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Lifestyle changes, including a balanced diet and physical exercise, are necessary to prevent these undesirable changes. Strength training (ST) has been widely used because of the muscle and metabolic benefits it provides. Our study aims to evaluate the effects of ST on hepatic steatosis and insulin resistance in ovariectomized mice fed a high-fat diet (HFD) divided into four groups as follows: simulated sedentary surgery (SHAM-SED), trained simulated surgery (SHAM-EXE), sedentary ovariectomy (OVX-SED), and trained ovariectomy (OVX-EXE). They were fed an HFD for 9 weeks. ST was performed thrice a week. ST efficiently reduced body weight and fat percentage and increased lean mass in OVX mice. Furthermore, ST reduced the accumulation of ectopic hepatic lipids, increased AMPK phosphorylation, and inhibited the de novo lipogenesis pathway. OVX-EXE mice also showed a better glycemic profile, associated with greater insulin sensitivity identified by the euglycemic\u2013hyperinsulinemic clamp, and reduced markers of hepatic oxidative stress compared with sedentary animals. Our data support the idea that ST can be indicated as a non-pharmacological treatment approach to mitigate metabolic changes resulting from menopause.<\/jats:p>","DOI":"10.3390\/ijms25105066","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T06:53:27Z","timestamp":1715064807000},"page":"5066","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-3617","authenticated-orcid":false,"given":"Jessica D. M.","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Physiology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 F. T.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-561X","authenticated-orcid":false,"given":"Ester dos S.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-5969","authenticated-orcid":false,"given":"Alessandra G.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne R. M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-4817","authenticated-orcid":false,"given":"Felipe N.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos H. Z.","family":"Talarico","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-0657","authenticated-orcid":false,"given":"Carlos A. 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Metabolites, 12.","DOI":"10.3390\/metabo12100954"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrendo.2017.180","article-title":"Symptoms of menopause\u2014Global prevalence, physiology and implications","volume":"14","author":"Monteleone","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/GRF.0000000000000378","article-title":"Managing Menopause by Combining Evidence With Clinical Judgment","volume":"61","author":"Shufelt","year":"2018","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ko, S.H., and Kim, H.S. (2020). Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women. Nutrients, 12.","DOI":"10.3390\/nu12010202"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ogc.2019.04.008","article-title":"Menopause: Hormones, Lifestyle, and Optimizing Aging","volume":"46","author":"Minkin","year":"2019","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e13605","DOI":"10.1111\/obr.13605","article-title":"Impact of estrogens on resting energy expenditure: A systematic review","volume":"24","author":"Weidlinger","year":"2023","journal-title":"Obes. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/13697137.2023.2202809","article-title":"Understanding of and clinical approach to cardiometabolic transition at the menopause","volume":"27","author":"Lambrinoudaki","year":"2024","journal-title":"Climacteric"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ko, S.H., and Jung, Y. (2021). Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women. Nutrients, 13.","DOI":"10.3390\/nu13124556"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1113\/JP279501","article-title":"The role of oestrogen in determining sexual dimorphism in energy balance","volume":"601","author":"Henry","year":"2023","journal-title":"J. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nishio, E., Hayashi, T., Nakatani, M., Aida, N., Suda, R., Fujii, T., Wakatsuki, T., Honda, S., Harada, N., and Shimono, Y. (2019). Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities. Biochem. Biophys. Rep., 20.","DOI":"10.1016\/j.bbrep.2019.100671"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.3390\/cimb44100320","article-title":"Western Diet-Fed ApoE Knockout Male Mice as an Experimental Model of Non-Alcoholic Steatohepatitis","volume":"44","author":"Camargo","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1210\/en.2012-1989","article-title":"Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance","volume":"154","author":"Camporez","year":"2013","journal-title":"Endocrinology"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mahboobifard, F., Pourgholami, M.H., Jorjani, M., Dargahi, L., Amiri, M., Sadeghi, S., and Tehrani, F.R. (2022). Estrogen as a key regulator of energy homeostasis and metabolic health. Biomed. Pharmacother., 156.","DOI":"10.1016\/j.biopha.2022.113808"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1113\/JP277270","article-title":"Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance","volume":"597","author":"Camporez","year":"2019","journal-title":"J. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1215947","DOI":"10.3389\/fendo.2023.1215947","article-title":"Membrane estrogen receptor-alpha contributes to female protection against high-fat diet-induced metabolic disorders","volume":"14","author":"Fabre","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2015.01.012","article-title":"Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes","volume":"160","author":"Perry","year":"2015","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Schorr, M., Dichtel, L.E., Gerweck, A.V., Valera, R.D., Torriani, M., Miller, K.K., and Bredella, M.A. (2018). Sex differences in body composition and association with cardiometabolic risk. Biol. Sex Differ., 9.","DOI":"10.1186\/s13293-018-0189-3"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2337\/db11-1718","article-title":"Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance","volume":"62","author":"Zhu","year":"2013","journal-title":"Diabetes"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"108363","DOI":"10.1016\/j.isci.2023.108363","article-title":"Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma","volume":"26","author":"Smiriglia","year":"2023","journal-title":"iScience"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Araujo, L.C.C., Cruz, A.G., Camargo, F.N., Sucupira, F.G., Moreira, G.V., Matos, S.L., Amaral, A.G., Murata, G.M., Carvalho, C.R.O., and Camporez, J.P. (2023). Estradiol Protects Female ApoE KO Mice against Western-Diet-Induced Non-Alcoholic Steatohepatitis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24129845"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Nassir, F. (2022). NAFLD: Mechanisms, Treatments, and Biomarkers. Biomolecules, 12.","DOI":"10.3390\/biom12060824"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gao, Y., Zhang, W., Zeng, L.Q., Bai, H., Li, J., Zhou, J., Zhou, G.Y., Fang, C.W., Wang, F., and Qin, X.J. (2020). Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy. Redox Biol., 36.","DOI":"10.1016\/j.redox.2020.101635"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jhep.2012.02.023","article-title":"Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis","volume":"57","author":"Keating","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"759677","DOI":"10.3389\/fphys.2021.759677","article-title":"Strength Training Volume to Increase Muscle Mass Responsiveness in Older Individuals: Weekly Sets Based Approach","volume":"12","author":"Castro","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"eAO4784","DOI":"10.31744\/einstein_journal\/2020AO4784","article-title":"Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity","volume":"18","author":"Guedes","year":"2020","journal-title":"Einstein"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"31106","DOI":"10.1038\/srep31106","article-title":"Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals","volume":"6","author":"Botezelli","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/JOE-18-0567","article-title":"Short-term strength training reduces gluconeogenesis and NAFLD in obese mice","volume":"241","author":"Pereira","year":"2019","journal-title":"J. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jshs.2023.09.012","article-title":"Effect of resistance training volume on body adiposity, metabolic risk, and inflammation in postmenopausal and older females: Systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Nunes","year":"2023","journal-title":"J. Sport Health Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11010-020-03879-4","article-title":"Ovariectomized rodents as a menopausal metabolic syndrome model. A minireview","volume":"475","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/aje\/kwh244","article-title":"The effect of menopause on grip and pinch strength: Results from the Chicago, Illinois, site of the Study of Women\u2019s Health Across the Nation","volume":"160","author":"Kurina","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/jcsm.13031","article-title":"Influence of oestrogen on satellite cells and myonuclear domain size in skeletal muscles following resistance exercise","volume":"13","author":"Hung","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1073\/pnas.1525795113","article-title":"Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice","volume":"113","author":"Camporez","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s13105-021-00794-0","article-title":"Weight-bearing exercise prevents skeletal muscle atrophy in ovariectomized rats","volume":"77","author":"Tang","year":"2021","journal-title":"J. Physiol. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s40520-019-01155-0","article-title":"Long-term strength and balance training in prevention of decline in muscle strength and mobility in older adults","volume":"32","author":"Aartolahti","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e14502","DOI":"10.14814\/phy2.14502","article-title":"Muscle hypertrophy and ladder-based resistance training for rodents: A systematic review and meta-analysis","volume":"8","author":"Lourenco","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.6061\/clinics\/2013(09)12","article-title":"Effects of ovariectomy and resistance training on oxidative stress markers in the rat liver","volume":"68","author":"Rodrigues","year":"2013","journal-title":"Clinics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1017\/jns.2013.38","article-title":"Lower resting and total energy expenditure in postmenopausal compared with premenopausal women matched for abdominal obesity","volume":"3","author":"Hodson","year":"2014","journal-title":"J. Nutr. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1113\/jphysiol.2011.206078","article-title":"Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats","volume":"589","author":"Camporez","year":"2011","journal-title":"J. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e13256","DOI":"10.1111\/obr.13256","article-title":"Effect of exercise training on weight loss, body composition changes, and weight maintenance in adults with overweight or obesity: An overview of 12 systematic reviews and 149 studies","volume":"22","author":"Bellicha","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.maturitas.2009.07.005","article-title":"Resistance training attenuates fat mass regain after weight loss in ovariectomized rats","volume":"64","author":"Pighon","year":"2009","journal-title":"Maturitas"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s12011-021-02655-9","article-title":"Effects of Ovariectomy and Exercise Training on Mineral Status in a High-Fat Diet-Induced Obesity Rat Model","volume":"200","author":"Masanova","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"119639","DOI":"10.1016\/j.lfs.2021.119639","article-title":"Strength training improves insulin resistance and differently affects mitochondria in skeletal muscle and visceral adipose tissue in high-fat fed mice","volume":"278","author":"Costa","year":"2021","journal-title":"Life Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"118868","DOI":"10.1016\/j.lfs.2020.118868","article-title":"Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-alpha signaling in obese mice","volume":"266","author":"Diniz","year":"2021","journal-title":"Life Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1249\/MSS.0000000000000242","article-title":"Aerobic and strength training in concomitant metabolic syndrome and type 2 diabetes","volume":"46","author":"Earnest","year":"2014","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1111\/obr.12719","article-title":"The effect of exercise training on intrahepatic triglyceride and hepatic insulin sensitivity: A systematic review and meta-analysis","volume":"19","author":"Sargeant","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.maturitas.2008.02.005","article-title":"Resistance training prevents liver fat accumulation in ovariectomized rats","volume":"59","author":"Corriveau","year":"2008","journal-title":"Maturitas"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"E11285","DOI":"10.1073\/pnas.1716990115","article-title":"Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice","volume":"114","author":"Camporez","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1194\/jlr.M054080","article-title":"ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content","volume":"56","author":"Camporez","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2018.12.003","article-title":"Ectopic lipid deposition mediates insulin resistance in adipose specific 11beta-hydroxysteroid dehydrogenase type 1 transgenic mice","volume":"93","author":"Abulizi","year":"2019","journal-title":"Metabolism"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1210\/en.2013-1191","article-title":"Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice","volume":"154","author":"Camporez","year":"2013","journal-title":"Endocrinology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1172\/JCI86013","article-title":"Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance","volume":"126","author":"Petersen","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of Insulin Action and Insulin Resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s00421-011-2098-6","article-title":"Resistance training restores the gene expression of molecules related to fat oxidation and lipogenesis in the liver of ovariectomized rats","volume":"112","author":"Domingos","year":"2012","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1139\/H08-132","article-title":"Effect of different models of physical exercise on oxidative stress markers in mouse liver","volume":"34","author":"Pinho","year":"2009","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_58","first-page":"369","article-title":"The 6-week Effects of HIIT on Biomarkers of Tissue and Oxidative Damage in Wistar Rats Previously Supplemented with Pyridoxine","volume":"14","author":"Aidar","year":"2021","journal-title":"Int. J. Exerc. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1139\/h04-002","article-title":"Physiological hypertrophy of the FHL muscle following 8 weeks of progressive resistance exercise in the rat","volume":"29","author":"Hornberger","year":"2004","journal-title":"Can. J. Appl. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8574","DOI":"10.1038\/s41598-021-88105-x","article-title":"Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL\/6 mice","volume":"11","author":"Bronczek","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.33549\/physiolres.933256","article-title":"Responses of skeletal muscle hypertrophy in Wistar rats to different resistance exercise models","volume":"66","author":"Luciano","year":"2017","journal-title":"Physiol. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5066\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:40:40Z","timestamp":1760107240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,7]]},"references-count":63,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["ijms25105066"],"URL":"https:\/\/doi.org\/10.3390\/ijms25105066","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,7]]}}}