{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:41:19Z","timestamp":1792932079495,"version":"4.5.0"},"reference-count":134,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Medical University of Lublin","doi-asserted-by":"publisher","award":["DS121"],"award-info":[{"award-number":["DS121"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility is caused by a wide range of abnormalities affecting the female reproductive tract, from oocyte quality impairment to disturbances in the eutopic endometrium or mechanical abnormalities resulting from disease progression. Since supportive antioxidant therapies, in addition to surgical treatment or assisted reproductive techniques (ARTs), have overall been proven to be effective tools in endometriosis management, the objective of our review was to analyze the role of antioxidant substances, including vitamins, micronutrients, N-acetylcysteine (NAC), curcumin, melatonin, and resveratrol, in endometriosis-related infertility. Most of these substances have been proven to alleviate the systemic oxidant predominance, which has been expressed through decreased oxidative stress (OS) markers and enhanced antioxidative defense. In addition, we demonstrated that the predominant effect of the aforementioned substances is the inhibition of the development of endometriotic lesions as well as the suppression of pro-inflammatory molecules. Although we can undoubtedly conclude that antioxidants are beneficial in fertility support, further studies explaining the detailed pathways of their action are needed.<\/jats:p>","DOI":"10.3390\/ijms25126298","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T04:38:56Z","timestamp":1717735136000},"page":"6298","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Oxidative Imbalance in Endometriosis-Related Infertility\u2014The Therapeutic Role of Antioxidants"],"prefix":"10.3390","volume":"25","author":[{"given":"Izabela","family":"Dymanowska-Dyjak","sequence":"first","affiliation":[{"name":"Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-5989","authenticated-orcid":false,"given":"Karolina","family":"Frankowska","sequence":"additional","affiliation":[{"name":"Student Scientific Association, Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5931-2741","authenticated-orcid":false,"given":"Monika","family":"Abramiuk","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-2893","authenticated-orcid":false,"given":"Grzegorz","family":"Polak","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Minimally Invasive Gynecology and Gynecological Endocrinology, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and Management of Infertility: A Review","volume":"326","author":"Carson","year":"2021","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"The Guideline Group on Unexplained Infertility, Romualdi, D., Ata, B., Bhattacharya, S., Bosch, E., Costello, M., Gersak, K., Homburg, R., Mincheva, M., and Norman, R.J. (2023). Evidence-Based Guideline: Unexplained Infertility. Hum. Reprod., 38, 1881\u20131890.","DOI":"10.1093\/humrep\/dead150"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e057132","DOI":"10.1136\/bmjopen-2021-057132","article-title":"Worldwide Prevalence, Risk Factors and Psychological Impact of Infertility among Women: A Systematic Review and Meta-Analysis","volume":"12","author":"Norhayati","year":"2022","journal-title":"BMJ Open"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10815-010-9436-1","article-title":"Endometriosis and Infertility","volume":"27","author":"Bulletti","year":"2010","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102454","DOI":"10.1016\/j.bpobgyn.2023.102454","article-title":"Epidemiology of Infertility in Women with Endometriosis","volume":"92","author":"Chiappa","year":"2024","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e070750","DOI":"10.1136\/bmj-2022-070750","article-title":"Pathophysiology, Diagnosis, and Management of Endometriosis","volume":"379","author":"Horne","year":"2022","journal-title":"BMJ"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.fertnstert.2023.03.018","article-title":"Association of Endometriosis and Adenomyosis with Pregnancy and Infertility","volume":"119","author":"Vercellini","year":"2023","journal-title":"Fertil. Steril."