{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:56:28Z","timestamp":1765961788756,"version":"build-2065373602"},"reference-count":170,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG)","award":["SFB TRR219-M07","S199\/10084\/2021"],"award-info":[{"award-number":["SFB TRR219-M07","S199\/10084\/2021"]}]},{"name":"Corona Foundation","award":["SFB TRR219-M07","S199\/10084\/2021"],"award-info":[{"award-number":["SFB TRR219-M07","S199\/10084\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Circulating low-density lipoprotein (LDL) levels are a major risk factor for cardiovascular diseases (CVD), and even though current treatment strategies focusing on lowering lipid levels are effective, CVD remains the primary cause of death worldwide. Atherosclerosis is the major cause of CVD and is a chronic inflammatory condition in which various cell types and protein kinases play a crucial role. However, the underlying mechanisms of atherosclerosis are not entirely understood yet. Notably, protein kinases are highly druggable targets and represent, therefore, a novel way to target atherosclerosis. In this review, the potential role of the calcium\/calmodulin-dependent protein kinase-like (CaMKL) family and its role in atherosclerosis will be discussed. This family consists of 12 subfamilies, among which are the well-described and conserved liver kinase B1 (LKB1) and 5\u2032 adenosine monophosphate-activated protein kinase (AMPK) subfamilies. Interestingly, LKB1 plays a key role and is considered a master kinase within the CaMKL family. It has been shown that LKB1 signaling leads to atheroprotective effects, while, for example, members of the microtubule affinity-regulating kinase (MARK) subfamily have been described to aggravate atherosclerosis development. These observations highlight the importance of studying kinases and their signaling pathways in atherosclerosis, bringing us a step closer to unraveling the underlying mechanisms of atherosclerosis.<\/jats:p>","DOI":"10.3390\/ijms25116213","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T05:59:42Z","timestamp":1717567182000},"page":"6213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Navigating the Maze of Kinases: CaMK-like Family Protein Kinases and Their Role in Atherosclerosis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4179-3409","authenticated-orcid":false,"given":"Jules T. J.","family":"Teuwen","sequence":"first","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-6278","authenticated-orcid":false,"given":"Emiel P. C.","family":"van der Vorst","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80336 M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-8901","authenticated-orcid":false,"given":"Sanne L.","family":"Maas","sequence":"additional","affiliation":[{"name":"Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"ref_1","unstructured":"British_Heart_Foundation (2024, May 27). Global Heart & Circulatory Diseases Factsheet. Available online: https:\/\/www.bhf.org.uk\/-\/media\/files\/for-professionals\/research\/heart-statistics\/bhf-cvd-statistics-global-factsheet.pdf?rev=e61c05db17e9439a8c2e4720f6ca0a19&hash=6350DE1B2A19D939431D876311077C7B."},{"key":"ref_2","unstructured":"European_Society_of_Cardiology (2024, May 27). Understanding the Burden of CVD. Available online: https:\/\/www.escardio.org\/The-ESC\/Advocacy\/understanding-the-burden-of-cvd-facts-and-figures."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1001\/jama.1990.03450230083034","article-title":"Lipoproteins and atherogenesis. Current concepts","volume":"264","author":"Steinberg","year":"1990","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/2231159a0","article-title":"Arterial wall shear and distribution of early atheroma in man","volume":"223","author":"Caro","year":"1969","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41569-023-00883-1","article-title":"Flow-induced reprogramming of endothelial cells in atherosclerosis","volume":"20","author":"Tamargo","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/ncomms2199","article-title":"Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo","volume":"3","author":"Orsenigo","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1161\/01.ATV.9.6.908","article-title":"Initiation of atherosclerotic lesions in cholesterol-fed rabbits. II. Selective retention of LDL vs. selective increases in LDL permeability in susceptible sites of arteries","volume":"9","author":"Schwenke","year":"1989","journal-title":"Arteriosclerosis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.ATV.15.4.534","article-title":"Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media","volume":"15","author":"Nordestgaard","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/CIRCRESAHA.110.223875","article-title":"Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity","volume":"108","author":"Miller","year":"2011","journal-title":"Circ. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1093\/eurheartj\/eht532","article-title":"Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo","volume":"35","author":"Akhmedov","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1124\/jpet.102.034959","article-title":"Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: Role of LOX-1","volume":"302","author":"Li","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/ATVBAHA.116.308367","article-title":"Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP\/ApoE\u2212\/\u2212 Reporter Mouse-Brief Report","volume":"37","author":"McNeill","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"14519","DOI":"10.1016\/S0021-9258(18)98717-X","article-title":"Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages","volume":"266","author":"Lougheed","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0005-2760(92)90287-6","article-title":"The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages","volume":"1126","author":"Jessup","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1161\/CIRCRESAHA.107.149724","article-title":"Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet","volume":"100","author":"Mehta","year":"2007","journal-title":"Circ. