{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:20:51Z","timestamp":1790659251574,"version":"4.1.0"},"reference-count":145,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad de Guadalajara","award":["266214-2022"],"award-info":[{"award-number":["266214-2022"]}]},{"name":"Universidad de Guadalajara","award":["271879-2023"],"award-info":[{"award-number":["271879-2023"]}]},{"name":"IECD","award":["266214-2022"],"award-info":[{"award-number":["266214-2022"]}]},{"name":"IECD","award":["271879-2023"],"award-info":[{"award-number":["271879-2023"]}]},{"name":"CONAHCYT (Doctorado en Ciencias en Biolog\u00eda Molecular en Medicina, CUCS, UdeG)","award":["266214-2022"],"award-info":[{"award-number":["266214-2022"]}]},{"name":"CONAHCYT (Doctorado en Ciencias en Biolog\u00eda Molecular en Medicina, CUCS, UdeG)","award":["271879-2023"],"award-info":[{"award-number":["271879-2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Leptin regulates lipid metabolism, maximizing insulin sensitivity; however, peripheral leptin resistance is not fully understood, and its contribution to metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear. This study evaluated the contribution of the leptin axis to MASLD in humans. Forty-three participants, mostly female (86.04%), who underwent cholecystectomy were biopsied. Of the participants, 24 were healthy controls, 8 had MASLD, and 11 had metabolic dysfunction-associated steatohepatitis (MASH). Clinical and biochemical data and the gene expression of leptin, leptin receptor (LEPR), suppressor of cytokine signaling 3 (SOCS3), sterol regulatory element-binding transcription factor 1 (SREBF1), stearoyl-CoA desaturase-1 (SCD1), and patatin-like phospholipase domain-containing protein 2 (PNPLA2), were determined from liver and adipose tissue. Higher serum leptin and LEPR levels in the omental adipose tissue (OAT) and liver with MASH were found. In the liver, LEPR was positively correlated with leptin expression in adipose tissue, and SOCS3 was correlated with SREBF1-SCD1. In OAT, SOCS3 was correlated with insulin resistance and transaminase enzymes (p &lt; 0.05 for all. In conclusion, we evidenced the correlation between the peripheral leptin resistance axis in OAT\u2013liver crosstalk and the complications of MASLD in humans.<\/jats:p>","DOI":"10.3390\/ijms25126420","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T12:11:00Z","timestamp":1718107860000},"page":"6420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-0005","authenticated-orcid":false,"given":"Lucia","family":"De la Cruz-Color","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Biotecnolog\u00eda Microbiana y Alimentaria, Divisi\u00f3n de Desarrollo Biotecnol\u00f3gico, Centro Universitario de la Ci\u00e9nega, Universidad de Guadalajara, Ocotl\u00e1n 47820, C.P., Mexico"},{"name":"Instituto de Investigaci\u00f3n en Enfermedades Cr\u00f3nicas Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-5855","authenticated-orcid":false,"given":"Jose Alfredo","family":"Dominguez-Rosales","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Enfermedades Cr\u00f3nicas Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9012-8619","authenticated-orcid":false,"given":"Montserrat","family":"Maldonado-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Microbiolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha","family":"Ru\u00edz-Madrigal","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Microbiolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha P.","family":"S\u00e1nchez Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Nuevo Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Unidad de Cirug\u00eda Bari\u00e1trica y Metab\u00f3lica, Guadalajara 44340, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vianney Alejandrina","family":"Zaragoza-Guerra","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey, Campus Guadalajara, Escuela de Medicina y Ciencias de la Salud, Zapopan 45201, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H.","family":"Espinoza-Padilla","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Enfermedades Cr\u00f3nicas Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-5337","authenticated-orcid":false,"given":"Elizabeth del C.","family":"Ruelas-Cinco","sequence":"additional","affiliation":[{"name":"Laboratorio Estatal de Transplantes, Edificio B, Zoquipan, Zapopan 45170, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-6946","authenticated-orcid":false,"given":"Sandra M.","family":"Ram\u00edrez-Meza","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de la Licenciatura en Nutrici\u00f3n, Divisi\u00f3n de Estudios de la Salud Centro Universitario de los Valles, Universidad de Guadalajara, Ameca Km. 45.5, Ameca 46600, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R.","family":"Torres Baranda","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Microbiolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del R.","family":"Gonz\u00e1lez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico y de Estudios Superiores de Monterrey, Campus Guadalajara, Escuela de Medicina y Ciencias de la Salud, Zapopan 45201, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-8470","authenticated-orcid":false,"given":"Zamira Helena","family":"Hernandez Nazara","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Enfermedades Cr\u00f3nicas Degenerativas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, C.P., Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref_1","unstructured":"World Obesity Federation (2024, March 27). 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