{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:07:44Z","timestamp":1789132064400,"version":"build-2803163510"},"reference-count":171,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The review examines the impact of maternal preeclampsia (PE) on the cardiometabolic and cardiovascular health of offspring. PE, a hypertensive disorder of pregnancy, is responsible for 2 to 8% of pregnancy-related complications. It significantly contributes to adverse outcomes for their infants, affecting the time of birth, the birth weight, and cardiometabolic risk factors such as blood pressure, body mass index (BMI), abdominal obesity, lipid profiles, glucose, and insulin. Exposure to PE in utero predisposes offspring to an increased risk of cardiometabolic diseases (CMD) and cardiovascular diseases (CVD) through mechanisms that are not fully understood. The incidence of CMD and CVD is constantly increasing, whereas CVD is the main cause of morbidity and mortality globally. A complex interplay of genes, environment, and developmental programming is a plausible explanation for the development of endothelial dysfunction, which leads to atherosclerosis and CVD. The underlying molecular mechanisms are angiogenic imbalance, inflammation, alterations in the renin\u2013angiotensin\u2013aldosterone system (RAAS), endothelium-derived components, serotonin dysregulation, oxidative stress, and activation of both the hypothalamic\u2013pituitary\u2013adrenal axis and hypothalamic\u2013pituitary\u2013gonadal axis. Moreover, the potential role of epigenetic factors, such as DNA methylation and microRNAs as mediators of these effects is emphasized, suggesting avenues for future research and therapeutic interventions.<\/jats:p>","DOI":"10.3390\/ijms25105455","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:26:29Z","timestamp":1715919989000},"page":"5455","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0953-9544","authenticated-orcid":false,"given":"Asimenia","family":"Svigkou","sequence":"first","affiliation":[{"name":"Independent Researcher, 163 42 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Katsi","sequence":"additional","affiliation":[{"name":"Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios G.","family":"Kordalis","sequence":"additional","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tsioufis","sequence":"additional","affiliation":[{"name":"Cardiology Department, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101982","DOI":"10.1016\/j.cpcardiol.2023.101982","article-title":"Hypertensive Disorders in Pregnancy: Global Burden from 1990 to 2019, Current Research Hotspots and Emerging Trends","volume":"48","author":"Fu","year":"2023","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_2","unstructured":"Karrar, S.A., and Hong, P.L. (2024). StatPearls [Internet], StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the management of arterial hypertension the Task Force for the management of arterial hypertension of the European Society of Hypertension","volume":"41","author":"Mancia","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_4","unstructured":"Lim, K.H., Steinberg, G., and Ramus, R.M. (2022). Preeclampsia, Medscape."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/HYPERTENSIONAHA.123.21061","article-title":"Long-Term Impacts of Preeclampsia on the Cardiovascular System of Mother and Offspring","volume":"80","author":"Yang","year":"2023","journal-title":"Hypertension"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4314\/ejhs.v26i2.12","article-title":"No Hypertensive Disorder of Pregnancy; No Preeclampsia-eclampsia; No Gestational Hypertension; No Hellp Syndrome. Vascular Disorder of Pregnancy Speaks for All","volume":"26","author":"Berhan","year":"2016","journal-title":"Ethiop. J. Health Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e007809","DOI":"10.1161\/JAHA.117.007809","article-title":"Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis","volume":"7","author":"Wu","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.14744\/AnatolJCardiol.2023.2865","article-title":"Literature Overview of Association Between Preeclampsia and Cardiovascular Risk","volume":"27","author":"Yang","year":"2023","journal-title":"Anatol. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"R521","DOI":"10.1152\/ajpregu.00218.2017","article-title":"Risk of cardiovascular disease, end-stage renal disease, and stroke in postpartum women and their fetuses after a hypertensive pregnancy","volume":"315","author":"Cunningham","year":"2018","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e2242064","DOI":"10.1001\/jamanetworkopen.2022.42064","article-title":"Association of Maternal Preeclampsia with Offspring Risks of Ischemic Heart Disease and Stroke in Nordic Countries","volume":"5","author":"Yang","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Calcaterra, V., and Zuccotti, G. (2022). Prevention and Treatment of Cardiometabolic Diseases in Children with Overweight and Obesity: The Future of Healthcare. Children, 9.","DOI":"10.3390\/children9020176"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13052-022-01250-5","article-title":"Cardiovascular risk in children: A burden for future generations","volume":"48","author":"Candelino","year":"2022","journal-title":"Ital. J. