{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:45:43Z","timestamp":1793609143987,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Israel Science Foundation","award":["#2054\/19"],"award-info":[{"award-number":["#2054\/19"]}]},{"name":"Israel Science Foundation","award":["#RA2000000457"],"award-info":[{"award-number":["#RA2000000457"]}]},{"name":"Ariel University Research and Development Department","award":["#2054\/19"],"award-info":[{"award-number":["#2054\/19"]}]},{"name":"Ariel University Research and Development Department","award":["#RA2000000457"],"award-info":[{"award-number":["#RA2000000457"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The relationship between rheumatoid arthritis (RA) and early onset atherosclerosis is well depicted, each with an important inflammatory component. Glycoprotein acetyls (GlycA), a novel biomarker of inflammation, may play a role in the manifestation of these two inflammatory conditions. The present study examined a potential mediating role of GlycA within the RA\u2013atherosclerosis relationship to determine whether it accounts for the excess risk of cardiovascular disease over that posed by lipid risk factors. The UK Biobank dataset was acquired to establish associations among RA, atherosclerosis, GlycA, and major lipid factors: total cholesterol (TC), high- and low-density lipoprotein (HDL, LDL) cholesterol, and triglycerides (TGs). Genome-wide association study summary statistics were collected from various resources to perform genetic analyses. Causality among variables was tested using Mendelian Randomization (MR) analysis. Genes of interest were identified using colocalization analysis and gene enrichment analysis. MR results appeared to indicate that the genetic relationship between GlycA and RA and also between RA and atherosclerosis was explained by horizontal pleiotropy (p-value = 0.001 and &lt;0.001, respectively), while GlycA may causally predict atherosclerosis (p-value = 0.017). Colocalization analysis revealed several functionally relevant genes shared between GlycA and all the variables assessed. Two loci were apparent in all relationships tested and included the HLA region as well as SLC22A1. GlycA appears to mediate the RA\u2013atherosclerosis relationship through several possible pathways. GlycA, although pleiotropically related to RA, appears to causally predict atherosclerosis. Thus, GlycA is suggested as a significant factor in the etiology of atherosclerosis development in RA.<\/jats:p>","DOI":"10.3390\/ijms25115981","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T10:42:34Z","timestamp":1717065754000},"page":"5981","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Glycoprotein Acetyls Is a Novel Biomarker Predicting Cardiovascular Complications in Rheumatoid Arthritis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-4787","authenticated-orcid":false,"given":"Melody","family":"Kasher","sequence":"first","affiliation":[{"name":"Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 4070000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-6259","authenticated-orcid":false,"given":"Maxim B.","family":"Freidin","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M. K.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King\u2019s College London, London WC2R 2LS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-3352","authenticated-orcid":false,"given":"Stacey S.","family":"Cherny","sequence":"additional","affiliation":[{"name":"Human Population Biology Research Unit, Department of Anatomy and Anthropology, School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"},{"name":"Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-0679","authenticated-orcid":false,"given":"Shai","family":"Ashkenazi","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 4070000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-7493","authenticated-orcid":false,"given":"Gregory","family":"Livshits","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, Adelson School of Medicine, Ariel University, Ariel 4070000, Israel"},{"name":"Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King\u2019s College London, London WC2R 2LS, UK"},{"name":"Human Population Biology Research Unit, Department of Anatomy and Anthropology, School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.berh.2008.07.001","article-title":"Epidemiology of Rheumatic Musculoskeletal Disorders in the Developing World","volume":"22","author":"Chopra","year":"2008","journal-title":"Best Pract. 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