{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:01:30Z","timestamp":1787742090123,"version":"build-2784847793"},"reference-count":231,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>For the past 70 years, the dopamine hypothesis has been the key working model in schizophrenia. This has contributed to the development of numerous inhibitors of dopaminergic signaling and antipsychotic drugs, which led to rapid symptom resolution but only marginal outcome improvement. Over the past decades, there has been limited research on the quantifiable pathological changes in schizophrenia, including premature cellular\/neuronal senescence, brain volume loss, the attenuation of gamma oscillations in electroencephalograms, and the oxidation of lipids in the plasma and mitochondrial membranes. We surmise that the aberrant activation of the aryl hydrocarbon receptor by toxins derived from gut microbes or the environment drives premature cellular and neuronal senescence, a hallmark of schizophrenia. Early brain aging promotes secondary changes, including the impairment and loss of mitochondria, gray matter depletion, decreased gamma oscillations, and a compensatory metabolic shift to lactate and lactylation. The aim of this narrative review is twofold: (1) to summarize what is known about premature cellular\/neuronal senescence in schizophrenia or schizophrenia-like disorders, and (2) to discuss novel strategies for improving long-term outcomes in severe mental illness with natural senotherapeutics, membrane lipid replacement, mitochondrial transplantation, microbial phenazines, novel antioxidant phenothiazines, inhibitors of glycogen synthase kinase-3 beta, and aryl hydrocarbon receptor antagonists.<\/jats:p>","DOI":"10.3390\/ijms25115904","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T13:32:55Z","timestamp":1716903175000},"page":"5904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel Insights into Psychosis and Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-715X","authenticated-orcid":false,"given":"Adonis","family":"Sfera","sequence":"first","affiliation":[{"name":"Patton State Hospital, 3102 Highland Ave., Patton, CA 92369, USA"},{"name":"University of California Riverside, Riverside 900 University Ave., Riverside, CA 92521, USA"},{"name":"Loma Linda University, 11139 Anderson St., Loma Linda, CA 92350, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Imran","sequence":"additional","affiliation":[{"name":"Patton State Hospital, 3102 Highland Ave., Patton, CA 92369, USA"},{"name":"University of California Riverside, Riverside 900 University Ave., Riverside, CA 92521, USA"},{"name":"Loma Linda University, 11139 Anderson St., Loma Linda, CA 92350, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan O.","family":"Sfera","sequence":"additional","affiliation":[{"name":"Patton State Hospital, 3102 Highland Ave., Patton, CA 92369, USA"},{"name":"University of California Riverside, Riverside 900 University Ave., Riverside, CA 92521, USA"},{"name":"Loma Linda University, 11139 Anderson St., Loma Linda, CA 92350, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob J.","family":"Anton","sequence":"additional","affiliation":[{"name":"California Baptist University, Riverside, CA 92521, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3836-7209","authenticated-orcid":false,"given":"Zisis","family":"Kozlakidis","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer, 69372 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hazan","sequence":"additional","affiliation":[{"name":"ProgenaBiome, Ventura, CA 93003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref_1","first-page":"899","article-title":"Deinstitutionalization and the homeless mentally ill","volume":"35","author":"Lamb","year":"1984","journal-title":"Hosp. Community Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1192\/bjp.162.3.314","article-title":"Homelessness and mental illness","volume":"162","author":"Scott","year":"1993","journal-title":"Br. J. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature09552","article-title":"Rethinking schizophrenia","volume":"468","author":"Insel","year":"2010","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2017.03.026","article-title":"The monoamine oxidase inhibition properties of selected structural analogues of methylene blue","volume":"325","author":"Delport","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_5","first-page":"1296","article-title":"A Systematic Review and Meta-Analysis of Recovery in Schizophrenia","volume":"39","author":"Juola","year":"2012","journal-title":"Schizophr. Bull."},{"key":"ref_6","unstructured":"Warner, R. (1997). Recovery from Schizophrenia Psychiatry and Political Economy, Brunner-Routledge. [3rd ed.]."},{"key":"ref_7","first-page":"37","article-title":"One year outcome in first episode schizophrenia: Predictors of relapse","volume":"256","author":"Polat","year":"2005","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/acps.13254","article-title":"Employment among people with schizophrenia or bipolar disorder: A population-based study using nationwide registers","volume":"143","author":"Holm","year":"2020","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_9","first-page":"460","article-title":"Homeless youth with first-episode psychosis: A 2-year outcome study","volume":"216","year":"2019","journal-title":"Schizophr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e4654","DOI":"10.1097\/MD.0000000000004654","article-title":"Gray matter increases in fronto-parietal regions of depression patients with aripiprazole monotherapy: An exploratory study","volume":"95","author":"Lai","year":"2016","journal-title":"Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1016\/S0014-2999(97)81951-6","article-title":"Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation","volume":"338","author":"Rollema","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1258\/jrsm.2011.110051","article-title":"Schizophrenia as segmental progeria","volume":"104","author":"Papanastasiou","year":"2011","journal-title":"J. R. Soc. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.schres.2018.07.015","article-title":"Shorter telomere length in schizophrenia: Evidence from a real-world population and meta-analysis of Most recent literature","volume":"202","author":"Russo","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"113646","DOI":"10.1016\/j.psychres.2020.113646","article-title":"Biological aging in schizophrenia and psychosis severity: DNA methylation analysis","volume":"296","author":"Dada","year":"2021","journal-title":"Psychiatry Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1176\/appi.ajp.2015.15070922","article-title":"Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study","volume":"173","author":"Schnack","year":"2016","journal-title":"Am. J. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Langhi Prata, L.G.P., Tchkonia, T., and Kirkland, J.L. (2023). Cell senescence, the senescence-associated secretory phenotype, and cancers. PLoS Biol., 21.","DOI":"10.1371\/journal.pbio.3002326"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: The good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Stec, A., Maciejewska, M., Zaremba, M., Paralusz-Stec, K., Michalska, M., Rudnicka, L., and Sikora, M. (2023). The Clinical Significance of Serum Biomarkers of the Intestinal Barrier in Systemic Sclerosis: A Cross-Sectional Study. J. Pers. Med., 13.","DOI":"10.3390\/jpm13040678"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"eabc4552","DOI":"10.1126\/science.abc4552","article-title":"The microbiome and human cancer","volume":"371","author":"Zitvogel","year":"2021","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.molcel.2020.08.021","article-title":"Gut Microbes\u2019 Impact on Oncogenic Drivers: Location Matters","volume":"79","author":"White","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1130562","DOI":"10.3389\/fphar.2023.1130562","article-title":"Understanding the role of the gut microbiome in gastrointestinal cancer: A review","volume":"14","author":"Cocozza","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mijit, M., Caracciolo, V., Melillo, A., Amicarelli, F., and Giordano, A. (2020). Role of p53 in the Regulation of Cellular Senescence. Biomolecules, 10.","DOI":"10.3390\/biom10030420"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neulet.2005.06.050","article-title":"Human p53 tumor suppressor gene (TP53) and schizophrenia: Case-control and family studies","volume":"388","author":"Ni","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_24","first-page":"vdac054","article-title":"Glioma and the gut-brain axis: Opportunities and future perspectives","volume":"4","author":"Dono","year":"2022","journal-title":"Neurooncol. Adv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12974-023-02728-7","article-title":"Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-\u03baappa B activation and cause neuronal damage in vivo in a murine model","volume":"20","author":"Palacios","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41537-023-00370-z","article-title":"Microglia and cognitive impairment in schizophrenia: Translating scientific progress into novel therapeutic interventions","volume":"9","author":"Zhuo","year":"2023","journal-title":"Schizophrenia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/npp.2016.185","article-title":"Microglia Priming with Aging and Stress","volume":"42","author":"Niraula","year":"2017","journal-title":"Neuropsychopharmacol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12288-011-0109-8","article-title":"Hemolysis in E. coli O104, H4 Infection","volume":"28","author":"Wiwanitkit","year":"2012","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neurobiolaging.2017.05.006","article-title":"Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: A meta-analysis","volume":"57","author":"Karrer","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.stem.2023.12.012","article-title":"SARS-CoV-2 infection causes dopaminergic neuron senescence","volume":"31","author":"Yang","year":"2024","journal-title":"Cell Stem Cell"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Fettucciari, K., Fruganti, A., Stracci, F., Spaterna, A., Marconi, P., and Bassotti, G. (2023). Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098155"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Vinithakumari, A.A., Padhi, P., Hernandez, B., Lin, S.J., Dunkerson-Kurzhumov, A., Showman, L., Breitzman, M., Stokes, C., Sulaiman, Y., and Tangudu, C. (2022). Clostridioides difficile Infection Dysregulates Brain Dopamine Metabolism. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.00073-22"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1105987","DOI":"10.3389\/fpsyt.2023.1105987","article-title":"Schizophrenia and cell senescence candidate genes screening, machine learning, diagnostic models, and drug prediction","volume":"14","author":"Feng","year":"2023","journal-title":"Front. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41586-024-07109-5","article-title":"A concerted neuron\u2013astrocyte program declines in ageing and schizophrenia","volume":"627","author":"Ling","year":"2024","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/npr2.12227","article-title":"Gut permeability and its clinical relevance in schizophrenia","volume":"42","author":"Ishida","year":"2022","journal-title":"Neuropsychopharmacol. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e3011","DOI":"10.1002\/brb3.3011","article-title":"Association between gut permeability, brain volume, and cognition in healthy participants and patients with schizophrenia spectrum disorder","volume":"13","author":"Scheurink","year":"2023","journal-title":"Brain Behav."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"114459","DOI":"10.1016\/j.bbr.2023.114459","article-title":"Intestinal permeability and its significance in psychiatric disorders\u2014A narrative review and future perspectives","volume":"448","author":"Wasiak","year":"2023","journal-title":"Behav. Brain Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1038\/s41380-023-01979-3","article-title":"Perturbed iron biology in the prefrontal cortex of people with schizophrenia","volume":"28","author":"Lotan","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e02624-18","DOI":"10.1128\/mBio.02624-18","article-title":"Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice","volume":"10","author":"Dichtl","year":"2019","journal-title":"mBio"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"load033","DOI":"10.1093\/lifemeta\/load033","article-title":"Lactate as a regulator of iron homeostasis","volume":"2","author":"Anderson","year":"2023","journal-title":"Life Metab."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cai, Z., Deng, L., Fan, Y., Ren, Y., Ling, Y., Tu, J., Cai, Y., Xu, X., and Chen, M. (2024). Dysregulation of Ceramide Metabolism Is Linked to Iron Deposition and Activation of Related Pathways in the Aorta of Atherosclerotic Miniature Pigs. Antioxidants, 13.","DOI":"10.3390\/antiox13010004"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"S231","DOI":"10.3233\/JAD-2012-111727","article-title":"Triangulated mal-signaling in Alzheimer\u2019s disease: Roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed","volume":"30","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41537-022-00293-1","article-title":"In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia","volume":"8","author":"Ravanfar","year":"2022","journal-title":"Schizophrenia"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Feng, S., Chen, J., Qu, C., Yang, L., Wu, X., Wang, S., Yang, T., Liu, H., Fang, Y., and Sun, P. (2022). Identification of Ferroptosis-Related Genes in Schizophrenia Based on Bioinformatic Analysis. Genes, 13.","DOI":"10.3390\/genes13112168"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ibneur.2024.01.007","article-title":"Hub genes, a diagnostic model, and immune infiltration based on ferroptosis-linked genes in schizophrenia","volume":"16","author":"Lian","year":"2024","journal-title":"IBRO Neurosci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s13770-021-00346-z","article-title":"The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis","volume":"18","author":"Go","year":"2021","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.redox.2017.08.015","article-title":"Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis","volume":"14","author":"Masaldan","year":"2018","journal-title":"Redox Biol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sfera, A., Osorio, C., Maguire, G., Rahman, L., Afzaal, J., Cummings, M., and Maldonado, J.C. (2021). COVID-19, ferrosenescence and neurodegeneration, a mini-review. Prog. Neuropsychopharmacol. Biol. Psychiatry, 109.","DOI":"10.1016\/j.pnpbp.2020.110230"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mad.2017.11.012","article-title":"Ferrosenescence: The iron age of neurodegeneration?","volume":"174","author":"Sfera","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/mds.28891","article-title":"The Myelin-Weighted Connectome in Parkinson\u2019s Disease","volume":"37","author":"Boshkovski","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41380-022-01568-w","article-title":"Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy","volume":"29","author":"Belaidi","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1097\/00001756-199704140-00040","article-title":"Apolipoprotein E genotype in schizophrenia: Frequency, age of onset, and neuropathologic features","volume":"8","author":"Arnold","year":"1997","journal-title":"Neuroreport."