{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:53:24Z","timestamp":1792900404082,"version":"4.5.0"},"reference-count":172,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>While much has been learned about sphingolipids, originally named for their sphinx-like enigmatic properties, there are still many unanswered questions about the possible effect(s) of the composition of ceramide on the synthesis and\/or behavior of a glycosphingolipid (GSL). Over time, studies of their ceramide component, the sphingoid base containing the lipid moiety of GSLs, were frequently distinct from those performed to ascertain the roles of the carbohydrate moieties. Due to the number of classes of GSLs that can be derived from ceramide, this review focuses on the possible role(s) of ceramide in the synthesis\/function of just one GSL class, derived from glucosylceramide (Glc-Cer), namely sialylated ganglio derivatives, initially characterized and named gangliosides (GGs) due to their presence in ganglion cells. While much is known about their synthesis and function, much is still being learned. For example, it is only within the last 15\u201320 years or so that the mechanism by which the fatty acyl component of ceramide affected its transport to different sites in the Golgi, where it is used for the synthesis of Glu- or galactosyl-Cer (Gal-Cer) and more complex GSLs, was defined. Still to be fully addressed are questions such as (1) whether ceramide composition affects the transport of partially glycosylated GSLs to sites where their carbohydrate chain can be elongated or affects the activity of glycosyl transferases catalyzing that elongation; (2) what controls the differences seen in the ceramide composition of GGs that have identical carbohydrate compositions but vary in that of their ceramide and vice versa; (3) how alterations in ceramide composition affect the function of membrane GGs; and (4) how this knowledge might be applied to the development of therapies for treating diseases that correlate with abnormal expression of GGs. The availability of an updatable data bank of complete structures for individual classes of GSLs found in normal tissues as well as those associated with disease would facilitate research in this area.<\/jats:p>","DOI":"10.3390\/ijms25126312","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T08:05:17Z","timestamp":1717747517000},"page":"6312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sphingolipids: Less Enigmatic but Still Many Questions about the Role(s) of Ceramide in the Synthesis\/Function of the Ganglioside Class of Glycosphingolipids"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9894-9684","authenticated-orcid":false,"given":"Cara-Lynne","family":"Schengrund","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"ref_1","unstructured":"Thudichum, J.L.W. (1884). A Treatise on the Chemical Constitution of the Brain: Based throughout upon Original Researches, Bailliere, Tindall, and Cox. Available online: https:\/\/wellcomecollection.org\/works\/zcf2rr7p."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Klenk, E. (1942). \u00dcber Die Ganglioside, Eine Neue Gruppe von Zuckerhaltigen Gehirnlipoiden. Biol. Chem., 273.","DOI":"10.1515\/bchm2.1942.273.1-2.76"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/glycob\/1.6.623","article-title":"Synergistic Effect of Two Cell Recognition Systems: Glycosphingolipid-Glycosphingolipid Interaction and Integrin Receptor Interaction with Pericellular Matrix Protein","volume":"1","author":"Kojima","year":"1991","journal-title":"Glycobiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional Rafts in Cell Membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1023\/A:1011070425430","article-title":"Affinity Enhancement by Multivalent Lectin\u2013Carbohydrate Interaction","volume":"17","author":"Lee","year":"2000","journal-title":"Glycoconj. J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sasaki, N., Toyoda, M., and Ishiwata, T. (2021). Gangliosides as Signaling Regulators in Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105076"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Schengrund, C.-L., and Yu, R.K. (2023). Carbohydrates: Binding Sites and Potential Drug Targets for Neural-Affecting Pathogens. Glycobiology of the Nervous System, Springer International Publishing.","DOI":"10.1007\/978-3-031-12390-0_15"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"572965","DOI":"10.3389\/fnins.2020.572965","article-title":"Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications","volume":"14","author":"Sipione","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41586-020-2609-x","article-title":"Serine Restriction Alters Sphingolipid Diversity to Constrain Tumour Growth","volume":"586","author":"Muthusamy","year":"2020","journal-title":"Nature"},{"key":"ref_10","first-page":"1637","article-title":"Metabolism of Sphingosine Bases, VIII. Distribution, Isolation and Properties of D-3-Oxosphinganine Reductase. Stereospecificity of the NADPH-Dependent Reduction Reaction of 3-Oxodihydrosphingosine(2-Amino-1-Hydroxyoctadecane-3-One)","volume":"349","author":"Stoffel","year":"1968","journal-title":"Biol. