{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:55:10Z","timestamp":1783698910780,"version":"3.55.0"},"reference-count":175,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH National Institute of Dental and Craniofacial Research (NIDCR)","award":["R01 DE028536"],"award-info":[{"award-number":["R01 DE028536"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Streptococcus gordonii (S. gordonii, Sg) is one of the early colonizing, supragingival commensal bacterium normally associated with oral health in human dental plaque. MicroRNAs (miRNAs) play an important role in the inflammation-mediated pathways and are involved in periodontal disease (PD) pathogenesis. PD is a polymicrobial dysbiotic immune-inflammatory disease initiated by microbes in the gingival sulcus\/pockets. The objective of this study is to determine the global miRNA expression kinetics in S. gordonii DL1-infected C57BL\/6J mice. All mice were randomly divided into four groups (n = 10 mice\/group; 5 males and 5 females). Bacterial infection was performed in mice at 8 weeks and 16 weeks, mice were euthanized, and tissues harvested for analysis. We analyzed differentially expressed (DE) miRNAs in the mandibles of S. gordonii-infected mice. Gingival colonization\/infection by S. gordonii and alveolar bone resorption (ABR) was confirmed. All the S. gordonii-infected mice at two specific time points showed bacterial colonization (100%) in the gingival surface, and a significant increase in mandible and maxilla ABR (p &lt; 0.0001). miRNA profiling revealed 191 upregulated miRNAs (miR-375, miR-34b-5p) and 22 downregulated miRNAs (miR-133, miR-1224) in the mandibles of S. gordonii-infected mice at the 8-week mark. Conversely, at 16 weeks post-infection, 10 miRNAs (miR-1902, miR-203) were upregulated and 32 miRNAs (miR-1937c, miR-720) were downregulated. Two miRNAs, miR-210 and miR-423-5p, were commonly upregulated, and miR-2135 and miR-145 were commonly downregulated in both 8- and 16-week-infected mice mandibles. Furthermore, we employed five machine learning (ML) algorithms to assess how the number of miRNA copies correlates with S. gordonii infections in mice. In the ML analyses, miR-22 and miR-30c (8-week), miR-720 and miR-339-5p (16-week), and miR-720, miR-22, and miR-339-5p (combined 8- and 16-week) emerged as the most influential miRNAs.<\/jats:p>","DOI":"10.3390\/ijms25116217","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T11:50:09Z","timestamp":1717588209000},"page":"6217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Streptococcus gordonii Supragingival Bacterium Oral Infection-Induced Periodontitis and Robust miRNA Expression Kinetics"],"prefix":"10.3390","volume":"25","author":[{"given":"Chairmandurai","family":"Aravindraja","sequence":"first","affiliation":[{"name":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-8619","authenticated-orcid":false,"given":"Syam","family":"Jeepipalli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3106-400X","authenticated-orcid":false,"given":"Krishna Mukesh","family":"Vekariya","sequence":"additional","affiliation":[{"name":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaik O.","family":"Rahaman","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward K. L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-8656","authenticated-orcid":false,"given":"Lakshmyya","family":"Kesavalu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"},{"name":"Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abranches, J., Zeng, L., Kajfasz, J.K., Palmer, S.R., Chakraborty, B., Wen, Z.T., Richards, V.P., Brady, L.J., and Lemos, J.A. (2018). Biology of Oral Streptococci. Microbiol. Spectr.","DOI":"10.1128\/microbiolspec.GPP3-0042-2018"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/1348-0421.13028","article-title":"Oral mitis group streptococci: A silent majority in our oral cavity","volume":"66","author":"Okahashi","year":"2022","journal-title":"Microbiol. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tripleo.2004.10.008","article-title":"Streptococci from root canals in teeth with apical periodontitis receiving endodontic treatment","volume":"100","author":"Svensater","year":"2005","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol. Endod."},{"key":"ref_4","first-page":"7127848","article-title":"Streptococcus gordonii: A Rare Cause of Infective Endocarditis","volume":"2019","author":"Mosailova","year":"2019","journal-title":"Case Rep. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"omab145","DOI":"10.1093\/omcr\/omab145","article-title":"Acute abdomen revealed Streptococcus gordonii infective endocarditis with systemic embolism","volume":"2022","author":"Chang","year":"2022","journal-title":"Oxf. Med. Case Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijid.2019.03.007","article-title":"Detection of pathogens from resected heart valves of patients with infective endocarditis by next-generation sequencing","volume":"83","author":"Cheng","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1128\/JB.186.13.4246-4253.2004","article-title":"Involvement of Streptococcus gordonii beta-glucoside metabolism systems in adhesion, biofilm formation, and in vivo gene expression","volume":"186","author":"Kilic","year":"2004","journal-title":"J. Bacteriol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrmicro2381","article-title":"Oral multispecies biofilm development and the key role of cell-cell distance","volume":"8","author":"Kolenbrander","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"717843","DOI":"10.1155\/2012\/717843","article-title":"The role of hydrogen peroxide in environmental adaptation of oral microbial communities","volume":"2012","author":"Zhu","year":"2012","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Park, O.J., Kwon, Y., Park, C., So, Y.J., Park, T.H., Jeong, S., Im, J., Yun, C.H., and Han, S.H. (2020). Streptococcus gordonii: Pathogenesis and Host Response to Its Cell Wall Components. Microorganisms, 8.","DOI":"10.3390\/microorganisms8121852"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1128\/IAI.00366-08","article-title":"Interaction of Porphyromonas gingivalis with oral streptococci requires a motif that resembles the eukaryotic nuclear receptor box protein-protein interaction domain","volume":"76","author":"Daep","year":"2008","journal-title":"Infect. Immun."