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10038-004-0157-0","article-title":"Apolipoprotein E polymorphism is associated with age of onset in schizophrenia","volume":"49","author":"Kampman","year":"2004","journal-title":"J. Hum. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"102736","DOI":"10.1016\/j.nicl.2021.102736","article-title":"Brain iron assessment in patients with First-episode schizophrenia using quantitative susceptibility mapping","volume":"31","author":"Xu","year":"2021","journal-title":"Neuroimage Clin."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3389\/fphys.2019.01523","article-title":"Where Metabolism Meets Senescence: Focus on Endothelial Cells","volume":"10","author":"Sabbatinelli","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.schres.2020.09.003","article-title":"Evidence for altered energy metabolism, increased lactate, and decreased pH in schizophrenia brain: A focused review and meta-analysis of human postmortem and magnetic resonance spectroscopy studies","volume":"223","author":"Pruett","year":"2020","journal-title":"Schizophr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.14336\/AD.2023.0214","article-title":"Neuronal Senescence in the Aged Brain","volume":"14","author":"Chou","year":"2023","journal-title":"Aging Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"116826","DOI":"10.1016\/j.neuroimage.2020.116826","article-title":"Gamma oscillations weaken with age in healthy elderly in human EEG","volume":"215","author":"Murty","year":"2020","journal-title":"Neuroimage"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s12602-021-09903-3","article-title":"Emerging Interrelationship between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities","volume":"14","author":"Sharma","year":"2022","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrgastro.2017.146","article-title":"Cellular senescence in gastrointestinal diseases: From pathogenesis to therapeutics","volume":"15","author":"Frey","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s12640-018-9987-y","article-title":"In Schizophrenia, Increased Plasma IgM\/IgA Responses to Gut Commensal Bacteria Are Associated with Negative Symptoms, Neurocognitive Impairments, and the Deficit Phenotype","volume":"35","author":"Maes","year":"2019","journal-title":"Neurotox. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/1559827616629117","article-title":"Nutritional Immunity: Starving Pathogens of Trace Minerals","volume":"10","author":"Hennigar","year":"2016","journal-title":"Am. J. Lifestyle Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3389\/fnins.2018.00851","article-title":"Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer\u2019s Type Dementia","volume":"12","author":"Pretorius","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"26331055211018709","DOI":"10.1177\/26331055211018709","article-title":"Is There a Brain Microbiome?","volume":"16","author":"Link","year":"2021","journal-title":"Neurosci. Insights"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nrmicro2453","article-title":"Exit from dormancy in microbial organisms","volume":"8","author":"Dworkin","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Peyrusson, F., Nguyen, T.K., Najdovski, T., and Van Bambeke, F. (2022). Host Cell Oxidative Stress Induces Dormant Staphylococcus aureus Persisters. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.02313-21"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jbspin.2012.08.002","article-title":"Evidence supporting a role for dormant bacteria in the pathogenesis of spondylarthritis","volume":"80","author":"Berthelot","year":"2013","journal-title":"Jt. Bone Spine"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"102083","DOI":"10.1016\/j.arr.2023.102083","article-title":"A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases","volume":"91","author":"Sienkiewicz","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41537-022-00244-w","article-title":"Estimation of the bidirectional relationship between schizophrenia and inflammatory bowel disease using the mendelian randomization approach","volume":"8","author":"Qian","year":"2022","journal-title":"Schizophrenia"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Bartocci, B., Dal Buono, A., Gabbiadini, R., Busacca, A., Quadarella, A., Repici, A., Mencaglia, E., Gasparini, L., and Armuzzi, A. (2023). Mental Illnesses in Inflammatory Bowel Diseases: Mens sana in corpore sano. Medicina, 59.","DOI":"10.3390\/medicina59040682"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/COH.0000000000000234","article-title":"Microbial translocation and microbiome dysbiosis in HIV-associated immune activation","volume":"11","author":"Zevin","year":"2016","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_72","first-page":"1","article-title":"F-652 (Recombinant Human Interleukin-22) For Schizophrenia","volume":"3","author":"Sfera","year":"2023","journal-title":"Arch. Pharmacal Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.schres.2015.02.002","article-title":"Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: Potential roles in GABAergic interneuron pathology","volume":"167","author":"Schubert","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Juricek, L., and Coumoul, X. (2018). The Aryl Hydrocarbon Receptor and the Nervous System. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092504"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"33969","DOI":"10.1038\/srep33969","article-title":"Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice","volume":"6","author":"Murray","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1042\/BCJ20200440","article-title":"Dopamine is an aryl hydrocarbon receptor agonist","volume":"477","author":"Park","year":"2020","journal-title":"Biochem. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/02698811211055811","article-title":"Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction","volume":"36","author":"Fehsel","year":"2022","journal-title":"J. Psychopharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature13684","article-title":"AhR sensing of bacterial pigments regulates antibacterial defence","volume":"512","author":"Houthuys","year":"2014","journal-title":"Nature"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41419-022-04562-w","article-title":"Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice","volume":"13","author":"Bai","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0742-8413(87)90025-9","article-title":"Intracellular injection of dopamine enhances acetylcholine responses of neuron R2 in the Aplysia abdominal ganglion","volume":"87","author":"Yurchenko","year":"1987","journal-title":"Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.tcb.2020.08.009","article-title":"Cellular Senescence Variation by Metabolic and Epigenomic Remodeling","volume":"30","author":"Nakao","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhang, X., Meng, F., Lyu, W., He, J., Wei, R., Du, Z., and Zhang, C. (2023). Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming. bioRxiv.","DOI":"10.1101\/2023.05.26.542348"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"949252","DOI":"10.3389\/fgene.2022.949252","article-title":"The role and mechanism of histone lactylation in health and diseases","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12974-023-02879-7","article-title":"H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer\u2019s disease through the NF\u03baB signaling pathway","volume":"20","author":"Wei","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/febs.16315","article-title":"Untangling senescent and damage-associated microglia in the aging and diseased brain","volume":"290","author":"Ng","year":"2023","journal-title":"FEBS J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fnmol.2017.00421","article-title":"Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan","volume":"10","author":"Tay","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12974-023-02901-y","article-title":"Noteworthy perspectives on microglia in neuropsychiatric disorders","volume":"20","author":"Zhu","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Galle, E., Wong, C.W., Ghosh, A., Desgeorges, T., Melrose, K., Hinte, L.C., Castellano-Castillo, D., Engl, M., de Sousa, J.A., and Ruiz-Ojeda, F.J. (2022). H3K18 lactylation marks tissue-specific active enhancers. Genome Biol., 23.","DOI":"10.1186\/s13059-022-02775-y"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"109820","DOI":"10.1016\/j.celrep.2021.109820","article-title":"Protein lactylation induced by neural excitation","volume":"37","author":"Hagihara","year":"2021","journal-title":"Cell Rep."},{"key":"ref_91","first-page":"6","article-title":"Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches","volume":"5","author":"Doyle","year":"2019","journal-title":"Mol. Neuropsychiatry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e158447","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging","volume":"132","author":"Miwa","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cmet.2016.05.010","article-title":"From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence","volume":"23","author":"Wiley","year":"2016","journal-title":"Cell Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"688910","DOI":"10.3389\/fimmu.2021.688910","article-title":"Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/sj.jes.7500589","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin in maternal breast milk newborn head circumference","volume":"18","author":"Nishijo","year":"2008","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/schbul\/sbp023","article-title":"Relation of schizophrenia prevalence to latitude, climate, fish consumption, infant mortality, and skin color: A role for prenatal vitamin d deficiency and infections?","volume":"35","author":"Kinney","year":"2009","journal-title":"Schizophr. Bull."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41386-022-01426-x","article-title":"Neuroimaging in schizophrenia: An overview of findings and their implications for synaptic changes","volume":"48","author":"Howes","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/schbul\/sbp099","article-title":"Gray Matter in First-Episode Schizophrenia Before and After Antipsychotic Drug Treatment. Anatomical Likelihood Estimation Meta-analyses with Sample Size Weighting","volume":"37","author":"Leung","year":"2009","journal-title":"Schizophr. Bull."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.neubiorev.2013.06.001","article-title":"Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies","volume":"37","author":"Smieskova","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Veijola, J., Guo, J.Y., Moilanen, J.S., J\u00e4\u00e4skel\u00e4inen, E., Miettunen, J., Kyll\u00f6nen, M., Haapea, M., Huhtaniska, S., Alar\u00e4is\u00e4nen, A., and M\u00e4ki, P. (2014). Longitudinal changes in total brain volume in schizophrenia: Relation to symptom severity, cognition and antipsychotic medication. PLoS ONE., 18.","DOI":"10.1371\/journal.pone.0101689"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1001\/archpsyc.59.11.1002","article-title":"Brain volume changes in first-episode schizophrenia: A 1-year follow-up study","volume":"59","author":"Cahn","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/mds.29172","article-title":"Parkinson\u2019s Progression Markers Initiative; Hoenig MC, van Eimeren T. Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson\u2019s Disease Subtypes","volume":"37","author":"Banwinkler","year":"2022","journal-title":"Mov Disord."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e2672","DOI":"10.1212\/WNL.0000000000201269","article-title":"Association between White Matter Networks and the Pattern of Striatal Dopamine Depletion in Patients with Parkinson Disease","volume":"99","author":"Chung","year":"2022","journal-title":"Neurology"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Dean, D.C., Sojkova, J., Hurley, S., Kecskemeti, S., Okonkwo, O., Bendlin, B.B., Theisen, F., Johnson, S.C., Alexander, A.L., and Gallagher, C.L. (2016). Alterations of Myelin Content in Parkinson\u2019s Disease: A Cross-Sectional Neuroimaging Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163774"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/schbul\/sbm147","article-title":"Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: An endocrine-disruption theory of schizophrenia","volume":"35","author":"Brown","year":"2009","journal-title":"Schizophr. Bull."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1192\/bjp.2021.119","article-title":"Association between air pollution exposure and mental health service use among individuals with first presentations of psychotic and mood disorders: Retrospective cohort study","volume":"219","author":"Newbury","year":"2021","journal-title":"Br. J. Psychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bcp.2018.06.016","article-title":"Activation of aryl hydrocarbon receptor regulates the LPS\/IFN\u03b3-induced inflammatory response by inducing ubiquitin-proteosomal and lysosomal degradation of RelA\/p65","volume":"155","author":"Vega","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0893-133X(98)00082-7","article-title":"Clozapine Preferentially Increases Dopamine Release in the Rhesus Monkey Prefrontal Cortex Compared with the Caudate Nucleus","volume":"20","author":"Youngren","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/s41386-020-0665-4","article-title":"Progressive subcortical volume loss in treatment-resistant schizophrenia patients after commencing clozapine treatment","volume":"45","author":"Tronchin","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.biopsych.2018.04.023","article-title":"Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta analysis (ENIGMA) consortium","volume":"84","author":"Walton","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s12264-018-0234-6","article-title":"Progressive Grey Matter Volume Changes in Patients with Schizophrenia over 6 Weeks of Antipsychotic Treatment and Their Relationship to Clinical Improvement","volume":"34","author":"Zhang","year":"2018","journal-title":"Neurosci. Bull."