{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:13:45Z","timestamp":1789787625977,"version":"4.0.1"},"reference-count":92,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Science Foundation","award":["23-15-00060"],"award-info":[{"award-number":["23-15-00060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In this exploratory study, we searched for associations between the two most common diseases of the oral cavity\u2014dental caries and periodontal diseases\u2014taking into account additional factors, such as personalized clinical pictures (the individual risk factors of the patient), based on the method of a multivariate data analysis of the molecular changes in the composition of human gingival crevicular fluid (GCF). For this purpose, a set of synchrotron Fourier-transform infrared spectroscopy (FTIR) spectra of gingival crevicular fluid samples from patients with different demographics, levels of dental caries development and periodontal diseases, and the presence\/absence of concomitant chronic diseases were obtained and analyzed. Using a set of techniques (v-, F-, Chi-square tests; a principal component analysis (PCA); and the hierarchical clustering of principal components (HCPCs)) implemented in the R package FactoMineR allowed us to assess the relationship between the principal components (PCs) and characteristics of the respondents. By identifying the features (vibrational modes in the FTIR spectra) that contribute most to the differentiation of the spectral dataset, and by taking into account the interrelationships between the patients\u2019 characteristics, we were able to match specific biological markers (specific molecular groups) to the two factors of interest\u2014two types of oral pathologies. The results obtained show that the observed changes in the quantitative and qualitative composition of the modes in the infrared (IR) spectra of the GCF samples from patients with different dental caries developments and periodontal diseases present confirm the difficulty of identifying patient-specific spectral information. At the same time, different periodontal pathologies are more closely associated with other characteristics of the patients than the level of their caries development. The multivariate analysis performed on the spectral dataset indicates the need to take into account not only the co-occurrence of oral diseases, but also some other factors. The lack of this consideration (typical in lots of studies in this area) may lead to misinterpretations and consequently to a loss of data when searching for biological markers of certain oral diseases.<\/jats:p>","DOI":"10.3390\/ijms25126395","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T10:08:43Z","timestamp":1718014123000},"page":"6395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Study of the Association between Primary Oral Pathologies (Dental Caries and Periodontal Diseases) Using Synchrotron Molecular FTIR Spectroscopy in View of the Patient\u2019s Personalized Clinical Picture (Demographics and Anamnesis)"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-0063","authenticated-orcid":false,"given":"Pavel","family":"Seredin","sequence":"first","affiliation":[{"name":"Department of Solid-State Physics and Nanostructures, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-3700","authenticated-orcid":false,"given":"Tatiana","family":"Litvinova","sequence":"additional","affiliation":[{"name":"Department of Solid-State Physics and Nanostructures, Voronezh State University, 394018 Voronezh, Russia"},{"name":"Psycholinguistic Textual Modelling Lab, Voronezh State Pedagogical University, 394043 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Ippolitov","sequence":"additional","affiliation":[{"name":"Department of Solid-State Physics and Nanostructures, Voronezh State University, 394018 Voronezh, Russia"},{"name":"Department of Pediatric Dentistry with Orthodontia, Voronezh State Medical University, 394006 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Goloshchapov","sequence":"additional","affiliation":[{"name":"Department of Solid-State Physics and Nanostructures, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslav","family":"Peshkov","sequence":"additional","affiliation":[{"name":"Department of Solid-State Physics and Nanostructures, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Kashkarov","sequence":"additional","affiliation":[{"name":"Department of Solid-State Physics and Nanostructures, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ippolitov","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry with Orthodontia, Voronezh State Medical University, 394006 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boknam","family":"Chae","sequence":"additional","affiliation":[{"name":"Pohang Accelerator Laboratory, Beamline Research Division, Pohang 37673, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"971223","DOI":"10.3389\/froh.2022.971223","article-title":"Your Health Is in Your Mouth: A Comprehensive View to Promote General Wellness","volume":"3","year":"2022","journal-title":"Front. 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