{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:48:15Z","timestamp":1791244095297,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003336","name":"Bulgarian National Science Fund","doi-asserted-by":"publisher","award":["KP-06-N33\/9"],"award-info":[{"award-number":["KP-06-N33\/9"]}],"id":[{"id":"10.13039\/501100003336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The diagnosis of osteoarthritis (OA) is based on radiological changes that are delayed, along with clinical symptoms. Early and very early diagnosis at the stage of molecular pathology may eventually offer an opportunity for early therapeutic intervention that may retard and prevent future damage. Cartilage oligomeric matrix protein (COMP) is a non-collagenous extracellular matrix protein that promotes the secretion and aggregation of collagen and contributes to the stability of the extracellular matrix. There are contradictory literature data and currently, the parameter is used only for scientific purposes and its significance is not well-determined. The serum level of COMP in patients with metabolic type OA of the knee has not been evaluated. The aim of the study was to analyze serum COMP levels in metabolic knee OA and controls with different BMI. Our results showed that the mean COMP values were significantly higher in the control group (1518.69 \u00b1 232.76 ng\/mL) compared to the knee OA patients (1294.58 \u00b1 360.77 ng\/mL) (p = 0.0012). This may be related to the smaller cartilage volume in OA patients. Additionally, COMP levels negatively correlated with disease duration (p = 0.04). The COMP level in knee OA with BMI below 30 kg\/m2 (n = 61, 1304.50 \u00b1 350.60 ng\/mL) was higher compared to cases with BMI \u2265 30 kg\/m2 (n = 76, 1286.63 \u00b1 370.86 ng\/mL), but the difference was not significant (p = 0.68). Whether this finding is related to specific features in the evolution of the metabolic type of knee OA remains to be determined. Interestingly, comparison of COMP levels in the controls with different BMI revealed significantly higher values in overweight and obese individuals (1618.36 \u00b1 203.76 ng\/mL in controls with BMI \u2265 25 kg\/m2, n = 18, 1406.61 \u00b1 216.41 ng\/mL, n = 16; p = 0.0092). Whether this finding is associated with increased expression of COMP in the adipose tissue or with more intensive cartilage metabolism in relation to higher biomechanical overload in obese patients, considering the earlier development of metabolic type knee OA as an isolated finding, remains to be determined.<\/jats:p>","DOI":"10.3390\/ijms25105263","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:03:08Z","timestamp":1715673788000},"page":"5263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cartilage Oligomeric Matrix Protein in Osteoarthritis and Obesity\u2014Do New Considerations Emerge?"],"prefix":"10.3390","volume":"25","author":[{"given":"Sevdalina Nikolova","family":"Lambova","sequence":"first","affiliation":[{"name":"Department of Propaedeutics of Internal Diseases \u201cProf Dr Anton Mitov\u201d, Faculty of Medicine, Medical University\u2014Plovdiv, 4000 Plovdiv, Bulgaria"},{"name":"Department of Rheumatology, MHAT \u201cSveti Mina\u201d, 4000 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-1945","authenticated-orcid":false,"given":"Tsvetelina","family":"Batsalova","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-5214","authenticated-orcid":false,"given":"Dzhemal","family":"Moten","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8052-5840","authenticated-orcid":false,"given":"Balik","family":"Dzhambazov","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Paisii Hilendarski University of Plovdiv, 4000 Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5574582","DOI":"10.1155\/2021\/5574582","article-title":"Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions","volume":"2021","author":"Kumavat","year":"2021","journal-title":"Mediat. 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