical Pain: A Systematic Review and Component Network Meta-Analysis","volume":"26","author":"Allen","year":"2022","journal-title":"Eur. J. Pain"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5435\/JAAOS-D-14-00259","article-title":"Current Strategies in Anesthesia and Analgesia for Total Knee Arthroplasty","volume":"24","author":"Moucha","year":"2016","journal-title":"JAAOS\u2014J. Am. Acad. Orthop. Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e00205","DOI":"10.1002\/prp2.205","article-title":"Mechanisms of the Gabapentinoids and \u03b1 2 \u0394-1 Calcium Channel Subunit in Neuropathic Pain","volume":"4","author":"Patel","year":"2016","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1213\/ANE.0b013e3181c4273a","article-title":"Perioperative Oral Pregabalin Reduces Chronic Pain after Total Knee Arthroplasty: A Prospective, Randomized, Controlled Trial","volume":"110","author":"Buvanendran","year":"2010","journal-title":"Anesth. Analg."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/bja\/aev217","article-title":"Pregabalin and Pain after Total Knee Arthroplasty: A Double-Blind, Randomized, Placebo-Controlled, Multidose Trial","volume":"115","author":"YaDeau","year":"2015","journal-title":"BJA Br. J. Anaesth."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1213\/ANE.0b013e318249d36e","article-title":"The Prevention of Chronic Postsurgical Pain Using Gabapentin and Pregabalin: A Combined Systematic Review and Meta-Analysis","volume":"115","author":"Clarke","year":"2012","journal-title":"Anesth. Analg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3344\/kjp.23080","article-title":"Practical Strategies for the Prevention and Management of Chronic Postsurgical Pain","volume":"36","author":"Kim","year":"2023","journal-title":"Korean J. Pain"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jbspin.2016.06.001","article-title":"Management of Neuropathic Pain after Knee Surgery","volume":"83","year":"2016","journal-title":"Joint Bone Spine"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"15543","DOI":"10.1038\/s41598-023-42608-x","article-title":"Peripheral Nerve Stimulation for the Treatment of Chronic Knee Pain","volume":"13","author":"Sargut","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/papr.12481","article-title":"A Comparison of Genicular Nerve Treatment Using Either Radiofrequency or Analgesic Block with Corticosteroid for Pain after a Total Knee Arthroplasty: A Double-Blind, Randomized Clinical Study","volume":"17","year":"2017","journal-title":"Pain Pract."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/9\/4722\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:33:49Z","timestamp":1760106829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/9\/4722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":115,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["ijms25094722"],"URL":"https:\/\/doi.org\/10.3390\/ijms25094722","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]}}}