{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:05:53Z","timestamp":1784865953660,"version":"3.55.0"},"reference-count":161,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"USARMY Medical Research Acquisition Activities","award":["VR210010"],"award-info":[{"award-number":["VR210010"]}]},{"name":"USARMY Medical Research Acquisition Activities","award":["EY02520"],"award-info":[{"award-number":["EY02520"]}]},{"name":"US National Institutes of Health (NIH)","award":["VR210010"],"award-info":[{"award-number":["VR210010"]}]},{"name":"US National Institutes of Health (NIH)","award":["EY02520"],"award-info":[{"award-number":["EY02520"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alterations in intraocular and external pressure critically involve the pathogenesis of glaucoma, traumatic retinal injury (TRI), and other retinal disorders, and retinal neurons have been reported to express multiple mechanical-sensitive channels (MSCs) in recent decades. However, the role of MSCs in visual functions and pressure-related retinal conditions has been unclear. This review will focus on the variety and functional significance of the MSCs permeable to K+, Na+, and Ca2+, primarily including the big potassium channel (BK); the two-pore domain potassium channels TRAAK and TREK; Piezo; the epithelial sodium channel (ENaC); and the transient receptor potential channels vanilloid TRPV1, TRPV2, and TRPV4 in retinal photoreceptors, bipolar cells, horizontal cells, amacrine cells, and ganglion cells. Most MSCs do not directly mediate visual signals in vertebrate retinas. On the other hand, some studies have shown that MSCs can open in physiological conditions and regulate the activities of retinal neurons. While these data reasonably predict the crossing of visual and mechanical signals, how retinal light pathways deal with endogenous and exogenous mechanical stimulation is uncertain.<\/jats:p>","DOI":"10.3390\/ijms25094877","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T03:30:49Z","timestamp":1714534249000},"page":"4877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Variety of Mechanosensitive Ion Channels in Retinal Neurons"],"prefix":"10.3390","volume":"25","author":[{"given":"Ji-Jie","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jcjo.2016.07.013","article-title":"Glaucoma treatment trends: A review","volume":"52","author":"Conlon","year":"2017","journal-title":"Can. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/1120672119866974","article-title":"Ocular changes in traumatic brain injury: A review","volume":"30","author":"Mufti","year":"2020","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"108102","DOI":"10.1016\/j.exer.2020.108102","article-title":"Assessment of necroptosis in the retina in a repeated primary ocular blast injury mouse model","volume":"197","author":"Thomas","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref_6","first-page":"e11686","article-title":"Epidemiology of Glaucoma: The Past, Present, and Predictions for the Future","volume":"12","author":"Allison","year":"2020","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/jovr.jovr_35_18","article-title":"Intraocular Pressure Fluctuation: Is It Important?","volume":"13","author":"Kim","year":"2018","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/1673-5374.286953","article-title":"Roles of the ocular pressure, pressure-sensitive ion channel, and elasticity in pressure-induced retinal diseases","volume":"16","author":"Pang","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2015.02.067","article-title":"Forcing open TRP channels: Mechanical gating as a unifying activation mechanism","volume":"460","author":"Liu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13578-020-00522-z","article-title":"Structure, kinetic properties and biological function of mechanosensitive Piezo channels","volume":"11","author":"Fang","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1242\/jcs.01232","article-title":"Mechanosensitive ion channels: Molecules of mechanotransduction","volume":"117","author":"Martinac","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Piskova, T., Kozyrina, A.N., and Di, R.J. (2023). Mechanobiological implications of age-related remodelling in the outer retina. Biomater. Adv., 147.","DOI":"10.1016\/j.bioadv.2023.213343"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"796540","DOI":"10.3389\/fphys.2021.796540","article-title":"Structural and Functional Coupling of Calcium-Activated BK Channels and Calcium-Permeable Channels within Nanodomain Signaling Complexes","volume":"12","author":"Shah","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/emboj\/17.12.3297","article-title":"A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids","volume":"17","author":"Fink","year":"1998","journal-title":"EMBO J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Pang, J.J., Gao, F., and