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41398-020-0828-4","article-title":"Characteristics of gray matter alterations in never-treated and treated chronic schizophrenia patients","volume":"10","author":"Liu","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/sj.npp.1301347","article-title":"Focal gray matter changes in schizophrenia across the course of the illness: A 5-year follow-up study","volume":"32","author":"Schnack","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Alamri, A.S., Alhomrani, M., Alsanie, W.F., Alyami, H., Shakya, S., Habeeballah, H., Abdulaziz, O., Alamri, A., Alkhatabi, H.A., and Felimban, R.I. (2022). Spectroscopic and Molecular Docking Analysis of \u03c0-Acceptor Complexes with the Drug Barbital. Appl. Sci., 12.","DOI":"10.3390\/app121910130"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Refat, M.S., Gaber, A., Althobaiti, Y.S., Alyami, H., Alsanie, W.F., Shakya, S., Adam, A.M.A., Kobeasy, M.I., and Asla, K.A. (2022). Spectroscopic and Molecular Docking Studies of Cu(II), Ni(II), Co(II), and Mn(II) Complexes with Anticonvulsant Therapeutic Agent Gabapentin. Molecules, 27.","DOI":"10.3390\/molecules27134311"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1001\/archpsyc.58.12.1118","article-title":"Focal gray matter density changes in schizophrenia","volume":"58","author":"Schnack","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Winkler, T.E., Lederer, S.L., Kim, E., Ben-Yoav, H., Kelly, D.L., Payne, G.F., and Ghodssi, R. (2017). Molecular processes in an electrochemical clozapine sensor. Biointerphases, 12.","DOI":"10.1116\/1.4982709"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"119092","DOI":"10.1016\/j.molliq.2022.119092","article-title":"Charge-transfer complexes of antipsychotic drug sulpiride with inorganic and organic acceptors generated through two different approaches: Spectral characterization","volume":"357","author":"Adam","year":"2022","journal-title":"J. Mol. Liq."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Chartoumpekis, D.V., Zaravinos, A., Apidianakis, Y., and Lagoumintzis, G. (2022). Editorial: Microbiota and mitochondria: Impact on cell signaling, physiology, and disease. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1056499"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Boguszewska, K., Szewczuk, M., Ka\u017amierczak-Bara\u0144ska, J., and Karwowski, B.T. (2020). The Similarities between Human Mitochondria and Bacteria in the Context of Structure, Genome, and Base Excision Repair System. Molecules, 25.","DOI":"10.3390\/molecules25122857"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/s41467-020-16274-w","article-title":"Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels","volume":"11","author":"Johnson","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"30701","DOI":"10.1074\/jbc.270.51.30701","article-title":"Role of ceramide in cellular senescence","volume":"270","author":"Venable","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/s41467-019-09654-4","article-title":"Ceramides bind VDAC2 to trigger mitochondrial apoptosis","volume":"10","author":"Dadsena","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.bbabio.2010.01.021","article-title":"Ceramide channels and their role in mitochondria-mediated apoptosis","volume":"1797","author":"Colombini","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/s42255-023-00873-0","article-title":"A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels","volume":"5","author":"Dutta","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/ATVBAHA.122.318048","article-title":"Ceramide Metabolism in Cardiovascular Disease: A Network with High Therapeutic Potential","volume":"42","author":"Zietzer","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/schbul\/sbs058","article-title":"Skin ceramide alterations in first-episode schizophrenia indicate abnormal sphingolipid metabolism","volume":"39","author":"Smesny","year":"2013","journal-title":"Schizophr. Bull."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41398-022-01999-7","article-title":"Acid sphingomyelinase\/ceramide system in schizophrenia: Implications for therapeutic intervention as a potential novel target","volume":"12","author":"Zhuo","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"100298","DOI":"10.1016\/j.jlr.2022.100298","article-title":"Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia","volume":"63","author":"Yuan","year":"2022","journal-title":"J. Lipid Res."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Xia, Q.S., Wu, F., Wu, W.B., Dong, H., Huang, Z.Y., Xu, L., Lu, F.E., and Gong, J. (2022). Berberine reduces hepatic ceramide levels to improve insulin resistance in HFD-fed mice by inhibiting HIF-2\u03b1. Biomed. Pharmacother., 150.","DOI":"10.1016\/j.biopha.2022.112955"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Torralba, D., Baixauli, F., and S\u00e1nchez-Madrid, F. (2016). Mitochondria know no boundaries: Mechanisms and functions of intercellular mitochondrial transfer. Front. Cell. Dev. Biol., 4.","DOI":"10.3389\/fcell.2016.00107"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Fairley, L.H., Grimm, A., and Eckert, A. (2022). Mitochondria transfer in brain injury and disease. Cells, 11.","DOI":"10.3390\/cells11223603"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/glia.23252","article-title":"Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns","volume":"66","author":"Jackson","year":"2018","journal-title":"Glia"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1017\/cjn.2016.25","article-title":"The Prevalence and Incidence of Frontotemporal Dementia: A Systematic Review","volume":"43","author":"Hogan","year":"2016","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.12688\/f1000research.7864.1","article-title":"Transporting mitochondria in neurons","volume":"5","author":"Course","year":"2016","journal-title":"F1000Research"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Nu\u00f1ez, M.T., and Chana-Cuevas, P. (2018). New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases. Pharmaceuticals, 11.","DOI":"10.3390\/ph11040109"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41419-020-03297-w","article-title":"Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis","volume":"12","author":"Thayyullathil","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_139","first-page":"290","article-title":"The effect of different antidepressant drugs on oxidative stress after lipopolysaccharide administration in mice","volume":"10","author":"Morsy","year":"2011","journal-title":"EXCLI J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fphar.2011.00090","article-title":"The energy demand of fast neuronal network oscillations: Insights from brain slice preparations","volume":"2","author":"Kann","year":"2012","journal-title":"Front. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1038\/s41386-020-00819-0","article-title":"GSK3\u03b2 inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia","volume":"45","author":"Nakao","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"9993","DOI":"10.1523\/JNEUROSCI.2057-04.2004","article-title":"Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis","volume":"24","author":"Linseman","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/YCO.0000000000000244","article-title":"Gamma band oscillations: A key to understanding schizophrenia symptoms and neural circuit abnormalities","volume":"29","author":"McNally","year":"2016","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41398-023-02511-5","article-title":"Alterations of auditory-evoked gamma oscillations are more pronounced than alterations of spontaneous power of gamma oscillation in early stages of schizophrenia","volume":"13","author":"Tada","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1503\/jpn.100021","article-title":"Gamma oscillations and schizophrenia","volume":"35","author":"Williams","year":"2010","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.neuron.2022.10.036","article-title":"Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms","volume":"111","author":"Veit","year":"2023","journal-title":"Neuron"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1523\/JNEUROSCI.0261-20.2020","article-title":"Parvalbumin and Somatostatin Interneurons Contribute to the Generation of Hippocampal Gamma Oscillations","volume":"40","author":"Antonoudiou","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Betterton, R., Mellor, J., and Tsaneva-Atanasova, K. (2015). Modulation of hippocampal gamma oscillations by acetylcholine: Insights from mathematical and in vitro optogenetic models. BMC Neurosci., 16.","DOI":"10.1186\/1471-2202-16-S1-P267"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbi.2021.10.007","article-title":"Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus","volume":"99","author":"French","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Chen, Y., Xu, J., and Chen, Y. (2021). Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. Nutrients, 13.","DOI":"10.3390\/nu13062099"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4161\/pri.23499","article-title":"Grey matter damage in multiple sclerosis: A pathology perspective","volume":"7","author":"Klaver","year":"2013","journal-title":"Prion"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1111\/ejn.15216","article-title":"Cingulate networks associated with gray matter loss in Parkinson\u2019s disease show high expression of cholinergic genes in the healthy brain","volume":"53","author":"Keo","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.tips.2022.09.006","article-title":"Muscarinic acetylcholine receptors for psychotic disorders: Bench-side to clinic","volume":"43","author":"Yohn","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1146687","DOI":"10.3389\/fnint.2023.1146687","article-title":"Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: Opportunities and challenges ahead","volume":"17","author":"Sahu","year":"2023","journal-title":"Front. Integr. Neurosci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1334887","DOI":"10.3389\/fnagi.2024.1334887","article-title":"Transcutaneous vagus nerve stimulation: A new strategy for Alzheimer\u2019s disease intervention through the brain-gut-microbiota axis?","volume":"16","author":"Yan","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"106335","DOI":"10.1016\/j.psyneuen.2023.106335","article-title":"Gut microbiota alterations in schizophrenia might be related to stress exposure: Findings from the machine learning analysis","volume":"155","author":"Kujawa","year":"2023","journal-title":"Psychoneuroendocrinology"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.schres.2016.10.003","article-title":"Environmental pollution and risk of psychotic disorders: A review of the science to date","volume":"181","author":"Attademo","year":"2017","journal-title":"Schizophr. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jagp.2023.09.014","article-title":"Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology with Geriatric Mental Health Research","volume":"32","author":"Sehgal","year":"2024","journal-title":"Geriatr. Psychiatry"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Seeman, M.V. (2023). Subjective Overview of Accelerated Aging in Schizophrenia. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20010737"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41514-023-00105-5","article-title":"Recent insights into the crosstalk between senescent cells and CD8 T lymphocytes","volume":"9","author":"Marin","year":"2023","journal-title":"NPJ Aging"},{"key":"ref_161","first-page":"369","article-title":"New-onset psychosis in HIV-infected patients","volume":"52","author":"Harris","year":"1991","journal-title":"J. Clin. Psychiatry"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e242538","DOI":"10.1136\/bcr-2021-242538","article-title":"New-onset psychosis due to COVID-19","volume":"14","author":"Kozato","year":"2021","journal-title":"BMJ Case Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"958563","DOI":"10.3389\/fnut.2022.958563","article-title":"Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging\u2014From theory to practice","volume":"9","author":"Maduro","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"31535","DOI":"10.1073\/pnas.1920338117","article-title":"Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts","volume":"117","author":"An","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e40314","DOI":"10.7554\/eLife.40314","article-title":"Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms","volume":"7","author":"Solis","year":"2018","journal-title":"eLife"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Deakin, B., Suckling, J., Dazzan, P., Joyce, E., Lawrie, S.M., Upthegrove, R., Husain, N., Chaudhry, I.B., Dunn, G., and Jones, P.B. (2019). Minocycline for Negative Symptoms of Schizophrenia and Possible Mechanistic Actions: The BeneMin RCT, NIHR Journals Library.","DOI":"10.3310\/eme06070"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1002\/fsn3.3523","article-title":"Pharmacological potentials of lycopene against aging and aging-related disorders: A review","volume":"11","author":"Abir","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11357-017-9970-1","article-title":"Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells","volume":"39","author":"Perrott","year":"2017","journal-title":"Geroscience"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Elsallabi, O., Patruno, A., Pesce, M., Cataldi, A., Carradori, S., and Gallorini, M. (2022). Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection. Molecules, 27.","DOI":"10.3390\/molecules27030738"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10522-018-9785-1","article-title":"Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K\/Akt\/mTOR pathway and induces senescent cell death by regulation of Bax\/Bcl-2 pathway","volume":"20","author":"Kumar","year":"2019","journal-title":"Biogerontology"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"771","DOI":"10.18632\/aging.101787","article-title":"The curcumin analog EF24 is a novel senolytic agent","volume":"11","author":"Li","year":"2019","journal-title":"Aging"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e13060","DOI":"10.1111\/acel.13060","article-title":"Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression","volume":"19","author":"Dang","year":"2020","journal-title":"Aging Cell"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e13767","DOI":"10.1111\/acel.13767","article-title":"Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age","volume":"22","author":"Islam","year":"2023","journal-title":"Aging Cell"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"12844","DOI":"10.18632\/aging.102557","article-title":"Targeting senescent cells: Approaches, opportunities, challenges","volume":"11","year":"2019","journal-title":"Aging"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/s43587-021-00151-2","article-title":"Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice","volume":"1","author":"Suda","year":"2021","journal-title":"Nat. Aging"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"20358","DOI":"10.1038\/s41598-021-99852-2","article-title":"Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker","volume":"11","author":"Poblocka","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Nicolson, G.L., Ferreira de Mattos, G., Ash, M., Settineri, R., and Escrib\u00e1, P.V. (2021). Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms While Restoring Function in Chronic Illnesses and Aging. Membranes, 11.","DOI":"10.3390\/membranes11120944"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"481405","DOI":"10.1155\/2015\/481405","article-title":"Protective Effects of Kaempferol against Myocardial Ischemia\/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3\u03b2","volume":"2015","author":"Zhou","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.2174\/1389450110607011421","article-title":"Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions","volume":"7","author":"Jope","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Jin, S., Zhang, L., and Wang, L. (2023). Kaempferol, a potential neuroprotective agent in neurodegenerative diseases: From chemistry to medicine. Biomed. Pharmacother., 165.","DOI":"10.1016\/j.biopha.2023.115215"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.bbamem.2017.04.013","article-title":"Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues","volume":"1859 Pt B","author":"Nicolson","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_182","first-page":"5","article-title":"Unraveling the Antibacterial and Iron Chelating Activity of N-Oxide Hydroxy-Phenazine natural Products and Synthetic Analogs against Staphylococcus aureus","volume":"63","author":"Nadeem","year":"2023","journal-title":"Isr. J. Chem."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Heitmann, A.S.B., Zanjani, A.A.H., Klenow, M.B., Mularski, A., S\u00f8nder, S.L., Lund, F.W., Boye, T.L., Dias, C., Bendix, P.M., and Simonsen, A.C. (2021). Phenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair. J. Biol. Chem., 297.","DOI":"10.1016\/j.jbc.2021.101012"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"6720","DOI":"10.1021\/ja200079a","article-title":"Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization","volume":"133","author":"Schmidt","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.sbi.2014.08.013","article-title":"The structural biology of phenazine biosynthesis","volume":"29","author":"Blankenfeldt","year":"2014","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00253-010-2509-3","article-title":"Metabolism and function of phenazines in bacteria: Impacts on the behavior of bacteria in the environment and biotechnological processes","volume":"86","author":"Pierson","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12934-023-02122-1","article-title":"Pseudomonas aeruginosa\u2019s greenish-blue pigment pyocyanin: Its production and biological activities","volume":"22","author":"Abdelaziz","year":"2023","journal-title":"Microb. Cell Fact."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1021\/np2009626","article-title":"Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species","volume":"75","author":"Ohlendorf","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1176\/appi.ajp.21101083","article-title":"Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia","volume":"179","author":"Paul","year":"2022","journal-title":"Am. J. Psychiatry"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1021\/acs.jnatprod.9b00289","article-title":"Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces","volume":"82","author":"Wang","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1016\/j.bmcl.2015.10.019","article-title":"Pontemazines a and B, phenazine derivatives containing a methylamine linkage from Streptomyces sp. UT1123 and their protective effect to HT-22 neuronal cells","volume":"25","author":"Cha","year":"2015","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"758","DOI":"10.7164\/antibiotics.52.758","article-title":"Phenazostatin C, a new diphenazine with neuronal cell protecting activity from Streptomyces sp.","volume":"52","author":"Kim","year":"1999","journal-title":"J. Antibiot."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.7164\/antibiotics.46.1485","article-title":"Phenazoviridin, a novel free radical scavenger from Streptomyces sp. taxonomy, fermentation, isolation, structure elucidation and biological properties","volume":"46","author":"Kato","year":"1993","journal-title":"J. Antibiot."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1021\/acs.jpclett.5b02405","article-title":"Bilayer Deformation, Pores, and Micellation Induced by Oxidized Lipids","volume":"6","author":"Boonnoy","year":"2015","journal-title":"J. Phys. Chem. Lett."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Voronova, O., Zhuravkov, S., Korotkova, E., Artamonov, A., and Plotnikov, E. (2022). Antioxidant Properties of New Phenothiazine Derivatives. Antioxidants, 11.","DOI":"10.3390\/antiox11071371"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1111\/cbdd.13572","article-title":"N10-carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress","volume":"94","author":"Keynes","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00249-016-1113-6","article-title":"Binding of phenothiazines into allosteric hydrophobic pocket of human thioredoxin 1","volume":"45","author":"Philot","year":"2016","journal-title":"Eur. Biophys. J."