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1020827","DOI":"10.3389\/fendo.2022.1020827","article-title":"Endometriosis-Associated Infertility: From Pathophysiology to Tailored Treatment","volume":"13","author":"Bonavina","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e13593","DOI":"10.1111\/aji.13593","article-title":"Oxidative Stress-related Effects on Various Aspects of Endometriosis","volume":"88","author":"Ansariniya","year":"2022","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7265238","DOI":"10.1155\/2017\/7265238","article-title":"Oxidative Stress and Endometriosis: A Systematic Review of the Literature","volume":"2017","author":"Scutiero","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Didziokaite, G., Biliute, G., Gudaite, J., and Kvedariene, V. (2023). Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043809"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"hoac009","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE Guideline: Endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum. Reprod. Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.beem.2018.10.001","article-title":"Assisted Reproduction in Endometriosis","volume":"33","author":"Pirtea","year":"2019","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Abramiuk, M., Mertowska, P., Frankowska, K., \u015awiechowska-Starek, P., Satora, M., Polak, G., Dymanowska-Dyjak, I., and Grywalska, E. (2024). How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?. Nutrients, 16.","DOI":"10.3390\/nu16010154"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ijgo.12576","article-title":"Systematic Review and Meta-analysis of Complementary Treatments for Women with Symptomatic Endometriosis","volume":"143","author":"Mira","year":"2018","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1089891","DOI":"10.3389\/fnut.2023.1089891","article-title":"Nutrition in the Prevention and Treatment of Endometriosis: A Review","volume":"10","author":"Barnard","year":"2023","journal-title":"Front. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1021\/acs.jafc.7b05830","article-title":"Antioxidants: Differing Meanings in Food Science and Health Science","volume":"66","author":"Yang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Costa, M.I., Sarmento-Ribeiro, A.B., and Gon\u00e7alves, A.C. (2023). Zinc: From Biological Functions to Therapeutic Potential. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054822"},{"key":"ref_20","first-page":"13","article-title":"Health Benefits of Resveratrol Administration","volume":"66","author":"Galiniak","year":"2019","journal-title":"Acta Biochim. Pol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zheng, S.-H., Chen, X.-X., Chen, Y., Wu, Z.-C., Chen, X.-Q., and Li, X.-L. (2023). Antioxidant Vitamins Supplementation Reduce Endometriosis Related Pelvic Pain in Humans: A Systematic Review and Meta-Analysis. Reprod. Biol. Endocrinol., 21.","DOI":"10.1186\/s12958-023-01126-1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13668-022-00432-1","article-title":"Effect of Antioxidant Supplementation on Endometriosis-Related Pain: A Systematic Review","volume":"11","author":"Sukan","year":"2022","journal-title":"Curr. Nutr. Rep."},{"key":"ref_23","first-page":"CD007807","article-title":"Antioxidants for Female Subfertility","volume":"2020","author":"Showell","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00404-012-2439-7","article-title":"Oxidative Stress Biomarkers in Patients with Endometriosis: Systematic Review","volume":"286","author":"Carvalho","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_25","first-page":"CD012179","article-title":"Blood Biomarkers for the Non-Invasive Diagnosis of Endometriosis","volume":"2016","author":"Nisenblat","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.fertnstert.2019.06.006","article-title":"Endometriosis: A Complex Systemic Disease with Multiple Manifestations","volume":"112","author":"Taylor","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/09513590802485012","article-title":"The Role of the Oxidative-Stress in the Endometriosis-Related Infertility","volume":"25","author":"Augoulea","year":"2009","journal-title":"Gynecol. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lu, J., Wang, Z., Cao, J., Chen, Y., and Dong, Y. (2018). A Novel and Compact Review on the Role of Oxidative Stress in Female Reproduction. Reprod. Biol. Endocrinol., 16.","DOI":"10.1186\/s12958-018-0391-5"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.fertnstert.2022.03.015","article-title":"Infertility Workup: Identifying Endometriosis","volume":"118","author":"Pirtea","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1080\/14647273.2023.2230360","article-title":"Oxidative Stress and Female Infertility: The Role of Follicular Fluid Soluble Receptor of Advanced Glycation End-Products (sRAGE) in Women with Endometriosis","volume":"26","author":"Sopasi","year":"2023","journal-title":"Hum. Fertil."