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yang, R., Liu, T., Pang, C., Cai, Y., Lin, Z., Guo, L., and Wei, X. (2022). The Regulatory Effect of Coaggregation Between Fusobacterium nucleatum and Streptococcus gordonii on the Synergistic Virulence to Human Gingival Epithelial Cells. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.879423"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/jre.13173","article-title":"New putative periodontopathogens and periodontal health-associated species: A systematic review and meta-analysis","volume":"58","author":"Antezack","year":"2023","journal-title":"J. Periodontal Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: From microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e32826","DOI":"10.1097\/MD.0000000000032826","article-title":"MicroRNA-375 in extracellular vesicles\u2014Novel marker for esophageal cancer diagnosis","volume":"102","author":"Chen","year":"2023","journal-title":"Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.3748\/wjg.v19.i27.4289","article-title":"miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis","volume":"19","author":"Coskun","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mehterov, N., Vladimirov, B., Sacconi, A., Pulito, C., Rucinski, M., Blandino, G., and Sarafian, V. (2021). Salivary miR-30c-5p as Potential Biomarker for Detection of Oral Squamous Cell Carcinoma. Biomedicines, 9.","DOI":"10.3390\/biomedicines9091079"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s11033-019-04614-z","article-title":"Serum miR-30c-5p is a potential biomarker for multiple system atrophy","volume":"46","author":"Vallelunga","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Aravindraja, C., Kashef, M.R., Vekariya, K.M., Ghanta, R.K., Karanth, S., Chan, E.K.L., and Kesavalu, L. (2022). Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095107"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e0058621","DOI":"10.1128\/iai.00586-21","article-title":"Streptococcus gordonii-Induced miRNAs Regulate CCL20 Responses in Human Oral Epithelial Cells","volume":"90","author":"Alimova","year":"2022","journal-title":"Infect. Immun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.molimm.2018.05.008","article-title":"MicroRNA-21 down-regulates insflammation and inhibits periodontitis","volume":"101","author":"Zhou","year":"2018","journal-title":"Mol. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/jcb.29482","article-title":"IL1\u03b2 inhibits differentiation of cementoblasts via microRNA-325-3p","volume":"121","author":"Wang","year":"2020","journal-title":"J. Cell Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Aravindraja, C., Jeepipalli, S., Duncan, W., Vekariya, K.M., Bahadekar, S., Chan, E.K.L., and Kesavalu, L. (2023). Unique miRomics Expression Profiles in Tannerella forsythia-Infected Mandibles during Periodontitis Using Machine Learning. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216393"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1128\/IAI.01062-10","article-title":"Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-\/- mice during experimental periodontal disease","volume":"79","author":"Nahid","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Aravindraja, C., Jeepipalli, S., Vekariya, K.M., Botello-Escalante, R., Chan, E.K.L., and Kesavalu, L. (2023). Oral Spirochete Treponema denticola Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during Periodontitis. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202307.0887.v1"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1902\/jop.2015.150319","article-title":"Evaluation of MicroRNA-146a and Its Targets in Gingival Tissues of Patients With Chronic Periodontitis","volume":"86","author":"Motedayyen","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4248\/IJOS11046","article-title":"Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues","volume":"3","author":"Xie","year":"2011","journal-title":"Int. J. Oral. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/odi.12994","article-title":"Comparison of miRNA expression profiles in individuals with chronic or aggressive periodontitis","volume":"25","author":"Amaral","year":"2019","journal-title":"Oral. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"587381","DOI":"10.3389\/fphys.2020.587381","article-title":"Plasma- and Saliva Exosome Profile Reveals a Distinct MicroRNA Signature in Chronic Periodontitis","volume":"11","author":"Awang","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Aravindraja, C., Vekariya, K.M., Botello-Escalante, R., Rahaman, S.O., Chan, E.K.L., and Kesavalu, L. (2023). Specific microRNA Signature Kinetics in Porphyromonas gingivalis-Induced Periodontitis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032327"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1128\/IAI.01511-14","article-title":"Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-\/-) mice causally links periodontal disease and atherosclerosis","volume":"82","author":"Chukkapalli","year":"2014","journal-title":"Infect. Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jdsr.2021.09.005","article-title":"Mechanism of alveolar bone destruction in periodontitis\u2014Periodontal bacteria and inflammation","volume":"57","author":"Usui","year":"2021","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1007\/s00784-022-04465-2","article-title":"Oral bacteria in infective endocarditis requiring surgery: A retrospective analysis of 134 patients","volume":"26","author":"Deppe","year":"2022","journal-title":"Clin. Oral. Investig."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Gallelli, L., Cione, E., Peltrone, F., Siviglia, S., Verano, A., Chirchiglia, D., Zampogna, S., Guidetti, V., Sammartino, L., and Montana, A. (2019). Hsa-miR-34a-5p and hsa-miR-375 as Biomarkers for Monitoring the Effects of Drug Treatment for Migraine Pain in Children and Adolescents: A Pilot Study. J. Clin. Med., 8.","DOI":"10.3390\/jcm8070928"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.redox.2017.03.001","article-title":"Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK\/GSK3beta-Nrf2 signal axis","volume":"12","author":"Lv","year":"2017","journal-title":"Redox Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1002\/jcp.26274","article-title":"miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin","volume":"233","author":"Xie","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12974-017-0832-7","article-title":"MicroRNA-142 regulates inflammation and T cell differentiation in an animal model of multiple sclerosis","volume":"14","author":"Talebi","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/bpa.12865","article-title":"Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation","volume":"30","author":"Korotkov","year":"2020","journal-title":"Brain Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1073\/pnas.1018493108","article-title":"A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1177\/0885328218763318","article-title":"Released fibroblast growth factor18 from a collagen membrane induces osteoblastic activity involved with downregulation of miR-133a and miR-135a","volume":"32","author":"Imamura","year":"2018","journal-title":"J. Biomater. Appl."},{"key":"ref_41","first-page":"2393","article-title":"MicroRNA-135a-5p is involved in osteoporosis progression through regulation of osteogenic differentiation by targeting RUNX2","volume":"18","author":"Shi","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"59S","DOI":"10.1177\/0022034514568197","article-title":"Upregulation of gingival tissue miR-200b in obese periodontitis subjects","volume":"94","author":"Kalea","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_43","first-page":"4792","article-title":"miR-485-5p promotes osteoporosis via targeting Osterix","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1515\/revneuro-2022-0039","article-title":"The role of microRNA-485 in neurodegenerative diseases","volume":"34","author":"Ryu","year":"2023","journal-title":"Rev. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kearney, M., Cooper, P.R., Smith, A.J., and Duncan, H.F. (2023). Characterisation of miRNA Expression in Dental Pulp Cells during Epigenetically-Driven Reparative Processes. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108631"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.aohep.2019.12.003","article-title":"Identification and study of differentially expressed miRNAs in aged NAFLD rats based on high-throughput sequencing","volume":"19","author":"Zhang","year":"2020","journal-title":"Ann. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Choi, M.R., Han, J.S., Jin, Y.B., Lee, S.R., Choi, I.Y., Lee, H., Cho, H., and Kim, D.J. (2020). Differential expression of microRNAs in the hippocampi of male and female rodents after chronic alcohol administration. Biol. Sex. Differ., 11.","DOI":"10.1186\/s13293-020-00342-3"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s41598-022-04800-3","article-title":"Construction of a potential microRNA and messenger RNA regulatory network of acute lung injury in mice","volume":"12","author":"Zhang","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10399","DOI":"10.1007\/s11033-022-07918-9","article-title":"Circulating miRNA profiles in mice plasma following flavonoid intake","volume":"49","author":"Murata","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/SHK.0000000000001701","article-title":"Mesenchymal Stem\/Stromal Cells Increase Cardiac miR-187-3p Expression in a Polymicrobial Animal Model of Sepsis","volume":"56","author":"Ektesabi","year":"2021","journal-title":"Shock"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Sinha, A., Bhattacharjee, R., Bhattacharya, B., Nandi, A., Shekhar, R., Jana, A., Saha, K., Kumar, L., Patro, S., and Panda, P.K. (2023). The paradigm of miRNA and siRNA influence in Oral-biome. Biomed. Pharmacother., 159.","DOI":"10.1016\/j.biopha.2023.114269"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13075-022-02964-x","article-title":"circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p\/Satb2 signaling pathway","volume":"24","author":"Fan","year":"2022","journal-title":"Arthritis Res. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Yang, L., Du, X., Liu, L., Cao, Q., Pan, Z., and Li, Q. (2019). miR-1306 Mediates the Feedback Regulation of the TGF-beta\/SMAD Signaling Pathway in Granulosa Cells. Cells, 8.","DOI":"10.3390\/cells8040298"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Yoshioka, H., Wang, Y.Y., Suzuki, A., Shayegh, M., Gajera, M.V., Zhao, Z., and Iwata, J. (2021). Overexpression of miR-1306-5p, miR-3195, and miR-3914 Inhibits Ameloblast Differentiation through Suppression of Genes Associated with Human Amelogenesis Imperfecta. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042202"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00418-020-01878-6","article-title":"Functional analysis of miR-767-5p during the progression of hepatocellular carcinoma and the clinical relevance of its dysregulation","volume":"154","author":"Zhang","year":"2020","journal-title":"Histochem. Cell Biol."