Wu, S.M. (2021). Generators of Pressure-Evoked Currents in Vertebrate Outer Retinal Neurons. Cells, 10.","DOI":"10.3390\/cells10061288"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4161\/chan.5.5.16469","article-title":"Molecular regulations governing TREK and TRAAK channel functions","volume":"5","author":"Noel","year":"2011","journal-title":"Channels"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2006980118","DOI":"10.1073\/pnas.2006980118","article-title":"Ultrasound activates mechanosensitive TRAAK K(+) channels through the lipid membrane","volume":"118","author":"Sorum","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1038\/ncomms8223","article-title":"Piezo1 ion channel pore properties are dictated by C-terminal region","volume":"6","author":"Coste","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ctm.2016.11.007","article-title":"A Tour de Force: The Discovery, Properties, and Function of Piezo Channels","volume":"79","author":"Gottlieb","year":"2017","journal-title":"Curr. Top. Membr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00424-016-1811-z","article-title":"Piezo1-dependent regulation of urinary osmolarity","volume":"468","author":"Martins","year":"2016","journal-title":"Pflugers Arch."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s12551-019-00584-5","article-title":"Piezo1 mechanosensitive channels: What are they and why are they important","volume":"11","author":"Ridone","year":"2019","journal-title":"Biophys. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Barbeau, S., Gilbert, G., Cardouat, G., Baudrimont, I., Freund-Michel, V., Guibert, C., Marthan, R., Vacher, P., Quignard, J.F., and Ducret, T. (2021). Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension. Biomolecules, 11.","DOI":"10.3390\/biom11091389"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Stewart, L., and Turner, N.A. (2021). Channelling the Force to Reprogram the Matrix: Mechanosensitive Ion Channels in Cardiac Fibroblasts. Cells, 10.","DOI":"10.3390\/cells10050990"},{"key":"ref_24","first-page":"4795","article-title":"The epithelial sodium channel in the Australian lungfish, Neoceratodus forsteri (Osteichthyes: Dipnoi)","volume":"279","author":"Uchiyama","year":"2012","journal-title":"Proc. Biol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Shabbir, W., Topcagic, N., Aufy, M., and Oz, M. (2021). CRISPR\/Cas9 Mediated Knock Down of \u00ce\u00b4-ENaC Blunted the TNF-Induced Activation of ENaC in A549 Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041858"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lemmens-Gruber, R., and Tzotzos, S. (2023). The Epithelial Sodium Channel-An Underestimated Drug Target. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097775"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/18906","article-title":"A capsaicin-receptor homologue with a high threshold for noxious heat","volume":"398","author":"Caterina","year":"1999","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1167\/iovs.16-20279","article-title":"TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles","volume":"57","author":"McGahon","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/01.RES.0000097263.10220.0C","article-title":"TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes","volume":"93","author":"Muraki","year":"2003","journal-title":"Circ. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"22664","DOI":"10.1074\/jbc.M302561200","article-title":"Impaired pressure sensation in mice lacking TRPV4","volume":"278","author":"Suzuki","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41419-019-1576-3","article-title":"The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells","volume":"10","author":"Gao","year":"2019","journal-title":"Cell Death.Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"C195","DOI":"10.1152\/ajpcell.00365.2003","article-title":"TRPV4 calcium entry channel: A paradigm for gating diversity","volume":"286","author":"Nilius","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/35036318","article-title":"OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity","volume":"2","author":"Strotmann","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1744-8069-5-5","article-title":"Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C","volume":"5","author":"Cao","year":"2009","journal-title":"Mol. Pain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00424-005-1424-4","article-title":"The mechanosensitive nature of TRPV channels","volume":"451","author":"Heller","year":"2005","journal-title":"Pflugers Arch."