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zaha, I., Muresan, M., Tulcan, C., Huniadi, A., Naghi, P., Sandor, M., Tripon, R., Gaspar, C., Klaudia-Melinda, M., and Sachelarie, L. (2023). The Role of Oxidative Stress in Infertility. J. Pers. Med., 13.","DOI":"10.3390\/jpm13081264"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.reprotox.2013.08.005","article-title":"Markers of Oxidative Stress in Follicular Fluid of Women with Endometriosis and Tubal Infertility Undergoing IVF","volume":"42","author":"Singh","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Lin, X., Dai, Y., Tong, X., Xu, W., Huang, Q., Jin, X., Li, C., Zhou, F., Zhou, H., and Lin, X. (2020). Excessive Oxidative Stress in Cumulus Granulosa Cells Induced Cell Senescence Contributes to Endometriosis-Associated Infertility. Redox Biol., 30.","DOI":"10.1016\/j.redox.2020.101431"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/path.6079","article-title":"Integrative Analysis of Transcriptomic and Metabolomic Profiles Reveals Abnormal Phosphatidylinositol Metabolism in Follicles from Endometriosis-associated Infertility Patients","volume":"260","author":"Dai","year":"2023","journal-title":"J. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2022.12.105","article-title":"Iron Overload Modulates Follicular Microenvironment via ROS\/HIF-1\u03b1\/FSHR Signaling","volume":"196","author":"Wu","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Malvezzi, H., Cestari, B.A., Meola, J., and Podgaec, S. (2023). Higher Oxidative Stress in Endometriotic Lesions Upregulates Senescence-Associated P16ink4a and \u03b2-Galactosidase in Stromal Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24020914"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/humrep\/deac112","article-title":"Stromal Cell Senescence Contributes to Impaired Endometrial Decidualization and Defective Interaction with Trophoblast Cells","volume":"37","author":"Deryabin","year":"2022","journal-title":"Hum. Reprod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/REP-21-0436","article-title":"Dysregulation of X-Ray Repair Cross-Complementing 4 Expression in the Eutopic Endometrium of Women with Endometriosis","volume":"163","author":"Bane","year":"2022","journal-title":"Reproduction"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"153050","DOI":"10.1016\/j.tox.2021.153050","article-title":"Iron Overload Inhibits Cell Proliferation and Promotes Autophagy via PARP1\/SIRT1 Signaling in Endometriosis and Adenomyosis","volume":"465","author":"Zhou","year":"2022","journal-title":"Toxicology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"154847","DOI":"10.1016\/j.prp.2023.154847","article-title":"Endometriosis: Classification, Pathophysiology, and Treatment Options","volume":"251","author":"Tambuwala","year":"2023","journal-title":"Pathol.-Res. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2353\/ajpath.2009.080804","article-title":"Reactive Oxygen Species Controls Endometriosis Progression","volume":"175","author":"Nicco","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_42","first-page":"1400","article-title":"High Mobility Group Box-1 Promotes Inflammation in Endometriotic Stromal Cells through Toll-like Receptor 4\/Nuclear Factor-Kappa B","volume":"13","author":"Yun","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41420-022-00821-z","article-title":"Endometrial Stromal Cell Ferroptosis Promotes Angiogenesis in Endometriosis","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/molehr\/gax028","article-title":"Dysregulation of the ADAM17\/Notch Signalling Pathways in Endometriosis: From Oxidative Stress to Fibrosis","volume":"23","author":"Santulli","year":"2017","journal-title":"MHR Basic Sci. Reprod. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"112891","DOI":"10.1016\/j.ejmech.2020.112891","article-title":"Oxidative Stress Mitigation by Antioxidants\u2014An Overview on Their Chemistry and Influences on Health Status","volume":"209","author":"Pisoschi","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5529741","DOI":"10.1155\/2021\/5529741","article-title":"The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial","volume":"2021","author":"Amini","year":"2021","journal-title":"Pain Res. Manag."