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Flynn, J., Ingelfinger, J., and Redwine, K. (2018). Pediatric Hypertension, Springer.","DOI":"10.1007\/978-3-319-31107-4"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gootjes, D.V., Posthumus, A.G., Jaddoe, V.W.V., van Rijn, B.B., and Steegers, E.A.P. (2021). Maternal hypertensive disorders in pregnancy and early childhood cardiometabolic risk factors: The Generation R Study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0261351"},{"key":"ref_16","unstructured":"(2023, November 07). High Blood Pressure in Kids and Teens, Available online: https:\/\/www.cdc.gov\/bloodpressure\/youth.htm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e13411","DOI":"10.1111\/obr.13411","article-title":"Long-term effects of preeclampsia on metabolic and biochemical outcomes in offspring: What can be expected from a meta-analysis?","volume":"23","author":"Bi","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ijgo.13195","article-title":"Global burden of preterm birth","volume":"150","author":"Walani","year":"2020","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wojczakowski, W., Kimber-Trojnar, \u017b., Dziwisz, F., S\u0142odzi\u0144ska, M., S\u0142odzi\u0144ski, H., and Leszczy\u0144ska-Gorzelak, B. (2021). Preeclampsia and Cardiovascular Risk for Offspring. J. Clin. Med., 10.","DOI":"10.3390\/jcm10143154"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.preghy.2018.02.003","article-title":"Maternal pre-eclampsia and long-term offspring health: Is there a shadow cast?","volume":"12","author":"Goffin","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_21","unstructured":"Suman, V., and Luther, E.E. (2021). StatPearls [Internet], StatPearls Publishing."},{"key":"ref_22","first-page":"950","article-title":"Preeclampsia and fetal growth","volume":"96","author":"Vatten","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, W., Lin, R., Yang, L., Wang, Y., Mao, B., Xu, X., and Yu, J. (2023). Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia Pregnancies. Diagnostics, 13.","DOI":"10.3390\/diagnostics13040812"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jpeds.2018.12.008","article-title":"Cardiovascular Risk Factors in Offspring of Preeclamptic Pregnancies\u2014Systematic Review and Meta-Analysis","volume":"208","author":"Andraweera","year":"2019","journal-title":"J. Pediatr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.preghy.2019.09.010","article-title":"Preeclampsia exposed offspring have greater body mass index than non-exposed offspring during peripubertal life: A meta-analysis","volume":"19","author":"Wang","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Benagiano, M., Mancuso, S., Brosens, J.J., and Benagiano, G. (2021). Long-Term Consequences of Placental Vascular Pathology on the Maternal and Offspring Cardiovascular Systems. Biomolecules, 11.","DOI":"10.3390\/biom11111625"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41574-019-0310-7","article-title":"Waist circumference as a vital sign in clinical practice: A Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity","volume":"16","author":"Ross","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e3502","DOI":"10.1002\/dmrr.3502","article-title":"Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors","volume":"38","author":"Rossi","year":"2022","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Stadler, J.T., Scharnagl, H., Wadsack, C., and Marsche, G. (2023). Preeclampsia Affects Lipid Metabolism and HDL Function in Mothers and Their Offspring. Antioxidants, 12.","DOI":"10.3390\/antiox12040795"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/HYPERTENSIONAHA.116.07586","article-title":"Association of Maternal Antiangiogenic Profile at Birth with Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies","volume":"68","author":"Yu","year":"2016","journal-title":"Hypertension"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S2040174420000896","article-title":"Hypertensive disorders of pregnancy and later cardiovascular disease risk in mothers and children","volume":"12","author":"Plummer","year":"2020","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Stojanovska, V., Scherjon, S.A., and Pl\u00f6sch, T. (2016). Preeclampsia as Modulator of Offspring Health. Biol. Reprod., 94.","DOI":"10.1095\/biolreprod.115.135780"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.celrep.2014.02.033","article-title":"The Number of Fetal Nephron Progenitor Cells Limits Ureteric Branching and Adult Nephron Endowment","volume":"7","author":"Cebrian","year":"2014","journal-title":"Cell Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-15-0309","article-title":"Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment","volume":"228","author":"Jonker","year":"2015","journal-title":"J. Endocrinol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11906-017-0781-7","article-title":"Vascular Dysfunction in Mother and Offspring during Preeclampsia: Contributions from Latin-American Countries","volume":"19","author":"Giachini","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_36","first-page":"89","article-title":"Early left ventricular diastolic dysfunction in premature infants born to preeclamptic mothers","volume":"39","author":"Bostan","year":"2011","journal-title":"J. Perinat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"F1315","DOI":"10.1152\/ajprenal.00071.2020","article-title":"Preeclampsia beyond pregnancy: Long-term consequences for mother and child","volume":"318","author":"Turbeville","year":"2020","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"E275","DOI":"10.1055\/s-0039-1695004","article-title":"Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism","volume":"9","author":"Lu","year":"2019","journal-title":"Am. J. Perinatol. