{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:58Z","timestamp":1787028538937,"version":"build-2736575974"},"reference-count":43,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is a novel and uncommon type of renal cell carcinoma, which has been recently recognized and introduced as a distinct entity in the WHO 2022 kidney tumor classification. Previously known as \u201cunclassified RCC\u201d, followed by \u201ctuberous sclerosis complex (TSC)-associated RCC\u201d, ESC-RCC is now a distinct category of kidney tumor, with its own name, with specific clinical manifestations, and a unique morphological, immunohistochemical and molecular profile. Due to its recent introduction and the limited available data, the diagnosis of ESC-RCC is still a complex challenge, and it is probably frequently misdiagnosed. The secret of diagnosing this tumor lies in the pathologists\u2019 knowledge, and keeping it up to date through research, thereby limiting the use of outdated nomenclature. The aim of our case-based review is to provide a better understanding of this pathology and to enrich the literature with a new case report, which has some particularities compared to the existing cases.<\/jats:p>","DOI":"10.3390\/ijms25115982","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T10:42:34Z","timestamp":1717065754000},"page":"5982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Eosinophilic Solid and Cystic Renal Cell Carcinoma\u2014A Case Report and Literature Review"],"prefix":"10.3390","volume":"25","author":[{"given":"Andrada","family":"Loghin","sequence":"first","affiliation":[{"name":"Histology Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7690-9701","authenticated-orcid":false,"given":"Maria","family":"Popelea","sequence":"additional","affiliation":[{"name":"Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Todea-Moga","sequence":"additional","affiliation":[{"name":"Urology Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Urology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-2433","authenticated-orcid":false,"given":"Iuliu","family":"Cocuz","sequence":"additional","affiliation":[{"name":"Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania"},{"name":"Pathophysiology Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Borda","sequence":"additional","affiliation":[{"name":"Histology Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Department of Pathology, Targu-Mure\u0219 Emergency County Hospital, 540139 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13000-023-01341-9","article-title":"Eosinophilic Solid and Cystic Renal Cell Carcinoma with TSC2 Mutation: A Case Report and Literature Review","volume":"18","author":"He","year":"2023","journal-title":"Diagn. 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