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.trsl.2012.05.001","article-title":"Antioxidant Supplementation Reduces Endometriosis-Related Pelvic Pain in Humans","volume":"161","author":"Santanam","year":"2013","journal-title":"Transl. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ijgo.2007.08.018","article-title":"Effect of Vitamins C and E Supplementation on Peripheral Oxidative Stress Markers and Pregnancy Rate in Women with Endometriosis","volume":"100","year":"2008","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mier-Cabrera, J., Aburto-Soto, T., Burrola-M\u00e9ndez, S., Jim\u00e9nez-Zamudio, L., Tolentino, M.C., Casanueva, E., and Hern\u00e1ndez-Guerrero, C. (2009). Women with Endometriosis Improved Their Peripheral Antioxidant Markers after the Application of a High Antioxidant Diet. Reprod. Biol. Endocrinol., 7.","DOI":"10.1186\/1477-7827-7-54"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1177\/0300060518786918","article-title":"Effects of Vitamin C on the Outcome of in Vitro Fertilization\u2013Embryo Transfer in Endometriosis: A Randomized Controlled Study","volume":"46","author":"Lu","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.fertnstert.2007.10.072","article-title":"Lipid Peroxidation and Vitamin E in Serum and Follicular Fluid of Infertile Women with Peritoneal Endometriosis Submitted to Controlled Ovarian Hyperstimulation: A Pilot Study","volume":"90","author":"Ferriani","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_52","first-page":"372","article-title":"The Expression and Role of Oxidative Stress Markers in the Serum and Follicular Fluid of Patients with Endometriosis","volume":"40","author":"Liu","year":"2013","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_53","first-page":"174550572210962","article-title":"The Effectiveness of Antioxidant Therapy (Vitamin C) in an Experimentally Induced Mouse Model of Ovarian Endometriosis","volume":"18","author":"Hoorsan","year":"2022","journal-title":"Womens Health"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.tjog.2015.07.004","article-title":"Vitamin C Is Effective for the Prevention and Regression of Endometriotic Implants in an Experimentally Induced Rat Model of Endometriosis","volume":"55","author":"Erten","year":"2016","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/jog.12050","article-title":"Effect of Vitamin C on the Growth of Experimentally Induced Endometriotic Cysts","volume":"39","author":"Durak","year":"2013","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1038\/s41598-021-86586-4","article-title":"The Effectiveness of Rutin for Prevention of Surgical Induced Endometriosis Development in a Rat Model","volume":"11","author":"Talebi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41419-022-05037-8","article-title":"Iron-Overloaded Follicular Fluid Increases the Risk of Endometriosis-Related Infertility by Triggering Granulosa Cell Ferroptosis and Oocyte Dysmaturity","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10787-017-0309-4","article-title":"Antioxidant and Anti-Inflammatory Effects of Zinc. Zinc-Dependent NF-\u03baB Signaling","volume":"25","author":"Jarosz","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnut.2014.00014","article-title":"Zinc Is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health","volume":"1","author":"Prasad","year":"2014","journal-title":"Front. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Marreiro, D., Cruz, K., Morais, J., Beserra, J., Severo, J., and De Oliveira, A. (2017). Zinc and Oxidative Stress: Current Mechanisms. Antioxidants, 6.","DOI":"10.3390\/antiox6020024"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.reprotox.2017.09.001","article-title":"Decreased Zinc and Increased Lead Blood Levels Are Associated with Endometriosis in Asian Women","volume":"74","author":"Lai","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"ref_62","first-page":"1049","article-title":"Zinc Deficiency Is Associated with the Development of Ovarian Endometrial Cysts","volume":"13","author":"Onuma","year":"2023","journal-title":"Am. J. Cancer Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"114593","DOI":"10.1016\/j.ecoenv.2023.114593","article-title":"Zinc Deficiency Compromises the Maturational Competence of Porcine Oocyte by Inducing Mitophagy and Apoptosis","volume":"252","author":"Lai","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Maia, L.B., Maiti, B.K., Moura, I., and Moura, J.J.G. (2023). Selenium\u2014More