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1017\/S2040174420000094","article-title":"Mechanisms linking exposure to preeclampsia in utero and the risk for cardiovascular disease","volume":"11","author":"Andraweera","year":"2020","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1177\/1099800417754140","article-title":"Associating Symptom Phenotype and Genotype in Preeclampsia","volume":"20","author":"Founds","year":"2018","journal-title":"Biol. Res. Nurs."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1042\/CS20180436","article-title":"Recent developments in genetic\/genomic medicine","volume":"133","author":"Horton","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_42","first-page":"178","article-title":"Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22","volume":"4","author":"Johnson","year":"2024","journal-title":"Pregnancy Hypertens."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.placenta.2014.11.017","article-title":"Gene expression profile in cardiovascular disease and preeclampsia: A meta-analysis of the transcriptome based on raw data from human studies deposited in Gene Expression Omnibus","volume":"36","author":"Sitras","year":"2015","journal-title":"Placenta"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tjog.2017.01.001","article-title":"Fetal programming of the metabolic syndrome","volume":"56","author":"Marciniak","year":"2017","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0022-3476(96)70333-5","article-title":"Increased blood pressure in neonates and infants whose mothers smoked during pregnancy","volume":"128","author":"Beratis","year":"1996","journal-title":"J. Pediatr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1113\/JP271745","article-title":"Programming of maternal and offspring disease: Impact of growth restriction, fetal sex and transmission across generations","volume":"594","author":"Cheong","year":"2016","journal-title":"J. Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.reprotox.2019.04.004","article-title":"Heightened susceptibility: A review of how pregnancy and chemical exposures influence maternal health","volume":"92","author":"Varshavsky","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2020.02.004","article-title":"Review of the environmental prenatal exposome and its relationship to maternal and fetal health","volume":"98","author":"Rager","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"101054","DOI":"10.1016\/j.mam.2021.101054","article-title":"Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption","volume":"87","author":"Lorigo","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.fertnstert.2019.06.014","article-title":"Phytoestrogen exposure alters endometrial stromal cells and interferes with decidualization signaling","volume":"112","author":"Salsano","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1002\/bdr2.1752","article-title":"Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes","volume":"112","author":"Ramadan","year":"2020","journal-title":"Birth Defects Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tem.2020.03.003","article-title":"Placenta Disrupted: Endocrine Disrupting Chemicals and Pregnancy","volume":"31","author":"Gingrich","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1471-0528.1992.tb13719.x","article-title":"Fetal growth and adult disease","volume":"99","author":"Barker","year":"1992","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1651-2227.2004.tb00236.x","article-title":"The developmental origins of chronic adult disease","volume":"93","author":"Barker","year":"2004","journal-title":"Acta Paediatr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"R27","DOI":"10.1530\/JOE-16-0340","article-title":"Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia","volume":"232","author":"Boeldt","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/CIRCULATIONAHA.110.941203","article-title":"Pulmonary and Systemic Vascular Dysfunction in Young Offspring of Mothers with Preeclampsia","volume":"122","author":"Jayet","year":"2010","journal-title":"Circulation"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/HYPERTENSIONAHA.116.08414","article-title":"Hypertension in Pregnancy and Offspring Cardiovascular Risk in Young Adulthood: Prospective and Sibling Studies in the HUNT Study (Nord-Tr\u00f8ndelag Health Study) in Norway","volume":"69","author":"Alsnes","year":"2017","journal-title":"Hypertension"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41576-018-0074-2","article-title":"Clinical epigenetics: Seizing opportunities for translation","volume":"20","author":"Berdasco","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s10815-020-02047-3","article-title":"Deregulation of imprinted genes expression and epigenetic regulators in placental tissue from intrauterine growth restriction","volume":"38","author":"Vasconcelos","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_60","first-page":"5294","article-title":"Promoter Methylation Status of WNT2 in Placenta from Patients with Preeclampsia","volume":"23","author":"Liu","year":"2017","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11906-017-0745-y","article-title":"The