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/cr.2017.8","article-title":"Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis","volume":"27","author":"Luo","year":"2017","journal-title":"Cell Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1194\/jlr.M060053","article-title":"ABCA1 contributes to macrophage deposition of extracellular cholesterol","volume":"56","author":"Jin","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_19","first-page":"e427","article-title":"Fibrous Caps in Atherosclerosis Form by Notch-Dependent Mechanisms Common to Arterial Media Development","volume":"41","author":"Caballero","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41569-019-0227-9","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"16","author":"Basatemur","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1073\/pnas.87.13.5134","article-title":"Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells","volume":"87","author":"Cushing","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1161\/ATVBAHA.119.312434","article-title":"Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis","volume":"39","author":"Wang","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014An inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fcvm.2017.00002","article-title":"Eating the Dead to Keep Atherosclerosis at Bay","volume":"4","author":"Brophy","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI25074","article-title":"Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice","volume":"116","author":"Gough","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.ATV.11.5.1223","article-title":"Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells","volume":"11","author":"Amento","year":"1991","journal-title":"Arterioscler. Thromb."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00395-010-0135-y","article-title":"Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability","volume":"106","author":"Erbel","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00428-006-0176-7","article-title":"Atherosclerosis research from past to present--on the track of two pathologists with opposing views, Carl von Rokitansky and Rudolf Virchow","volume":"449","author":"Mayerl","year":"2006","journal-title":"Virchows Arch."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jaccao.2022.09.005","article-title":"LAG3 Regulates T Cell Activation and Plaque Infiltration in Atherosclerotic Mice","volume":"4","author":"Mulholland","year":"2022","journal-title":"JACC Cardio Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"42526","DOI":"10.1038\/srep42526","article-title":"Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice with Macrophage-Specific Loss of Trpc3","volume":"7","author":"Solanki","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","article-title":"Inflammation and atherosclerosis: Signaling pathways and therapeutic intervention","volume":"7","author":"Kong","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_32","unstructured":"Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. (2024, June 01). General Principles of Cell Communication, Molecular Biology of the Cell, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK26813\/."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41586-022-05575-3","article-title":"An atlas of substrate specificities for the human serine\/threonine kinome","volume":"613","author":"Johnson","year":"2023","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"E127","DOI":"10.1038\/ncb0502-e127","article-title":"The origins of protein phosphorylation","volume":"4","author":"Cohen","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"106847","DOI":"10.1016\/j.phrs.2023.106847","article-title":"Small molecule protein kinase inhibitors approved by regulatory agencies outside of the United States","volume":"194","author":"Roskoski","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_36","unstructured":"NC-IUBMB (2024, January 31). Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes by the Reactions They Catalyse. Available online: https:\/\/iubmb.qmul.ac.uk\/enzyme\/."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(91)00125-G","article-title":"Protein kinase classification","volume":"200","author":"Hunter","year":"1991","journal-title":"Methods Enzymol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.molcel.2022.05.007","article-title":"A journey from phosphotyrosine to phosphohistidine and beyond","volume":"82","author":"Hunter","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ijbiomac.2021.01.015","article-title":"Protein arginine phosphorylation in organisms","volume":"171","author":"Huang","year":"2021","journal-title":"Int. J. Biol. Macro Mol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1096\/fasebj.9.8.7768349","article-title":"Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification","volume":"9","author":"Hanks","year":"1995","journal-title":"FASEB J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1042\/BCJ20220217","article-title":"How many kinases are druggable? A review of our current understanding","volume":"480","author":"Anderson","year":"2023","journal-title":"Biochem. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"100128","DOI":"10.1016\/j.xcrm.2020.100128","article-title":"The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer","volume":"1","author":"Essegian","year":"2020","journal-title":"Cell Rep. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1074\/jbc.271.15.8675","article-title":"Non-catalytic beta- and gamma-subunit isoforms of the 5\u2032-AMP-activated protein kinase","volume":"271","author":"Gao","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41422-020-0301-1","article-title":"Signaling networks in immunometabolism","volume":"30","author":"Saravia","year":"2020","journal-title":"Cell Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature11862","article-title":"Metabolism of inflammation limited by AMPK and pseudo-starvation","volume":"493","author":"Hardie","year":"2013","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1189\/jlb.0313157","article-title":"AMPKalpha1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling","volume":"94","author":"Carroll","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1172\/JCI81676","article-title":"MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis","volume":"125","author":"Ouimet","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"34561","DOI":"10.1074\/jbc.M109.028043","article-title":"Activation of AMP-activated protein kinase suppresses oxidized low-density lipoprotein-induced macrophage proliferation","volume":"284","author":"Ishii","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3892\/etm.2022.11573","article-title":"Metformin suppresses foam cell formation, inflammation and ferroptosis via the AMPK\/ERK signaling pathway in ox-LDL-induced THP-1 monocytes","volume":"24","author":"Zhao","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2015.08.012","article-title":"AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A\/NF-\u03baappaB\/LOX-1 pathway","volume":"85","author":"Chen","year":"2016","journal-title":"Vascul. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"113784","DOI":"10.1016\/j.yexcr.2023.113784","article-title":"AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway","volume":"432","author":"Owaki","year":"2023","journal-title":"Exp. Cell Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.2337\/db15-0917","article-title":"Myeloid Deletion of alpha1AMPK Exacerbates Atherosclerosis in LDL Receptor Knockout (LDLRKO) Mice","volume":"65","author":"Cao","year":"2016","journal-title":"Diabetes"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/CIRCULATIONAHA.109.900928","article-title":"Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo","volume":"121","author":"Dong","year":"2010","journal-title":"Circulation"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Fisslthaler, B., Zippel, N., Abdel Malik, R., Delgado Lagos, F., Zukunft, S., Thoele, J., Siuda, D., Soehnlein, O., Wittig, I., and Heidler, J. (2019). Myeloid-Specific Deletion of the AMPKalpha2 Subunit Alters Monocyte Protein Expression and Atherogenesis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20123005"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1074\/jbc.M117.779447","article-title":"AMP-activated protein kinase alpha1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation","volume":"292","author":"Zhang","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1194\/jlr.RA120001040","article-title":"Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice","volume":"61","author":"LeBlond","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1055\/a-2201-8728","article-title":"Chloroquine Alleviates Atherosclerosis by Modulating Regulatory T Cells Through the ATM\/AMPK\/mTOR Signaling Pathway in ApoE\u2212\/\u2212 Mice","volume":"131","author":"Liu","year":"2023","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12933-017-0623-6","article-title":"Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17\/Treg balance in AMPK-dependent mechanisms","volume":"16","author":"Tian","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fimmu.2019.00115","article-title":"Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis","volume":"10","author":"Cluxton","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.119.316461","article-title":"Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression","volume":"127","author":"Sharma","year":"2020","journal-title":"Circ. Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Cheng, Y.F., Young, G.H., Lin, J.T., Jang, H.H., Chen, C.C., Nong, J.Y., Chen, P.K., Kuo, C.Y., Kao, S.H., and Liang, Y.J. (2015). Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142283"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1161\/ATVBAHA.111.237453","article-title":"AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300","volume":"31","author":"Zhang","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"9173530","DOI":"10.1155\/2020\/9173530","article-title":"Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK\/SIRT1 Pathway","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2017.09.026","article-title":"AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species","volume":"21","author":"Rabinovitch","year":"2017","journal-title":"Cell Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/cr.2011.20","article-title":"Mitochondrial ROS fuel the inflammasome","volume":"21","author":"Sorbara","year":"2011","journal-title":"Cell Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Niyonzima, N., Bakke, S.S., Gregersen, I., Holm, S., Sandanger, O., Orrem, H.L., Sporsheim, B., Ryan, L., Kong, X.Y., and Dahl, T.B. (2020). Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis. eBioMedicine, 60.","DOI":"10.1016\/j.ebiom.2020.102985"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jacc.2014.11.039","article-title":"Cholesterol crystals associate with coronary plaque vulnerability in vivo","volume":"65","author":"Kataoka","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_72","first-page":"cm1","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1038\/s41467-018-07132-x","article-title":"PRKAA1\/AMPKalpha1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis","volume":"9","author":"Yang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1111\/jcmm.13196","article-title":"C1q\/TNF-related protein 9 inhibits the cholesterol-induced Vascular smooth muscle cell phenotype switch and cell dysfunction by activating AMP-dependent kinase","volume":"21","author":"Liu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"12348","DOI":"10.3892\/mmr.2021.12348","article-title":"Metformin inhibits cholesterol-induced adhesion molecule expression via activating the AMPK signaling pathway in vascular smooth muscle cells","volume":"24","author":"Liu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/labinvest.2016.116","article-title":"CD68\/macrosialin: Not just a histochemical marker","volume":"97","author":"Chistiakov","year":"2017","journal-title":"Lab. Investig."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/CIRCRESAHA.116.308301","article-title":"Ablation of Adenosine Monophosphate-Activated Protein Kinase alpha1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo","volume":"119","author":"Cai","year":"2016","journal-title":"Circ. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/CIRCRESAHA.116.308689","article-title":"AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability","volume":"119","author":"Ding","year":"2016","journal-title":"Circ. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00109-018-1627-8","article-title":"AMPKalpha inactivation destabilizes atherosclerotic plaque in streptozotocin-induced diabetic mice through AP-2alpha\/miRNA-124 axis","volume":"96","author":"Liang","year":"2018","journal-title":"J. Mol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nm.3866","article-title":"KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis","volume":"21","author":"Shankman","year":"2015","journal-title":"Nat. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1007\/s00018-014-1666-4","article-title":"Functional interplay between ATM\/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress","volume":"71","author":"Yan","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1101\/gad.14.12.1439","article-title":"Aberrant cell cycle checkpoint function and early embryonic death in Chk1(\u2212\/\u2212) mice","volume":"14","author":"Takai","year":"2000","journal-title":"Genes Dev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41556-023-01096-x","article-title":"SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence","volume":"25","author":"Gioia","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cardiores.2006.03.002","article-title":"DNA damage and repair in atherosclerosis","volume":"71","author":"Mahmoudi","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/hh0701.088684","article-title":"Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering","volume":"88","author":"Martinet","year":"2001","journal-title":"Circ. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"14608","DOI":"10.1038\/s41598-021-94097-5","article-title":"Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis","volume":"11","author":"Honda","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"74473","DOI":"10.18632\/oncotarget.12578","article-title":"7-Ketocholesterol induces ATM\/ATR, Chk1\/Chk2, PI3K\/Akt signalings, cytotoxicity and IL-8 production in endothelial cells","volume":"7","author":"Chang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"106177","DOI":"10.18632\/oncotarget.22425","article-title":"Lysophosphatidylcholine induces cytotoxicity\/apoptosis and IL-8 production of human endothelial cells: Related mechanisms","volume":"8","author":"Chang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1187490","DOI":"10.3389\/fcvm.2023.1187490","article-title":"Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition","volume":"10","author":"Nguyen","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.atherosclerosis.2020.09.014","article-title":"The phosphorylation of CHK1 at Ser345 regulates the phenotypic switching of vascular smooth muscle cells both in vitro and in vivo","volume":"313","author":"Xin","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.emboj.7600110","article-title":"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1","volume":"23","author":"Lizcano","year":"2004","journal-title":"EMBO J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.febslet.2005.01.042","article-title":"Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate","volume":"579","author":"Jaleel","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.cub.2003.10.031","article-title":"LKB1 is the upstream kinase in the AMP-activated protein kinase cascade","volume":"13","author":"Woods","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.1062074","article-title":"Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice","volume":"293","author":"Ylikorkala","year":"2001","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"131363","DOI":"10.1016\/j.ijcard.2023.131363","article-title":"LKB1 delays atherosclerosis by inhibiting phenotypic transformation of vascular smooth muscle cells","volume":"394","author":"Chen","year":"2024","journal-title":"Int. J. Cardiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/ncb2884","article-title":"A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway","volume":"16","author":"Mohseni","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2020.01.015","article-title":"AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control","volume":"31","author":"Gonzalez","year":"2020","journal-title":"Cell Metab."