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1194\/jlr.M800158-JLR200","article-title":"2-Hydroxy-Ceramide Synthesis by Ceramide Synthase Family: Enzymatic Basis for the Preference of FA Chain Length","volume":"49","author":"Mizutani","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"25512","DOI":"10.1074\/jbc.M202947200","article-title":"Identification and Characterization of a Sphingolipid \u03944-Desaturase Family","volume":"277","author":"Ternes","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"27855","DOI":"10.1074\/jbc.R111.254359","article-title":"Many Ceramides","volume":"286","author":"Hannun","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"37355","DOI":"10.1074\/jbc.M113.494740","article-title":"A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis","volume":"288","author":"Abuhusain","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-physiol-031620-093815","article-title":"Ceramides in Metabolism: Key Lipotoxic Players","volume":"83","author":"Chaurasia","year":"2021","journal-title":"Annu. Rev. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1073\/pnas.79.11.3470","article-title":"Possible Role of Ceramide in Defining Structure and Function of Membrane Glycolipids","volume":"79","author":"Kannagi","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/BF02531030","article-title":"A Comparative Study of Gangliosides from the Brains of Various Species","volume":"4","author":"Schengrund","year":"1969","journal-title":"Lipids"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1021\/jasms.1c00088","article-title":"Gangliosides of Human Glioblastoma Multiforme: A Comprehensive Mapping and Structural Analysis by Ion Mobility Tandem Mass Spectrometry","volume":"32","author":"Sarbu","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00018-012-1038-x","article-title":"Ceramide Function in the Brain: When a Slight Tilt Is Enough","volume":"70","author":"Mencarelli","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1073\/pnas.91.5.1974","article-title":"Ceramide Structure Predicts Tumor Ganglioside Immunosuppressive Activity","volume":"91","author":"Ladisch","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/glycob\/cwab046","article-title":"Glucosylceramide and Galactosylceramide, Small Glycosphingolipids with Significant Impact on Health and Disease","volume":"31","author":"Reza","year":"2021","journal-title":"Glycobiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1194\/jlr.R026682","article-title":"Role of Sulfatide in Normal and Pathological Cells and Tissues","volume":"53","author":"Takahashi","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"15591","DOI":"10.1073\/pnas.2002391117","article-title":"Subunit Composition of the Mammalian Serine-Palmitoyltransferase Defines the Spectrum of Straight and Methyl-Branched Long-Chain Bases","volume":"117","author":"Lone","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jmb.2007.04.086","article-title":"The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis","volume":"370","author":"Yard","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/002215540305100514","article-title":"Characterization of Serine Palmitoyltransferase in Normal Human Tissues","volume":"51","author":"Batheja","year":"2003","journal-title":"J. Histochem. Cytochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1073\/pnas.0811269106","article-title":"Identification of Small Subunits of Mammalian Serine Palmitoyltransferase That Confer Distinct Acyl-CoA Substrate Specificities","volume":"106","author":"Han","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/85879","article-title":"Mutations in SPTLC1, Encoding Serine Palmitoyltransferase, Long Chain Base Subunit-1, Cause Hereditary Sensory Neuropathy Type I","volume":"27","author":"Dawkins","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_28","first-page":"1","article-title":"SPTLC1 Mutations Associated with Early Onset Amyotrophic Lateral Sclerosis","volume":"34","author":"Gable","year":"2020","journal-title":"FASEB J."},{"key":"ref_29","unstructured":"(2024, March 15). The Human Protein Atlas Feb. Available online: https:\/\/www.proteinatlas.org\/ENSG00000119537-KDSR\/tissue."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"111415","DOI":"10.1016\/j.celrep.2022.111415","article-title":"De Novo Sphingolipid Biosynthesis Necessitates Detoxification in Cancer Cells","volume":"40","author":"Spears","year":"2022","journal-title":"Cell Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41375-021-01378-z","article-title":"3-Ketodihydrosphingosine Reductase Maintains ER Homeostasis and Unfolded Protein Response in Leukemia","volume":"36","author":"Liu","year":"2022","journal-title":"Leukemia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/iub.319","article-title":"Mammalian Ceramide Synthases","volume":"62","author":"Levy","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00418-007-0344-0","article-title":"Differential Expression of (Dihydro)Ceramide Synthases in Mouse Brain: Oligodendrocyte-Specific Expression of CerS2\/Lass2","volume":"129","author":"Becker","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.canlet.2007.06.003","article-title":"Clinical Relevance of Ceramide Metabolism in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma (HNSCC): Attenuation of C18-Ceramide in HNSCC Tumors Correlates with Lymphovascular Invasion and Nodal Metastasis","volume":"256","author":"Karahatay","year":"2007","journal-title":"Cancer Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neurobiolaging.2016.03.027","article-title":"Loss of Ceramide Synthase 2 Activity, Necessary for Myelin Biosynthesis, Precedes Tau Pathology in the Cortical Pathogenesis of Alzheimer\u2019s Disease","volume":"43","author":"Couttas","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/1346-8138.15725","article-title":"Comprehensive Stratum Corneum Ceramide Profiling Reveals Reduced Acylceramides in Ichthyosis Patient with CERS3 Mutations","volume":"48","author":"Yamamoto","year":"2021","journal-title":"J. Dermatol."