Epigenetic Machinery in Vascular Dysfunction and Hypertension","volume":"19","author":"Levy","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"T105","DOI":"10.1530\/JOE-19-0009","article-title":"Epigenetic responses and the developmental origins of health and disease","volume":"242","author":"Goyal","year":"2019","journal-title":"J. Endocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/apha.12702","article-title":"Pregnancy as a critical window for blood pressure regulation in mother and child: Programming and reprogramming","volume":"219","author":"Paauw","year":"2016","journal-title":"Acta Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bcp.2015.04.012","article-title":"Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia","volume":"95","author":"Shah","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/cphy.c140036","article-title":"Fetal programming and cardiovascular pathology","volume":"5","author":"Alexander","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The two-stage placental model of preeclampsia: An update","volume":"134\u2013135","author":"Staff","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/HJH.0000000000001901","article-title":"Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia","volume":"37","author":"Spradley","year":"2019","journal-title":"J. Hypertens."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"432.e1","DOI":"10.1016\/j.ajog.2009.01.044","article-title":"The effect of prepregnancy obesity and sFlt-1\u2013induced preeclampsia-like syndrome on fetal programming of adult vascular function in a mouse model","volume":"200","author":"Byers","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"418.e1","DOI":"10.1016\/j.ajog.2007.06.064","article-title":"Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life","volume":"197","author":"Lu","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/HYPERTENSIONAHA.114.04662","article-title":"Elevated Blood Pressure in Preterm-Born Offspring Associates with a Distinct Antiangiogenic State and Microvascular Abnormalities in Adult Life","volume":"65","author":"Lewandowski","year":"2015","journal-title":"Hypertension"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/eurheartj\/eht389","article-title":"Maternal and foetal angiogenic imbalance in congenital heart defects","volume":"35","author":"Llurba","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11040","article-title":"Cardiac angiogenic imbalance leads to peripartum cardiomyopathy","volume":"485","author":"Patten","year":"2012","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/apha.12562","article-title":"Sex-specific placental differences as a contributor to sex-specific metabolic programming?","volume":"215","author":"Pruis","year":"2015","journal-title":"Acta Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"542.e1","DOI":"10.1016\/j.ajog.2014.01.010","article-title":"The effect of prenatal pravastatin treatment on altered fetal programming of postnatal growth and metabolic function in a preeclampsia-like murine model","volume":"210","author":"McDonnold","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Bl\u00e1zquez-Medela, A.M., Garc\u00eda-Ortiz, L., A G\u00f3mez-Marcos, M., I Recio-Rodr\u00edguez, J., S\u00e1nchez-Rodr\u00edguez, A., L\u00f3pez-Novoa, J.M., and Mart\u00ednez-Salgado, C. (2010). Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients. BMC Med., 8.","DOI":"10.1186\/1741-7015-8-86"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1152\/ajpregu.00052.2016","article-title":"Identifying immune mechanisms mediating the hypertension during preeclampsia","volume":"311","author":"LaMarca","year":"2016","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.preghy.2018.10.011","article-title":"Preeclampsia: Disease biology and burden, its management strategies with reference to India","volume":"15","author":"Malik","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jri.2015.09.003","article-title":"Preeclampsia is associated with an increased pro-inflammatory profile in newborns","volume":"112","author":"Guillemette","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1038\/s41467-019-10703-1","article-title":"Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia","volume":"10","author":"Hu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.atherosclerosis.2015.11.028","article-title":"Prenatal hypoxia promotes atherosclerosis via vascular inflammation in the offspring rats","volume":"245","author":"Zhang","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"18154","DOI":"10.1073\/pnas.0602235103","article-title":"Prolyl hydroxylase-1 negatively regulates I\u03baB kinase-\u03b2, giving insight into hypoxia-induced NF\u03baB activity","volume":"103","author":"Cummins","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40256-014-0094-z","article-title":"Role of Vascular Inflammation in Coronary Artery Disease: Potential of Anti-inflammatory Drugs in the Prevention of Atherothrombosis. Inflammation and anti-inflammatory drugs in coronary artery disease","volume":"15","author":"Moreira","year":"2014","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/CS20171550","article-title":"Fetal programming and the angiotensin-(1-7) axis: A review of the experimental and clinical data","volume":"133","author":"South","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3389\/fendo.2019.00563","article-title":"Causes