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccr.2004.06.007","article-title":"The LKB1 tumor suppressor negatively regulates mTOR signaling","volume":"6","author":"Shaw","year":"2004","journal-title":"Cancer Cell"},{"key":"ref_101","unstructured":"Hawley, S.A., Boudeau, J., Reid, J.L., Mustard, K.J., Udd, L., Makela, T.P., Alessi, D.R., and Hardie, D.G. (2003). Complexes between the LKB1 tumor suppressor, STRAD alpha\/beta and MO25 alpha\/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol., 2."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/CIRCRESAHA.122.321322","article-title":"MST1 Suppresses Disturbed Flow Induced Atherosclerosis","volume":"131","author":"Quan","year":"2022","journal-title":"Circ. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2007.09.019","article-title":"Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR\u2212\/\u2212 mice despite severe hypercholesterolemia","volume":"198","author":"Mueller","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/CIRCRESAHA.117.311546","article-title":"Macrophage Liver Kinase B1 Inhibits Foam Cell Formation and Atherosclerosis","volume":"121","author":"Liu","year":"2017","journal-title":"Circ. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"990","DOI":"10.4049\/jimmunol.1900117","article-title":"Tim-4 Inhibits NLRP3 Inflammasome via the LKB1\/AMPKalpha Pathway in Macrophages","volume":"203","author":"Liu","year":"2019","journal-title":"J. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1515\/hsz-2018-0461","article-title":"LncRNA DYNLRB2-2 inhibits THP-1 macrophage foam cell formation by enhancing autophagy","volume":"400","author":"Li","year":"2019","journal-title":"Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1074\/jbc.M114.616441","article-title":"Liver kinase B1 suppresses lipopolysaccharide-induced nuclear factor kappaB (NF-\u03baappaB) activation in macrophages","volume":"290","author":"Liu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00109-021-02090-2","article-title":"LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1","volume":"99","author":"Pandit","year":"2021","journal-title":"J. Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/j.celrep.2019.05.020","article-title":"Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of T(reg) Cells","volume":"27","author":"Timilshina","year":"2019","journal-title":"Cell Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.atherosclerosis.2011.03.043","article-title":"Activation of Th17\/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome","volume":"217","author":"Zhao","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.imbio.2010.11.002","article-title":"Transcriptional regulation of Foxp3 in regulatory T cells","volume":"216","author":"Haiqi","year":"2011","journal-title":"Immunobiology"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"de Boer, O.J., van der Meer, J.J., Teeling, P., van der Loos, C.M., and van der Wal, A.C. (2007). Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000779"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"15876","DOI":"10.1038\/ncomms15876","article-title":"Lkb1 maintains T(reg) cell lineage identity","volume":"8","author":"Wu","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-beta activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1161\/CIRCULATIONAHA.119.045344","article-title":"CD4(+) T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation","volume":"142","author":"Cui","year":"2020","journal-title":"Circulation"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41419-023-06054-x","article-title":"Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6","volume":"14","author":"Deng","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zhang, T., Li, H., Ouyang, C., Cao, G., Gao, J., Wu, J., Yang, J., Yu, N., Min, Q., and Zhang, C. (2021). Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1. Redox Biol., 38.","DOI":"10.1016\/j.redox.2020.101828"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1096\/fj.09-148064","article-title":"Structure and function of polarity-inducing kinase family MARK\/Par-1 within the branch of AMPK\/Snf1-related kinases","volume":"24","author":"Marx","year":"2010","journal-title":"FASEB J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.compbiolchem.2018.11.010","article-title":"Conditional GWAS revealing genetic impacts of lifestyle behaviors on low-density lipoprotein (LDL)","volume":"78","author":"Liu","year":"2019","journal-title":"Comput. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"11307","DOI":"10.1111\/jcmm.15710","article-title":"LKB1-MARK2 signalling mediates lipopolysaccharide-induced production of cytokines in mouse macrophages","volume":"24","author":"Deng","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1161\/ATVBAHA.119.312478","article-title":"MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report","volume":"39","author":"Clement","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molcel.2017.08.017","article-title":"NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation","volume":"68","author":"Song","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/boc.201400004","article-title":"Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways","volume":"106","author":"Feng","year":"2014","journal-title":"Biol. Cell"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1007\/s10753-020-01204-1","article-title":"Suberoylanilide Hydroxamic Acid Attenuates Interleukin-1beta-Induced Interleukin-6 Upregulation by Inhibiting the Microtubule Affinity-Regulating Kinase 4\/Nuclear Factor-kappaB Pathway in Synovium-Derived Mesenchymal Stem Cells from the Temporomandibular Joint","volume":"43","author":"Sun","year":"2020","journal-title":"Inflammation"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"21382","DOI":"10.1038\/srep21382","article-title":"Mark4 promotes oxidative stress and inflammation via binding to PPARgamma and activating NF-\u03baappaB pathway in mice adipocytes","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcp.30530","article-title":"Microtubule affinity regulating kinase 4: A promising target in the pathogenesis of atherosclerosis","volume":"237","author":"Qin","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1021\/acsptsci.3c00084","article-title":"Synthesis, Structural Modification, and Bioactivity Evaluation of Substituted Acridones as Potent Microtubule Affinity-Regulating Kinase 4 Inhibitors","volume":"6","author":"Voura","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41419-018-0489-x","article-title":"Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38\/MELK activity","volume":"9","author":"Seong","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"8642","DOI":"10.1074\/jbc.M311466200","article-title":"Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1","volume":"279","author":"Vulsteke","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"9751","DOI":"10.1158\/0008-5472.CAN-04-4531","article-title":"Maternal embryonic leucine zipper kinase\/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers","volume":"65","author":"Gray","year":"2005","journal-title":"Cancer Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"40003","DOI":"10.1074\/jbc.M507274200","article-title":"Substrate specificity and activity regulation of protein kinase MELK","volume":"280","author":"Beullens","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.freeradbiomed.2021.06.012","article-title":"Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis","volume":"172","author":"Tang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3389\/fonc.2020.01123","article-title":"Cytosolic NUAK1 Enhances ATP Production by Maintaining Proper Glycolysis and Mitochondrial Function in Cancer Cells","volume":"10","author":"Escalona","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41420-024-01814-w","article-title":"ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells","volume":"10","author":"Karnan","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1038\/s41467-024-46146-6","article-title":"The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions","volume":"15","author":"Lanfranchi","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3892\/etm.2021.10129","article-title":"Role of ARK5 in cancer and other diseases (Review)","volume":"22","author":"Mo","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4103\/0022-3859.113836","article-title":"Transcription activity of MMP-2 and MMP-9 metalloproteinase genes and their tissue inhibitor (TIMP-2) in acute coronary syndrome patients","volume":"59","author":"Dabek","year":"2013","journal-title":"J. Postgrad. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1038\/s41598-022-06796-2","article-title":"Loss of LKB1-NUAK1 signalling enhances NF-\u03baappaB activity in a spheroid model of high-grade serous ovarian cancer","volume":"12","author":"Buensuceso","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2337\/db17-0745","article-title":"Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans","volume":"67","author":"Li","year":"2018","journal-title":"Diabetes"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/ATVBAHA.106.131755","article-title":"Adipose tissue and atherosclerosis: Exploring the connection","volume":"27","author":"Fantuzzi","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/01.CIR.67.5.968","article-title":"Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study","volume":"67","author":"Hubert","year":"1983","journal-title":"Circulation"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e771","DOI":"10.1002\/ctm2.771","article-title":"GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2","volume":"12","author":"Lin","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"44005","DOI":"10.1074\/jbc.M111.254995","article-title":"Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion","volume":"286","author":"Semplici","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1007\/s00125-016-4025-1","article-title":"Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production","volume":"59","author":"Semplici","year":"2016","journal-title":"Diabetologia"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Hinds, T.D., Kipp, Z.A., Xu, M., Yiannikouris, F.B., Morris, A.J., Stec, D.F., Wahli, W., and Stec, D.E. (2021). Adipose-Specific PPARalpha Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue. Cells, 11.","DOI":"10.3390\/cells11010004"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fphar.2015.00238","article-title":"Nuciferine downregulates Per-Arnt-Sim kinase expression during its alleviation of lipogenesis and inflammation on oleic acid-induced hepatic steatosis in HepG2 cells","volume":"6","author":"Zhang","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"12867","DOI":"10.1074\/jbc.M111.307249","article-title":"Transcriptional