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1001\/archgenpsychiatry.2010.199","article-title":"Long-term antipsychotic treatment and brain volumes: A longitudinal study of first-episode schizophrenia","volume":"68","author":"Ho","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Engwa, G.A., Ayuk, E.L., Igbojekwe, B.U., and Unaegbu, M. (2016). Potential Antioxidant Activity of New Tetracyclic and Pentacyclic Nonlinear Phenothiazine Derivatives. Biochem. Res. Int., 2016.","DOI":"10.1155\/2016\/9896575"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/295605a0","article-title":"Mitochondrial transformation of mammalian cells","volume":"295","author":"Clark","year":"1982","journal-title":"Nature"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/rej.2007.0575","article-title":"Xenogenic transfer of isolated murine mitochondria into human rho0 cells can improve respiratory function","volume":"10","author":"Katrangi","year":"2007","journal-title":"Rejuvenation Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1242\/bio.201511478","article-title":"Actin-dependent mitochondrial internalization in cardiomyocytes: Evidence for rescue of mitochondrial function","volume":"4","author":"Pacak","year":"2015","journal-title":"Biol. Open"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1083\/jcb.201312123","article-title":"Mitochondrial trafficking and anchoring in neurons: New insight and implications","volume":"204","author":"Sheng","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"C489","DOI":"10.1152\/ajpcell.00152.2021","article-title":"Mitochondrial transplantation in cardiomyocytes: Foundation, methods, and outcomes","volume":"321","author":"Hosseinian","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1038\/s41598-022-08583-5","article-title":"Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect","volume":"12","author":"Sasaki","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.freeradbiomed.2023.07.034","article-title":"Mitochondrial transplantation rescues neuronal cells from ferroptosis","volume":"208","author":"Chen","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Um, J.-H., Lee, K.-M., Kim, Y.-Y., Lee, D.-Y., Kim, E., Kim, D.-H., and Yun, J. (2024). Berberine Induces Mitophagy through Adenosine Monophosphate-Activated Protein Kinase and Ameliorates Mitochondrial Dysfunction in PINK1 Knockout Mouse Embryonic Fibroblasts. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010219"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Goya-Jorge, E., Jorge Rodr\u00edguez, M.E., Veit\u00eda, M.S., and Giner, R.M. (2021). Plant Occurring Flavonoids as Modulators of the Aryl Hydrocarbon Receptor. Molecules, 26.","DOI":"10.3390\/molecules26082315"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.phymed.2014.10.010","article-title":"Original mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida)","volume":"22","author":"Linck","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Cordaro, M., Cuzzocrea, S., and Crupi, R. (2020). An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events. Antioxidants, 9.","DOI":"10.3390\/antiox9030216"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1158\/1535-7163.MCT-21-0984","article-title":"Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression","volume":"21","author":"McGovern","year":"2022","journal-title":"Mol. Cancer Ther."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1289\/ehp.6322","article-title":"Flavonoids as aryl hydrocarbon receptor agonists\/antagonists: Effects of structure and cell context","volume":"111","author":"Zhang","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"112193","DOI":"10.1016\/j.celrep.2023.112193","article-title":"Aryl hydrocarbon receptor activity downstream of IL-10 signaling is required to promote regulatory functions in human dendritic cells","volume":"42","author":"Avancini","year":"2023","journal-title":"Cell Rep."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1053\/j.gastro.2011.04.007","article-title":"Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract","volume":"141","author":"Monteleone","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1177\/02698811221085286","article-title":"Clozapine and the aryl hydrocarbon receptor","volume":"36","author":"Anderson","year":"2022","journal-title":"J. Psychopharmacol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1042\/BCJ20210851","article-title":"Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth","volume":"479","author":"Korac","year":"2022","journal-title":"Biochem. J."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1242\/jcs.111.22.3311","article-title":"Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis","volume":"111","author":"Alexander","year":"1998","journal-title":"J. Cell Sci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/toxsci\/kfp044","article-title":"The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages","volume":"109","author":"Matsunawa","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_220","first-page":"126","article-title":"Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands","volume":"54","author":"Manzella","year":"2020","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1684\/ejd.2022.4262","article-title":"The aryl hydrocarbon receptor pathway plays a central role in the cutaneous response to pollutants","volume":"32","author":"Guillon","year":"2022","journal-title":"Eur. J. Dermatol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1021\/acs.jmedchem.2c00208","article-title":"Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice","volume":"65","author":"Joo","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Kang, S., Lee, A.G., Im, S., Oh, S.J., Yoon, H.J., Park, J.H., and Pak, Y.K. (2022). A Novel Aryl Hydrocarbon Receptor Antagonist HBU651 Ameliorates Peripheral and Hypothalamic Inflammation in High-Fat Diet-Induced Obese Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314871"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Zai, W., Chen, W., Liu, H., and Ju, D. (2021). Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121912"},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Sfera, A. (2023). Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?. Reports, 6.","DOI":"10.3390\/reports6030036"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Shi, C., Su, C., Cen, L., Han, L., Tang, J., Wang, Z., Shi, X., Ju, D., Cao, Y., and Zhu, H. (2023). Vunakizumab-IL22, a Novel Fusion Protein, Promotes Intestinal Epithelial Repair and Protects against Gut Injury Induced by the Influenza Virus. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041160"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/mi.2012.72","article-title":"A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis","volume":"5","author":"Kim","year":"2012","journal-title":"Mucosal Immunol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"e07994","DOI":"10.1016\/j.heliyon.2021.e07994","article-title":"Lipid nanostructures for targeting brain cancer","volume":"7","author":"Nsairat","year":"2021","journal-title":"Heliyon"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Aldosari, B.N., Alfagih, I.M., and Almurshedi, A.S. (2021). Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13020206"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11095-022-03460-2","article-title":"Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery","volume":"40","author":"Sun","year":"2023","journal-title":"Pharm. Res."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/jns.12519","article-title":"Liver-directed drugs for transthyretin-mediated amyloidosis","volume":"27","author":"Brannagan","year":"2022","journal-title":"J. Peripher. Nerv. 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