{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:16:26Z","timestamp":1790702186467,"version":"4.1.0"},"reference-count":131,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin condition with a considerable impact on patients\u2019 quality of life. Its etiology is multifactorial and, among the predisposing factors, a role is played by oxidative stress. Pollution, recurrent infections, and psychological stress contribute to oxidative stress, amplifying the production of proinflammatory cytokines and worsening barrier damage. There are various oxidative stress mechanisms involved in the pathogenesis of AD. Moreover, AD often appears to be associated with psychological disorders such as alexithymia, depression, and anxiety due to severe itching and related insomnia, as well as social distress and isolation. The increasing incidence of AD requires the evaluation of additional therapeutic approaches in order to reduce the psychological burden of this condition. Our review aims to evaluate the role of some nutraceuticals in AD treatment and its related psychological comorbidities. The combination of some natural compounds (flavonoids, alkaloids, terpenes, isothiocyanates) with traditional AD treatments might be useful in improving the effectiveness of therapy, by reducing chronic inflammation and preventing flare-ups, and in promoting corticosteroid sparing. In addition, some of these nutraceuticals also appear to have a role in the treatment of psychological disorders, although the underlying oxidative stress mechanisms are different from those already known for AD.<\/jats:p>","DOI":"10.3390\/ijms25095020","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T15:05:01Z","timestamp":1715007901000},"page":"5020","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["An Overview on Atopic Dermatitis, Oxidative Stress, and Psychological Stress: Possible Role of Nutraceuticals as an Additional Therapeutic Strategy"],"prefix":"10.3390","volume":"25","author":[{"given":"Clara","family":"Alessandrello","sequence":"first","affiliation":[{"name":"School and Operative Unit of Allergy and Clinical Immunology, University Hospital of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Sanfilippo","sequence":"additional","affiliation":[{"name":"School and Operative Unit of Allergy and Clinical Immunology, University Hospital of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola L.","family":"Minciullo","sequence":"additional","affiliation":[{"name":"School and Operative Unit of Allergy and Clinical Immunology, University Hospital of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gangemi","sequence":"additional","affiliation":[{"name":"School and Operative Unit of Allergy and Clinical Immunology, University Hospital of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Grze\u015bk-Kaczy\u0144ska, M., Petrus-Halicka, J., Kaczy\u0144ski, S., Bartuzi, Z., and Ukleja-Soko\u0142owska, N. (2024). Should Emollients Be Recommended for the Prevention of Atopic Dermatitis?\u2014New Evidence and Current State of Knowledge. J. Clin. Med., 13.","DOI":"10.3390\/jcm13030863"},{"key":"ref_2","first-page":"145","article-title":"Clinical practice guidelines for the diagnosis and management of atopic dermatitis","volume":"39","author":"Kulthanan","year":"2021","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.anai.2020.11.008","article-title":"Childhood Atopic Dermatitis Is Associated with Cognitive Dysfunction: A National Health Interview Survey Study from 2008 to 2018","volume":"126","author":"Cole","year":"2021","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1201989","DOI":"10.3389\/fimmu.2023.1201989","article-title":"Common Pathogenetic Traits of Atopic Dermatitis and Autism Spectrum Disorders, Potential Connections and Treatments: Trivial Th2 Inflammation or Much More?","volume":"14","author":"Peterle","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/ced.13377","article-title":"What\u2019s New in Atopic Eczema? An Analysis of Systematic Reviews Published in 2015. Part 1: Epidemiology and Methodology","volume":"43","author":"Davies","year":"2018","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"606","DOI":"10.20344\/amp.11963","article-title":"Update on Atopic Dermatitis","volume":"32","author":"Torres","year":"2019","journal-title":"Acta Medica Port."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000370220","article-title":"Atopic Dermatitis: Global Epidemiology and Risk Factors","volume":"66","author":"Nutten","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.det.2017.02.006","article-title":"An Update on the Pathophysiology of Atopic Dermatitis","volume":"35","author":"Malik","year":"2017","journal-title":"Dermatol. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4168\/aair.2018.10.3.207","article-title":"Significance of Skin Barrier Dysfunction in Atopic Dermatitis","volume":"10","author":"Kim","year":"2018","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13223-018-0281-6","article-title":"Atopic Dermatitis","volume":"14","author":"Kapur","year":"2018","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/08820139.2018.1508228","article-title":"Analysis of the Association of Polymorphisms rs5743708 in TLR2 and rs4986790 in TLR4 with Atopic Dermatitis Risk","volume":"48","author":"Zhang","year":"2018","journal-title":"Immunol. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jdermsci.2017.05.005","article-title":"Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition","volume":"88","author":"Danso","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jaci.2014.09.023","article-title":"The role of air pollutants in atopic dermatitis","volume":"134","author":"Ahn","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1172\/JCI124612","article-title":"Environmental exposures and mechanisms in allergy and asthma development","volume":"129","author":"Murrison","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1203304","DOI":"10.3389\/falgy.2023.1203304","article-title":"Phenotypes, endotypes and genotypes of atopic dermatitis and allergy in populations of African ancestry on the continent and diaspora","volume":"4","author":"Lunjani","year":"2024","journal-title":"Front. Allergy"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12264-012-1207-9","article-title":"Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice","volume":"28","author":"Liu","year":"2012","journal-title":"Neurosci. Bull."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0024-3205(01)01124-9","article-title":"Increased oxidative stress in childhood atopic dermatitis","volume":"69","author":"Omata","year":"2001","journal-title":"Life Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/S0026-0495(03)00310-X","article-title":"High levels of urinary pentosidine, an advanced glycation end product, in children with acute exacerbation of atopic dermatitis: Relationship with oxidative stress","volume":"52","author":"Tsukahara","year":"2003","journal-title":"Metabolism"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bertino, L., Guarneri, F., Cannav\u00f2, S.P., Casciaro, M., Pioggia, G., and Gangemi, S. (2020). Oxidative Stress and Atopic Dermatitis. Antioxidants, 9.","DOI":"10.3390\/antiox9030196"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/ced.13674","article-title":"Bilirubin oxidation derived from oxidative stress is associated with disease severity of atopic dermatitis in adults","volume":"44","author":"Shibama","year":"2018","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/exd.14148","article-title":"NADPH oxidase inhibition rescues keratinocytes from elevated oxidative stress in a 2D atopic dermatitis and psoriasis model","volume":"29","author":"Emmert","year":"2020","journal-title":"Exp. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Borgia, F., Pomi, F.L., Vaccaro, M., Alessandrello, C., Papa, V., and Gangemi, S. (2022). Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives. Biomolecules, 12.","DOI":"10.3390\/biom12121904"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Galiniak, S., Mo\u0142o\u0144, M., Biesiadecki, M., Bo\u017cek, A., and Rachel, M. (2022). The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria. Antioxidants, 11.","DOI":"10.3390\/antiox11081590"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00403-020-02054-5","article-title":"A novel oxidative stress marker of atopic dermatitis in infants: Thiol\u2013disulfide balance","volume":"312","author":"Karacan","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Simonetti, O., Bacchetti, T., Ferretti, G., Molinelli, E., Rizzetto, G., Bellachioma, L., and Offidani, A. (2021). Oxidative Stress and Alterations of Paraoxonases in Atopic Dermatitis. Antioxidants, 10.","DOI":"10.3390\/antiox10050697"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/ced.13219","article-title":"Association of oxidative stress and dynamic thiol-disulphide homeostasis with atopic dermatitis severity and chronicity in children: A prospective study","volume":"43","author":"Uysal","year":"2017","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/j.1468-3083.2009.03327.x","article-title":"Urinary biomarker of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis","volume":"23","author":"Nakai","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chen, P.-Y., Chen, C.-W., Su, Y.-J., Chang, W.-H., Kao, W.-F., Yang, C.-C., and Wang, I.-J. (2020). Associations between Levels of Urinary Oxidative Stress of 8-OHdG and Risk of Atopic Diseases in Children. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17218207"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/S0024-3205(03)00145-0","article-title":"Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis","volume":"72","author":"Tsukahara","year":"2003","journal-title":"Life Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.21315\/mjms2023.30.1.2","article-title":"Reactive Oxygen Species and Antioxidant System in Selected Skin Disorders","volume":"30","author":"Jaffri","year":"2023","journal-title":"Malays. J. Med Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4103\/idoj.IDOJ_77_20","article-title":"Role of serum melatonin and oxidative stress in childhood atopic dermatitis: A prospective study","volume":"11","author":"Sarkar","year":"2020","journal-title":"Indian Dermatol. Online J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cordiano, R., Di Gioacchino, M., Mangifesta, R., Panzera, C., Gangemi, S., and Minciullo, P.L. (2023). Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update. Molecules, 28.","DOI":"10.3390\/molecules28165979"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000051814","article-title":"Decreased Oxidative State in Non-Lesional Skin of Atopic Dermatitis","volume":"204","author":"Antille","year":"2002","journal-title":"Dermatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jaci.2016.01.020","article-title":"Prenatal maternal distress affects atopic dermatitis in offspring mediated by oxidative stress","volume":"138","author":"Chang","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archderm.137.1.53","article-title":"Psychological Stress Perturbs Epidermal Permeability Barrier Homeostasis: Implications for the Pathogenesis of Stress-Associated Skin Disorders","volume":"137","author":"Garg","year":"2001","journal-title":"Arch. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1346-8138.2005.tb00738.x","article-title":"Psychosomatic Analysis of Atopic Dermatitis Using a Psychological Test","volume":"32","author":"Arima","year":"2005","journal-title":"J. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1365-4362.1995.tb01589.x","article-title":"Co-morbidity between dermatologic diseases and psychiatric disorders in Papua New Guinea","volume":"34","author":"Johnson","year":"1995","journal-title":"Int. J. Dermatol."},{"key":"ref_38","unstructured":"Taylor, G.J., Bagby, R.M., and Parker, J.D.A. Disorders of Affect Regulation: Alexithymia in Medical and Psychiatric Illness; Cambridge University Press, 1999; ISBN 0521778506."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000075537","article-title":"New Trends in Alexithymia Research","volume":"73","author":"Taylor","year":"2004","journal-title":"Psychother. Psychosom."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1176\/appi.neuropsych.14070169","article-title":"Alexithymia in Neurological Disease: A Review","volume":"27","author":"Ricciardi","year":"2015","journal-title":"J. Neuropsychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0022-3999(01)00253-7","article-title":"Alexithymia Following Myocardial Infarction: Psychometric Properties and Correlates of the Toronto Alexithymia Scale","volume":"51","author":"Kojima","year":"2001","journal-title":"J. Psychosom. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1183\/09031936.06.00008105","article-title":"Alexithymia: A relevant psychological variable in near-fatal asthma","volume":"28","author":"Serrano","year":"2006","journal-title":"Eur. Respir. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1365-4632.2008.03726.x","article-title":"Alexithymia and dermatology: The state of the art","volume":"47","author":"Willemsen","year":"2008","journal-title":"Int. J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1037\/bul0000391","article-title":"Child maltreatment and alexithymia: A meta-analytic review","volume":"149","author":"Ditzer","year":"2023","journal-title":"Psychol. Bull."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1159\/000524736","article-title":"Alexithymia and Cutaneous Disease Morbidity: A Systematic Review","volume":"238","author":"Holmes","year":"2022","journal-title":"Dermatology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2340\/00015555-1074","article-title":"A Case-control Study on Family Dysfunction in Patients with Alopecia Areata, Psoriasis and Atopic Dermatitis","volume":"91","author":"Poot","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000507246","article-title":"Disease Severity Is Associated with Alexithymia in Patients with Atopic Dermatitis","volume":"236","author":"Chiricozzi","year":"2020","journal-title":"Dermatology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1016\/S0140-6736(16)30381-6","article-title":"Anxiety","volume":"388","author":"Craske","year":"2016","journal-title":"Lancet"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 354 Diseases and Injuries for 195 Countries and Territories, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Collaborators","year":"2018","journal-title":"Lancet"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0140-6736(05)66665-2","article-title":"Depression in the Elderly","volume":"365","author":"Alexopoulos","year":"2005","journal-title":"Lancet"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: Classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/exd.14563","article-title":"Impact of psychiatric comorbidities in psoriasis, hidradenitis suppurativa and atopic dermatitis: The importance of a psychodermatological approach","volume":"31","author":"Iannone","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neubiorev.2016.07.003","article-title":"Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms","volume":"74","author":"Penninx","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00006842-199401000-00005","article-title":"Depression modulates pruritus perception: A study of pruritus in psoriasis, atopic dermatitis, and chronic idiopathic urticaria","volume":"56","author":"Gupta","year":"1994","journal-title":"Psychosom. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/jid.2014.530","article-title":"The Psychological Burden of Skin Diseases: A Cross-Sectional Multicenter Study among Dermatological Out-Patients in 13 European Countries","volume":"135","author":"Dalgard","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.anai.2019.06.002","article-title":"Depression and psychological distress in US adults with atopic dermatitis","volume":"123","author":"Cheng","year":"2019","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1346-8138.2012.01513.x","article-title":"Patients with psoriasis and atopic dermatitis show distinct anxiety profiles","volume":"39","author":"Takahashi","year":"2012","journal-title":"J. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Long, Q., Jin, H., You, X., Liu, Y., Teng, Z., Chen, Y., Zhu, Y., and Zeng, Y. (2022). Eczema is a shared risk factor for anxiety and depression: A meta-analysis and systematic review. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0263334"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jaci.2012.10.041","article-title":"Mental health comorbidity in patients with atopic dermatitis","volume":"131","author":"Yaghmaie","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2340\/00015555-2797","article-title":"Psychological Health Status and Health-related Quality of Life in Adults with Atopic Dermatitis: A Nationwide Cross-sectional Study in South Korea","volume":"98","author":"Lee","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_62","first-page":"528","article-title":"Anxiety and Atopic Disease: Comorbidity in a Youth Mental Health Setting","volume":"48","author":"Diaz","year":"2016","journal-title":"Child Psychiatry Hum. Dev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jaad.2017.04.019","article-title":"Impact of atopic dermatitis on health-related quality of life and productivity in adults in the United States: An analysis using the National Health and Wellness Survey","volume":"77","author":"Eckert","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-4362.1993.tb04021.x","article-title":"Role of emotional factors in adults with atopic dermatitis","volume":"32","author":"Ginsburg","year":"1993","journal-title":"Int. J. Dermatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.jpsychires.2010.11.003","article-title":"Specificity in the association of anxiety, depression, and atopic disorders in a community sample of adolescents","volume":"45","author":"Slattery","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0923-1811(96)00553-1","article-title":"Anxiety, depression and psychosomatic symptoms in patients with atopic dermatitis: Comparison with normal controls and among groups of different degrees of severity","volume":"14","author":"Hashiro","year":"1997","journal-title":"J. Dermatol. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1365-2133.2006.07186.x","article-title":"Do patients with skin allergies have higher levels of anxiety than patients with allergic respiratory diseases? Results of a large-scale cross-sectional study in a French population","volume":"154","author":"Beyer","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3999(03)00572-5","article-title":"The impact of psychological and clinical factors on quality of life in individuals with atopic dermatitis","volume":"57","author":"Wittkowski","year":"2004","journal-title":"J. Psychosom. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jad.2015.02.025","article-title":"Risk of developing major depressive disorder and anxiety disorders among adolescents and adults with atopic dermatitis: A nationwide longitudinal study","volume":"178","author":"Cheng","year":"2015","journal-title":"J. Affect. Disord."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1398-9995.2009.02249.x","article-title":"Associations among Eczema, Asthma, Serum Immunoglobulin E and Depression in Adults: A Population-Based Study","volume":"65","author":"Yang","year":"2010","journal-title":"Allergy"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jad.2016.06.012","article-title":"Risk of developing major depression and bipolar disorder among adolescents with atopic diseases: A nationwide longitudinal study in Taiwan","volume":"203","author":"Wei","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00403-023-02538-0","article-title":"The role of insomnia in the vulnerability to depressive and anxiety symptoms in atopic dermatitis adult patients","volume":"315","author":"Salfi","year":"2023","journal-title":"Arch. Dermatol. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/bjd.18252","article-title":"Depression and anxiety in atopic dermatitis: Increasing recognition and opportunities to intervene","volume":"181","author":"Nicholas","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1046\/j.1365-4362.2001.01272.x","article-title":"Anxiety Level and Severity of Skin Condition Predicts Outcome of Psychotherapy in Atopic Dermatitis Patients","volume":"40","author":"Linnet","year":"2001","journal-title":"Int. J. Dermatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/bjd.13084","article-title":"Psychodermatological aspects of atopic dermatitis","volume":"170","author":"Senra","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.psychres.2004.02.005","article-title":"Is Seasonality of Suicides Stronger in Victims with Hospital-Treated Atopic Disorders?","volume":"126","author":"Timonen","year":"2004","journal-title":"Psychiatry Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.4088\/JCP.v66n0917c","article-title":"Differential Modulation of Cerebrospinal Fluid Neurotrophins in Patients With Atopic Dermatitis Who Attempted Suicide","volume":"66","author":"Kimata","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.mehy.2006.11.018","article-title":"Atopic dermatitis and anxiety: Possible role of brain-derived neurotrophic factor (BDNF)","volume":"68","author":"Cremona","year":"2007","journal-title":"Med. Hypotheses"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1365-2230.2009.03771.x","article-title":"Efficacy of a 5-HT1a receptor agonist in atopic dermatitis","volume":"35","author":"Kawana","year":"2010","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/pai.12518","article-title":"Maternal psychologic problems increased the risk of childhood atopic dermatitis","volume":"27","author":"Wang","year":"2016","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/DER.0000000000000548","article-title":"Maternal Depression and Atopic Dermatitis in American Children and Adolescents","volume":"31","author":"McKenzie","year":"2020","journal-title":"Dermatitis"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.aller.2016.08.014","article-title":"Sleep-related disorders in Latin-American children with atopic dermatitis: A case control study","volume":"45","author":"Rosario","year":"2017","journal-title":"Allergol. Immunopathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2340\/00015555-1221","article-title":"Itch Severity and Quality of Life in Patients with Pruritus: Preliminary Validity of a Danish Adaptation of the Itch Severity Scale","volume":"92","author":"Zachariae","year":"2012","journal-title":"Acta Derm. Venereol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12016-021-08880-3","article-title":"Update on the Pathogenesis and Therapy of Atopic Dermatitis","volume":"61","author":"Li","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-021-01920-3","article-title":"Emerging Nanomedicines for the Treatment of Atopic Dermatitis","volume":"22","author":"Parekh","year":"2021","journal-title":"Aaps Pharmscitech"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jaip.2019.06.044","article-title":"Update on Atopic Dermatitis: Diagnosis, Severity Assessment, and Treatment Selection","volume":"8","author":"Fishbein","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.jaad.2017.12.022","article-title":"Dupilumab: A review of its use in the treatment of atopic dermatitis","volume":"78","author":"Gooderham","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/12034754221130969","article-title":"Treatment With Dupilumab in Patients With Atopic Dermatitis: Systematic Review and Meta-Analysis","volume":"26","author":"Koskeridis","year":"2022","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"adv00764","DOI":"10.2340\/actadv.v102.2075","article-title":"Comparative Efficacy and Safety of Monoclonal Antibodies and Janus Kinase Inhibitors in Moderate-to-severe Atopic Dermatitis: A Systematic Review and Meta-analysis","volume":"102","author":"Sedeh","year":"2022","journal-title":"Acta Derm. Venereol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.alit.2021.10.002","article-title":"Exacerbating factors and disease burden in patients with atopic dermatitis","volume":"71","author":"Murota","year":"2021","journal-title":"Allergol. Int."