{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:09:47Z","timestamp":1782472187128,"version":"3.54.5"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Myocardial infarction activates an intense fibro-inflammatory reaction that is essential for cardiac remodeling and heart failure (HF). Bioactive peptide galanin plays a critical role in regulating cardiovascular homeostasis; however, its specific functional relevance in post-infarction fibro-inflammatory reprogramming remains obscure. Here, we show that galanin coordinates the fibro-inflammatory trajectory and mitochondrial integrity in post-infarction reperfusion injury. Aberrant deposition of collagen was associated with a marked increase in CD68-positive macrophage infiltration in cardiac tissue in mice subjected to myocardial ischemia\/reperfusion (I\/R) for 14 days compared to sham controls. Furthermore, we found that the myocardial expression level of a specific marker of M2 macrophages, CD206, was significantly down-regulated in I\/R-challenged mice. In contrast, galanin treatment started during the reperfusion phase blunted the fibro-inflammatory responses and promoted the expression of CD206 in I\/R-remodeled hearts. In addition, we found that the anti-apoptotic and anti-hypertrophic effects of galanin were associated with the preservation of mitochondrial integrity and promotion of mitochondrial biogenesis. These findings depict galanin as a key arbitrator of fibro-inflammatory responses to cardiac I\/R injury and offer a promising therapeutic trajectory for the treatment of post-infarct cardiovascular complications.<\/jats:p>","DOI":"10.3390\/ijms25116211","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T05:59:42Z","timestamp":1717567182000},"page":"6211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury"],"prefix":"10.3390","volume":"25","author":[{"given":"Lesia","family":"Savchenko","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Poltava State Medical University, 23 Shevchenko, 36000 Poltava, Ukraine"},{"name":"National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomiia","family":"Kramar","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France"},{"name":"Histology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika","family":"Todua","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-5514","authenticated-orcid":false,"given":"Dimitri","family":"Marsal","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-128X","authenticated-orcid":false,"given":"Ryeonshi","family":"Kang","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Swiader","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Pizzinat","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Kunduzova","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104565","DOI":"10.1016\/j.mvr.2023.104565","article-title":"Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention","volume":"149","author":"Liu","year":"2023","journal-title":"Microvasc. 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