{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:50:36Z","timestamp":1778104236068,"version":"3.51.4"},"reference-count":15,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neuroinflammatory conditions in the central nervous system (CNS) are implicated in the pathogenesis of several neuroimmune disorders such as acquired demyelinating syndromes, autoimmune encephalopathies, acute or chronic bacterial and viral CNS infections as well as multiple sclerosis (MS) [...]<\/jats:p>","DOI":"10.3390\/ijms25115973","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T10:42:34Z","timestamp":1717065754000},"page":"5973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroinflammation: From Molecular Basis to Therapy"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3902-3376","authenticated-orcid":false,"given":"Isabella","family":"Zanella","sequence":"first","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy"},{"name":"Cytogenetics and Molecular Genetics Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1347987","DOI":"10.3389\/fnagi.2024.1347987","article-title":"The role of neuroinflammation in neurodegenerative diseases: Current understanding and future therapeutic targets","volume":"16","author":"Adamu","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6890","DOI":"10.1038\/s41467-022-34735-2","article-title":"Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.it.2022.06.003","article-title":"The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder","volume":"43","author":"Sreeram","year":"2022","journal-title":"Trends Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11481-020-09907-w","article-title":"The far-reaching HAND of cART: cART effects on astrocytes","volume":"16","author":"Gonzalez","year":"2021","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/COH.0000000000000016","article-title":"Can antiretroviral therapy prevent HIV-associated cognitive disorders?","volume":"9","author":"Winston","year":"2014","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s40265-020-01379-9","article-title":"HIV-1 Integrase Inhibitors: A Comparative Review of Efficacy and Safety","volume":"80","author":"Scarsi","year":"2020","journal-title":"Drugs"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Foster, E.G., Gendelman, H.E., and Bade, A.N. (2022). HIV-1 Integrase Strand Transfer Inhibitors and Neurodevelopment. Pharmaceuticals, 15.","DOI":"10.3390\/ph15121533"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1007\/s12035-021-02508-5","article-title":"Dolutegravir Inhibition of Matrix Metalloproteinases Affects Mouse Neurodevelopment","volume":"58","author":"Bade","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12013-023-01185-6","article-title":"Fatty Acids and their Proteins in Adipose Tissue Inflammation","volume":"82","author":"Mallick","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mcn.2017.02.004","article-title":"Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation","volume":"80","author":"Duffy","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tins.2017.02.005","article-title":"Obesity-Induced Neuroinflammation: Beyond the Hypothalamus","volume":"40","author":"Muccioli","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3389\/fendo.2017.00366","article-title":"Organotins in Neuronal Damage, Brain Function, and Behavior: A Short Review","volume":"8","author":"Graceli","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3389\/fnins.2020.00577","article-title":"LRRK2 and \u03b1-Synuclein: Distinct or Synergistic Players in Parkinson\u2019s Disease?","volume":"14","author":"Pawar","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00417-016-3548-y","article-title":"The neurovascular unit and the pathophysiologic basis of diabetic retinopathy","volume":"255","author":"Gardner","year":"2017","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/11\/5973\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:50:35Z","timestamp":1760107835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/11\/5973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,29]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ijms25115973"],"URL":"https:\/\/doi.org\/10.3390\/ijms25115973","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,29]]}}}