},{"key":"ref_37","first-page":"18","article-title":"Ceramide- and Keratolytic-Containing Body Cleanser and Cream Application in Patients with Psoriasis: Outcomes from a Consumer Usage Study","volume":"12","year":"2019","journal-title":"J. Clin. Anesth. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"16249","DOI":"10.1038\/s41598-023-43557-1","article-title":"Ceramide Synthase CERS4 Gene Downregulation Is Associated with KRAS Mutation in Colorectal Cancer","volume":"13","author":"Hayama","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"33735","DOI":"10.1074\/jbc.M506485200","article-title":"LASS5 Is a Bona Fide Dihydroceramide Synthase That Selectively Utilizes Palmitoyl-CoA as Acyl Donor","volume":"280","author":"Lahiri","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"El-Hindi, K., Brachtendorf, S., Hartel, J.C., Oertel, S., Birod, K., Trautmann, S., Thomas, D., Ulsh\u00f6fer, T., Weigert, A., and Uterm\u00f6hlen, O. (2020). Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation. Cancers, 12.","DOI":"10.3390\/cancers12071753"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41419-018-0964-4","article-title":"Ceramide Synthase-6 Confers Resistance to Chemotherapy by Binding to CD95\/Fas in T-Cell Acute Lymphoblastic Leukemia","volume":"9","author":"Verlekar","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4048\/jbc.2022.25.e47","article-title":"Ceramide Synthase 6 Mediates Triple-Negative Breast Cancer Response to Chemotherapy Through RhoA- and EGFR-Mediated Signaling Pathways","volume":"25","author":"Chen","year":"2022","journal-title":"J. Breast Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbalip.2014.09.021","article-title":"Dihydroceramide Desaturase 1, the Gatekeeper of Cramide Induced Lipotoxicity","volume":"1851","author":"Barbarroja","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e162957","DOI":"10.1172\/JCI162957","article-title":"Sphingolipid Desaturase DEGS1 Is Essential for Mitochondria-Associated Membrane Integrity","volume":"133","author":"Launay","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"101236","DOI":"10.1016\/j.plipres.2023.101236","article-title":"The Pathophysiological Role of Dihydroceramide Desaturase in the Nervous System","volume":"91","author":"Tzou","year":"2023","journal-title":"Prog. Lipid Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.1074\/jbc.M409290200","article-title":"CERT Mediates Intermembrane Transfer of Various Molecular Species of Ceramides","volume":"280","author":"Kumagai","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"426","DOI":"10.2183\/pjab.86.426","article-title":"Intracellular Trafficking of Ceramide by Ceramide Transfer Protein","volume":"86","author":"Hanada","year":"2010","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hanada, K., Sakai, S., and Kumagai, K. (2022). Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042098"},{"key":"ref_49","first-page":"40","article-title":"CERT-Dependent Ceramide Transport, A Crucial Process in Cells","volume":"3","author":"Bandet","year":"2021","journal-title":"J. Diabetes Clin. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1002\/1873-3468.13511","article-title":"Structure, Functions and Regulation of CERT, a Lipid-Transfer Protein for the Delivery of Ceramide at the ER\u2013Golgi Membrane Contact Sites","volume":"593","author":"Kumagai","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature14135","article-title":"Large-Scale Discovery of Novel Genetic Causes of Developmental Disorders","volume":"519","author":"Fitzgerald","year":"2015","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bbalip.2008.06.002","article-title":"Ceramidases: Regulators of Cellular Responses Mediated by Ceramide, Sphingosine, and Sphingosine-1-Phosphate","volume":"1781","author":"Mao","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1016\/j.jmb.2016.06.012","article-title":"Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis","volume":"428","author":"Xiong","year":"2016","journal-title":"J. Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Duarte, C., Akkaoui, J., Yamada, C., Ho, A., Mao, C., and Movila, A. (2020). Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration. Cells, 9.","DOI":"10.3390\/cells9061379"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kleynerman, A., Rybova, J., Faber, M.L., McKillop, W.M., Levade, T., and Medin, J.A. (2023). Acid Ceramidase Deficiency: Bridging Gaps between Clinical Presentation, Mouse Models, and Future Therapeutic Interventions. Biomolecules, 13.","DOI":"10.3390\/biom13020274"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1194\/jlr.D061564","article-title":"Activity of Neutral and Alkaline Ceramidases on Fluorogenic N-Acylated Coumarin-Containing Aminodiols","volume":"56","author":"Casasampere","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Gomez-Larrauri, A., Das Adhikari, U., Aramburu-Nu\u00f1ez, M., Custodia, A., and Ouro, A. (2021). Ceramide Metabolism Enzymes\u2014Therapeutic Targets against Cancer. Medicina, 57.","DOI":"10.3390\/medicina57070729"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1096\/fj.201600611R","article-title":"Role of Neutral Ceramidase in Colon Cancer","volume":"30","author":"Coant","year":"2016","journal-title":"FASEB J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/sj.jid.5701025","article-title":"Upregulation of the Human Alkaline Ceramidase 1 and Acid Ceramidase Mediates Calcium-Induced Differentiation of Epidermal Keratinocytes","volume":"128","author":"Sun","year":"2008","journal-title":"J. Investig. Derm."