induction of salt-inducible kinase 1 by transforming growth factor beta leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase","volume":"287","author":"Lonn","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1111\/j.1742-4658.2007.05889.x","article-title":"TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain","volume":"274","author":"Takemori","year":"2007","journal-title":"FEBS J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature06128","article-title":"Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2","volume":"449","author":"Dentin","year":"2007","journal-title":"Nature"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"ra83","DOI":"10.1126\/scisignal.2004214","article-title":"The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis","volume":"6","author":"Kotla","year":"2013","journal-title":"Sci. Signal."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1096\/fj.12-205609","article-title":"Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability","volume":"26","author":"Eneling","year":"2012","journal-title":"FASEB J."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/BCJ20160646","article-title":"Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages","volume":"474","author":"Darling","year":"2017","journal-title":"Biochem. J."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1189\/jlb.2A0715-307R","article-title":"SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype","volume":"99","author":"Lombardi","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1185587","DOI":"10.3389\/fimmu.2023.1185587","article-title":"Macrophage polarization states in atherosclerosis","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"12468","DOI":"10.1073\/pnas.1412308111","article-title":"Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells","volume":"111","author":"Sundberg","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"eaat9356","DOI":"10.1126\/scitranslmed.aat9356","article-title":"The PTH\/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling","volume":"10","author":"Csukasi","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molmet.2019.07.009","article-title":"Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue","volume":"28","author":"Li","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.2337\/db12-1081","article-title":"Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation","volume":"62","author":"Li","year":"2013","journal-title":"Diabetes"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e012792","DOI":"10.1161\/JAHA.119.012792","article-title":"Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart","volume":"8","author":"Thirugnanam","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1038\/s41467-019-10116-0","article-title":"Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK\/NF-\u03baappaB\/p65 regulatory axis","volume":"10","author":"Lu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1056\/NEJMoa2215024","article-title":"Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients","volume":"388","author":"Nissen","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1194\/jlr.M035212","article-title":"ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK","volume":"54","author":"Filippov","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41574-023-00833-4","article-title":"Metformin: Update on mechanisms of action and repurposing potential","volume":"19","author":"Foretz","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejphar.2019.03.006","article-title":"Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A","volume":"852","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"155160","DOI":"10.1016\/j.metabol.2022.155160","article-title":"Metformin and the heart: Update on mechanisms of cardiovascular protection with special reference to comorbid type 2 diabetes and heart failure","volume":"130","author":"Schernthaner","year":"2022","journal-title":"Metabolism"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41416-023-02279-x","article-title":"A Phase 1\/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer","volume":"129","author":"Kristeleit","year":"2023","journal-title":"Br. J. Cancer"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ygyno.2022.09.019","article-title":"A Phase 2 study of prexasertib (LY2606368) in platinum resistant or refractory recurrent ovarian cancer","volume":"167","author":"Konstantinopoulos","year":"2022","journal-title":"Gynecol. Oncol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1158\/1078-0432.CCR-12-2442","article-title":"Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias","volume":"18","author":"Karp","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"TPS5616","DOI":"10.1200\/JCO.2022.40.16_suppl.TPS5616","article-title":"GRN300\u2013001: Phase 1\/1B evaluation of the safety, pharmacokinetics, and efficacy of GRN-300, a salt-inducible kinase inhibitor, alone and in combination with paclitaxel, in recurrent ovarian, primary peritoneal, and fallopian tube cancers","volume":"40","author":"Fu","year":"2022","journal-title":"J. Clin. Oncol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/11\/6213\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:54:02Z","timestamp":1760108042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/11\/6213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":170,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ijms25116213"],"URL":"https:\/\/doi.org\/10.3390\/ijms25116213","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2024,6,5]]}}}