{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:15:58Z","timestamp":1791483358891,"version":"4.3.4"},"reference-count":177,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Institute of Health Carlos III","doi-asserted-by":"publisher","award":["PI22\/00726"],"award-info":[{"award-number":["PI22\/00726"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Institute of Health Carlos III","doi-asserted-by":"publisher","award":["CP22\/00022"],"award-info":[{"award-number":["CP22\/00022"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Institute of Health Carlos III","doi-asserted-by":"publisher","award":["CIBERFES;CB16\/10\/00475"],"award-info":[{"award-number":["CIBERFES;CB16\/10\/00475"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Regional Development Fund (FEDER)","award":["PI22\/00726"],"award-info":[{"award-number":["PI22\/00726"]}]},{"name":"European Regional Development Fund (FEDER)","award":["CP22\/00022"],"award-info":[{"award-number":["CP22\/00022"]}]},{"name":"European Regional Development Fund (FEDER)","award":["CIBERFES;CB16\/10\/00475"],"award-info":[{"award-number":["CIBERFES;CB16\/10\/00475"]}]},{"name":"CIBER of Frailty and Healthy Aging","award":["PI22\/00726"],"award-info":[{"award-number":["PI22\/00726"]}]},{"name":"CIBER of Frailty and Healthy Aging","award":["CP22\/00022"],"award-info":[{"award-number":["CP22\/00022"]}]},{"name":"CIBER of Frailty and Healthy Aging","award":["CIBERFES;CB16\/10\/00475"],"award-info":[{"award-number":["CIBERFES;CB16\/10\/00475"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This article reviews the role of fibroblast growth factor 23 (FGF23) protein in phosphate metabolism, highlighting its regulation of vitamin D, parathyroid hormone, and bone metabolism. Although it was traditionally thought that phosphate\u2013calcium homeostasis was controlled exclusively by parathyroid hormone (PTH) and calcitriol, pathophysiological studies revealed the influence of FGF23. This protein, expressed mainly in bone, inhibits the renal reabsorption of phosphate and calcitriol formation, mediated by the \u03b1-klotho co-receptor. In addition to its role in phosphate metabolism, FGF23 exhibits pleiotropic effects in non-renal systems such as the cardiovascular, immune, and metabolic systems, including the regulation of gene expression and cardiac fibrosis. Although it has been proposed as a biomarker and therapeutic target, the inhibition of FGF23 poses challenges due to its potential side effects. However, the approval of drugs such as burosumab represents a milestone in the treatment of FGF23-related diseases.<\/jats:p>","DOI":"10.3390\/ijms25094875","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T03:30:49Z","timestamp":1714534249000},"page":"4875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Non-Classical Effects of FGF23: Molecular and Clinical Features"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9330-8108","authenticated-orcid":false,"given":"Luis","family":"Mart\u00ednez-Heredia","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada, 18014 Granada, Spain"},{"name":"Biomedical Research Network in Fragility and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-3052","authenticated-orcid":false,"given":"Juan Manuel","family":"Canelo-Moreno","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit, University Hospital Juan Ram\u00f3n Jim\u00e9nez, 21005 Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-5561","authenticated-orcid":false,"given":"Beatriz","family":"Garc\u00eda-Fontana","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada, 18014 Granada, Spain"},{"name":"Biomedical Research Network in Fragility and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Endocrinology and Nutrition Unit, University Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"},{"name":"Department of Cell Biology, University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-3260","authenticated-orcid":false,"given":"Manuel","family":"Mu\u00f1oz-Torres","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada, 18014 Granada, Spain"},{"name":"Biomedical Research Network in Fragility and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Endocrinology and Nutrition Unit, University Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"},{"name":"Department of Medicine, University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.18632\/aging.100195","article-title":"Klotho Interferes with a Novel FGF-Signalling Pathway and Insulin\/Igf-like Signalling to Improve Longevity and Stress Resistance in Caenorhabditis Elegans","volume":"2","author":"Araiz","year":"2010","journal-title":"Aging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.metabol.2016.02.009","article-title":"Exercise-Stimulated FGF23 Promotes Exercise Performance via Controlling the Excess Reactive Oxygen Species Production and Enhancing Mitochondrial Function in Skeletal Muscle","volume":"65","author":"Li","year":"2016","journal-title":"Metab.\u2014Clin. 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