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We aimed to compare the molecular and genetic differences in psoriasis patients who achieved complete response from secukinumab and Dead Sea climatotherapy treatments. We performed quantitative immunohistochemical and transcriptomic analysis, in addition to digital spatial profiling of skin punch biopsies. Histologically, both treatments resulted in a normalization of the lesional skin to a level resembling nonlesional skin. Interestingly, the transcriptome was not normalized by either treatments. We revealed 479 differentially expressed genes between secukinumab and Dead Sea climatotherapy at the end of treatment, with a psoriasis panel identifying SERPINB4, SERPINB13, IL36G, IL36RN, and AKR1B10 as upregulated in Dead Sea climatotherapy compared with secukinumab. Using digital spatial profiling, pan-RAS was observed to be differentially expressed in the microenvironment surrounding CD103+ cells, and IDO1 was differentially expressed in the dermis when comparing the two treatments. The differences observed between secukinumab and Dead Sea climatotherapy suggest the presence of a molecular scar, which may stem from mechanistically different pathways and potentially contribute to disease recurrence. This may be important for determining treatment response duration and disease memory.<\/jats:p>","DOI":"10.3390\/ijms25116086","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T11:43:48Z","timestamp":1717155828000},"page":"6086","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Secukinumab and Dead Sea Climatotherapy Impact Resolved Psoriasis Skin Differently Potentially Affecting Disease Memory"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-6409","authenticated-orcid":false,"given":"Thomas","family":"Emmanuel","sequence":"first","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital, 8200 Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University Hospital, 8200 Aarhus, 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Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis. Redox Biol., 41.","DOI":"10.1016\/j.redox.2021.101924"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/2040622317738910","article-title":"Secukinumab: A review of the anti-IL-17A biologic for the treatment of psoriasis","volume":"9","author":"Frieder","year":"2018","journal-title":"Ther. Adv. Chronic. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2340\/00015555-3233","article-title":"Non-random Plaque-site Recurrence of Psoriasis in Patients Treated with Dead Sea Climatotherapy","volume":"99","author":"Emmanuel","year":"2019","journal-title":"Acta Derm. Venereol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.4049\/jimmunol.1302313","article-title":"Epidermal Th22 and Tc17 Cells Form a Localized Disease Memory in Clinically Healed Psoriasis","volume":"192","author":"Cheuk","year":"2014","journal-title":"J. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/bjd.20963","article-title":"The biological basis of disease recurrence in psoriasis: A historical perspective and current models","volume":"186","author":"Puig","year":"2022","journal-title":"Br. J. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Emmanuel, T., Misteg\u00e5rd, J., Bregnh\u00f8j, A., Johansen, C., and Iversen, L. (2021). Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22169004"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/bjd\/ljad303","article-title":"Resident cutaneous memory T-cells: A clinical review of their role in chronic inflammatory dermatoses and potential as therapeutic targets","volume":"189","author":"Pham","year":"2023","journal-title":"Br. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41590-021-01004-1","article-title":"Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity","volume":"22","author":"Christo","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature21379","article-title":"Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism","volume":"543","author":"Christo","year":"2017","journal-title":"Nature"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1172\/JCI81261","article-title":"Inflammatory IL-15 is required for optimal memory T cell responses","volume":"125","author":"Richer","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/nm.3962","article-title":"Hair follicle\u2013derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma","volume":"21","author":"Adachi","year":"2015","journal-title":"Nat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"R\u00f8nholt, K., and Iversen, L. (2017). Old and New Biological Therapies for Psoriasis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112297"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/09546634.2020.1772454","article-title":"Assessment of the benefit of achieving complete versus almost complete skin clearance in psoriasis: A patient\u2019s perspective","volume":"33","author":"Korman","year":"2022","journal-title":"J. Dermatol. Treat."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s13555-021-00599-5","article-title":"Real-World Satisfaction with Secukinumab in Clearing the Skin of Patients with Plaque Psoriasis through 24 Months of Follow-Up: Results from US Dermatology Electronic Medical Records","volume":"11","author":"Armstrong","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1111\/jdv.17433","article-title":"Complete clearance and Psoriasis Area and Severity Index response for brodalumab and ustekinumab by previous treatment history in AMAGINE-2 and AMAGINE-3","volume":"35","author":"Reich","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/PTT.S294173","article-title":"Key Signaling Pathways in Psoriasis: Recent Insights from Antipsoriatic Therapeutics","volume":"11","author":"Johansen","year":"2021","journal-title":"Psoriasis Targets Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1111\/jdv.14979","article-title":"Secukinumab treatment in new-onset psoriasis: Aiming to understand the potential for disease modification\u2014Rationale and design of the randomized, multicenter STEPIn study","volume":"32","author":"Iversen","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/jdv.18846","article-title":"Secukinumab demonstrates superiority over narrow-band ultraviolet B phototherapy in new-onset moderate to severe plaque psoriasis patients: Week 52 results from the STEPIn study","volume":"37","author":"Iversen","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e049822","DOI":"10.1136\/bmjopen-2021-049822","article-title":"IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: Rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants with moderate-to-severe plaque-type psoriasis (GUIDE)","volume":"11","author":"Eyerich","year":"2021","journal-title":"BMJ Open"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.immuni.2017.01.009","article-title":"CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin","volume":"46","author":"Cheuk","year":"2017","journal-title":"Immunity"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nm1605","article-title":"\u03b11\u03b21 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis","volume":"13","author":"Conrad","year":"2007","journal-title":"Nat. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/jid.2010.280","article-title":"Resolved psoriasis lesions retain expression of a subset of disease-related genes","volume":"131","author":"Lowes","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Schwingen, J., Kaplan, M., and Kurschus, F.C. (2020). Review\u2014Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030699"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jdermsci.2022.08.004","article-title":"Transcriptome profiling in psoriasis: NB-UVB treatment-associated transcriptional changes and modulation of autoinflammation in perilesional skin in early-phase disease","volume":"107","author":"Vacharanukrauh","year":"2022","journal-title":"J. Dermatol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/jid.2010.36","article-title":"Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes and Comparisons with In Vitro Models","volume":"130","author":"Gudjonsson","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.3389\/fimmu.2021.667690","article-title":"Exploring the Pathogenesis of Psoriasis Complicated with Atherosclerosis via Microarray Data Analysis","volume":"12","author":"Su","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Rioux, G., Ridha, Z., Simard, M., Turgeon, F., Gu\u00e9rin, S.L., and Pouliot, R. (2020). Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis. Genes, 11.","DOI":"10.3390\/genes11101155"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1038\/s41598-018-22284-y","article-title":"Genome-wide transcriptome analysis identifies alternative splicing regulatory network and key splicing factors in mouse and human psoriasis","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"244ra90","DOI":"10.1126\/scitranslmed.3008946","article-title":"Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema","volume":"6","author":"Quaranta","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/jdv.13269","article-title":"Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity","volume":"30","author":"Wagenpfeil","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1038\/jid.2012.184","article-title":"Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis","volume":"132","author":"Li","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Su\u00e1rez-Fari\u00f1as, M., Lowes, M.A., Zaba, L.C., and Krueger, J.G. (2010). Evaluation of the Psoriasis Transcriptome across Different Studies by Gene Set Enrichment Analysis (GSEA). PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010247"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/jid.2012.33","article-title":"Combined Use of Laser Capture Microdissection and cDNA Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions","volume":"132","author":"Mitsui","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1084\/jem.20151093","article-title":"Melanocyte antigen triggers autoimmunity in human psoriasis","volume":"212","author":"Arakawa","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41587-020-0472-9","article-title":"Multiplex digital spatial profiling of proteins and RNA in fixed tissue","volume":"38","author":"Merritt","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jaci.2014.10.037","article-title":"Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection","volume":"135","author":"Esaki","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e13326","DOI":"10.1111\/sji.13326","article-title":"Method for high-plex analysis of immune cells in human skin using the GeoMx system","volume":"99","author":"Ignatov","year":"2023","journal-title":"Scand. J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00281-019-00766-z","article-title":"Resolution of plaque-type psoriasis: What is left behind (and reinitiates the disease)","volume":"41","author":"Benezeder","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/1523-1747.ep12465094","article-title":"Epidermal Changes in Human Skin Following Irradiation with Either UVB or UVA","volume":"88","author":"Pearse","year":"1987","journal-title":"J. Investig. Dermatol."},{"key":"ref_53","first-page":"1136","article-title":"Climatotherapy at the Dead Sea for psoriasis is a highly effective anti-inflammatory treatment in the short term: An immunohistochemical study","volume":"31","author":"Emmanuel","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1046\/j.0022-202x.2001.01478.x","article-title":"Solar-Simulated Skin Adaptation and its Effect on Subsequent UV-Induced Epidermal DNA Damage","volume":"117","author":"Pavel","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ni.3523","article-title":"CD1a on Langerhans cells controls inflammatory skin disease","volume":"17","author":"Kim","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jaci.2019.04.029","article-title":"IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis","volume":"144","author":"Krueger","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1084\/jem.20071094","article-title":"Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses","volume":"204","author":"Zaba","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Tsoi, L.C., Xing, X., Xing, E., Wasikowski, R., Shao, S., Zeng, C., Plazyo, O., Kirma, J., Jiang, Y., and Billi, A.C. (2021). Non-invasive tape-stripping with high-resolution RNA profiling effectively captures a pre-inflammatory state in nonlesional psoriatic skin. J. Investig. Dermatol., 142.","DOI":"10.1016\/j.jid.2021.09.038"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1084\/jem.20030451","article-title":"Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris","volume":"199","author":"Lee","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/physiolgenomics.00157.2002","article-title":"Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array","volume":"13","author":"Zhou","year":"2003","journal-title":"Physiol. Genom."