{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:29:46Z","timestamp":1769279386964,"version":"3.49.0"},"reference-count":117,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Government Assignment for Research, Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["122041800164-3"],"award-info":[{"award-number":["122041800164-3"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The review discusses the potential relationship between hypoxia resistance and longevity, the influence of carbon dioxide on the mechanisms of aging of the mammalian organism, and intermittent hypercapnic\u2013hypoxic effects on the signaling pathways of aging mechanisms. In the article, we focused on the potential mechanisms of the gero-protective efficacy of carbon dioxide when combined with hypoxia. The review summarizes the possible influence of intermittent hypoxia and hypercapnia on aging processes in the nervous system. We considered the perspective variants of the application of hypercapnic\u2013hypoxic influences for achieving active longevity and the prospects for the possibilities of developing hypercapnic\u2013hypoxic training methods.<\/jats:p>","DOI":"10.3390\/ijms25126512","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T03:52:53Z","timestamp":1718337173000},"page":"6512","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship between Hypoxia and Hypercapnia Tolerance and Life Expectancy"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3650-6121","authenticated-orcid":false,"given":"Pavel P.","family":"Tregub","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"},{"name":"Brain Science Institute, Research Center of Neurology, 125367 Moscow, Russia"},{"name":"Scientific and Educational Resource Center \u201cInnovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis\u201d, RUDN University, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-8356","authenticated-orcid":false,"given":"Yulia K.","family":"Komleva","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Research Center of Neurology, 125367 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4869-5465","authenticated-orcid":false,"given":"Vladimir P.","family":"Kulikov","sequence":"additional","affiliation":[{"name":"Department of Ultrasound and Functional Diagnostics, Altay State Medical University, 656040 Barnaul, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel A.","family":"Chekulaev","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana F.","family":"Tregub","sequence":"additional","affiliation":[{"name":"Independent Researcher, 127055 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa D.","family":"Maltseva","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaripat Sh.","family":"Manasova","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga A.","family":"Popova","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia S.","family":"Andriutsa","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V.","family":"Samburova","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla B.","family":"Salmina","sequence":"additional","affiliation":[{"name":"Brain Science Institute, Research Center of Neurology, 125367 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Litvitskiy","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. 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B"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3389\/fgene.2020.00743","article-title":"Cross-Species Insights Into Genomic Adaptations to Hypoxia","volume":"11","author":"Pamenter","year":"2020","journal-title":"Front. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Omotoso, O., Gladyshev, V.N., and Zhou, X. (2021). Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation. Front. Cell. Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.704966"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.celrep.2014.12.008","article-title":"Insights into the Evolution of Longevity from the Bowhead Whale Genome","volume":"10","author":"Keane","year":"2015","journal-title":"Cell Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.celrep.2014.07.030","article-title":"Adaptations to a Subterranean Environment and Longevity Revealed by the Analysis of Mole Rat Genomes","volume":"8","author":"Fang","year":"2014","journal-title":"Cell Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s10517-009-0529-8","article-title":"Development of Resistance of an Organism under Various Conditions of Hypoxic Preconditioning: Role of the Hypoxic Period and Reoxygenation","volume":"147","author":"Lukyanova","year":"2009","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/TP.0b013e3181bb4a07","article-title":"Repetitive Hypoxic Preconditioning Attenuates Renal Ischemia\/Reperfusion Induced Oxidative Injury via Upregulating HIF-1 Alpha-Dependent Bcl-2 Signaling","volume":"88","author":"Yang","year":"2009","journal-title":"Transplantation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1088\/1361-6579\/37\/12\/2299","article-title":"Effect of Intermittent Hypoxic Training on Hypoxia Tolerance Based on Brain Functional Connectivity","volume":"37","author":"Li","year":"2016","journal-title":"Physiol. Meas."