},{"key":"ref_57","first-page":"55","article-title":"miR-767-5p inhibits glioma proliferation and metastasis by targeting SUZ12","volume":"42","author":"Zhang","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10735-022-10107-4","article-title":"Exosomal miR-767 from senescent endothelial-derived accelerating skin fibroblasts aging via inhibiting TAB1","volume":"54","author":"Li","year":"2023","journal-title":"J. Mol. Histol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.3233\/JAD-190583","article-title":"A New Discovery of MicroRNA-455-3p in Alzheimer\u2019s Disease","volume":"72","author":"Kumar","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/JAD-215223","article-title":"Cerebrovascular microRNA Expression Profile During Early Development of Alzheimer\u2019s Disease in a Mouse Model","volume":"85","author":"Chum","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_61","first-page":"59","article-title":"Differential expression of microRNAs in cardiac myocytes compared to undifferentiated P19 cells","volume":"28","author":"Hu","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1161\/CIRCULATIONAHA.109.928424","article-title":"MicroRNA-210 as a novel therapy for treatment of ischemic heart disease","volume":"122","author":"Hu","year":"2010","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00109-018-1624-y","article-title":"Identification of novel microRNA inhibiting actin cytoskeletal rearrangement thereby suppressing osteoblast differentiation","volume":"96","author":"John","year":"2018","journal-title":"J. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"14791641231172139","DOI":"10.1177\/14791641231172139","article-title":"miR-1187 induces podocyte injury and diabetic nephropathy through autophagy","volume":"20","author":"Chen","year":"2023","journal-title":"Diab. Vasc. Dis. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3892\/ijmm.2012.888","article-title":"The regulatory role of microRNA-1187 in TNF-alpha-mediated hepatocyte apoptosis in acute liver failure","volume":"29","author":"Yu","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/kjm2.12134","article-title":"MiR-291a-3p regulates the BMSCs differentiation via targeting DKK1 in dexamethasone-induced osteoporosis","volume":"36","author":"Li","year":"2020","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12944-022-01725-8","article-title":"Induction mechanism of cigarette smoke components (CSCs) on dyslipidemia and hepatic steatosis in rats","volume":"21","author":"Ge","year":"2022","journal-title":"Lipids Health Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2022.05.095","article-title":"Targeting circNCLN\/miR-291a-3p\/TSLP signaling axis alleviates lipopolysaccharide-induced acute lung injury","volume":"617","author":"Cao","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e11454","DOI":"10.7717\/peerj.11454","article-title":"Identification of key microRNAs and the underlying molecular mechanism in spinal cord ischemia-reperfusion injury in rats","volume":"9","author":"Chen","year":"2021","journal-title":"PeerJ"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s10157-021-02091-y","article-title":"miR-1968-5p is involved in the pathogenesis of lupus nephritis of NZBWF1 mice by targeting csf1","volume":"25","author":"Li","year":"2021","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/hepr.13419","article-title":"Identification of two microRNA nodes as potential cooperative modulators of liver metabolism","volume":"49","author":"Hochreuter","year":"2019","journal-title":"Hepatol. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.margen.2015.07.004","article-title":"Draft genome assemblies and predicted microRNA complements of the intertidal lophotrochozoans Patella vulgata (Mollusca, Patellogastropoda) and Spirobranchus (Pomatoceros) lamarcki (Annelida, Serpulida)","volume":"24 Pt 2","author":"Kenny","year":"2015","journal-title":"Mar. Genom."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"12691","DOI":"10.1080\/21655979.2021.2019876","article-title":"Long non-coding RNA ZFY-AS1 represses periodontitis tissue inflammation and oxidative damage via modulating microRNA-129-5p\/DEAD-Box helicase 3 X-linked axis","volume":"13","author":"Cheng","year":"2022","journal-title":"Bioengineered"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"154","DOI":"10.21037\/atm-20-8079","article-title":"The protective effects of the miR-129-5p\/keap-1\/Nrf2 axis on Ang II-induced cardiomyocyte hypertrophy","volume":"9","author":"Ye","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_75","first-page":"5901","article-title":"MicroRNA-129-3p functions as a tumor suppressor in serous ovarian cancer by targeting BZW1","volume":"11","author":"Liu","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/CJI.0b013e31827bec97","article-title":"Dendritic cell-based immunotherapy in prevention and treatment of renal cell carcinoma: Efficacy, safety, and activity of Ad-GM.CAIX in immunocompetent mouse models","volume":"36","author":"Birkhauser","year":"2013","journal-title":"J. Immunother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"12328","DOI":"10.1074\/jbc.M110.176099","article-title":"A Runx2\/miR-3960\/miR-2861 regulatory feedback loop during mouse osteoblast differentiation","volume":"286","author":"Hu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"28968","DOI":"10.1038\/srep28968","article-title":"miR-2861 acts as a tumor suppressor via targeting EGFR\/AKT2\/CCND1 pathway in cervical cancer induced by human papillomavirus virus 16 E6","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s12032-013-0577-9","article-title":"Upregulation of miR-2861 and miR-451 expression in papillary thyroid carcinoma with lymph node metastasis","volume":"30","author":"Wang","year":"2013","journal-title":"Med. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Ghafouri-Fard, S., Askari, A., Hussen, B.M., Rasul, M.F., Hatamian, S., Taheri, M., and Kiani, A. (2022). A review on the role of miR-671 in human disorders. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.1077968"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.2147\/OTT.S177325","article-title":"MicroRNA-671-3p promotes proliferation and migration of glioma cells via targeting CKAP4","volume":"11","author":"Lu","year":"2018","journal-title":"OncoTargets Ther."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1158\/0008-5472.CAN-12-3513","article-title":"Inherited variation in miR-290 expression suppresses breast cancer progression by targeting the metastasis susceptibility gene Arid4b","volume":"73","author":"Goldberger","year":"2013","journal-title":"Cancer Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/kjm2.12680","article-title":"Long non-coding RNA DANCR alleviates acute myocardial infarction damage via regulating microRNA-509-5p\/KLF transcription factor 13 pathway","volume":"39","author":"Tian","year":"2023","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e29705","DOI":"10.1097\/MD.0000000000029705","article-title":"Identification and validation of miR-509-5p as a prognosticator for favorable survival in osteosarcoma","volume":"101","author":"Guo","year":"2022","journal-title":"Medicine"},{"key":"ref_85","first-page":"9224","article-title":"miR-205 and HMGB1 expressions in chronic periodontitis patients and their associations with the inflammatory factors","volume":"13","author":"Jiang","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e743","DOI":"10.1002\/iid3.743","article-title":"Exosomal miR-205-5p derived from periodontal ligament stem cells attenuates the inflammation of chronic periodontitis via targeting XBP1","volume":"11","author":"Kang","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41419-020-03192-4","article-title":"Unveiling the ups and downs of miR-205 in physiology and cancer: Transcriptional and post-transcriptional mechanisms","volume":"11","author":"Ferrari","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e2220635120","DOI":"10.1073\/pnas.2220635120","article-title":"MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells","volume":"120","author":"Wang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fphys.2020.00614","article-title":"Identification of Novel miRNAs Involved in Cardiac Repair Following Infarction in Fetal and Adolescent Sheep Hearts","volume":"11","author":"Lock","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e63768","DOI":"10.7554\/eLife.63768","article-title":"MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs","volume":"10","author":"Chang","year":"2021","journal-title":"eLife"},{"key":"ref_91","unstructured":"Agarwal, A., Kansal, V., Farooqi, H., Singh, V.K., and Prasad, R. Differentially deregulated microRNAs contribute to ultraviolet radiation-induced photocarcinogenesis through immunomodulation: An-analysis of microRNAs expression profiling. bioRxiv."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Hsieh, C.H., Yang, J.C., Jeng, J.C., Chen, Y.C., Lu, T.H., Tzeng, S.L., Wu, Y.C., Wu, C.J., and Rau, C.S. (2013). Circulating microRNA signatures in mice exposed to lipoteichoic acid. J. Biomed. Sci., 20.","DOI":"10.1186\/1423-0127-20-2"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Al-Rawi, N.H., Al-Marzooq, F., Al-Nuaimi, A.S., Hachim, M.Y., and Hamoudi, R. (2020). Salivary microRNA 155, 146a\/b and 203: A pilot study for potentially non-invasive diagnostic biomarkers of periodontitis and diabetes mellitus. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237004"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1128\/IAI.00082-11","article-title":"Porphyromonas gingivalis induction of microRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells","volume":"79","author":"Moffatt","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1111\/odi.14132","article-title":"MicroRNA-203 mediates Porphyromonas gingivalis LPS-induced inflammation and differentiation of periodontal ligament cells","volume":"29","author":"Yang","year":"2023","journal-title":"Oral. Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12974-022-02451-9","article-title":"miR-203, fine-tunning neuroinflammation by juggling different components of NF-kappaB signaling","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_97","first-page":"466","article-title":"MicroRNAs: Critical mediators of differentiation, development and disease","volume":"139","author":"Friedman","year":"2009","journal-title":"Swiss Med. Wkly."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1038\/s41598-017-07578-x","article-title":"MicroRNA-98 negatively regulates myocardial infarction-induced apoptosis by down-regulating Fas and caspase-3","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/0022034511425045","article-title":"MicroRNA modulation in obesity and periodontitis","volume":"91","author":"Perri","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Pizzicannella, J., Cavalcanti, M., Trubiani, O., and Diomede, F. (2018). MicroRNA 210 Mediates VEGF Upregulation in Human Periodontal Ligament Stem Cells Cultured on 3DHydroxyapatite Ceramic Scaffold. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123916"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"104682","DOI":"10.1016\/j.yexmp.2021.104682","article-title":"miR-876-3p suppresses the progression of colon cancer and correlates the prognosis of patients","volume":"122","author":"Ma","year":"2021","journal-title":"Exp. Mol. Pathol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"17227","DOI":"10.18632\/aging.203201","article-title":"miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts","volume":"13","author":"Law","year":"2021","journal-title":"Aging"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.scr.2013.11.008","article-title":"Cardiomyogenesis is controlled by the miR-99a\/let-7c cluster and epigenetic modifications","volume":"12","author":"Coppola","year":"2014","journal-title":"Stem Cell Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41598-022-26421-6","article-title":"TNFalpha, IL-6, miR-103a-3p, miR-423-5p, miR-23a-3p, miR-15a-5p and miR-223-3p in the crevicular fluid of periodontopathic patients correlate with each other and at different stages of the disease","volume":"13","author":"Costantini","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/jcpe.13040","article-title":"Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects","volume":"46","author":"Naqvi","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"955461","DOI":"10.3389\/fnagi.2022.955461","article-title":"Exploring the role of non-coding RNAs as potential candidate biomarkers in the cross-talk between diabetes mellitus and Alzheimer\u2019s disease","volume":"14","author":"Ghiam","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/0022034519864519","article-title":"MiR-361-3p\/Nfat5 Signaling Axis Controls Cementoblast Differentiation","volume":"98","author":"Liao","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"30139","DOI":"10.1074\/jbc.M110.145698","article-title":"Proinflammatory role for let-7 microRNAS in experimental asthma","volume":"285","author":"Polikepahad","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_109","first-page":"3320","article-title":"The upregulation of miR-101 promotes vascular endothelial cell apoptosis and suppresses cell migration in acute coronary syndrome by targeting CDH5","volume":"12","author":"Cao","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ymthe.2017.01.018","article-title":"Targeting the HDAC2\/HNF-4A\/miR-101b\/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer\u2019s Disease","volume":"25","author":"Liu","year":"2017","journal-title":"Mol. Ther."},{"key":"ref_111","first-page":"9602","article-title":"Long non-coding RNA Linc01133 promotes osteogenic differentiation of human periodontal ligament stem cells via microRNA-30c \/ bone gamma-carboxyglutamate protein axis","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"493","DOI":"10.7150\/ijms.81990","article-title":"MiR-30 Family: A Novel Avenue for Treating Bone and Joint Diseases?","volume":"20","author":"Huang","year":"2023","journal-title":"Int. J. Med. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"118585","DOI":"10.1016\/j.lfs.2020.118585","article-title":"Evaluation of circulating miR-122, miR-30c and miR-33a levels and their association with lipids, lipoproteins in postprandial lipemia","volume":"264","author":"Yaman","year":"2021","journal-title":"Life Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"119065","DOI":"10.1016\/j.lfs.2021.119065","article-title":"Suppression of microRNA-323-3p restrains vascular endothelial cell apoptosis via promoting sirtuin-1 expression in coronary heart disease","volume":"270","author":"Du","year":"2021","journal-title":"Life Sci."},{"key":"ref_115","first-page":"1956","article-title":"LncRNA ANRIL regulates cell proliferation and migration via sponging miR-339-5p and regulating FRS2 expression in atherosclerosis","volume":"24","author":"Huang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s12013-014-9967-7","article-title":"Identification of the microRNA expression profile in the regenerative neonatal mouse heart by deep sequencing","volume":"70","author":"Liu","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/2211-5463.12238","article-title":"MicroRNA profiling in gingival crevicular fluid of periodontitis-a pilot study","volume":"7","author":"Saito","year":"2017","journal-title":"FEBS Open Bio."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3727\/096504021X16274672547967","article-title":"miR-142-5p Inhibits Cell Invasion and Migration by Targeting DNMT1 in Breast Cancer","volume":"28","author":"Li","year":"2022","journal-title":"Oncol. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"8523","DOI":"10.1038\/ncomms9523","article-title":"miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program","volume":"6","author":"Su","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00784-023-05404-5","article-title":"Differentially expressed miRNAs associated with generalized aggressive periodontitis","volume":"28","author":"Ozer","year":"2023","journal-title":"Clin. Oral. Investig."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"119323","DOI":"10.1016\/j.lfs.2021.119323","article-title":"MiR-375: A novel multifunctional regulator","volume":"275","author":"Liu","year":"2021","journal-title":"Life Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.7150\/jca.63836","article-title":"Downregulation of miR-375 contributes to ERBB2-mediated VEGFA overexpression in esophageal cancer","volume":"12","author":"Ren","year":"2021","journal-title":"J. Cancer"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/jcmm.14054","article-title":"Circulating miRNA-375 as a potential novel biomarker for active Kaposi\u2019s sarcoma in AIDS patients","volume":"23","author":"Piano","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni.1994","article-title":"Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk","volume":"12","author":"Biton","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Shafiee, M., Aleyasin, S.A., Mowla, S.J., Vasei, M., and Yazdanparast, S.A. (2016). The Effect of MicroRNA-375 Overexpression, an Inhibitor of Helicobacter pylori-Induced Carcinogenesis, on lncRNA SOX2OT. Jundishapur J. Microbiol., 9.","DOI":"10.5812\/jjm.23464"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1007\/s10571-023-01327-7","article-title":"The Role of MicroRNAs in Predicting the Neurological Outcome of Patients with Subarachnoid Hemorrhage: A Meta-analysis","volume":"43","author":"Li","year":"2023","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1195145","DOI":"10.3389\/fendo.2023.1195145","article-title":"Text mining-based identification of promising miRNA biomarkers for diabetes mellitus","volume":"14","author":"Li","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1244578","DOI":"10.3389\/fonc.2023.1244578","article-title":"Proposing new early detection indicators for pancreatic cancer: Combining machine learning and neural networks for serum miRNA-based diagnostic model","volume":"13","author":"Chi","year":"2023","journal-title":"Front. Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Wang, L., and Zhong, C. (2021). Prediction of miRNA-Disease Association Using Deep Collaborative Filtering. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/6652948"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Rivera, M.F., Lee, J.Y., Aneja, M., Goswami, V., Liu, L., Velsko, I.M., Chukkapalli, S.S., Bhattacharyya, I., Chen, H., and Lucas, A.R. (2013). Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057178"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"814","DOI":"10.20517\/cdr.2022.56","article-title":"Butein-instigated miR-186-5p-dependent modulation of TWIST1 affects resistance to cisplatin and bioenergetics of Malignant Pleural Mesothelioma cells","volume":"5","author":"Cioce","year":"2022","journal-title":"Cancer Drug Resist."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkab1079","article-title":"miRTarBase update 2022: An informative resource for experimentally validated miRNA-target interactions","volume":"50","author":"Huang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: Deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.2517-6161.1958.tb00292.x","article-title":"The Regression Analysis of Binary Sequences","volume":"20","author":"Cox","year":"1958","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00994018","article-title":"Support-vector networks","volume":"20","author":"Cortes","year":"1995","journal-title":"Mach. Learn."},{"key":"ref_138","unstructured":"Ho, T.K. (1995, January 14\u201316). Random decision forests. Proceedings of the 3rd International Conference on Document Analysis and Recognition, Montreal, QC, Canada."},{"key":"ref_139","unstructured":"Haykin, S. (1998). Neural Networks: A Comprehensive Foundation, Prentice Hall PTR."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Chen, T., and Guestrin, C. (2016, January 13\u201317). XGBoost: A Scalable Tree Boosting System. Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, New York, NY, USA.","DOI":"10.1145\/2939672.2939785"},{"key":"ref_141","unstructured":"Gillies S, o. (2024, April 29). Shapely: Manipulation and analysis of geometric objects. Available online: https:\/\/github.com\/Toblerity\/Shapely."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/omi.12165","article-title":"Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection","volume":"32","author":"Chukkapalli","year":"2017","journal-title":"Mol. Oral. Microbiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/odi.12118","article-title":"Dysregulation of miR-31 and miR-375 expression is associated with clinical outcomes in oral carcinoma","volume":"20","author":"Siow","year":"2014","journal-title":"Oral Dis."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Mitani, Y., Roberts, D.B., Fatani, H., Weber, R.S., Kies, M.S., Lippman, S.M., and El-Naggar, A.K. (2013). MicroRNA profiling of salivary adenoid cystic carcinoma: Association of miR-17-92 upregulation with poor outcome. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0066778"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"12220","DOI":"10.3892\/mmr.2021.12220","article-title":"Anti-inflammatory role of microRNA-429 in human gingival epithelial cells-inhibition of IL-8 production through direct binding to IKKbeta mRNA","volume":"24","author":"Kawasaki","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/1567202617666200128143634","article-title":"MicroRNA (miR)-429 Promotes Inflammatory Injury by Targeting Kruppel-like Factor 4 (KLF4) in Neonatal Pneumonia","volume":"17","author":"Zhang","year":"2020","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cca.2010.09.029","article-title":"Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans","volume":"412","author":"Li","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.omtn.2021.01.030","article-title":"Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice","volume":"23","author":"Krongbaramee","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1161\/STROKEAHA.119.027531","article-title":"MicroRNA-126-3p\/-5p Overexpression Attenuates Blood-Brain Barrier Disruption in a Mouse Model of Middle Cerebral Artery Occlusion","volume":"51","author":"Pan","year":"2020","journal-title":"Stroke"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1155\/2009\/641082","article-title":"MicroRNA microarray expression profiling in human myocardial infarction","volume":"27","author":"Bostjancic","year":"2009","journal-title":"Dis. Markers"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10735-021-10009-x","article-title":"MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4","volume":"52","author":"Fan","year":"2021","journal-title":"J. Mol. Histol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCRESAHA.116.309589","article-title":"Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function After Myocardial Infarction","volume":"120","author":"Lesizza","year":"2017","journal-title":"Circ. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s10753-021-01566-0","article-title":"Association of miR-155, miR-187 and Inflammatory Cytokines IL-6, IL-10 and TNF-alpha in Chronic Opium Abusers","volume":"45","author":"Purohit","year":"2022","journal-title":"Inflammation"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Deng, J., Xiao, J., Ma, P., Gao, B., Gong, F., Lv, L., Zhang, Y., and Xu, J. (2017). Manipulation of Viral MicroRNAs as a Potential Antiviral Strategy for the Treatment of Cytomegalovirus Infection. Viruses, 9.","DOI":"10.3390\/v9050118"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"147366","DOI":"10.1016\/j.gene.2023.147366","article-title":"MicroRNA-202-5p-dependent inhibition of Bcl-2 contributes to macrophage apoptosis and atherosclerotic plaque formation","volume":"867","author":"Xu","year":"2023","journal-title":"Gene"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"11877","DOI":"10.18632\/aging.202889","article-title":"Overexpression of microRNA-202-3p in bone marrow mesenchymal stem cells improves cerebral ischemia-reperfusion injury by promoting angiogenesis and inhibiting inflammation","volume":"13","author":"Yu","year":"2021","journal-title":"Aging"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"23107","DOI":"10.1074\/jbc.M109.013862","article-title":"Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes","volume":"284","author":"Benakanakere","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.omtn.2018.12.015","article-title":"Simultaneous Suppression of Multiple Programmed Cell Death Pathways by miRNA-105 in Cardiac Ischemic Injury","volume":"14","author":"Shin","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/jre.13081","article-title":"Six miRNA expressions in the saliva of smokers and non-smokers with periodontal disease","volume":"58","author":"Gokmenoglu","year":"2023","journal-title":"J. Periodontal Res."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Ostermann, E., Tuddenham, L., Macquin, C., Alsaleh, G., Schreiber-Becker, J., Tanguy, M., Bahram, S., Pfeffer, S., and Georgel, P. (2012). Deregulation of type I IFN-dependent genes correlates with increased susceptibility to cytomegalovirus acute infection of dicer mutant mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043744"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1002\/1878-0261.12562","article-title":"miR-367 as a therapeutic target in stem-like cells from embryonal central nervous system tumors","volume":"13","author":"Kaid","year":"2019","journal-title":"Mol. Oncol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"279ra238","DOI":"10.1126\/scitranslmed.3010841","article-title":"A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice","volume":"7","author":"Tian","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_163","first-page":"5592","article-title":"MiR-201-5p alleviates lipopolysaccharide-induced renal cell dysfunction by targeting NOTCH3","volume":"24","author":"Yuan","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2019.03.016","article-title":"Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease","volume":"285","author":"Moghaddam","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1128\/MCB.00016-13","article-title":"MicroRNA 33 regulates glucose metabolism","volume":"33","author":"Ramirez","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41467-021-21107-5","article-title":"microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity","volume":"12","author":"Horie","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e12606","DOI":"10.15252\/emmm.202012606","article-title":"miR-33 in cardiometabolic diseases: Lessons learned from novel animal models and approaches","volume":"13","author":"Price","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1038\/s41388-021-01973-5","article-title":"miR-22 promotes stem cell traits via activating Wnt\/beta-catenin signaling in cutaneous squamous cell carcinoma","volume":"40","author":"Yuan","year":"2021","journal-title":"Oncogene"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"173131","DOI":"10.1016\/j.ejphar.2020.173131","article-title":"Metformin ameliorates cardiac conduction delay by regulating microRNA-1 in mice","volume":"881","author":"Lv","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijcard.2017.06.054","article-title":"Diagnostic and prognostic value of miR-1 and miR-29b on adverse ventricular remodeling after acute myocardial infarction\u2014The SITAGRAMI-miR analysis","volume":"244","author":"Grabmaier","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Safa, A., Bahroudi, Z., Shoorei, H., Majidpoor, J., Abak, A., Taheri, M., and Ghafouri-Fard, S. (2020). miR-1: A comprehensive review of its role in normal development and diverse disorders. Biomed. Pharmacother., 132.","DOI":"10.1016\/j.biopha.2020.110903"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"116566","DOI":"10.1016\/j.bone.2022.116566","article-title":"MiR-1 is a critical regulator of chondrocyte proliferation and hypertrophy by inhibiting Indian hedgehog pathway during postnatal endochondral ossification in miR-1 overexpression transgenic mice","volume":"165","author":"Cong","year":"2022","journal-title":"Bone"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"115444","DOI":"10.1016\/j.bone.2020.115444","article-title":"MiR-1-3p regulates the differentiation of mesenchymal stem cells to prevent osteoporosis by targeting secreted frizzled-related protein 1","volume":"137","author":"Gu","year":"2020","journal-title":"Bone"},{"key":"ref_174","first-page":"3492","article-title":"Low expression of miR-1 promotes osteogenic repair of bone marrow mesenchymal stem cells by targeting TLR1","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1007\/s13577-021-00551-x","article-title":"miR-720 is a key regulator of glioma migration and invasion by controlling TARSL2 expression","volume":"34","author":"Liu","year":"2021","journal-title":"Hum. 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