than Just a Fortuitous Sulfur Substitute in Redox Biology. Molecules, 29.","DOI":"10.3390\/molecules29010120"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Mojadadi, A., Au, A., Salah, W., Witting, P., and Ahmad, G. (2021). Role for Selenium in Metabolic Homeostasis and Human Reproduction. Nutrients, 13.","DOI":"10.3390\/nu13093256"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1039\/C4MT00228H","article-title":"X-Ray Fluorescence Imaging and Other Analyses Identify Selenium and GPX1 as Important in Female Reproductive Function","volume":"7","author":"Ceko","year":"2015","journal-title":"Metallomics"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"213","DOI":"10.26444\/aaem\/75422","article-title":"Evaluation of Trace Metals in Follicular Fluid in ICSI-Treated Patients","volume":"25","author":"Wdowiak","year":"2018","journal-title":"Ann. Agric. Env. Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Kotha, R.R., and Luthria, D.L. (2019). Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects. Molecules, 24.","DOI":"10.3390\/molecules24162930"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/17425255.2019.1650914","article-title":"Is Curcumin Bioavailability a Problem in Humans: Lessons from Clinical Trials","volume":"15","author":"Kunnumakkara","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_70","first-page":"2184","article-title":"Curcumin Treats Endometriosis in Mice by the HIF Signaling Pathway","volume":"14","author":"Ding","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s10856-019-6337-4","article-title":"Curcumin-Loaded Nanofibers for Targeting Endometriosis in the Peritoneum of a Mouse Model","volume":"31","author":"Boroumand","year":"2020","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_72","first-page":"59","article-title":"Curcumin Arrests Endometriosis by Downregulation of Matrix Metalloproteinase-9 Activity","volume":"46","author":"Swarnakar","year":"2009","journal-title":"Indian J. Biochem. Biophys."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"207","DOI":"10.17219\/acem\/31186","article-title":"In Vivo Effects of Curcumin and Deferoxamine in Experimental Endometriosis","volume":"26","author":"Kizilay","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e14016","DOI":"10.14814\/phy2.14016","article-title":"Evaluation of Serum Cancer Antigen 125, Resistin, Leptin, Homocysteine, and Total Antioxidant Capacity in Rat Model of Endometriosis Treated with Curcumin","volume":"7","author":"Jelodar","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bcp.2011.12.030","article-title":"Curcumin as Anti-Endometriotic Agent: Implication of MMP-3 and Intrinsic Apoptotic Pathway","volume":"83","author":"Jana","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"101053","DOI":"10.1016\/j.gendis.2023.06.022","article-title":"Curcumin Modulates Oxidative Stress to Inhibit Pyroptosis and Improve the Inflammatory Microenvironment to Treat Endometriosis","volume":"11","author":"Ding","year":"2024","journal-title":"Genes Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.3892\/mmr.2017.7250","article-title":"Inhibitory Effect of Curcumin in Human Endometriosis Endometrial Cells via Downregulation of Vascular Endothelial Growth Factor","volume":"16","author":"Cao","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1530\/REP-22-0265","article-title":"Oxidative Phosphorylation Inhibitors Inhibit Proliferation of Endometriosis Cells","volume":"165","author":"Kapur","year":"2023","journal-title":"Reproduction"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1002\/jcp.27360","article-title":"Curcumin Attenuates Proangiogenic and Proinflammatory Factors in Human Eutopic Endometrial Stromal Cells through the NF-\u03baB Signaling Pathway","volume":"234","author":"Chowdhury","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Ke, J., Ye, J., Li, M., and Zhu, Z. (2021). The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target. Biomolecules, 11.","DOI":"10.3390\/biom11111739"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative Stress and Mitochondrial Dysfunction-Linked Neurodegenerative Disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jocn.2019.02.019","article-title":"Oxidative Stress-Induced Angiogenesis","volume":"63","author":"Huang","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"ref_83","first-page":"342","article-title":"Curcumin Delays Endometriosis Development by Inhibiting MMP-2 Activity","volume":"49","author":"Jana","year":"2012","journal-title":"Indian J. Biochem. Biophys."