{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:33:58Z","timestamp":1793846038381,"version":"4.6.1"},"reference-count":53,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sleep-disordered breathing (SDB), including obstructive and central sleep apnea, significantly exacerbates heart failure (HF) through adverse cardiovascular mechanisms. This review aims to synthesize existing literature to clarify the relationship between SDB and HF, focusing on the pathophysiological mechanisms, diagnostic challenges, and the effectiveness of treatment modalities like continuous positive airway pressure (CPAP) and adaptive servo-ventilation ASV. We analyzed peer-reviewed articles from 2003 to 2024 sourced from PubMed, EMBASE, Scopus, and Web of Science databases. The prevalence of SDB in HF patients is high, often underdiagnosed, and underappreciated. Management strategies, including CPAP and ASV, have been shown to mitigate symptoms and improve cardiac function. However, despite the availability of effective treatments, significant challenges in screening and diagnosis persist, affecting patient management and outcomes. DB significantly impacts HF prognosis. Enhanced screening strategies and broader utilization of therapeutic interventions like CPAP and ASV are essential to improve the management and outcomes of HF patients with concomitant SDB. Future research should focus on refining diagnostic and treatment protocols to optimize care for HF patients with SDB.<\/jats:p>","DOI":"10.3390\/ijms25105251","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:03:08Z","timestamp":1715673788000},"page":"5251","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Sleep Apnea and Heart Failure\u2014Current State-of-The-Art"],"prefix":"10.3390","volume":"25","author":[{"given":"Tushar","family":"Menon","sequence":"first","affiliation":[{"name":"Division of Cardiology, University of Louisville Hospital, 201 Abraham Flexner Way, Suite 600, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-4067","authenticated-orcid":false,"given":"Dinesh K.","family":"Kalra","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Louisville Hospital, 201 Abraham Flexner Way, Suite 600, Louisville, KY 40202, USA"},{"name":"Lipid Clinic & Infiltrative Heart Disease Program, Rudd Heart & Lung Center, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville School of Medicine, 201 Abraham Flexner Way, Suite 600, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s11897-017-0348-6","article-title":"Epidemiology of Sleep-Disordered Breathing and Heart Failure: What Drives What","volume":"14","author":"Dharia","year":"2017","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.23736\/S0026-4806.22.08190-3","article-title":"Obstructive sleep apnoea-hypopnoea syndrome: State of the art","volume":"114","author":"Tondo","year":"2023","journal-title":"Minerva Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17219\/dmp\/185395","article-title":"Sleep disorders and cardiovascular risk: Focusing on sleep fragmentation","volume":"61","author":"Martynowicz","year":"2024","journal-title":"Dent. Med. Probl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1161\/01.CIR.0000061757.12581.15","article-title":"Sleep Apnea and Heart Failure: Part I: Obstructive Sleep Apnea","volume":"107","author":"Bradley","year":"2003","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1161\/01.CIR.0000061758.05044.64","article-title":"Sleep Apnea and Heart Failure: Part II: Central Sleep Apnea","volume":"107","author":"Bradley","year":"2003","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/01.CIR.0000072346.56728.E4","article-title":"Sleep-Disordered Breathing and Cardiovascular Disease","volume":"108","author":"Wolk","year":"2003","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ga\u0107, P., Urbanik, D., Macek, P., Martynowicz, H., Mazur, G., and Por\u0119ba, R. (2022). Coexistence of cardiovascular risk factors and obstructive sleep apnoea in polysomnography. Respir. Physiol. Neurobiol., 295.","DOI":"10.1016\/j.resp.2021.103782"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0735-1097(03)00184-0","article-title":"Obstructive sleep apnea and cardiovascular disease","volume":"41","author":"Lattimore","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.sleep.2017.12.005","article-title":"Alcohol and the risk of sleep apnoea: A systematic review and meta-analysis","volume":"42","author":"Simou","year":"2018","journal-title":"Sleep Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1378\/chest.14-0772","article-title":"Where There Is Smoke\u2026There Is Sleep Apnea","volume":"146","author":"Krishnan","year":"2014","journal-title":"Chest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101441","DOI":"10.1016\/j.smrv.2021.101441","article-title":"The relationship between opioid use and obstructive sleep apnea: A systematic review and meta-analysis","volume":"58","author":"Ahmad","year":"2021","journal-title":"Sleep Med. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11325-011-0523-z","article-title":"Age- and gender-related characteristics of obstructive sleep apnea","volume":"16","author":"Gabbay","year":"2012","journal-title":"Sleep Breath."