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kashio, M., and Tominaga, M. (2022). TRP channels in thermosensation. Curr. Opin. Neurobiol., 75.","DOI":"10.1016\/j.conb.2022.102591"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature12822","article-title":"Structure of the TRPV1 ion channel determined by electron cryo-microscopy","volume":"504","author":"Liao","year":"2013","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e2300305120","DOI":"10.1073\/pnas.2300305120","article-title":"A suicidal mechanism for the exquisite temperature sensitivity of TRPV1","volume":"120","author":"Mugo","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jpain.2007.12.001","article-title":"TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat","volume":"9","author":"Lawson","year":"2008","journal-title":"J. Pain"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"203683","DOI":"10.1016\/j.cdev.2021.203683","article-title":"Mechanosensitive ion channels in cell migration","volume":"166","author":"Canales","year":"2021","journal-title":"Cells Dev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Vangeel, L., and Voets, T. (2019). Transient Receptor Potential Channels and Calcium Signaling. Cold Spring Harb. Perspect. Biol., 11.","DOI":"10.1101\/cshperspect.a035048"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Yang, T.H., Kang, E.Y., Lin, P.H., Wu, P.L., Sachs, J.A., and Wang, N.K. (2023). The Value of Electroretinography in Identifying Candidate Genes for Inherited Retinal Dystrophies: A Diagnostic Guide. Diagnostics, 13.","DOI":"10.3390\/diagnostics13193041"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10633-017-9579-9","article-title":"The importance of electrode position in visual electrophysiology","volume":"134","author":"Kurtenbach","year":"2017","journal-title":"Doc. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"722533","DOI":"10.3389\/fncel.2021.722533","article-title":"Dual-cell patch-clamp recording revealed a mechanism for a ribbon synapse to process both digital and analog inputs and outputs","volume":"15","author":"Pang","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1073\/pnas.0907178107","article-title":"Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry","volume":"107","author":"Pang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.1523\/JNEUROSCI.1572-05.2005","article-title":"Large-conductance calcium-activated potassium channels facilitate transmitter release in salamander rod synapse","volume":"25","author":"Xu","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jnr.21467","article-title":"Vertebrate rod photoreceptors express both BK and IK calcium-activated potassium channels, but only BK channels are involved in receptor potential regulation","volume":"86","author":"Pelucchi","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.1167\/iovs.16-20453","article-title":"Long-Term Protection of Genetically Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery","volume":"57","author":"Nagai","year":"2016","journal-title":"Investig. Ophthalmol.Vis. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/09687860500370703","article-title":"Activation of a mechanosensitive BK channel by membrane stress created with amphipaths","volume":"22","author":"Qi","year":"2005","journal-title":"Mol. Membr. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.bbamem.2017.05.013","article-title":"The temperature dependence of the BK channel activity\u2014Kinetics, thermodynamics, and long-range correlations","volume":"1859","author":"Dworakowska","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.18240\/ijo.2019.08.03","article-title":"Activation of the TRAAK two-pore domain potassium channels in rd1 mice protects photoreceptor cells from apoptosis","volume":"12","author":"Wang","year":"2019","journal-title":"Int. J. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"46085","DOI":"10.1038\/srep46085","article-title":"Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina","volume":"7","author":"Hughes","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbrc.2021.12.031","article-title":"Aprepitant is a novel, selective activator of the K2P channel TRAAK","volume":"588","author":"McCoull","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.mehy.2007.06.016","article-title":"Recent advance and possible future in TREK-2: A two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment","volume":"70","author":"Huang","year":"2008","journal-title":"Med. Hypotheses"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"101114","DOI":"10.1016\/j.preteyeres.2022.101114","article-title":"Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration","volume":"92","author":"Krizaj","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"839","DOI":"10.21037\/atm-21-6145","article-title":"Involvement of transient receptor potential channels in ocular diseases: A narrative review","volume":"10","author":"Yang","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"re3","DOI":"10.1126\/stke.2722005re3","article-title":"The TRP superfamily of cation channels","volume":"2005","author":"Montell","year":"2005","journal-title":"Sci. STKE"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1124\/pr.113.008268","article-title":"Transient