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8995","DOI":"10.1074\/jbc.M109.069203","article-title":"Substrate Specificity, Membrane Topology, and Activity Regulation of Human Alkaline Ceramidase 2 (ACER2)","volume":"285","author":"Sun","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1074\/jbc.M109.063586","article-title":"Alkaline Ceramidase 3 (ACER3) Hydrolyzes Unsaturated Long-Chain Ceramides, and Its down-Regulation Inhibits Both Cell Proliferation and Apoptosis","volume":"285","author":"Hu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1038\/s41467-018-07864-w","article-title":"Structure of a Human Intramembrane Ceramidase Explains Enzymatic Dysfunction Found in Leukodystrophy","volume":"9","author":"Healey","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e2124","DOI":"10.1038\/cddis.2016.36","article-title":"Alkaline Ceramidase 3 Deficiency Aggravates Colitis and Colitis-Associated Tumorigenesis in Mice by Hyperactivating the Innate Immune System","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Jiang, X.-C. (2022). Sphingomyelin Synthase Family and Phospholipase Cs. Sphingolipid Metabolism and Metabolic Disease, Springer Nature Singapore.","DOI":"10.1007\/978-981-19-0394-6_7"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1074\/jbc.M702423200","article-title":"Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells","volume":"282","author":"Tafesse","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8650","DOI":"10.1016\/S0021-9258(19)38937-9","article-title":"Sphingomyelin Synthesis in Rat Liver Occurs Predominantly at the Cis and Medial Cisternae of the Golgi Apparatus","volume":"265","author":"Futerman","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"29421","DOI":"10.1074\/jbc.R600021200","article-title":"The Multigenic Sphingomyelin Synthase Family","volume":"281","author":"Tafesse","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cmet.2017.02.010","article-title":"Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets","volume":"25","author":"Senkal","year":"2017","journal-title":"Cell Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1074\/jbc.M805768200","article-title":"The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-Associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria","volume":"284","author":"Stone","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1194\/jlr.M500313-JLR200","article-title":"Substrate Specificity of Human Ceramide Kinase","volume":"46","author":"Wijesinghe","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1194\/jlr.M700083-JLR200","article-title":"Ceramide Kinase Uses Ceramide Provided by Ceramide Transport Protein: Localization to Organelles of Eicosanoid Synthesis","volume":"48","author":"Lamour","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of Bioactive Lipid Signalling: Lessons from Sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1021\/bi00830a008","article-title":"Synthesis of Cerebroside by Brain from Uridine Diphosphate Galactose and Ceramide Containing Hydroxy Fatty Acid","volume":"8","author":"Morell","year":"1969","journal-title":"Biochemistry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0006-8993(72)90774-3","article-title":"Synthesis of Galactosyl Ceramide and Glucosyl Ceramide by Rat Brain: Assay Procedures and Changes with Age","volume":"36","author":"Brenkert","year":"1972","journal-title":"Brain Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"43156","DOI":"10.1074\/jbc.M112.380444","article-title":"The Lifetime of UDP-Galactose:Ceramide Galactosyltransferase Is Controlled by a Distinct Endoplasmic Reticulum-Associated Degradation (ERAD) Regulated by Sigma-1 Receptor Chaperones","volume":"287","author":"Hayashi","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/tra.12239","article-title":"Sphingolipid Metabolism and Interorganellar Transport: Localization of Sphingolipid Enzymes and Lipid Transfer Proteins","volume":"16","author":"Yamaji","year":"2015","journal-title":"Traffic"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"25880","DOI":"10.1074\/jbc.273.40.25880","article-title":"UDP-Galactose:Ceramide Galactosyltransferase Is a Class I Integral Membrane Protein of the Endoplasmic Reticulum","volume":"273","author":"Sprong","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1128\/AAC.48.5.1614-1623.2004","article-title":"Novel Polysulfated Galactose-Derivatized Dendrimers as Binding Antagonists of Human Immunodeficiency Virus Type 1 Infection","volume":"48","author":"Kensinger","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-2275(20)39839-4","article-title":"Krabbe Disease: A Galactosylsphingosine (Psychosine) Lipidosis","volume":"21","author":"Svennerholm","year":"1980","journal-title":"J. Lipid Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Chen, S., Wang, Y., Kong, L., Ji, Y., Cui, J., and Shen, W. (2023). Role of UDP-Glucose Ceramide Glucosyltransferase in Venous Malformation. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1178045"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41598-017-18405-8","article-title":"Alterations in the Properties of the Cell Membrane Due to Glycosphingolipid Accumulation in a Model of Gaucher Disease","volume":"8","author":"Batta","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1042\/BJ20111626","article-title":"Ceramide Synthases at the Centre of Sphingolipid Metabolism and Biology","volume":"441","author":"Mullen","year":"2012","journal-title":"Biochem. J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.bpj.2012.09.018","article-title":"Importance of the Sphingoid Base Length for the Membrane Properties of Ceramides","volume":"103","author":"Maula","year":"2012","journal-title":"Biophys. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1002\/2211-5463.13197","article-title":"The Structure of Gangliosides Hides a Code for Determining Neuronal Functions","volume":"11","author":"Lunghi","year":"2021","journal-title":"FEBS Open Bio"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.bbamem.2011.07.023","article-title":"Effect of Ceramide Structure on Membrane Biophysical Properties: The Role of Acyl Chain Length and Unsaturation","volume":"1808","author":"Pinto","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Biomembr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11746-009-1423-2","article-title":"A Comprehensive Evaluation of the Melting Points of Fatty Acids and Esters Determined by Differential Scanning Calorimetry","volume":"86","author":"Knothe","year":"2009","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1093\/jn\/134.11.3016","article-title":"Human and Bovine Milk Gangliosides Differ in Their Fatty Acid Composition","volume":"134","author":"Bode","year":"2004","journal-title":"J. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"16465","DOI":"10.1021\/acs.analchem.3c00737","article-title":"Defining the Ceramide Composition of Bovine and Human Milk Gangliosides by Direct Infusion ESI-CID Tandem Mass Spectrometry of Native and Permethylated Molecular Species","volume":"95","author":"Liyanage","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/emm.1996.5","article-title":"Changes of Gangliosides and Sialic Acid in Human Milk during Lactation","volume":"28","author":"Eom","year":"1996","journal-title":"Exp. Mol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature12423","article-title":"Vesicular and Non-Vesicular Transport Feed Distinct Glycosylation Pathways in the Golgi","volume":"501","author":"Uemura","year":"2013","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Chung, L., Liu, D., Liu, X., and Qi, Y. (2021). Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413184"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"100210","DOI":"10.1016\/j.jlr.2022.100210","article-title":"Sulfatide with Ceramide Composed of Phytosphingosine (T18:0) and 2-Hydroxy FAs in Renal Intercalated Cells","volume":"63","author":"Nakashima","year":"2022","journal-title":"J. Lipid Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbalip.2009.12.004","article-title":"Fatty Acid 2-Hydroxylation in Mammalian Sphingolipid Biology","volume":"1801","author":"Hama","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"101031","DOI":"10.1016\/j.plipres.2020.101031","article-title":"Emerging Roles for Human Glycolipid Transfer Protein Superfamily Members in the Regulation of Autophagy, Inflammation, and Cell Death","volume":"78","author":"Mishra","year":"2020","journal-title":"Prog. Lipid Res."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Backman, A.P.E., Halin, J., Nurmi, H., M\u00f6uts, A., Kjellberg, M.A., and Mattjus, P. (2018). Glucosylceramide Acyl Chain Length Is Sensed by the Glycolipid Transfer Protein. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0209230"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Lauria, I., van \u00dc\u00fcm, J., Mjumjunov-Crncevic, E., Walrafen, D., Spitta, L., Thiele, C., and Lang, T. (2013). GLTP Mediated Non-Vesicular GM1 Transport between Native Membranes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059871"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Nurmi, H., Backman, A.P.E., Halin, J., L\u00f6nnfors, M., Blom, T., Roos-Mattjus, P., and Mattjus, P. (2023). Glycolipid Transfer Protein Knockout Disrupts Vesicle Trafficking to the Plasma Membrane. J. Biol. Chem., 299.","DOI":"10.1016\/j.jbc.2023.104607"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S003358351400016X","article-title":"Sphingolipid Transfer Proteins Defined by the GLTP-Fold","volume":"48","author":"Simanshu","year":"2015","journal-title":"Q. Rev. Biophys."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.chemphyslip.2015.07.018","article-title":"Specificity of the Mammalian Glycolipid Transfer Proteins","volume":"194","author":"Mattjus","year":"2016","journal-title":"Chem. Phys. Lipids"},{"key":"ref_100","first-page":"29","article-title":"The Surface Coats of Animal Cells11Part of the Personal Work Mentioned in This Review Was Performed at the Institut de Recherches Scientifiques Sur Le Cancer, Villejuif, France","volume":"Volume 29","author":"Bourne","year":"1970","journal-title":"International Review of Cytology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1515\/BC.2001.031","article-title":"Segregation of Gangliosides GM1 and GD3 on Cell Membranes, Isolated Membrane Rafts, and Defined Supported Lipid Monolayers","volume":"382","author":"Vyas","year":"2001","journal-title":"Biol. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-3-031-12390-0_10","article-title":"Ganglioside Microdomains on Cellular and Intracellular Membranes Regulate Neuronal Cell Fate Determination","volume":"29","author":"Itokazu","year":"2023","journal-title":"Adv. Neurobiol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Chowdhury, S., and Ledeen, R. (2022). The Key Role of GM1 Ganglioside in Parkinson\u2019s Disease. Biomolecules, 12.","DOI":"10.3390\/biom12020173"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nature08021","article-title":"Genes That Mediate Breast Cancer Metastasis to the Brain","volume":"459","author":"Bos","year":"2009","journal-title":"Nature"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/s41598-019-57130-2","article-title":"B4GALNT1 Induces Angiogenesis, Anchorage Independence Growth and Motility, and Promotes Tumorigenesis in Melanoma by Induction of Ganglioside GM2\/GD2","volume":"10","author":"Yoshida","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"120748","DOI":"10.1155\/2015\/120748","article-title":"Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans","volume":"2015","author":"Iwabuchi","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0008-8749(92)90096-8","article-title":"Immunosuppression by human gangliosides: II. Carbohydrate structure and inhibition of human NK activity","volume":"139","author":"Grayson","year":"1992","journal-title":"Cell. Immun."