{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:56:24Z","timestamp":1789419384597,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pancreatic stone protein (PSP) is an acute-phase reactant mainly produced in response to stress. Its diagnostic and prognostic accuracy for several types of infection has been studied in several clinical settings. The aim of the current review was to assess all studies examining a possible connection of pancreatic stone protein levels with the severity and possible complications of patients diagnosed with infection. We performed a systematic search in PubMed, Scopus, the Cochrane Library and Clinicaltrials.gov to identify original clinical studies assessing the role of pancreatic stone protein in the diagnosis and prognosis of infectious diseases. We identified 22 eligible studies. Ten of them provided diagnostic aspects, ten studies provided prognostic aspects, and another two studies provided both diagnostic and prognostic information. The majority of the studies were performed in an intensive care unit (ICU) setting, five studies were on patients who visited the emergency department (ED), and three studies were on burn-injury patients. According to the literature, pancreatic stone protein has been utilized in patients with different sites of infection, including pneumonia, soft tissue infections, intra-abdominal infections, urinary tract infections, and sepsis. In conclusion, PSP appears to be a useful point-of-care biomarker for the ED and ICU due to its ability to recognize bacterial infections and sepsis early. Further studies are required to examine PSP\u2019s kinetics and utility in specific populations and conditions.<\/jats:p>","DOI":"10.3390\/ijms25116046","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T03:46:49Z","timestamp":1717127209000},"page":"6046","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic and Prognostic Ability of Pancreatic Stone Protein: A Scoping Review"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1712-9815","authenticated-orcid":false,"given":"Christos","family":"Michailides","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Themistoklis","family":"Paraskevas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5105-0196","authenticated-orcid":false,"given":"Silvia","family":"Demiri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3904-0002","authenticated-orcid":false,"given":"Charikleia","family":"Chourpiliadi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Papantoniou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-1485","authenticated-orcid":false,"given":"Ioanna","family":"Aggeletopoulou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni Konstantina","family":"Velissari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8900-0212","authenticated-orcid":false,"given":"Maria","family":"Lagadinou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"},{"name":"Medical School of Patras, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-8209","authenticated-orcid":false,"given":"Christos","family":"Triantos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9319-323X","authenticated-orcid":false,"given":"Dimitrios","family":"Velissaris","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"},{"name":"Medical School of Patras, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"ref_1","first-page":"303","article-title":"Biomarkers in clinical medicine","volume":"163","author":"Chen","year":"2011","journal-title":"IARC Sci. Publ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1128\/CMR.00016-12","article-title":"New approaches to sepsis: Molecular diagnostics and biomarkers","volume":"25","author":"Reinhart","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1097\/CCM.0b013e31819da7d6","article-title":"Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes","volume":"37","author":"Keel","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ventura, F., Eggimman, P., Daix, T., Francois, B., and Pugin, J. (2024). Pancreatic Stone Protein Measurement to Screen and Diagnose Sepsis in the Context of the Surviving Sepsis Campaign Recommendations. Med. Res. Arch., 11.","DOI":"10.18103\/mra.v11i12.4893"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1172529","DOI":"10.3389\/fmed.2023.1172529","article-title":"The critical role of pancreatic stone protein\/regenerating protein in sepsis-related multiorgan failure","volume":"10","author":"Hu","year":"2023","journal-title":"Front. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Michailides, C., Lagadinou, M., Paraskevas, T., Papantoniou, K., Kavvousanos, M., Vasileiou, A., Thomopoulos, K., Velissaris, D., and Marangos, M. (2023). The Role of the Pancreatic Stone Protein in Predicting Intra-Abdominal Infection-Related Complications: A Prospective Observational Single-Center Cohort Study. Microorganisms, 11.","DOI":"10.3390\/microorganisms11102579"},{"key":"ref_7","first-page":"6391","article-title":"The role of pancreatic stone protein as a prognostic factor for COVID-19 patients","volume":"26","author":"Lagadinou","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13054-021-03704-4","article-title":"Pancreatic stone protein for early mortality prediction in COVID-19 patients","volume":"25","author":"Brahier","year":"2021","journal-title":"Crit. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2217\/bmm-2019-0174","article-title":"Prognostic performance of pancreatic stone protein in critically ill patients with sepsis","volume":"13","author":"Berger","year":"2019","journal-title":"Biomark. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1378\/chest.15-0123","article-title":"Prognostication of Mortality in Critically Ill Patients With Severe Infections","volume":"148","author":"Que","year":"2015","journal-title":"Chest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/CCM.0b013e3182771193","article-title":"Pancreatic stone protein predicts outcome in patients with peritonitis in the ICU","volume":"41","author":"Gukasjan","year":"2013","journal-title":"Crit. Care Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1378\/chest.12-0730","article-title":"Pancreatic stone protein predicts positive sputum bacteriology in exacerbations of COPD","volume":"143","author":"Scherr","year":"2013","journal-title":"Chest"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1186\/cc11406","article-title":"Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management","volume":"16","author":"Que","year":"2012","journal-title":"Crit. Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1378\/chest.11-0018","article-title":"Pancreatic stone protein: A marker of organ failure and outcome in ventilator-associated pneumonia","volume":"140","author":"Boeck","year":"2011","journal-title":"Chest"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/jalm\/jfac031","article-title":"Added Diagnostic Value of Biomarkers in Patients with Suspected Sepsis: A Prospective Cohort Study in Out-Of-Hours Primary Care","volume":"7","author":"Loots","year":"2022","journal-title":"J. Appl. Lab. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e004914","DOI":"10.1136\/bmjopen-2014-004914","article-title":"Pancreatic stone protein (PSP) and pancreatitis-associated protein (PAP): A protocol of a cohort study on the diagnostic efficacy and prognostic value of PSP and PAP as postoperative markers of septic complications in patients undergoing abdominal surgery (PSP study)","volume":"4","author":"Fisher","year":"2014","journal-title":"BMJ Open"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"de Hond, T.A.P., Oosterheert, J.J., van Hemert-Glaubitz, S.J.M., Musson, R.E.A., and Kaasjager, K.A.H. (2022). Pancreatic Stone Protein as a Biomarker for Sepsis at the Emergency Department of a Large Tertiary Hospital. Pathogens, 11.","DOI":"10.3390\/pathogens11050559"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/eci.12732","article-title":"Pancreatic stone protein and soluble CD25 for infection and sepsis in an emergency department","volume":"47","author":"Berger","year":"2017","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1515\/cclm-2018-0154","article-title":"Analyzing the capability of PSP, PCT and sCD25 to support the diagnosis of infection in cancer patients with febrile neutropenia","volume":"57","author":"Berger","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Niggemann, P., Rittirsch, D., Buehler, P.K., Schweizer, R., Giovanoli, P., Reding, T., Graf, R., Plock, J.A., and Klein, H.J. (2021). Incidence and Time Point of Sepsis Detection as Related to Different Sepsis Definitions in Severely Burned Patients and Their Accompanying Time Course of Pro-Inflammatory Biomarkers. J. Pers. Med., 11.","DOI":"10.3390\/jpm11080701"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e1179","DOI":"10.1097\/SLA.0000000000003784","article-title":"Pancreatic Stone Protein Predicts Sepsis in Severely Burned Patients Irrespective of Trauma Severity: A Monocentric Observational Study","volume":"274","author":"Klein","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.burns.2020.04.039","article-title":"Response of routine inflammatory biomarkers and novel Pancreatic Stone Protein to inhalation injury and its interference with sepsis detection in severely burned patients","volume":"47","author":"Klein","year":"2021","journal-title":"Burns"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tschuor, C., Raptis, D.A., Limani, P., B\u00e4chler, T., Oberkofler, C.E., Breitenstein, S., and Graf, R. (2012). The value of pancreatic stone protein in predicting acute appendicitis in patients presenting at the emergency department with abdominal pain. BMC Gastroenterol., 12.","DOI":"10.1186\/1471-230X-12-154"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13054-021-03576-8","article-title":"Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: A prospective multicentric study","volume":"25","author":"Pugin","year":"2021","journal-title":"Crit. Care"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Klein, H.J., Csordas, A., Falk, V., Slankamenac, K., Rudiger, A., Sch\u00f6nrath, F., Rodriguez Cetina Biefer, H., Starck, C.T., and Graf, R. (2015). Pancreatic stone protein predicts postoperative infection in cardiac surgery patients irrespective of cardiopulmonary bypass or surgical technique. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120276"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/cc12588","article-title":"Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care","volume":"17","author":"Llewelyn","year":"2013","journal-title":"Crit. Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13054-021-03609-2","article-title":"Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: A systematic review and individual patient level meta-analysis","volume":"25","author":"Prazak","year":"2021","journal-title":"Crit. Care"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mai, B., Zhou, L., Wang, Q., Ding, B., Zhan, Y., Qin, S., Zhu, N., Li, Z., and Lei, Z. (2024). Diagnostic accuracy of pancreatic stone protein in patients with sepsis: A systematic review and meta-analysis. BMC Infect. Dis., 24.","DOI":"10.1186\/s12879-024-09347-4"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s15010-023-02093-w","article-title":"Discriminative performance of pancreatic stone protein in predicting ICU mortality and infection severity in adult patients with infection: A systematic review and individual patient level meta-analysis","volume":"51","author":"Zuercher","year":"2023","journal-title":"Infection"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/11\/6046\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:51:28Z","timestamp":1760107888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/11\/6046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ijms25116046"],"URL":"https:\/\/doi.org\/10.3390\/ijms25116046","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]}}}