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"941740","DOI":"10.3389\/fnins.2022.941740","article-title":"Intermittent Hypoxic Training as an Effective Tool for Increasing the Adaptive Potential, Endurance and Working Capacity of the Brain","volume":"16","author":"Rybnikova","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s003950200007","article-title":"Cardioprotective Effects of Chronic Hypoxia and Ischaemic Preconditioning Are Not Additive","volume":"97","year":"2002","journal-title":"Basic Res. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1089\/ham.2007.1053","article-title":"Effects of Intermittent Hypoxia Training on Exercise Performance, Hemodynamics, and Ventilation in Healthy Senior Men","volume":"9","author":"Shatilo","year":"2008","journal-title":"High Alt. Med. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/physrev.00039.2006","article-title":"Molecular physiology of preconditioning-induced brain tolerance to ischemia","volume":"88","author":"Obrenovitch","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1602\/neurorx.1.1.26","article-title":"Hypoxic preconditioning protects against ischemic brain injury","volume":"1","author":"Sharp","year":"2004","journal-title":"NeuroRx"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/CS20100596","article-title":"Hypobaric hypoxia preconditioning attenuates acute lung injury during high-altitude exposure in rats via up-regulating heat-shock protein 70","volume":"121","author":"Lin","year":"2011","journal-title":"Clin. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11055-009-9121-y","article-title":"The state of cerebral hemodynamics in conditions of prolonged adaptation to hypercapnic hypoxia","volume":"39","author":"Kulikov","year":"2009","journal-title":"Neurosci. Behav. Physiol."},{"key":"ref_18","first-page":"59","article-title":"Comparative efficacy of hypoxia, hypercapnia and hypercapnic hypoxia increases body resistance to acute hypoxia in rats","volume":"3","author":"Kulikov","year":"2013","journal-title":"Patol. Fiziol. Eksp. Ter."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pathophys.2013.09.001","article-title":"Tolerance to acute hypoxia maximally increases in case of joint effect of normobaric hypoxia and permissive hypercapnia in rats","volume":"20","author":"Tregub","year":"2013","journal-title":"Pathophysiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/ham.2015.0033","article-title":"Altitude Adaptation: A Glimpse Through Various Lenses","volume":"16","author":"Simonson","year":"2015","journal-title":"High Alt. Med. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1038\/s41467-018-07529-8","article-title":"Genetic Variation in PTPN1 Contributes to Metabolic Adaptation to High-Altitude Hypoxia in Tibetan Migratory Locusts","volume":"9","author":"Ding","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Y\u00e9pez, Y., Marcano-Ruiz, M., and Bortolini, M.C. (2024). Adaptive Strategies of Aquatic Mammals: Exploring the Role of the HIF Pathway and Hypoxia Tolerance. Genet. Mol. Biol., 46.","DOI":"10.1590\/1678-4685-gmb-2023-0140"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11459","DOI":"10.1073\/pnas.1002443107","article-title":"Natural Selection on EPAS1 (HIF2alpha) Associated with Low Hemoglobin Concentration in Tibetan Highlanders","volume":"107","author":"Beall","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/cr.2016.105","article-title":"Hypoxia Potentially Promotes Tibetan Longevity","volume":"27","author":"Li","year":"2017","journal-title":"Cell Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Basang, Z., Wang, B., Li, L., Yang, L., Liu, L., Cui, C., Lanzi, G., Yuzhen, N., Duo, J., and Zheng, H. (2015). HIF2A Variants Were Associated with Different Levels of High-Altitude Hypoxia among Native Tibetans. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137956"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/gbe\/evw037","article-title":"Evolutionary Genetics of Hypoxia Tolerance in Cetaceans during Diving","volume":"8","author":"Tian","year":"2016","journal-title":"Genome Biol. Evol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/gerona\/glt016","article-title":"Life-Span Extension from Hypoxia in Caenorhabditis Elegans Requires Both HIF-1 and DAF-16 and Is Antagonized by SKN-1","volume":"68","author":"Leiser","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1126\/science.1173507","article-title":"Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans","volume":"324","author":"Mehta","year":"2009","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cmet.2019.06.018","article-title":"Identification and Application of Gene Expression Signatures Associated with Lifespan Extension","volume":"30","author":"Tyshkovskiy","year":"2019","journal-title":"Cell Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature10533","article-title":"Genome Sequencing Reveals Insights into Physiology and Longevity of the Naked Mole Rat","volume":"479","author":"Kim","year":"2011","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00359-009-0420-0","article-title":"Extreme Tolerance to Ammonia Fumes in African Naked Mole-Rats: Animals That Naturally Lack Neuropeptides from Trigeminal Chemosensory Nerve Fibers","volume":"195","author":"Lavinka","year":"2009","journal-title":"J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1038\/ncomms4966","article-title":"Genome-Wide Adaptive Complexes to Underground Stresses in Blind Mole Rats Spalax","volume":"5","author":"Fang","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11357-018-0014-2","article-title":"Window into Extreme Longevity; the Circulating Metabolomic Signature of the Naked Mole-Rat, a Mammal That Shows Negligible Senescence","volume":"40","author":"Lewis","year":"2018","journal-title":"Geroscience"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.1132191","article-title":"Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span","volume":"314","author":"Conti","year":"2006","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10522-019-09848-9","article-title":"Metabolic Remodelling of Mice by Hypoxic-Hypercapnic Environment: Imitating the Naked Mole-Rat","volume":"21","author":"Tolstun","year":"2020","journal-title":"Biogerontology"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Jacobs, P.J., Hart, D.W., Merchant, H.N., Voigt, C., and Bennett, N.C. (2023). The Evolution and Ecology of Oxidative and Antioxidant Status: A Comparative Approach in African Mole-Rats. Antioxidants, 12.","DOI":"10.3390\/antiox12081486"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.23818\/limn.38.04","article-title":"Hypoxia Extends Lifespan of Brachionus Manjavacas (Rotifera)","volume":"38","author":"Snell","year":"2019","journal-title":"Limnetica"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1242\/jeb.044867","article-title":"Lifespan and Oxidative Stress Show a Non-Linear Response to Atmospheric Oxygen in Drosophila","volume":"213","author":"Harrison","year":"2010","journal-title":"J. Exp. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2014.04.051","article-title":"Neuroprotective Effects of Therapeutic Hypercapnia on Spatial Memory and Sensorimotor Impairment via Anti-Apoptotic Mechanisms after Focal Cerebral Ischemia\/Reperfusion","volume":"573","author":"Tao","year":"2014","journal-title":"Neurosci. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mehy.2018.08.002","article-title":"Intermittent Living; the Use of Ancient Challenges as a Vaccine against the Deleterious Effects of Modern Life-A Hypothesis","volume":"120","author":"Pruimboom","year":"2018","journal-title":"Med. Hypotheses"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.003","article-title":"Combined Exposure to Hypercapnia and Hypoxia Provides Its Maximum Neuroprotective Effect during Focal Ischemic Injury in the Brain","volume":"24","author":"Tregub","year":"2015","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10522-019-09821-6","article-title":"Hypercapnic Hypoxia as a Potential Means to Extend Life Expectancy and Improve Physiological Activity in Mice","volume":"20","author":"Kulikov","year":"2019","journal-title":"Biogerontology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4161\/oxim.3.3.12356","article-title":"Forever Young: Mechanisms of Natural Anoxia Tolerance and Potential Links to Longevity","volume":"3","author":"Krivoruchko","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10522-013-9472-1","article-title":"\u201cPull and Push Back\u201d Concepts of Longevity and Life Span Extension","volume":"14","author":"Muradian","year":"2013","journal-title":"Biogerontology"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Chung, D., Dzal, Y.A., Seow, A., Milsom, W.K., and Pamenter, M.E. (2016). Naked Mole Rats Exhibit Metabolic but Not Ventilatory Plasticity Following Chronic Sustained Hypoxia. Proc. Biol. Sci., 283.","DOI":"10.1098\/rspb.2016.0216"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10974-022-09623-3","article-title":"Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat","volume":"44","author":"Park","year":"2023","journal-title":"J. Muscle Res. Cell Motil."