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/08923973.2021.1889583","article-title":"Atopic dermatitis: New insight into the etiology, pathogenesis, diagnosis and novel treatment strategies","volume":"43","author":"Mandlik","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/YCO.0000000000000826","article-title":"Nutraceuticals in mood disorders: Current knowledge and future directions","volume":"36","author":"Travica","year":"2022","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/bjd.20092","article-title":"Relationship between Atopic Dermatitis, Depression and Anxiety: A Two-sample Mendelian Randomization Study","volume":"185","author":"Baurecht","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"132531","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Dias, M.C., Pinto, D.C.G.A., and Silva, A.M.S. (2021). Plant Flavonoids: Chemical Characteristics and Biological Activity. Molecules, 26.","DOI":"10.3390\/molecules26175377"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2174\/138955751512150731112836","article-title":"The Medical Use of Wheatgrass: Review of the Gap Between Basic and Clinical Applications","volume":"15","author":"Cohen","year":"2015","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Jurendi\u0107, T., and \u0160\u010detar, M. (2021). Aronia melanocarpa Products and By-Products for Health and Nutrition: A Review. Antioxidants, 10.","DOI":"10.3390\/antiox10071052"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Lee, J.-H., Lim, J.-Y., Jeon, Y.-D., Yun, D.-H., Lee, Y.-M., and Kim, D.-K. (2022). Extract of Wheatgrass and Aronia Mixture Ameliorates Atopic Dermatitis-Related Symptoms by Suppressing Inflammatory Response and Oxidative Stress In Vitro and In Vivo. Antioxidants, 12.","DOI":"10.3390\/antiox12010027"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Kim, T.-Y., Park, N.-J., Jegal, H., Paik, J.-H., Choi, S., Kim, S.-N., and Yang, M.H. (2023). Nymphoides Peltata Root Extracts Improve Atopic Dermatitis by Regulating Skin Inflammatory and Anti-Oxidative Enzymes in 2, 4-Dinitrochlorobenzene (DNCB)-Induced SKH-1 Hairless Mice. Antioxidants, 12.","DOI":"10.3390\/antiox12040873"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Chang, Q.-X., Lyu, J.-L., Wu, P.-Y., Wen, K.-C., Chang, C.-C., and Chiang, H.-M. (2023). Coffea arabica Extract Attenuates Atopic Dermatitis-like Skin Lesions by Regulating NLRP3 Inflammasome Expression and Skin Barrier Functions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512367"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"8417","DOI":"10.1038\/s41598-020-65502-2","article-title":"Caffeoyl\u2013Pro\u2013His amide relieve DNCB-Induced Atopic Dermatitis-Like phenotypes in BALB\/c mice","volume":"10","author":"Jang","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1039\/D0FO02966A","article-title":"Fermented Blueberry and Black Rice Containing Lactobacillus Plantarum MG4221: A Novel Functional Food for Particulate Matter (PM 2.5)\/Dinitrochlorobenzene (DNCB)-Induced Atopic Dermatitis","volume":"12","author":"Hong","year":"2021","journal-title":"Food Funct."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jdermsci.2007.01.001","article-title":"Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes: Suppressive effect of wogonin on mite antigen-induced TARC expression","volume":"46","author":"Lee","year":"2007","journal-title":"J. Dermatol. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/ped.2019.1137","article-title":"Quercetin Improves Inflammation, Oxidative Stress, and Impaired Wound Healing in Atopic Dermatitis Model of Human Keratinocytes","volume":"33","author":"Beken","year":"2020","journal-title":"Pediatr. Allergy Immunol. Pulmonol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Hashimoto-Hachiya, A., Tsuji, G., Murai, M., Yan, X., and Furue, M. (2018). Upregulation of FLG, LOR, and IVL Expression by Rhodiola Crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061654"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1179\/1476830511Y.0000000035","article-title":"Natural mood foods: The actions of polyphenols against psychiatric and cognitive disorders","volume":"15","author":"Nguyen","year":"2012","journal-title":"Nutr. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jns.2007.06.028","article-title":"Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects","volume":"262","author":"Bouayed","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1517\/13543784.2013.794783","article-title":"Natural polyphenols in the management of major depression","volume":"22","author":"Pathak","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"10270","DOI":"10.1021\/jf303055b","article-title":"Evaluation of the Inhibitory Effects of Quercetin-Related Flavonoids and Tea Catechins on the Monoamine Oxidase-A Reaction in Mouse Brain Mitochondria","volume":"60","author":"Bandaruk","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jnutbio.2009.01.008","article-title":"Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats","volume":"21","author":"Kawabata","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kishimoto, S., Sato, M., Tsunematsu, Y., and Watanabe, K. (2016). Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids. Molecules, 21.","DOI":"10.3390\/molecules21081078"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Bhambhani, S., Kondhare, K.R., and Giri, A.P. (2021). Diversity in Chemical Structures and Biological Properties of Plant Alkaloids. Molecules, 26.","DOI":"10.3390\/molecules26113374"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0002-9459(24)07817-3","article-title":"Ergot and Its Alkaloids","volume":"70","year":"2006","journal-title":"Am. J. Pharm. Educ."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/1568026613666131213155252","article-title":"Alkaloids in the nature: Pharmacological applications in clinical practice of berberine and mate tea","volume":"14","author":"Derosa","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Kim, T.-Y., Kim, Y.J., Jegal, J., Jo, B.-G., Choi, H.-S., and Yang, M.H. (2021). Haplopine Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice and TNF-\u03b1\/IFN-\u03b3-Induced Inflammation in Human Keratinocyte. Antioxidants, 10.","DOI":"10.3390\/antiox10050806"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e2100361119","DOI":"10.1073\/pnas.2100361119","article-title":"Origin and early evolution of the plant terpene synthase family","volume":"119","author":"Jia","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nchembio.2007.5","article-title":"The function of terpene natural products in the natural world","volume":"3","author":"Gershenzon","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Quah, Y., Lee, S.-J., Lee, E.-B., Birhanu, B.T., Ali, M.S., Abbas, M.A., Boby, N., Im, Z.-E., and Park, S.-C. (2020). Cornus Officinalis Ethanolic Extract with Potential Anti-Allergic, Anti-Inflammatory, and Antioxidant Activities. Nutrients, 12.","DOI":"10.3390\/nu12113317"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1007\/s00213-021-05922-8","article-title":"Loganin ameliorates depression-like behaviors of mice via modulation of serotoninergic system","volume":"238","author":"Pan","year":"2021","journal-title":"Psychopharmacology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1684\/ecn.2015.0364","article-title":"Arjunolic acid protects against DNCB-induced atopic dermatitis-like symptoms in mice by restoring a normal cytokine balance","volume":"26","author":"Alyoussef","year":"2015","journal-title":"Eur. Cytokine Netw."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"565285","DOI":"10.3389\/fimmu.2020.565285","article-title":"Improved Anti-Inflammatory Effects of Liposomal Astaxanthin on a Phthalic Anhydride-Induced Atopic Dermatitis Model","volume":"11","author":"Lee","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Rasmus, P., and Koz\u0142owska, E. (2023). Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview. Antioxidants, 12.","DOI":"10.3390\/antiox12030676"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e1700965","DOI":"10.1002\/mnfr.201700965","article-title":"Isothiocyanates: Translating the Power of Plants to People","volume":"62","author":"Palliyaguru","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/jmf.2018.0024","article-title":"Isothiocyanate from Broccoli, Sulforaphane, and Its Properties","volume":"22","author":"Vanduchova","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_125","first-page":"1761","article-title":"Sulforaphane Has a Therapeutic Effect in an Atopic Dermatitis Murine Model and Activates the Nrf2\/HO 1 Axis","volume":"20","author":"Wu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2015.12.030","article-title":"Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice","volume":"301","author":"Wu","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Yin, J., Yoon, S.H., Ahn, H.S., and Lee, M.W. (2018). Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB\/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica. Molecules, 23.","DOI":"10.3390\/molecules23020450"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fphar.2019.00742","article-title":"Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators","volume":"10","author":"Lee","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s12272-010-0515-8","article-title":"Il Prenylated Chalcone from Sophora Flavescens Suppresses Th2 Chemokine Expression Induced by Cytokines via Heme Oxygenase-1 in Human Keratinocytes","volume":"33","author":"Choi","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1089\/jmf.2009.1333","article-title":"Il (2 S)-2\u2032-Methoxykurarinone from Sophora Flavescens Suppresses Cutaneous T Cell-Attracting Chemokine\/CCL27 Expression Induced by Interleukin-\u03b2\/Tumor Necrosis Factor-\u03b1 via Heme Oxygenase-1 in Human Keratinocytes","volume":"13","author":"Jeong","year":"2010","journal-title":"J. Med. Food."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/1346-8138.13970","article-title":"Topical Treatment with Sacran, a Sulfated Polysaccharide from Aphanothece Sacrum, Improves Corneocyte-derived Parameters","volume":"44","author":"Doi","year":"2017","journal-title":"J. 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