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2133.2006.07628.x","article-title":"Genomic-scale analysis of psoriatic skin reveals differentially expressed insulin-like growth factor-binding protein-7 after phototherapy","volume":"156","author":"Hochberg","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/jid.2014.532","article-title":"IL-36\u03b3 (IL-1F9) Is a Biomarker for Psoriasis Skin Lesions","volume":"135","author":"Wagenpfeil","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Keermann, M., K\u00f5ks, S., Reimann, E., Prans, E., Abram, K., and Kingo, K. (2015). Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN. BMC Genom., 16.","DOI":"10.1186\/s12864-015-1508-2"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Gao, Y., Yi, X., and Ding, Y. (2017). Combined Transcriptomic Analysis Revealed AKR1B10 Played an Important Role in Psoriasis through the Dysregulated Lipid Pathway and Overproliferation of Keratinocyte. Biomed. Res. Int., 2017.","DOI":"10.1155\/2017\/8717369"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1056\/NEJMoa1314258","article-title":"Secukinumab in Plaque Psoriasis\u2014Results of Two Phase 3 Trials","volume":"371","author":"Langley","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0140-6736(08)60725-4","article-title":"Efficacy and safety of ustekinumab, a human interleukin-12\/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)","volume":"371","author":"Leonardi","year":"2008","journal-title":"Lancet"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0140-6736(18)31713-6","article-title":"Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): Results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials","volume":"392","author":"Gordon","year":"2018","journal-title":"Lancet"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Thomas, S.E., van den Reek, J.M.P.A., Seyger, M.M.B., and de Jong, E.M.G.J. How to define a \u2018super-responder\u2019 to biologics in psoriasis studies?. Br. J. Dermatol., 2023.","DOI":"10.1093\/bjd\/ljad280"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0140-6736(19)31773-8","article-title":"Guselkumab versus secukinumab for the treatment of moderate-to-severe psoriasis (ECLIPSE): Results from a phase 3, randomised controlled trial","volume":"394","author":"Reich","year":"2019","journal-title":"Lancet"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"100715","DOI":"10.1016\/j.xcrm.2022.100715","article-title":"A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17\/Tc17 identity","volume":"3","author":"Cook","year":"2022","journal-title":"Cell Rep. Med."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Zitti, B., Hoffer, E., Zheng, W., Pandey, R.V., Schlums, H., Casoni, G.P., Fusi, I., Nguyen, L., K\u00e4rner, J., and Kokkinou, E. (2023). Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a. Immunity, 56.","DOI":"10.1016\/j.immuni.2023.05.003"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"eabb7028","DOI":"10.1126\/scitranslmed.abb7028","article-title":"Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease","volume":"12","author":"Strobl","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Vu, T.T., Koguchi-Yoshioka, H., and Watanabe, R. (2021). Skin-Resident Memory T Cells: Pathogenesis and Implication for the Treatment of Psoriasis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10173822"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.3389\/fimmu.2022.827786","article-title":"T cell interaction with activated endothelial cells primes for tissue-residency","volume":"13","author":"Wienke","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Kasprowicz-Furma\u0144czyk, M., Czerwi\u0144ska, J., Placek, W., and Owczarczyk-Saczonek, A. (2021). Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182111251"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jdermsci.2019.06.002","article-title":"Significance of IL-17A-producing CD8+CD103+ skin resident memory T cells in psoriasis lesion and their possible relationship to clinical course","volume":"95","author":"Kurihara","year":"2019","journal-title":"J. Dermatol. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Fenix, K., Wijesundara, D.K., Cowin, A.J., Grubor-Bauk, B., and Kopecki, Z. (2020). Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197228"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.189.9.1363","article-title":"Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism","volume":"189","author":"Munn","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1038\/s41587-022-01483-z","article-title":"High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging","volume":"40","author":"He","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jvc2.63","article-title":"Early intervention and disease memory in psoriasis: A literature review","volume":"1","author":"Emmanuel","year":"2022","journal-title":"JEADV Clin. Pract."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Bellinato, F., Chiricozzi, A., Piaserico, S., Targher, G., and Gisondi, P. (2022). Could Targeted Pharmacotherapies Exert a \u201cDisease Modification Effect\u201d in Patients with Chronic Plaque Psoriasis?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112849"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Lebwohl, M., Iversen, L., Eidsmo, L., Krueger, J.G., Su\u00e1rez-Fari\u00f1as, M., Tomalin, L., Kolbinger, F., You, R., and Milutinovic, M. (2023). Investigation of plaque psoriasis relapse after secukinumab withdrawal in patients from two Phase 3 studies. Clin. Exp. Dermatol., llad329.","DOI":"10.1093\/ced\/llad329"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/dermatopathology9020011","article-title":"Quantification of Immunohistochemically Stained Cells in Skin Biopsies","volume":"9","author":"Emmanuel","year":"2022","journal-title":"Dermatopathology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/11\/6086\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:52:00Z","timestamp":1760107920000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/11\/6086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":84,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ijms25116086"],"URL":"https:\/\/doi.org\/10.3390\/ijms25116086","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]}}}