{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:29:02Z","timestamp":1764937742818,"version":"build-2065373602"},"reference-count":63,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Baccharis macraei Hook. &amp; Arn (Asteraceae), commonly known as Vautro, is found in the coastal areas of central-southern Chile, including the industrial zone of Quintero-Puchuncav\u00ed, known for the contamination of its soils with heavy metals, which together with other factors generate abiotic stress in plant species, against which they present defensive mechanisms. For this reason, the objective was to evaluate the effect of abiotic stress generated by the proximity of B. macraei to the industrial complex by assessing the physiological and metabolic states reported by the extracts and compounds isolated from the species, as well as the photosynthetic capacity, metal content and production, and antioxidant activity and cytotoxicity against tumorigenic cell lines of the phytoconstituents. To this end, B. macraei was collected at two different distances from the industrial complex, observing that the closer the species is, the greater the concentration of copper in the soil, generating a decrease in the rate of electron transport in situ, but an increase in antioxidant activity with low cytotoxicity. This activity could be due to the presence of flavonoids such as Hispidulin, Cirsimaritina, and Isokaempferida, as well as monoterpenes, oxygenated and non-oxygenated sesquiterpenes identified in this study.<\/jats:p>","DOI":"10.3390\/ijms25115993","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T10:42:34Z","timestamp":1717065754000},"page":"5993","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of the Proximity to the Quintero-Puchuncav\u00ed Industrial Zone on Compounds Isolated from Baccharis macraei Hook. &amp; Arn: Their Antioxidant and Cytotoxic Activity"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-3682","authenticated-orcid":false,"given":"Manuel","family":"Mart\u00ednez-Lobos","sequence":"first","affiliation":[{"name":"Programa de Doctorado Interdisciplinario en Ciencias Ambientales, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valpara\u00edso 2360004, Chile"},{"name":"Laboratorio de Productos Naturales y S\u00edntesis Org\u00e1nica, Universidad de Playa Ancha, Av. Leopoldo Carvallo 270, Valpara\u00edso 2360004, Chile"},{"name":"Departamento de Ciencias Naturales y Geograf\u00eda, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valpara\u00edso 2360004, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8379-8545","authenticated-orcid":false,"given":"Estela","family":"Tapia-Venegas","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Ingenier\u00eda para la Sostenibilidad, Facultad de Ingenier\u00eda, Universidad de Playa Ancha, Valpara\u00edso 2360004, Chile"},{"name":"Laboratorio de Bioprocesos, HUB Ambiental, Universidad de Playa Ancha, Valpara\u00edso 2360004, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-3787","authenticated-orcid":false,"given":"Paula","family":"Celis-Pl\u00e1","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Naturales y Geograf\u00eda, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valpara\u00edso 2360004, Chile"},{"name":"Laboratorio de Investigaci\u00f3n Ambiental Acu\u00e1tica (LACER), HUB Ambiental, Universidad de Playa Ancha, Valpara\u00edso 2360004, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-1454","authenticated-orcid":false,"given":"Joan","family":"Villena","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinario de Investigaci\u00f3n Biom\u00e9dica e Ingenier\u00eda Para la Salud (MEDING), Escuela de Medicina, Facultad de Medicina, Universidad de Valpara\u00edso, Valpara\u00edso 2540064, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Jara-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinario de Investigaci\u00f3n Biom\u00e9dica e Ingenier\u00eda Para la Salud (MEDING), Escuela de Kinesiolog\u00eda, Facultad de Medicina, Universidad de Valpara\u00edso, Valpara\u00edso 2540064, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Lobos-Pessini","sequence":"additional","affiliation":[{"name":"Laboratorio Silob Chile, Javiera Carrera 839, Valpara\u00edso 2390410, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9176-8044","authenticated-orcid":false,"given":"Daniela","family":"Rigano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Montesano 49, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmina","family":"Sirignano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Montesano 49, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-7032","authenticated-orcid":false,"given":"Alejandro","family":"Madrid-Villegas","sequence":"additional","affiliation":[{"name":"Laboratorio de Productos Naturales y S\u00edntesis Org\u00e1nica, Universidad de Playa Ancha, Av. 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