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1161\/CIRCULATIONAHA.115.016985","article-title":"Sex-Specific Association of Sleep Apnea Severity With Subclinical Myocardial Injury, Ventricular Hypertrophy, and Heart Failure Risk in a Community-Dwelling Cohort: The Atherosclerosis Risk in Communities\u2013Sleep Heart Health Study","volume":"132","author":"Roca","year":"2015","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1113\/jphysiol.2012.245159","article-title":"Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea","volume":"591","author":"White","year":"2013","journal-title":"J. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"zsac113","DOI":"10.1093\/sleep\/zsac113","article-title":"Central sleep apnea: Pathophysiologic classification","volume":"46","author":"Javaheri","year":"2023","journal-title":"Sleep"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jjcc.2012.05.013","article-title":"Sleep apnea and heart failure","volume":"60","author":"Kasai","year":"2012","journal-title":"J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrcardio.2012.141","article-title":"Mechanisms of cardiac dysfunction in obstructive sleep apnea","volume":"9","author":"Baguet","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/CIRCULATIONAHA.104.501841","article-title":"Obstructive Sleep Apnea Syndrome Affects Left Ventricular Diastolic Function: Effects of Nasal Continuous Positive Airway Pressure in Men","volume":"112","author":"Arias","year":"2005","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1183\/09031936.00111208","article-title":"Cardiovascular disease in obstructive sleep apnoea syndrome: The role of intermittent hypoxia and inflammation","volume":"33","author":"Garvey","year":"2009","journal-title":"Eur. Respir. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1001\/jama.290.14.1906","article-title":"Obstructive sleep apnea: Implications for cardiac and vascular disease","volume":"290","author":"Shamsuzzaman","year":"2003","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tondo, P., Fanfulla, F., Scioscia, G., Sabato, R., Salvemini, M., De Pace, C.C., Foschino Barbaro, M.P., and Lacedonia, D. (2022). The Burden of Respiratory Alterations during Sleep on Comorbidities in Obstructive Sleep Apnoea (OSA). Brain Sci., 12.","DOI":"10.3390\/brainsci12101359"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e003065","DOI":"10.1161\/CIRCHEARTFAILURE.116.003065","article-title":"Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure","volume":"9","author":"Lobo","year":"2016","journal-title":"Circ. Heart Fail."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jacc.2006.08.060","article-title":"Obstructive Sleep Apnea, Obesity, and the Risk of Incident Atrial Fibrillation","volume":"49","author":"Gami","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2174\/1573403X14666181012153252","article-title":"Ventricular Arrhythmias in Patients with Obstructive Sleep Apnea","volume":"15","author":"Marinheiro","year":"2018","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/CIRCULATIONAHA.113.005893","article-title":"Effects of Short-Term Continuous Positive Airway Pressure on Myocardial Sympathetic Nerve Function and Energetics in Patients With Heart Failure and Obstructive Sleep Apnea: A Randomized Study","volume":"130","author":"Hall","year":"2014","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.jacc.2005.11.054","article-title":"Obstructive Sleep Apnea Syndrome","volume":"47","author":"Shivalkar","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1161\/HYPERTENSIONAHA.120.15882","article-title":"Effect of Obstructive Sleep Apnea and Positive Airway Pressure Therapy on Cardiac Remodeling as Assessed by Cardiac Biomarker and Magnetic Resonance Imaging in Nonobese and Obese Adults","volume":"77","author":"Xu","year":"2021","journal-title":"Hypertension"},{"key":"ref_28","unstructured":"Mehra, R. (2024, January 01). Obstructive Sleep Apnea and Cardiovascular Disease in Adults. Available online: https:\/\/www.uptodate.cn\/home."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e008684","DOI":"10.1161\/JAHA.118.008684","article-title":"Sleep Apnea, the Risk of Developing Heart Failure, and Potential Benefits of Continuous Positive Airway Pressure (CPAP) Therapy","volume":"7","author":"Holt","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMoa1606599","article-title":"CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea","volume":"375","author":"McEvoy","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/clc.22738","article-title":"Obstructive sleep apnea is associated with increased readmission in heart failure patients","volume":"40","author":"Sommerfeld","year":"2017","journal-title":"Clin. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e028732","DOI":"10.1161\/JAHA.122.028732","article-title":"Positive Airway Pressure Adherence and Health Care Resource Utilization in Patients With Obstructive Sleep Apnea and Heart Failure With Reduced Ejection Fraction","volume":"12","author":"Malhotra","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ejhf.790","article-title":"Design of the effect of adaptive servo-ventilation on survival and cardiovascular hospital admissions in patients with heart failure and sleep apnoea: The ADVENT-HF trial","volume":"19","author":"Lyons","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"ref_34","first-page":"1323","article-title":"New developments in the use of positive airway pressure for obstructive sleep apnea","volume":"7","author":"Donovan","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1056\/NEJMoa1506459","article-title":"Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure","volume":"373","author":"Cowie","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/thoraxjnl-2021-217205","article-title":"Adaptive servo ventilation for sleep apnoea in heart failure: The FACE study 3-month data","volume":"77","author":"Tamisier","year":"2022","journal-title":"Thorax"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.jacc.2006.12.046","article-title":"Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart Failure","volume":"49","author":"Wang","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.sleep.2023.10.011","article-title":"Mortality in obstructive sleep apnea syndrome (OSAS) and overlap syndrome (OS): The role of nocturnal hypoxemia and CPAP compliance","volume":"112","author":"Tondo","year":"2023","journal-title":"Sleep Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1164\/rccm.201808-1509OC","article-title":"Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes","volume":"200","author":"Mazzotti","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"801167","DOI":"10.3389\/fneur.2022.801167","article-title":"Cardiovascular Outcomes in Sleep-Disordered Breathing: Are We Under-estimating?","volume":"13","author":"Yasir","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jacc.2021.05.048","article-title":"Sleep Disordered Breathing and Cardiovascular Disease","volume":"78","author":"Cowie","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101364","DOI":"10.1016\/j.cpcardiol.2022.101364","article-title":"Evaluation and Treatment of Central Sleep Apnea in Patients with Heart Failure","volume":"47","author":"Fudim","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.5664\/jcsm.10532","article-title":"Application of artificial intelligence in the diagnosis of sleep apnea","volume":"19","author":"Bazoukis","year":"2023","journal-title":"J. Clin. Sleep Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2101788","DOI":"10.1183\/13993003.01788-2021","article-title":"Novel avenues to approach non-CPAP therapy and implement comprehensive obstructive sleep apnoea care","volume":"59","author":"Eastwood","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"101809","DOI":"10.1016\/j.smrv.2023.101809","article-title":"Pharmacotherapy for obstructive sleep apnea\u2014A systematic review and meta-analysis of randomized controlled trials","volume":"70","author":"Lee","year":"2023","journal-title":"Sleep Med. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Carrasco-Llatas, M., O\u2019Connor-Reina, C., and Calvo-Henr\u00edquez, C. (2021). The Role of Myofunctional Therapy in Treating Sleep-Disordered Breathing: A State-of-the-Art Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18147291"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"803388","DOI":"10.3389\/fmed.2022.803388","article-title":"Management of Obstructive Sleep Apnea in Patients With Heart Failure","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s11325-021-02520-y","article-title":"Lateral pharyngoplasty vs. traditional uvulopalatopharyngoplasty for patients with OSA: Systematic review and meta-analysis","volume":"26","author":"Maniaci","year":"2022","journal-title":"Sleep Breath."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.14639\/0392-100X-N1871","article-title":"Management of pharyngeal collapse in patients affected by moderate obstructive sleep apnoea syndrome","volume":"42","author":"Lorusso","year":"2022","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s13665-019-0221-z","article-title":"Central Sleep Apnea: A Brief Review","volume":"8","author":"Badr","year":"2019","journal-title":"Curr. Pulmonol. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/B978-0-444-52006-7.00020-4","article-title":"Cardiovascular diseases and sleep apnea","volume":"Volume 98","author":"Javaheri","year":"2011","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40248-018-0157-0","article-title":"From CPAP to tailored therapy for obstructive sleep Apnoea","volume":"13","author":"Sutherland","year":"2018","journal-title":"Multidiscip. Respir. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"101458","DOI":"10.1016\/j.smrv.2021.101458","article-title":"MicroRNAs to guide medical decision-making in obstructive sleep apnea: A review","volume":"59","author":"Pinilla","year":"2021","journal-title":"Sleep Med. Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5251\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:40:45Z","timestamp":1760107245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,11]]},"references-count":53,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["ijms25105251"],"URL":"https:\/\/doi.org\/10.3390\/ijms25105251","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,11]]}}}