receptor potential channels as drug targets: From the science of basic research to the art of medicine","volume":"66","author":"Nilius","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.visres.2011.10.009","article-title":"TRP channel gene expression in the mouse retina","volume":"51","author":"Gilliam","year":"2011","journal-title":"Vision Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/cne.20144","article-title":"Vanilloid receptor like 1 (VRL1) immunoreactivity in mammalian retina: Colocalization with somatostatin and purinergic P2X1 receptors","volume":"474","author":"Yazulla","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/978-3-319-75402-4_67","article-title":"TRPV4 Does Not Regulate the Distal Retinal Light Response","volume":"1074","author":"Yarishkin","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"102588","DOI":"10.1016\/j.ceca.2022.102588","article-title":"TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Muller cells","volume":"104","author":"Jo","year":"2022","journal-title":"Cell Calcium."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12974-021-02315-8","article-title":"TRPV4-induced Muller cell gliosis and TNF-\u03b1 elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2\/STAT3\/NF-\u03baB pathway","volume":"18","author":"Li","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/glia.23979","article-title":"TRPV4 channels mediate the mechanoresponse in retinal microglia","volume":"69","author":"Redmon","year":"2021","journal-title":"Glia"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exer.2016.11.002","article-title":"Specific inhibition of TRPV4 enhances retinal ganglion cell survival in adult porcine retinal explants","volume":"154","author":"Taylor","year":"2016","journal-title":"Exp. Eye Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1523\/JNEUROSCI.0897-18.2018","article-title":"Retinal Detachment-Induced Muller Glial Cell Swelling Activates TRPV4 Ion Channels and Triggers Photoreceptor Death at Body Temperature","volume":"38","author":"Matsumoto","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)00143-4","article-title":"Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor","volume":"103","author":"Liedtke","year":"2000","journal-title":"Cell"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Madrid, R., and Bacigalupo, J. (2015). TRP Channels in Sensory Transduction, Springer International Publishing.","DOI":"10.1007\/978-3-319-18705-1"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1021\/acscentsci.1c00070","article-title":"Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression","volume":"7","author":"Conde","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Emir, T.L.R. (2017). Neurobiology of TRP Channels, CRC Press\/Taylor & Francis.","DOI":"10.4324\/9781315152837"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"806786","DOI":"10.3389\/fphys.2022.806786","article-title":"The Roles of Transient Receptor Potential Ion Channels in Pathologies of Glaucoma","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41594-018-0168-8","article-title":"Structures of TRPV2 in distinct conformations provide insight into role of the pore turret","volume":"26","author":"Dosey","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11130","DOI":"10.1038\/ncomms11130","article-title":"Structure of the full-length TRPV2 channel by cryo-EM","volume":"7","author":"Huynh","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/367463a0","article-title":"Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits","volume":"367","author":"Canessa","year":"1994","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0952523805222034","article-title":"Blockade of amiloride-sensitive sodium channels alters multiple components of the mammalian electroretinogram","volume":"22","author":"Brockway","year":"2005","journal-title":"Vis. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Aufy, M., Hussein, A.M., Stojanovic, T., Studenik, C.R., and Kotob, M.H. (2023). Proteolytic Activation of the Epithelial Sodium Channel (ENaC): Its Mechanisms and Implications. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417563"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1186\/s13063-021-05588-9","article-title":"Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS-a randomized, placebo-controlled, double-blind trial","volume":"22","author":"Schmid","year":"2021","journal-title":"Trials"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4161\/chan.21050","article-title":"Piezo1: Properties of a cation selective mechanical channel","volume":"6","author":"Gottlieb","year":"2012","journal-title":"Channels"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"109675","DOI":"10.1016\/j.exer.2023.109675","article-title":"Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles","volume":"236","author":"Zhu","year":"2023","journal-title":"Exp. Eye Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Bocchero, U., Falleroni, F., Mortal, S., Li, Y., Cojoc, D., Lamb, T., and Torre, V. (2020). Mechanosensitivity is an essential component of phototransduction in vertebrate rods. