{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:16:48Z","timestamp":1790997408562,"version":"4.1.0"},"reference-count":99,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas (CONAHCYT)","award":["774714"],"award-info":[{"award-number":["774714"]}]},{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas (CONAHCYT)","award":["660789"],"award-info":[{"award-number":["660789"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>LOX-1, ORL-1, or lectin-like oxidized low-density lipoprotein receptor 1 is a transmembrane glycoprotein that binds and internalizes ox-LDL in foam cells. LOX-1 is the main receptor for oxidized low-density lipoproteins (ox-LDL). The LDL comes from food intake and circulates through the bloodstream. LOX-1 belongs to scavenger receptors (SR), which are associated with various cardiovascular diseases. The most important and severe of these is the formation of atherosclerotic plaques in the intimal layer of the endothelium. These plaques can evolve into complicated thrombi with the participation of fibroblasts, activated platelets, apoptotic muscle cells, and macrophages transformed into foam cells. This process causes changes in vascular endothelial homeostasis, leading to partial or total obstruction in the lumen of blood vessels. This obstruction can result in oxygen deprivation to the heart. Recently, LOX-1 has been involved in other pathologies, such as obesity and diabetes mellitus. However, the development of atherosclerosis has been the most relevant due to its relationship with cerebrovascular accidents and heart attacks. In this review, we will summarize findings related to the physiologic and pathophysiological processes of LOX-1 to support the detection, diagnosis, and prevention of those diseases.<\/jats:p>","DOI":"10.3390\/ijms25105276","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:03:08Z","timestamp":1715673788000},"page":"5276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["LOX-1 in Cardiovascular Disease: A Comprehensive Molecular and Clinical Review"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-8291","authenticated-orcid":false,"given":"Maria Eugenia","family":"S\u00e1nchez-Le\u00f3n","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina-UNAM-UABJO, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6275-3233","authenticated-orcid":false,"given":"Karen Julissa","family":"Loaeza-Reyes","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina-UNAM-UABJO, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"},{"name":"Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3476-1743","authenticated-orcid":false,"given":"Carlos Alberto","family":"Matias-Cervantes","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina-UNAM-UABJO, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Mayoral-Andrade","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina-UNAM-UABJO, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L.","family":"P\u00e9rez-Campos","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico Nacional de M\u00e9xico\/IT Oaxaca, Oaxaca 68030, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4140-4661","authenticated-orcid":false,"given":"Laura","family":"P\u00e9rez-Campos-Mayoral","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina-UNAM-UABJO, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2182-2540","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Hern\u00e1ndez-Huerta","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas, Facultad de Medicina y Cirug\u00eda, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68120, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-4072","authenticated-orcid":false,"given":"Edgar","family":"Zenteno","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yobana","family":"P\u00e9rez-Cervera","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina-UNAM-UABJO, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"},{"name":"Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9486-5093","authenticated-orcid":false,"given":"Socorro","family":"Pina-Canseco","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Facultad de Medicina-UNAM-UABJO, Universidad Aut\u00f3noma \u201cBenito Ju\u00e1rez\u201d de Oaxaca, Oaxaca 68020, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1007\/s00018-012-1194-z","article-title":"LOX-1 in atherosclerosis: Biological functions and pharmacological modifiers","volume":"70","author":"Xu","year":"2013","journal-title":"Cell. 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