and Consequences of the Dysregulated Maternal Renin-Angiotensin System in Preeclampsia","volume":"10","author":"Lumbers","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1152\/ajpregu.00034.2013","article-title":"Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy","volume":"306","author":"Lumbers","year":"2014","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/HYPERTENSIONAHA.110.150961","article-title":"Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy","volume":"56","author":"Hering","year":"2010","journal-title":"Hypertension"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Yart, L., Bahmanyar, E.R., Cohen, M., and de Tejada, B.M. (2021). Role of the Uteroplacental Renin\u2013Angiotensin System in Placental Development and Function, and Its Implication in the Preeclampsia Pathogenesis. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101332"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-020-01098-2","article-title":"The Role of the Renin-Angiotensin-Aldosterone System in Preeclampsia: A Review","volume":"22","author":"Gathiram","year":"2020","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.placenta.2011.09.020","article-title":"The expression and localization of the human placental prorenin\/renin-angiotensin system throughout pregnancy: Roles in trophoblast invasion and angiogenesis?","volume":"32","author":"Pringle","year":"2011","journal-title":"Placenta"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/aji.12072","article-title":"Angiotensin II Type 1 Receptor Autoantibody (AT1-AA)-Mediated Pregnancy Hypertension","volume":"69","author":"Herse","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10641955.2015.1051227","article-title":"Linking the old and new\u2014Do angiotensin II type 1 receptor antibodies provide the missing link in the pathophysiology of preeclampsia?","volume":"34","author":"Aggarwal","year":"2015","journal-title":"Hypertens. Pregnancy"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e025167","DOI":"10.1161\/JAHA.121.025167","article-title":"JAHA Spotlight on Pregnancy and Its Impact on Maternal and Offspring Cardiovascular Health","volume":"11","author":"Russell","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/HYPERTENSIONAHA.107.091785","article-title":"Estrogen Protects Against Increased Blood Pressure in Postpubertal Female Growth Restricted Offspring","volume":"50","author":"Ojeda","year":"2007","journal-title":"Hypertension"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"R1199","DOI":"10.1152\/ajpregu.00219.2011","article-title":"Hypersensitivity to acute ANG II in female growth-restricted offspring is exacerbated by ovariectomy","volume":"301","author":"Ojeda","year":"2011","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1113\/expphysiol.2007.041806","article-title":"Tissue-specific regulation of ACE\/ACE2 and AT1\/AT2 receptor gene expression by oestrogen in apolipoprotein E\/oestrogen receptor-\u03b1 knock-out mice","volume":"93","author":"Brosnihan","year":"2008","journal-title":"Exp. Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1097\/HJH.0000000000001801","article-title":"Association between preterm birth and the renin\u2212angiotensin system in adolescence: Influence of sex and obesity","volume":"36","author":"South","year":"2018","journal-title":"J. Hypertens."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/1470320314526940","article-title":"The renin\u2013angiotensin\u2013aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia","volume":"16","author":"Washburn","year":"2014","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1084\/jem.20090872","article-title":"The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia","volume":"206","author":"Irani","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1089\/ars.2011.4365","article-title":"Increased Susceptibility to Metabolic Syndrome in Adult Offspring of Angiotensin Type 1 Receptor Autoantibody-Positive Rats","volume":"17","author":"Zhang","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2337\/diabetes.55.02.06.db05-1022","article-title":"Angiotensin II Type 1 Receptor Blockade Improves \u03b2-Cell Function and Glucose Tolerance in a Mouse Model of Type 2 Diabetes","volume":"55","author":"Chu","year":"2006","journal-title":"Diabetes"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"E75","DOI":"10.1161\/HYP.0000000000000227","article-title":"Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health across the Life Course: Moving the Field Forward: A Scientific Statement from the American Heart Association","volume":"80","author":"Alexander","year":"2023","journal-title":"Hypertension"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1053\/j.sempedsurg.2013.10.008","article-title":"Neonatal renal physiology","volume":"22","author":"Sulemanji","year":"2013","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1515\/jpm-2020-0024","article-title":"Fetal renal artery impedance in pregnancies affected by preeclampsia","volume":"48","author":"Krishnan","year":"2020","journal-title":"JPME"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"H1638","DOI":"10.1152\/ajpheart.01120.2007","article-title":"Chronic hypoxia increases fetoplacental vascular resistance and vasoconstrictor reactivity in the rat","volume":"294","author":"Jakoubek","year":"2008","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1042\/CS20090479","article-title":"Reduced nephron endowment due to fetal uninephrectomy impairs renal sodium handling in male sheep","volume":"118","author":"Singh","year":"2010","journal-title":"Clin. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/HJH.0000000000001942","article-title":"Hypermethylation of delta-like homolog 1\/maternally expressed gene 3 loci in human umbilical veins: Insights into offspring vascular dysfunction born after preeclampsia","volume":"37","author":"Yu","year":"2019","journal-title":"J. Hypertens."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Mannaerts, D., Faes, E., Gielis, J., Van Craenenbroeck, E., Cos, P., Spaanderman, M., Gyselaers, W., Cornette, J., and Jacquemyn, Y. (2018). Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study. BMC Pregnancy Childbirth, 18.","DOI":"10.1186\/s12884-018-1685-5"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000317739","article-title":"Maternal Protein Restriction Reduces Angiotensin II AT1 and AT2 Receptor Expression in the Fetal Rat Kidney","volume":"33","author":"Alwasel","year":"2010","journal-title":"Kidney Blood Press. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/STROKEAHA.108.538025","article-title":"Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring","volume":"40","author":"Kajantie","year":"2009","journal-title":"Stroke"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.placenta.2009.12.020","article-title":"Review: Adaptation in placental nutrient supply to meet fetal growth demand: Implications for programming","volume":"31","author":"Sibley","year":"2010","journal-title":"Placenta"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1111\/bph.12870","article-title":"Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: Role of ETA and ETB receptors","volume":"171","author":"Benedito","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/biolre\/ioz204","article-title":"Placental serotonin signaling, pregnancy outcomes, and regulation of fetal brain development","volume":"102","author":"Rosenfeld","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1178646919840321","DOI":"10.1177\/1178646919840321","article-title":"Altered Tryptophan Catabolism in Placentas from Women with Pre-eclampsia","volume":"12","author":"Keaton","year":"2019","journal-title":"Int. J. Tryptophan Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-021-01155-4","article-title":"The Serotonin-Immune Axis in Preeclampsia","volume":"23","author":"Gumusoglu","year":"2021","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1517\/13543784.12.5.805","article-title":"The role of 5-HT on the cardiovascular and renal systems and the clinical potential of 5-HT modulation","volume":"12","year":"2003","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fcvm.2017.00048","article-title":"The Effects of Serotonin in Immune Cells","volume":"4","author":"Herr","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fphys.2018.00602","article-title":"Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease","volume":"9","author":"Gonzalez","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.freeradbiomed.2010.07.011","article-title":"Oxidative stress in development: Nature or nurture?","volume":"49","author":"Dennery","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ejogrb.2013.07.031","article-title":"DNA damage and oxidative stress in patients with mild preeclampsia and offspring","volume":"170","author":"Hilali","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1447-0756.2009.01128.x","article-title":"Role of nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia","volume":"36","author":"Matsubara","year":"2010","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11906-016-0633-x","article-title":"Placental Ischemia and Resultant Phenotype in Animal Models of Preeclampsia","volume":"18","author":"Lamarca","year":"2016","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Aouache, R., Biquard, L., Vaiman, D., and Miralles, F. (2018). Oxidative Stress in Preeclampsia and Placental Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051496"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12944-022-01663-5","article-title":"Foetal lipoprotein oxidation and preeclampsia","volume":"21","author":"Ceballos","year":"2022","journal-title":"Lipids Health Dis."},{"key":"ref_124","first-page":"134","article-title":"Anti-oxidant profiles and markers of oxidative stress in preterm neonates","volume":"36","author":"Ghany","year":"2016","journal-title":"Ann. Trop. Paediatr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"F1013","DOI":"10.1152\/ajprenal.00354.2014","article-title":"Sex-specific effect of antenatal betamethasone exposure on renal oxidative stress induced by angiotensins in adult sheep","volume":"307","author":"Bi","year":"2014","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1152\/physrev.00015.2015","article-title":"In Utero Origins of Hypertension: Mechanisms and Targets for Therapy","volume":"96","author":"Morton","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.reprotox.2016.01.001","article-title":"Prenatal hypoxia enhanced angiotensin II-mediated vasoconstriction via increased oxidative signaling in fetal rats","volume":"60","author":"Zhu","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"582748","DOI":"10.1155\/2012\/582748","article-title":"Impact of Oxidative Stress in Fetal Programming","volume":"2012","author":"Thompson","year":"2012","journal-title":"J. Pregnancy"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Rodr\u00edguez, P., de Pablo, A.L.L., Garc\u00eda-Prieto, C.F., Somoza, B., Quintana-Villamandos, B., de Diego, J.J.G., Gutierrez-Arzapalo, P.Y., Ramiro-Cortijo, D., Gonz\u00e1lez, M.C., and Arribas, S.M. (2017). Long term effects of fetal undernutrition on rat heart. Role of hypertension and oxidative stress. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0171544"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/cen.13092","article-title":"Evidence for central hypercortisolism and elevated blood pressure in adolescent offspring of mothers with pre-eclampsia","volume":"85","author":"Henley","year":"2016","journal-title":"Clin. Endocrinol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1365-2265.2011.04308.x","article-title":"Birth weight is inversely associated with blood pressure and serum aldosterone and cortisol levels in children","volume":"76","author":"Aglony","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1017\/S2040174416000209","article-title":"Hypertensive disorders during pregnancy and health outcomes in the offspring: A systematic review","volume":"7","author":"Pinheiro","year":"2016","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.111.097550","article-title":"Prenatal Testosterone Exposure Leads to Hypertension That Is Gonadal Hormone-Dependent in Adult Rat Male and Female Offspring1","volume":"86","author":"Chinnathambi","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/01.HYP.36.3.411","article-title":"Angiotensin II Sensitivity Is Associated with the Angiotensin II Type 1 Receptor A1166C Polymorphism in Essential Hypertensives on a High Sodium Diet","volume":"36","author":"Spiering","year":"2000","journal-title":"Hypertension"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1179\/2046905514Y.0000000136","article-title":"Low birthweight or rapid catch-up growth: Which is more associated with cardiovascular disease and its risk factors in later life? A systematic review and cryptanalysis","volume":"35","author":"Kelishadi","year":"2015","journal-title":"Paediatr. Int. Child Health"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"More, A.S., Mishra, J.S., Hankins, G.D., and Kumar, S. (2016). Prenatal Testosterone Exposure Decreases Aldosterone Production but Maintains Normal Plasma Volume and Increases Blood Pressure in Adult Female Rats. Biol. Reprod., 95.","DOI":"10.1095\/biolreprod.116.141705"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Alsnes, I.V., Janszky, I., \u00c5svold, B.O., \u00d8kland, I., Forman, M.R., and Vatten, L.J. (2016). Maternal Preeclampsia and Androgens in the Offspring around Puberty: A Follow-Up Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167714"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1530\/REP-10-0210","article-title":"Prenatal testosterone and dihydrotestosterone exposure disrupts ovine testicular development","volume":"142","author":"Bormann","year":"2011","journal-title":"Reproduction"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA Methylation and Its Basic Function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature14192","article-title":"Function and information content of DNA methylation","volume":"517","year":"2015","journal-title":"Nature"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Apicella, C., Ruano, C.S.M., M\u00e9hats, C., Miralles, F., and Vaiman, D. (2019). The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112837"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1042\/CS20190070","article-title":"Epigenetic processes during preeclampsia and effects on fetal development and chronic health","volume":"135","author":"Ashraf","year":"2021","journal-title":"Clin. Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2217\/epi-2019-0065","article-title":"Epigenome-wide association data implicate fetal\/maternal adaptations contributing to clinical outcomes in preeclampsia","volume":"11","author":"Wang","year":"2019","journal-title":"Epigenomics"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Hogg, K., Blair, J.D., McFadden, D.E., von Dadelszen, P., and Robinson, W.P. (2013). Early Onset Pre-Eclampsia Is Associated with Altered DNA Methylation of Cortisol-Signalling and Steroidogenic Genes in the Placenta. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062969"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/molehr\/gat044","article-title":"Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia","volume":"19","author":"Blair","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Brodowski, L., Zindler, T., von Hardenberg, S., Schr\u00f6der-Heurich, B., von Kaisenberg, C.S., Frieling, H., Hubel, C.A., D\u00f6rk, T., and von Versen-H\u00f6ynck, F. (2019). Preeclampsia-Associated Alteration of DNA Methylation in Fetal Endothelial Progenitor Cells. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00032"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/HYPERTENSIONAHA.119.12634","article-title":"Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns","volume":"74","author":"Kazmi","year":"2019","journal-title":"Hypertension"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/bcpt.13118","article-title":"The developmental basis of disease: Update on environmental exposures and animal models","volume":"125","author":"Heindel","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"dvw002","DOI":"10.1093\/eep\/dvw002","article-title":"Developmental origins of epigenetic transgenerational inheritance","volume":"2","author":"Hanson","year":"2016","journal-title":"Environ. Epigenet."