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000750"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.bpj.2020.09.005","article-title":"Mechanisms of Light-Induced Deformations in Photoreceptors","volume":"119","author":"Boyle","year":"2020","journal-title":"Biophys. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1167\/tvst.7.6.29","article-title":"Light-Induced Length Shrinkage of Rod Photoreceptor Outer Segments","volume":"7","author":"Lu","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1002\/cne.24456","article-title":"Cone synapses in mammalian retinal rod bipolar cells","volume":"526","author":"Pang","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1113\/JP274132","article-title":"Calcium-activated BK(Ca) channels govern dynamic membrane depolarizations of horizontal cells in rodent retina","volume":"595","author":"Sun","year":"2017","journal-title":"J. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1469-7793.1997.571ba.x","article-title":"Electrical resonance and Ca2+ influx in the synaptic terminal of depolarizing bipolar cells from the goldfish retina","volume":"505","author":"Burrone","year":"1997","journal-title":"J. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0168-0102(97)01155-3","article-title":"Ca2+ -activated K+ current at presynaptic terminals of goldfish retinal bipolar cells","volume":"27","author":"Sakaba","year":"1997","journal-title":"Neurosci. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1523\/JNEUROSCI.4654-11.2012","article-title":"BK channels mediate pathway-specific modulation of visual signals in the in vivo mouse retina","volume":"32","author":"Tanimoto","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"9474","DOI":"10.1073\/pnas.0401702101","article-title":"Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency","volume":"101","author":"Sausbier","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fneur.2016.00059","article-title":"Effects of Primary Blast Overpressure on Retina and Optic Tract in Rats","volume":"7","author":"DeMar","year":"2016","journal-title":"Front. Neurol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1080\/02713683.2019.1567791","article-title":"Blast Exposure Induces Ocular Functional Changes with Increasing Blast Over-pressures in a Rat Model","volume":"44","author":"Zhu","year":"2019","journal-title":"Curr. Eye Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Naguib, S., Bernardo-Colon, A., Cencer, C., Gandra, N., and Rex, T.S. (2019). Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma. Neurobiol. Dis., 134.","DOI":"10.1016\/j.nbd.2019.104695"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/bs.pbr.2015.04.012","article-title":"Retinal ganglion cell dendrite pathology and synapse loss: Implications for glaucoma","volume":"220","author":"Agostinone","year":"2015","journal-title":"Prog. Brain Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1523\/JNEUROSCI.1419-14.2015","article-title":"Characteristic patterns of dendritic remodeling in early-stage glaucoma: Evidence from genetically identified retinal ganglion cell types","volume":"35","author":"Huberman","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Berry, R.H., Qu, J., John, S.W., Howell, G.R., and Jakobs, T.C. (2015). Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144341"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13041-014-0053-2","article-title":"Alterations of the synapse of the inner retinal layers after chronic intraocular pressure elevation in glaucoma animal model","volume":"7","author":"Park","year":"2014","journal-title":"Mol. Brain"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1089\/neu.2017.5394","article-title":"Long-Term Functional and Structural Consequences of Primary Blast Overpressure to the Eye","volume":"35","author":"Allen","year":"2018","journal-title":"J. Neurotrauma"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1167\/iovs.14-14353","article-title":"Molecular changes and vision loss in a mouse model of closed-globe blast trauma","volume":"55","author":"Rex","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1167\/iovs.09-3409","article-title":"Electrophysiological evidence of early functional damage in glaucoma and ocular hypertension","volume":"51","author":"North","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1167\/iovs.12-10581","article-title":"Elevated intraocular pressure causes inner retinal dysfunction before cell loss in a mouse model of experimental glaucoma","volume":"54","author":"Frankfort","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s41419-019-2140-x","article-title":"Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina","volume":"10","author":"Shen","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.63.5.2","article-title":"Sodium