{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:10:04Z","timestamp":1789690204229,"version":"4.0.1"},"reference-count":90,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Science and Innovation","award":["CEX2019-000968-M"],"award-info":[{"award-number":["CEX2019-000968-M"]}]},{"name":"C\u00e1tedra TimacAgro-UCO","award":["CEX2019-000968-M"],"award-info":[{"award-number":["CEX2019-000968-M"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The European \u201cGreen Deal\u201d policies are shifting toward more sustainable and environmentally conscious agricultural practices, reducing the use of chemical fertilizer and pesticides. This implies exploring alternative strategies. One promising alternative to improve plant nutrition and reinforce plant defenses is the use of beneficial microorganisms in the rhizosphere, such as \u201cPlant-growth-promoting rhizobacteria and fungi\u201d. Despite the great abundance of iron (Fe) in the Earth\u2019s crust, its poor solubility in calcareous soil makes Fe deficiency a major agricultural issue worldwide. Among plant promoting microorganisms, the yeast Debaryomyces hansenii has been very recently incorporated, for its ability to induce morphological and physiological key responses to Fe deficiency in plants, under hydroponic culture conditions. The present work takes it a step further and explores the potential of D. hansenii to improve plant nutrition and stimulate growth in cucumber plants grown in calcareous soil, where ferric chlorosis is common. Additionally, the study examines D. hansenii\u2019s ability to induce systemic resistance (ISR) through a comparative relative expression study by qRT-PCR of ethylene (ET) biosynthesis (ACO1), or ET signaling (EIN2 and EIN3), and salicylic acid (SA) biosynthesis (PAL)-related genes. The results mark a significant milestone since D. hansenii not only enhances nutrient uptake and stimulates plant growth and flower development but could also amplify induced systemic resistance (ISR). Although there is still much work ahead, these findings make D. hansenii a promising candidate to be used for sustainable and environmentally friendly integrated crop management.<\/jats:p>","DOI":"10.3390\/ijms25115729","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T11:17:52Z","timestamp":1716549472000},"page":"5729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploring the Role of Debaryomyces hansenii as Biofertilizer in Iron-Deficient Environments to Enhance Plant Nutrition and Crop Production Sustainability"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-9611","authenticated-orcid":false,"given":"Jes\u00fas","family":"Sevillano-Ca\u00f1o","sequence":"first","affiliation":[{"name":"Departamento de Agronom\u00eda (DAUCO) Mar\u00eda de Maeztu Unit of Excellence 2021\u20132024, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-7922","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Agronom\u00eda (DAUCO) Mar\u00eda de Maeztu Unit of Excellence 2021\u20132024, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"C\u00f3rdoba-Galv\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Agronom\u00eda (DAUCO) Mar\u00eda de Maeztu Unit of Excellence 2021\u20132024, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Luque-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Agronom\u00eda (DAUCO) Mar\u00eda de Maeztu Unit of Excellence 2021\u20132024, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-1140","authenticated-orcid":false,"given":"Carlos","family":"Agust\u00ed-Brisach","sequence":"additional","affiliation":[{"name":"Departamento de Agronom\u00eda (DAUCO) Mar\u00eda de Maeztu Unit of Excellence 2021\u20132024, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lucena","sequence":"additional","affiliation":[{"name":"Departamento de Agronom\u00eda (DAUCO) Mar\u00eda de Maeztu Unit of Excellence 2021\u20132024, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Ramos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Agr\u00edcola, Edafolog\u00eda y Microbiolog\u00eda, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-6173","authenticated-orcid":false,"given":"Rafael","family":"P\u00e9rez-Vicente","sequence":"additional","affiliation":[{"name":"Departamento de Bot\u00e1nica, Ecolog\u00eda y Fisiolog\u00eda Vegetal, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5086-5473","authenticated-orcid":false,"given":"Francisco Javier","family":"Romera","sequence":"additional","affiliation":[{"name":"Departamento de Agronom\u00eda (DAUCO) Mar\u00eda de Maeztu Unit of Excellence 2021\u20132024, Campus de Excelencia Internacional Agroalimentario de Rabanales (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fpls.2019.00287","article-title":"Induced Systemic Resistance (ISR) and Fe Deficiency Responses in Dicot Plants","volume":"10","author":"Romera","year":"2019","journal-title":"Front. 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