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s10753-023-01862-x","article-title":"TNF\u03b1-Induced Altered miRNA Expression Links to NF-\u03baB Signaling Pathway in Endometriosis","volume":"46","author":"Banerjee","year":"2023","journal-title":"Inflammation"},{"key":"ref_85","first-page":"87","article-title":"Inhibitory Effect of Curcumin on Angiogenesis in Ectopic Endometrium of Rats with Experimental Endometriosis","volume":"27","author":"Zhang","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/ptr.3694","article-title":"Curcumin Attenuates TNF-\u03b1-induced Expression of Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1 and Proinflammatory Cytokines in Human Endometriotic Stromal Cells","volume":"26","author":"Kim","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_87","first-page":"775","article-title":"Curcumin Improves Growth Factors Expression of Bovine Cumulus-Oocyte Complexes Cultured in Peritoneal Fluid of Women with Endometriosis","volume":"16","author":"Hendarto","year":"2019","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00394-019-02123-0","article-title":"Melatonin Supplementation and Pro-Inflammatory Mediators: A Systematic Review and Meta-Analysis of Clinical Trials","volume":"59","author":"Zarezadeh","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Chitimus, D.M., Popescu, M.R., Voiculescu, S.E., Panaitescu, A.M., Pavel, B., Zagrean, L., and Zagrean, A.-M. (2020). Melatonin\u2019s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease. Biomolecules, 10.","DOI":"10.3390\/biom10091211"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e12842","DOI":"10.1111\/jpi.12842","article-title":"Melatonin Inhibits Endometriosis Development by Disrupting Mitochondrial Function and Regulating tiRNAs","volume":"74","author":"Park","year":"2023","journal-title":"J. Pineal Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5152\/jtgga.2013.53179","article-title":"Melatonin Treatment Results in Regression of Endometriotic Lesions in an Ooferectomized Rat Endometriosis Model","volume":"14","author":"Attar","year":"2013","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.fertnstert.2009.09.021","article-title":"The Effects of Letrozole and Melatonin on Surgically Induced Endometriosis in a Rat Model: A Preliminary Study","volume":"93","author":"Yildirim","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.fertnstert.2007.04.023","article-title":"Regression of Endometrial Explants in a Rat Model of Endometriosis Treated with Melatonin","volume":"89","author":"Oral","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00404-014-3466-3","article-title":"The Effects of Different Doses of Melatonin Treatment on Endometrial Implants in an Oophorectomized Rat Endometriosis Model","volume":"291","author":"Cetinkaya","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00404-014-3599-4","article-title":"Melatonin Causes Regression of Endometriotic Implants in Rats by Modulating Angiogenesis, Tissue Levels of Antioxidants and Matrix Metalloproteinases","volume":"292","author":"Yilmaz","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/humrep\/dez082","article-title":"Melatonin Activity and Receptor Expression in Endometrial Tissue and Endometriosis","volume":"34","author":"Mosher","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"25","DOI":"10.12891\/ceog2035.2016","article-title":"The Effects of Melatonin on Endometriotic Lesions Induced by Implanting Human Endometriotic Cells in the First SCID-Mouse Endometriosis-Model Developed in Turkey","volume":"43","author":"Yesildaglar","year":"2016","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1600-079X.2007.00547.x","article-title":"Role of Melatonin in Regulating Matrix Metalloproteinase-9 via Tissue Inhibitors of Metalloproteinase-1 during Protection against Endometriosis","volume":"44","author":"Paul","year":"2008","journal-title":"J. Pineal Res."},{"key":"ref_99","first-page":"156","article-title":"Melatonin Protects against Endometriosis via Regulation of Matrix Metalloproteinase-3 and an Apoptotic Pathway: Regression of Endometriosis after Melatonin","volume":"49","author":"Paul","year":"2010","journal-title":"J. Pineal Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.lfs.2016.03.003","article-title":"A Minireview on N-Acetylcysteine: An Old Drug with New Approaches","volume":"151","author":"Jallouli","year":"2016","journal-title":"Life Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1111\/bph.15456","article-title":"N -acetylcysteine as a New Prominent Approach for Treating Psychiatric Disorders","volume":"178","author":"Smaga","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Anastasi, E., Scaramuzzino, S., Viscardi, M.F., Viggiani, V., Piccioni, M.G., Cacciamani, L., Merlino, L., Angeloni, A., Muzii, L., and Porpora, M.G. (2023). Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20064686"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"240702","DOI":"10.1155\/2013\/240702","article-title":"A Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine","volume":"2013","author":"Porpora","year":"2013","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1080\/01443615.2021.2006165","article-title":"Comparing the Effect of Adjunctive N-Acetylcysteine plus Low Dose Contraceptive with Low Dose Contraceptive Alone on Recurrence of Ovarian Endometrioma and Chronic Pelvic Pain after Conservative Laparoscopic Surgery: A Randomised Clinical Trial Study","volume":"42","author":"Asgari","year":"2022","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1016\/j.fertnstert.2010.06.038","article-title":"More than Antioxidant: N-Acetyl-L-Cysteine in a Murine Model of Endometriosis","volume":"94","author":"Pittaluga","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00404-013-2963-0","article-title":"Effects of Amifostine on Endometriosis, Comparison with N-Acetyl Cysteine, and Leuprolide as a New Treatment Alternative: A Randomized Controlled Trial","volume":"289","author":"Onalan","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"111521","DOI":"10.1016\/j.mad.2021.111521","article-title":"Coenzyme Q10 Supplementation\u2014In Ageing and Disease","volume":"197","author":"Aaseth","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2741\/4231","article-title":"Clinical Applications of Coenzyme Q10","volume":"19","author":"Cordero","year":"2014","journal-title":"Front. Biosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1080\/01443615.2022.2114322","article-title":"The Therapeutic Effects of Coenzyme Q10 on Surgically Induced Endometriosis in Sprague Dawley Rats","volume":"42","author":"Demirel","year":"2022","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_110","first-page":"283","article-title":"Coenzyme Q10 Improves the in Vitro Maturation of Oocytes Exposed to the Intrafollicular Environment of Patients on Fertility Treatment","volume":"24","author":"Romero","year":"2020","journal-title":"JBRA Assist. Reprod."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.mito.2013.05.003","article-title":"Mitochondrial NADH:Ubiquinone Oxidoreductase Alterations Are Associated with Endometriosis","volume":"13","author":"Govatati","year":"2013","journal-title":"Mitochondrion"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/jsfa.10152","article-title":"Resveratrol: A Review of Plant Sources, Synthesis, Stability, Modification and Food Application","volume":"100","author":"Tian","year":"2020","journal-title":"J. Sci. Food Agric."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L., and He, J. (2021). Anti-Inflammatory Action and Mechanisms of Resveratrol. Molecules, 26.","DOI":"10.3390\/molecules26010229"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"11468","DOI":"10.1038\/s41598-023-38692-8","article-title":"Natural Resveratrol Analogs Differentially Target Endometriotic Cells into Apoptosis Pathways","volume":"13","author":"Kaczmarek","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1080\/09513590.2019.1576612","article-title":"The Modulating Effects of Resveratrol on the Expression of MMP-2 and MMP-9 in Endometriosis Women: A Randomized Exploratory Trial","volume":"35","author":"Kodarahmian","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"103248","DOI":"10.1016\/j.jri.2020.103248","article-title":"A Randomized Exploratory Trial to Assess the Effects of Resveratrol on VEGF and TNF-\u03b1 2 Expression in Endometriosis Women","volume":"143","author":"Khodarahmian","year":"2021","journal-title":"J. Reprod. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2147\/IJWH.S36825","article-title":"Advantages of the Association of Resveratrol with Oral Contraceptives for Management of Endometriosis-Related Pain","volume":"4","author":"Maia","year":"2012","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"717808","DOI":"10.3389\/fimmu.2021.717808","article-title":"Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction","volume":"12","author":"Piccinni","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_119","first-page":"1","article-title":"Differential Expression of Egfr-1, Mmp-3, and Mmp-9 in Spontaneous Abortions, Induced Abortions, and Tubal Pregnancies","volume":"35","author":"Balci","year":"2019","journal-title":"Turk. J. Pathol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1017\/S0967199421000113","article-title":"Circulating MMP-7 and VEGF as Potential Predictive Biomarkers for Recurrent Implantation Failures","volume":"29","author":"Benkhalifa","year":"2021","journal-title":"Zygote"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.7150\/ijbs.35128","article-title":"Cyclooxygenase-2 in Endometriosis","volume":"15","author":"Lai","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_122","first-page":"647","article-title":"Role of Inflammation and Aromatase Expression in the Eutopic Endometrium and Its Relationship with the Development of Endometriosis","volume":"8","author":"Maia","year":"2012","journal-title":"Women\u2019s Health"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.2147\/DDDT.S323790","article-title":"Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model","volume":"15","author":"Wang","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2014.10.041","article-title":"Is Resveratrol a Potential Substitute for Leuprolide Acetate in Experimental Endometriosis?","volume":"184","author":"Guven","year":"2015","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"9979953","DOI":"10.1155\/2021\/9979953","article-title":"Lipidomic Alterations and PPAR\u03b1 Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models","volume":"2021","author":"Chen","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/humrep\/det031","article-title":"Resveratrol Is a Potent Inhibitor of Vascularization and Cell Proliferation in Experimental Endometriosis","volume":"28","author":"Menger","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1095\/biolreprod.110.086744","article-title":"Resveratrol Inhibits Development of Experimental Endometriosis In Vivo and Reduces Endometrial Stromal Cell Invasiveness In Vitro","volume":"84","author":"Osteen","year":"2011","journal-title":"Biol. Reprod."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1177\/1933719113483014","article-title":"Regression of Endometrial Implants by Resveratrol in an Experimentally Induced Endometriosis Model in Rats","volume":"20","author":"Yeniel","year":"2013","journal-title":"Reprod. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/humrep\/des369","article-title":"Natural Therapies Assessment for the Treatment of Endometriosis","volume":"28","author":"Ricci","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.rbmo.2022.02.008","article-title":"Resveratrol Impairs Cellular Mechanisms Associated with the Pathogenesis of Endometriosis","volume":"44","author":"Madanes","year":"2022","journal-title":"Reprod. BioMed. Online"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1038\/s41598-021-85512-y","article-title":"The Effects of Resveratrol on the Expression of VEGF, TGF-\u03b2, and MMP-9 in Endometrial Stromal Cells of Women with Endometriosis","volume":"11","author":"Arablou","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/jcmm.16178","article-title":"Resveratrol Treatment Reduces Expression of MCP-1, IL-6, IL-8 and RANTES in Endometriotic Stromal Cells","volume":"25","author":"Shidfar","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/jog.12252","article-title":"Resveratrol Suppresses Inflammatory Responses in Endometrial Stromal Cells Derived from Endometriosis: A Possible Role of the Sirtuin 1 Pathway","volume":"40","author":"Taguchi","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Zou, W., Wang, X., Xia, X., Zhang, T., Nie, M., Xiong, J., and Fang, X. (2024). Resveratrol Protected against the Development of Endometriosis by Promoting Ferroptosis through miR-21-3p\/P53\/SLC7A11 Signaling Pathway. Biochem. Biophys. Res. Commun., 692.","DOI":"10.1016\/j.bbrc.2023.149338"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/12\/6298\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:55:07Z","timestamp":1760108107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/12\/6298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,7]]},"references-count":134,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ijms25126298"],"URL":"https:\/\/doi.org\/10.3390\/ijms25126298","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,7]]}}}