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Svennerholm, L. (1980). Ganglioside Designation. Adv. Exp. Med. Biol., 125.","DOI":"10.1007\/978-1-4684-7844-0_2"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/1791088b0","article-title":"Proposed Nomenclature in the Field of Neuraminic and Sialic Acids","volume":"179","author":"Blix","year":"1957","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Svennerholm, L. (1980). Gangliosides and Synaptic Transmission. Structure and Function of Gangliosides, Springer.","DOI":"10.1007\/978-1-4684-7844-0"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"16135","DOI":"10.1038\/s41598-017-16389-z","article-title":"Age-Dependent and Regional Heterogeneity in the Long-Chain Base of A-Series Gangliosides Observed in the Rat Brain Using MALDI Imaging","volume":"7","author":"Caughlin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1074\/jbc.C000847200","article-title":"Mice Expressing Only Monosialoganglioside GM3 Exhibit Lethal Audiogenic Seizures","volume":"276","author":"Kawai","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/ng1460","article-title":"Infantile-Onset Symptomatic Epilepsy Syndrome Caused by a Homozygous Loss-of-Function Mutation of GM3 Synthase","volume":"36","author":"Simpson","year":"2004","journal-title":"Nat. Genet."},{"key":"ref_114","unstructured":"Sonnino, S., and Prinetti, A. (2018). Ganglioside Metabolism and Its Inherited Diseases. Gangliosides: Methods and Protocols, Springer New York."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/S0021-9258(17)35954-9","article-title":"Ganglioside-Mediated Modulation of Cell Growth. Specific Effects of GM3 on Tyrosine Phosphorylation of the Epidermal Growth Factor Receptor","volume":"261","author":"Bremer","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1073\/pnas.0503658102","article-title":"Ganglioside GD3 Promotes Cell Growth and Invasion through p130Cas and Paxillin in Malignant Melanoma Cells","volume":"102","author":"Hamamura","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/joa.13562","article-title":"The Role of Gangliosides in the Organisation of the Node of Ranvier Examined in Glycosyltransferase Transgenic Mice","volume":"241","author":"McGonigal","year":"2022","journal-title":"J. Anat."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00005053-188709000-00001","article-title":"On Arrested Cerebral Development, With Special Reference to Its Cortical Pathology","volume":"14","author":"Sachs","year":"1887","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bbalip.2010.01.008","article-title":"A\u03b2 Polymerization through Interaction with Membrane Gangliosides","volume":"1801","author":"Matsuzaki","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"8512","DOI":"10.1038\/s41598-019-44739-6","article-title":"Ganglioside GQ1b Ameliorates Cognitive Impairments in an Alzheimer\u2019s Disease Mouse Model, and Causes Reduction of Amyloid Precursor Protein","volume":"9","author":"Shin","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/glycob\/cwn114","article-title":"Ganglioside GM3 Inhibits VEGF\/VEGFR-2-Mediated Angiogenesis: Direct Interaction of GM3 with VEGFR-2","volume":"19","author":"Chung","year":"2009","journal-title":"Glycobiology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/glycob\/cwv091","article-title":"Symbol Nomenclature for Graphical Representations of Glycans","volume":"25","author":"Varki","year":"2015","journal-title":"Glycobiology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/glycob\/cwq098","article-title":"\u03924-Galactosyltransferase-5 Is a Lactosylceramide Synthase Essential for Mouse Extra-Embryonic Development","volume":"20","author":"Nishie","year":"2010","journal-title":"Glycobiology"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/glycob\/cwt054","article-title":"\u03b24GalT6 Is Involved in the Synthesis of Lactosylceramide with Less Intensity than \u03b24GalT5","volume":"23","author":"Tokuda","year":"2013","journal-title":"Glycobiology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.febslet.2015.09.018","article-title":"Ganglioside GM3 as a Gatekeeper of Obesity-Associated Insulin Resistance: Evidence and Mechanisms","volume":"589","author":"Lipina","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/glycob\/cwh135","article-title":"TNF\u03b1-Induced Insulin Resistance in Adipocytes as a Membrane Microdomain Disorder: Involvement of Ganglioside GM3","volume":"15","author":"Kabayama","year":"2005","journal-title":"Glycobiology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/bs.pmbts.2017.10.004","article-title":"Chapter Five\u2014Biology of GM3 Ganglioside","volume":"Volume 156","author":"Schnaar","year":"2018","journal-title":"Progress in Molecular Biology and Translational Science"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s40001-023-01523-7","article-title":"A Comprehensive Review of the Family of Very-Long-Chain Fatty Acid Elongases: Structure, Function, and Implications in Physiology and Pathology","volume":"28","author":"Wang","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Inokuchi, J.I., and Kanoh, H. (2022). Pathophysiological Significance of GM3 Ganglioside Molecular Species with a Particular Attention to the Metabolic Syndrome Focusing on Toll-Like Receptor 4 Binding. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.918346"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cmet.2016.11.009","article-title":"SREBP1 Contributes to Resolution of Pro-Inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism","volume":"25","author":"Oishi","year":"2017","journal-title":"Cell Metab."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1194\/jlr.M042002","article-title":"The Sphingoid Bases of Sphingolipids, Including Ceramides, Can Vary in Length from 12 to >20 Carbons","volume":"55","author":"Pinto","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/j.1471-4159.1990.tb04930.x","article-title":"Different Ceramide Compositions of Gangliosides between Human Motor and Sensory Nerves","volume":"55","author":"Funamoto","year":"1990","journal-title":"J. Neurochem."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Ma, L., Fong, B.Y., MacGibbon, A.K.H., and Norris, G. (2020). Qualitative and Quantitative Study of Glycosphingolipids in Human Milk and Bovine Milk Using High Performance Liquid Chromatography-Data-Dependent Acquisition-Mass Spectrometry. Molecules, 25.","DOI":"10.3390\/molecules25174024"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1194\/jlr.M055319","article-title":"Direct Interaction, Instrumental for Signaling Processes, between LacCer and Lyn in the Lipid Rafts of Neutrophil-like Cells","volume":"56","author":"Chiricozzi","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Chatterjee, S., Balram, A., and Li, W. (2021). Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041816"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1167\/iovs.04-1439","article-title":"Dietary Ganglioside and Long-Chain Polyunsaturated Fatty Acids Increase Ganglioside GD3 Content and Alter the Phospholipid Profile in Neonatal Rat Retina","volume":"46","author":"Park","year":"2005","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e101732","DOI":"10.15252\/embj.2019101732","article-title":"Homeostatic and Pathogenic Roles of GM 3 Ganglioside Molecular Species in TLR 4 Signaling in Obesity","volume":"39","author":"Kanoh","year":"2020","journal-title":"EMBO J."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Veillon, L., Go, S., Matsuyama, W., Suzuki, A., Nagasaki, M., Yatomi, Y., and Inokuchi, J.-I. (2015). Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129645"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1021\/cn100096h","article-title":"Molecular Microscopy of Brain Gangliosides: Illustrating Their Distribution in Hippocampal Cell Layers","volume":"2","author":"Colsch","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/glycob\/cwp149","article-title":"Characterization of GD3 Ganglioside as a Novel Biomarker of Mouse Neural Stem Cells","volume":"20","author":"Nakatani","year":"2010","journal-title":"Glycobiology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"750","DOI":"10.4161\/auto.27959","article-title":"Evidence for the Involvement of GD3 Ganglioside in Autophagosome Formation and Maturation","volume":"10","author":"Matarrese","year":"2014","journal-title":"Autophagy"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/jnr.490120208","article-title":"Fatty Acid and Long-Chain Base Composition of Gangliosides Isolated from Adult Human Brain","volume":"12","author":"Ando","year":"1984","journal-title":"J. Neurosci. Res."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Schengrund, C. (2023). The Ying and Yang of Ganglioside Function in Cancer. Cancers, 15.","DOI":"10.3390\/cancers15225362"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Vajn, K., Viljetic, B., Degmecic, V., Schnaar, R.L., and Heffer, M. (2013). Differential Distribution of Major Brain Gangliosides in the Adult Mouse Central Nervous System. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075720"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1007\/s12035-015-9136-z","article-title":"GM1 Ganglioside: Past Studies and Future Potential","volume":"53","author":"Aureli","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1038\/s41467-021-23961-9","article-title":"Ceramide Structure Dictates Glycosphingolipid Nanodomain Assembly and Function","volume":"12","author":"Arumugam","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"111063","DOI":"10.1016\/j.celrep.2022.111063","article-title":"Structural Basis for Acyl Chain Control over Glycosphingolipid Sorting and Vesicular Trafficking","volume":"40","author":"Schmieder","year":"2022","journal-title":"Cell Rep."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Chowdhury, S., Wu, G., Lu, Z.-H., Kumar, R., and Ledeen, R. (2023). Age-Related Decline in Gangliosides GM1 and GD1a in Non-CNS Tissues of Normal Mice: Implications for Peripheral Symptoms of Parkinson\u2019s Disease. Biomedicines, 11.","DOI":"10.3390\/biomedicines11010209"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"11239","DOI":"10.1074\/jbc.M107756200","article-title":"Overexpression of Ganglioside GM1 Results in the Dispersion of Platelet-Derived Growth Factor Receptor from Glycolipid-Enriched Microdomains and in the Suppression of Cell Growth Signals","volume":"277","author":"Mitsuda","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1248\/bpb.b12-00400","article-title":"An Approach to Glycobiology from Glycolipidomics: Ganglioside Molecular Scanning in the Brains of Patients with Alzheimer\u2019s Disease by TLC-Blot\/Matrix Assisted Laser Desorption\/Ionization-Time of Flight MS","volume":"35","author":"Taki","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Sarbu, M., Ica, R., and Zamfir, A.D. (2022). Gangliosides as Biomarkers of Human Brain Diseases: Trends in Discovery and Characterization by High-Performance Mass Spectrometry. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020693"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10719-015-9579-5","article-title":"GM1 Ganglioside and Alzheimer\u2019s Disease","volume":"32","author":"Yanagisawa","year":"2015","journal-title":"Glycoconj. J."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/jns.12359","article-title":"Myelin Uncompaction and Axo-glial Detachment in Chronic Ataxic Neuropathy with Monospecific IgM Antibody to Ganglioside GD1b","volume":"25","author":"Tagliapietra","year":"2020","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e102214","DOI":"10.15252\/embj.2019102214","article-title":"GT1b Functions as a Novel Endogenous Agonist of Toll-like Receptor 2 Inducing Neuropathic Pain","volume":"39","author":"Lim","year":"2020","journal-title":"EMBO J."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Ica, R., Mlinac-Jerkovic, K., Ilic, K., Sajko, T., Munteanu, C.V.A., Zamfir, A.D., and Kalanj-Bognar, S. (2022). Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry. Molecules, 27.","DOI":"10.3390\/molecules27134056"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000063604","article-title":"Alzheimer Disease\u2013Effect of Continuous Intracerebroventricular Treatment with GM1 Ganglioside and a Systematic Activation Programme","volume":"14","author":"Svennerholm","year":"2002","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Schneider, J.S. (2018). Altered Expression of Genes Involved in Ganglioside Biosynthesis in Substantia Nigra Neurons in Parkinson\u2019s Disease. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199189"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3389\/fneur.2019.00859","article-title":"Gangliosides: Treatment Avenues in Neurodegenerative Disease","volume":"10","author":"Magistretti","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Groux-Degroote, S., and Delannoy, P. (2021). Cancer-Associated Glycosphingolipids as Tumor Markers and Targets for Cancer Immunotherapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116145"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1182\/blood.V75.7.1564.1564","article-title":"Shed Tumor Gangliosides and Progression of Human Neuroblastoma","volume":"75","author":"Valentino","year":"1990","journal-title":"Blood"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10555-023-10108-z","article-title":"Current State-of-the-Art on Ganglioside-Mediated Immune Modulation in the Tumor Microenvironment","volume":"42","author":"Windhouwer","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e28031","DOI":"10.1002\/pbc.28031","article-title":"The Ganglioside GD2 as a Circulating Tumor Biomarker for Neuroblastoma","volume":"67","author":"Balis","year":"2020","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3389\/fonc.2020.01000","article-title":"Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy","volume":"10","author":"Nazha","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/MPH.0000000000001369","article-title":"Advances in Anti-GD2 Immunotherapy for Treatment of High-Risk Neuroblastoma","volume":"41","author":"Voeller","year":"2019","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1200\/JCO.2008.16.6785","article-title":"The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report","volume":"27","author":"Cohn","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1200\/JCO.21.02478","article-title":"Outcomes Following GD2-Directed Postconsolidation Therapy for Neuroblastoma After Cessation of Random Assignment on ANBL0032: A Report from the Children\u2019s Oncology Group","volume":"40","author":"Desai","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and Dysfunction of the Blood-Brain Barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/10826076.2020.1856136","article-title":"A New LC-MS\/MS Technique for Separation of Gangliosides Using a Phenyl-Hexyl Column: Systematic Separation According to Sialic Acid Class and Ceramide Subclass","volume":"44","author":"Gobburi","year":"2021","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Biricioiu, M.R., Sarbu, M., Ica, R., Vukeli\u0107, \u017d., Kalanj-Bognar, S., and Zamfir, A.D. (2024). Advances in Mass Spectrometry of Gangliosides Expressed in Brain Cancers. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021335"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1021\/jacsau.2c00230","article-title":"Decoding Distinct Ganglioside Patterns of Native and Differentiated Mesenchymal Stem Cells by a Novel Glycolipidomics Profiling Strategy","volume":"2","author":"Hohenwallner","year":"2022","journal-title":"JACS Au"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1R","DOI":"10.1093\/glycob\/cwl052","article-title":"Gangliosides as Components of Lipid Membrane Domains","volume":"17","author":"Sonnino","year":"2007","journal-title":"Glycobiology"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s42004-024-01102-9","article-title":"A Modular Chemoenzymatic Cascade Strategy for the Structure-Customized Assembly of Ganglioside Analogs","volume":"7","author":"Jin","year":"2024","journal-title":"Commun. 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