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-015-0052-x","article-title":"Genome-scale hypomethylation in the cord blood DNAs associated with early onset preeclampsia","volume":"7","author":"Ching","year":"2015","journal-title":"Clin. Epigenet."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.peptides.2016.11.002","article-title":"High sucrose intake during gestation increases angiotensin II type 1 receptor-mediated vascular contractility associated with epigenetic alterations in aged offspring rats","volume":"86","author":"Wu","year":"2016","journal-title":"Peptides"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s40572-016-0092-1","article-title":"Environmental Health and Long Non-coding RNAs","volume":"3","author":"Karlsson","year":"2016","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/jcp.27291","article-title":"Roles of microRNAs in preeclampsia","volume":"234","author":"Lv","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-42059-2_1","article-title":"Non-coding RNAs: Classification, biology and functioning","volume":"937","author":"Hombach","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Brodowski, L., Schr\u00f6der-Heurich, B., von Hardenberg, S., Richter, K., von Kaisenberg, C.S., Dittrich-Breiholz, O., Meyer, N., D\u00f6rk, T., and von Versen-H\u00f6ynck, F. (2021). MicroRNA Profiles of Maternal and Neonatal Endothelial Progenitor Cells in Preeclampsia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105320"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","article-title":"Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches","volume":"96","author":"Beermann","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Pan, H.-T., Shi, X.-L., Fang, M., Sun, X.-M., Chen, P.-P., Ding, J.-L., Xia, G.-Y., Yu, B., Zhang, T., and Zhu, H.-D. (2022). Profiling of exosomal microRNAs expression in umbilical cord blood from normal and preeclampsia patients. BMC Pregnancy Childbirth, 22.","DOI":"10.1186\/s12884-022-04449-w"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Colpaert, R.M., and Calore, M. (2019). MicroRNAs in Cardiac Diseases. Cells, 8.","DOI":"10.3390\/cells8070737"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/molehr\/gaz004","article-title":"The role of oxygen in regulating microRNAs in control of the placental renin\u2013angiotensin system","volume":"25","author":"Arthurs","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/10641955.2015.1122034","article-title":"Plasma levels of increased miR-195-5p correlates with the sFLT-1 levels in preeclampsia","volume":"35","author":"Sandrim","year":"2016","journal-title":"Hypertens. Pregnancy"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Ali, A., Hadlich, F., Abbas, M.W., Iqbal, M.A., Tesfaye, D., Bouma, G.J., Winger, Q.A., and Ponsuksili, S. (2021). MicroRNA\u2013mRNA Networks in Pregnancy Complications: A Comprehensive Downstream Analysis of Potential Biomarkers. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052313"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41526-020-00108-6","article-title":"Interactome of miRNAs and transcriptome of human umbilical cord endothelial cells exposed to short-term simulated microgravity","volume":"6","author":"Kasiviswanathan","year":"2020","journal-title":"NPJ Microgravity"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/HYPERTENSIONAHA.118.11343","article-title":"Neonatal MicroRNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies","volume":"72","author":"Yu","year":"2018","journal-title":"Hypertension"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1210\/jc.2017-00849","article-title":"Preeclampsia Downregulates MicroRNAs in Fetal Endothelial Cells: Roles of miR-29a\/c-3p in Endothelial Function","volume":"102","author":"Zhou","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1161\/HYPERTENSIONAHA.122.20682","article-title":"Fetal Exposure to Preeclampsia and Later Risk of Cardiometabolic Disorders: A Population-Based Cohort Study","volume":"80","author":"Paramsothy","year":"2023","journal-title":"Hypertension"},{"key":"ref_166","first-page":"e603","article-title":"Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement from the American Heart Association","volume":"139","author":"Steinberger","year":"2019","journal-title":"Circulation"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41569-021-00647-9","article-title":"Prevention of atherosclerosis from childhood","volume":"19","author":"Raitakari","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.preghy.2018.06.013","article-title":"Prenatal exposure to preeclampsia as an independent risk factor for long-term cardiovascular morbidity of the offspring","volume":"13","author":"Sacks","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-018-0869-8","article-title":"Preeclampsia and Related Cardiovascular Risk: Common Genetic Background","volume":"20","author":"Lisowska","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11906-020-01097-3","article-title":"Preventing Premature Atherosclerotic Disease","volume":"22","author":"Smith","year":"2020","journal-title":"Curr. Hypertens. 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