Hyaluronate-Induced Ocular Hypertension in Rats Damages the Direction-Selective Circuit and Inner\/Outer Retinal Plexiform Layers","volume":"63","author":"Noailles","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1167\/iovs.15-16622","article-title":"The Effect of PKCalpha on the Light Response of Rod Bipolar Cells in the Mouse Retina","volume":"56","author":"Xiong","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fphar.2019.00006","article-title":"TRPV, T.1016790A Regulates the Membrane Expression of TRPV4 Channels","volume":"10","author":"Baratchi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/sj.bjp.0705443","article-title":"Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4","volume":"140","author":"Xu","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1523\/JNEUROSCI.1064-19.2019","article-title":"Phosphorylation of TRPV1 S801 Contributes to Modality-Specific Hyperalgesia in Mice","volume":"39","author":"Joseph","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"13596","DOI":"10.1523\/JNEUROSCI.2655-11.2011","article-title":"Relief of Mg2+-dependent inhibition of TRPM1 by PKC\u03b1 at the rod bipolar cell synapse","volume":"31","author":"Rampino","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e67777","DOI":"10.7554\/eLife.67777","article-title":"Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice","volume":"10","author":"Daneva","year":"2021","journal-title":"Elife"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1085\/jgp.20028478","article-title":"Mechanism of generation of spontaneous miniature outward currents (SMOCs) in retinal amacrine cells","volume":"119","author":"Mitra","year":"2002","journal-title":"J. Gen. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nn.2302","article-title":"BK channels modulate pre- and postsynaptic signaling at reciprocal synapses in retina","volume":"12","author":"Grimes","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41374-019-0347-1","article-title":"TRPC5 regulates axonal outgrowth in developing retinal ganglion cells","volume":"100","author":"Oda","year":"2020","journal-title":"Lab. Investig."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1152\/jn.01085.2012","article-title":"A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells","volume":"109","author":"Ford","year":"2013","journal-title":"J. Neurophysiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1471-4159.2005.03177.x","article-title":"Subunits of the epithelial sodium channel family are differentially expressed in the retina of mice with ocular hypertension","volume":"94","author":"Dyka","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1167\/iovs.11-8581","article-title":"Four subunits (\u03b1\u03b2\u03b3\u03b4) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations","volume":"53","author":"Krueger","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1023\/B:NEUR.0000046574.72380.e8","article-title":"Localization of vanilloid receptor 1 (TRPV1\/VR1)-like immunoreactivity in goldfish and zebrafish retinas: Restriction to photoreceptor synaptic ribbons","volume":"33","author":"Zimov","year":"2004","journal-title":"J. Neurocytol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1523\/JNEUROSCI.0359-11.2011","article-title":"The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells","volume":"31","author":"Ryskamp","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1167\/iovs.14-14421","article-title":"Loss of outer retinal neurons and circuitry alterations in the DBA\/2J mouse","volume":"55","author":"Brecha","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_117","first-page":"1258","article-title":"Retinal morphology and ERG response in the DBA\/2NNia mouse model of angle-closure glaucoma","volume":"42","author":"Bayer","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1073\/pnas.1419921112","article-title":"Elevated intraocular pressure decreases response sensitivity of inner retinal neurons in experimental glaucoma mice","volume":"112","author":"Pang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","first-page":"2696","article-title":"Immunohistochemical changes in rat retinas at various time periods of elevated intraocular pressure","volume":"15","author":"Hernandez","year":"2009","journal-title":"Mol. Vis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00441-004-1062-8","article-title":"Changes in retinal neuronal populations in the DBA\/2J mouse","volume":"320","author":"Moon","year":"2005","journal-title":"Cell Tissue Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/cne.24074","article-title":"Amacrine cells coupled to ganglion cells via gap junctions are highly vulnerable in glaucomatous mouse retinas","volume":"527","author":"Akopian","year":"2019","journal-title":"J. Comp. Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuint.2007.08.014","article-title":"Effect of ocular hypertension on retinal GABAergic activity","volume":"52","author":"Moreno","year":"2008","journal-title":"Neurochem. Int."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Tang, J., Liu, Z., Han, J., Xue, J., Liu, L., Lin, J., Wu, C., Zhang, Q., Wu, S., and Liu, C. (2022). Increased Mobile Zinc Regulates Retinal Ganglion Cell Survival via Activating Mitochondrial OMA1 and Integrated Stress Response. Antioxidants, 11.","DOI":"10.3390\/antiox11102001"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"12221","DOI":"10.1074\/jbc.M110.202945","article-title":"Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions","volume":"286","author":"Lambert","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jnr.10830","article-title":"Maturation of spiking activity in trout retinal ganglion cells coincides with upregulation of Kv3.1- and BK-related potassium channels","volume":"75","author":"Henne","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/jn.1998.79.1.151","article-title":"Calcium-activated potassium conductances in retinal ganglion cells of the ferret","volume":"79","author":"Wang","year":"1998","journal-title":"J. Neurophysiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.visres.2008.11.008","article-title":"Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina","volume":"49","author":"Nemargut","year":"2009","journal-title":"Vision Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0306-4522(99)00484-4","article-title":"Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system","volume":"95","author":"Reyes","year":"2000","journal-title":"Neuroscience"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1113\/JP272374","article-title":"GABAB receptors enhance excitatory responses in isolated rat retinal ganglion cells","volume":"594","author":"Garaycochea","year":"2016","journal-title":"J. Physiol."},{"key":"ref_130","first-page":"924","article-title":"Elevated expression of TREK-TRAAK K(2P) channels in the retina of adult rd1 mice","volume":"12","author":"Zhang","year":"2019","journal-title":"Int. J. Ophthalmol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"eabn8785","DOI":"10.1126\/sciadv.abn8785","article-title":"Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina","volume":"8","author":"Wen","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature10812","article-title":"Piezo proteins are pore-forming subunits of mechanically activated channels","volume":"483","author":"Coste","year":"2012","journal-title":"Nature"},{"key":"ref_133","first-page":"749","article-title":"Astrocytes in the optic nerve head express putative mechanosensitive channels","volume":"21","author":"Choi","year":"2015","journal-title":"Mol. Vis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"107900","DOI":"10.1016\/j.exer.2019.107900","article-title":"Piezo channel plays a part in retinal ganglion cell damage","volume":"191","author":"Morozumi","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1161\/CIRCRESAHA.122.320827","article-title":"Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries","volume":"130","author":"Harraz","year":"2022","journal-title":"Circ. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/iovs.64.7.1","article-title":"The Mechanosensitive Piezo1 Channel Mediates Mechanochemical Transmission in Myopic Eyes","volume":"64","author":"Zhong","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"19013","DOI":"10.1038\/s41598-020-76026-0","article-title":"Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice","volume":"10","author":"Baxter","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_138","unstructured":"Pang, J.J., and Wu, S.M. (2021). Ocular Pressure-Volume Relationship and Ganglion Cell Death in Glaucoma. OBM Neurobiol., 5."},{"key":"ref_139","first-page":"1","article-title":"Retinal Ganglion Cell Death is correlated with Eyeball Expansion in Mammals","volume":"1","author":"Pang","year":"2014","journal-title":"J. Ophthalmol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41586-021-03196-w","article-title":"Visualization of the mechanosensitive ion channel MscS under membrane tension","volume":"590","author":"Zhang","year":"2021","journal-title":"Nature"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e13811","DOI":"10.1111\/apha.13811","article-title":"ENaC activation by proteases","volume":"235","author":"Anand","year":"2022","journal-title":"Acta Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1076\/0271-3683(200009)2131-RFT703","article-title":"The epithelial sodium channel (ENaC) in rodent retina, ontogeny and molecular identity","volume":"21","author":"Golestaneh","year":"2000","journal-title":"Curr. Eye Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10571-012-9904-5","article-title":"Retinal cell death induced by TRPV1 activation involves NMDA signaling and upregulation of