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FGF23 and inflammation are common characteristics in CKD, and both are associated with worse disease progression and the occurrence of complications. The existence of an interaction between FGF23 and inflammation has been suggested, each of which influences the expression and activity of the other, leading to a vicious feedback loop with adverse outcomes, including cardiovascular disease and mortality. In this work, we determined circulating FGF23 levels in a group of patients with CKD stages 3 and 4 subjected to elective femoral endarterectomy due to established peripheral artery disease (PAD), a condition resulting from an athero-inflammatory process, and we studied its associations with different inflammatory markers and mediators. We evaluated its association with serum tumor necrosis factor (TNF)\u03b1, interleukin (IL) 6, and IL10, as well as with the gene expression levels of these parameters and A disintegrin and metalloproteinase domain-containing protein (ADAM) 17 in femoral vascular tissue and peripheral blood circulating cells (PBCCs). We also analyzed its association with serum concentrations of C-reactive protein (CRP), the systemic immune inflammation index (SII), and the neutrophil-to-lymphocyte ratio (NLR). Finally, we determined the vascular immunoreactivity of protein TNF\u03b1 in a subgroup of patients. FGF23 concentrations were independently associated with circulating and PBCC mRNA levels of TNF\u03b1. Worst kidney function and diabetes were also found to be contributing to FGF23 levels. Patients with higher levels of FGF23 also had greater vascular immunoreactivity for TNF\u03b1.<\/jats:p>","DOI":"10.3390\/ijms25105457","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:26:29Z","timestamp":1715919989000},"page":"5457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["FGF23 as a Potential Pathophysiological Factor in Peripheral Arterial Disease Associated with Chronic Kidney Disease"],"prefix":"10.3390","volume":"25","author":[{"given":"Javier","family":"Donate-Correa","sequence":"first","affiliation":[{"name":"Research Unit, University Hospital Nuestra Se\u00f1ora de Candelaria (UHNSC), 38010 Santa Cruz de Tenerife, Spain"},{"name":"GEENDIAB (Grupo Espa\u00f1ol Para el Estudio de la Nefropat\u00eda Diab\u00e9tica), Sociedad Espa\u00f1ola de Nefrolog\u00eda, 39000 Santander, Spain"},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38000 Santa Cruz de Tenerife, Spain"},{"name":"RICORS2040 (RD21\/0005\/0013), Instituto de Salud Carlos III, 28000 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0341-0956","authenticated-orcid":false,"given":"Ernesto","family":"Mart\u00edn-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital Nuestra Se\u00f1ora de Candelaria (UHNSC), 38010 Santa Cruz de Tenerife, Spain"},{"name":"Navarrabiomed (Miguel Servet Foundation), Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Hern\u00e1ndez-Carballo","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital Nuestra Se\u00f1ora de Candelaria (UHNSC), 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Gonz\u00e1lez-Luis","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital Nuestra Se\u00f1ora de Candelaria (UHNSC), 38010 Santa Cruz de Tenerife, Spain"},{"name":"Doctoral and Graduate School, University of La Laguna, 38200 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mora-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital Nuestra Se\u00f1ora de Candelaria (UHNSC), 38010 Santa Cruz de Tenerife, Spain"},{"name":"GEENDIAB (Grupo Espa\u00f1ol Para el Estudio de la Nefropat\u00eda Diab\u00e9tica), Sociedad Espa\u00f1ola de Nefrolog\u00eda, 39000 Santander, Spain"},{"name":"RICORS2040 (RD21\/0005\/0013), Instituto de Salud Carlos III, 28000 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mart\u00edn-Olivera","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital Nuestra Se\u00f1ora de Candelaria (UHNSC), 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-3604","authenticated-orcid":false,"given":"Sergio","family":"Rodr\u00edguez-Ramos","sequence":"additional","affiliation":[{"name":"Transplant Coordination, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purificaci\u00f3n","family":"Cerro-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Transplant Coordination, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"L\u00f3pez-Castillo","sequence":"additional","affiliation":[{"name":"Vascular Surgery Service, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Delgado-Molinos","sequence":"additional","affiliation":[{"name":"Vascular Surgery Service, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria Castro","family":"L\u00f3pez-Tarruella","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Service, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-7474","authenticated-orcid":false,"given":"Juan 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N. 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Nephrol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5457\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:43:47Z","timestamp":1760107427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["ijms25105457"],"URL":"https:\/\/doi.org\/10.3390\/ijms25105457","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]}}}