nitric oxide synthases","volume":"33","author":"Leonelli","year":"2013","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/19336950.2015.1009272","article-title":"Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress","volume":"9","author":"Sappington","year":"2015","journal-title":"Channels"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fncel.2018.00353","article-title":"Polymodal TRPV1 and TRPV4 Sensors Colocalize but Do Not Functionally Interact in a Subpopulation of Mouse Retinal Ganglion Cells","volume":"12","author":"Lakk","year":"2018","journal-title":"Front. Cell Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"14531","DOI":"10.1073\/pnas.2235619100","article-title":"Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans","volume":"100","author":"Liedtke","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"13698","DOI":"10.1073\/pnas.1735416100","article-title":"Abnormal osmotic regulation in trpv4\u2212\/\u2212 mice","volume":"100","author":"Liedtke","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Orduna, R.M., Noguez, I.R., Godinez, N.M.H., Cortes, A.M.B., Escalante, D.D.L., Liedtke, W., Martinez, T.A., Concha, L., and Thebault, S. (2019). TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0212158"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e155128","DOI":"10.1172\/jci.insight.155128","article-title":"Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats","volume":"7","author":"Esquiva","year":"2022","journal-title":"JCI Insight"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1109\/TNSRE.2018.2822322","article-title":"Mechanical Stimulation of the Retina: Therapeutic Feasibility and Cellular Mechanism","volume":"26","author":"Rountree","year":"2018","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"603419","DOI":"10.3389\/fncel.2020.603419","article-title":"TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress","volume":"14","author":"Risner","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"ref_152","first-page":"2616","article-title":"The planarian TRPA1 homolog mediates extraocular behavioral responses to near-ultraviolet light","volume":"220","author":"Birkholz","year":"2017","journal-title":"J. Exp. Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1073\/pnas.1117433109","article-title":"G-protein-mediated inhibition of the Trp channel TRPM1 requires the G\u03b2\u03b3 dimer","volume":"109","author":"Shen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"20940","DOI":"10.1038\/srep20940","article-title":"The TRPM1 channel in ON-bipolar cells is gated by both the \u03b1 and the \u03b2\u03b3 subunits of the G-protein Go","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Jimenez, I., Prado, Y., Marchant, F., Otero, C., Eltit, F., Cabello-Verrugio, C., Cerda, O., and Simon, F. (2020). TRPM Channels in Human Diseases. Cells, 9.","DOI":"10.3390\/cells9122604"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Contreras, E., Nobleman, A.P., Robinson, P.R., and Schmidt, T.M. (2021). Melanopsin phototransduction: Beyond canonical cascades. J. Exp. Biol., 224.","DOI":"10.1242\/jeb.226522"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.molmet.2018.01.003","article-title":"TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation","volume":"9","author":"Sachdeva","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Brown, R.L., Xiong, W.H., Peters, J.H., Tekmen-Clark, M., Strycharska-Orczyk, I., Reed, B.T., Morgans, C.W., and Duvoisin, R.M. (2015). TRPM3 expression in mouse retina. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117615"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"ENEURO-19","DOI":"10.1523\/ENEURO.0175-19.2020","article-title":"The Impact of Steroid Activation of TRPM3 on Spontaneous Activity in the Developing Retina","volume":"7","author":"Webster","year":"2020","journal-title":"eNeuro"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Martinez-Gil, N., Kutsyr, O., Fernandez-Sanchez, L., Sanchez-Saez, X., Albertos-Arranz, H., Sanchez-Castillo, C., Vidal-Gil, L., Cuenca, N., Lax, P., and Maneu, V. (2023). Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216068"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/APO.0000000000000447","article-title":"Potential Protective Role of TRPM7 and Involvement of PKC\/ERK Pathway in Blue Light-Induced Apoptosis in Retinal Pigment Epithelium Cells In Vitro","volume":"10","author":"Hu","year":"2021","journal-title":"Asia Pac. J. Ophthalmol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/9\/4877\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:36:45Z","timestamp":1760107005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/9\/4877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":161,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["ijms25094877"],"URL":"https:\/\/doi.org\/10.3390\/ijms25094877","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]}}}