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1126\/science.aab3896","article-title":"Fructose-Driven Glycolysis Supports Anoxia Resistance in the Naked Mole-Rat","volume":"356","author":"Park","year":"2017","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Tregub, P.P., Kulikov, V.P., Ibrahimli, I., Tregub, O.F., Volodkin, A.V., Ignatyuk, M.A., Kostin, A.A., and Atiakshin, D.A. (2024). Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073665"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.freeradbiomed.2022.03.021","article-title":"The Multimodal Action of Genistein in Alzheimer\u2019s and Other Age-Related Diseases","volume":"183","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00702-023-02698-3","article-title":"Pharmacological Modulation of HIF-1 in the Treatment of Neuropsychiatric Disorders","volume":"130","author":"Sharma","year":"2023","journal-title":"J. Neural Transm."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/s43587-023-00512-z","article-title":"CD133+ Endothelial-like Stem Cells Restore Neovascularization and Promote Longevity in Progeroid and Naturally Aged Mice","volume":"3","author":"Sun","year":"2023","journal-title":"Nat. Aging"},{"key":"ref_52","first-page":"24","article-title":"The role of VEGF, HSP-70 and protein S-100B in the potentiation effect of the neuroprotective effect of hypercapnic hypoxia","volume":"2","author":"Bespalov","year":"2014","journal-title":"Patol. Fiziol. Eksp. Ter."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neurobiolaging.2023.12.004","article-title":"The Effect of Exercise on Blood Concentrations of Angiogenesis Markers in Older Adults: A Systematic Review and Meta-Analysis","volume":"135","author":"Song","year":"2024","journal-title":"Neurobiol. Aging"},{"key":"ref_54","first-page":"215","article-title":"Challenges and strategies in the treatment of neovascular age-related macular degeneration","volume":"60","author":"Dai","year":"2024","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/03635465231225244","article-title":"A Combined Treatment of BMP2 and Soluble VEGFR1 for the Enhancement of Tendon-Bone Healing by Regulating Injury-Activated Skeletal Stem Cell Lineage","volume":"52","author":"Wang","year":"2024","journal-title":"Am. J. Sports Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0940-2993(98)80026-2","article-title":"Influence of hypoxia and hypoxia\/hypercapnia upon brain and blood peroxidative and glutathione status in normal weight and growth-restricted newborn piglets","volume":"50","author":"Barth","year":"1998","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_57","first-page":"335","article-title":"The role of carbon dioxide in free radical reactions of the organism","volume":"51","author":"Wilhelm","year":"2002","journal-title":"Physiol. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"28233","DOI":"10.1074\/jbc.274.40.28233","article-title":"Bicarbonate Enhances the Peroxidase Activity of Cu,Zn-Superoxide Dismutase. Role of Carbonate Anion Radical","volume":"274","author":"Goss","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_59","first-page":"869","article-title":"Why does iron abrogate the cytotoxic effect of S-nitrosothiols on human and animal cultured cells?","volume":"52","author":"Serezhenkov","year":"2007","journal-title":"Biofizika"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3109\/10715762.2014.951839","article-title":"Reactivity of Hypotaurine and Cysteine Sulfinic Acid toward Carbonate Radical Anion and Nitrogen Dioxide as Explored by the Peroxidase Activity of Cu, Zn Superoxide Dismutase and by Pulse Radiolysis","volume":"48","author":"Conrado","year":"2014","journal-title":"Free Radic. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.freeradbiomed.2019.02.026","article-title":"Carbon Dioxide-Catalyzed Peroxynitrite Reactivity-The Resilience of the Radical Mechanism after Two Decades of Research","volume":"135","author":"Augusto","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbpb.2014.01.006","article-title":"Recovery from Hypoxia and Hypercapnic Hypoxia: Impacts on the Transcription of Key Antioxidants in the Shrimp Litopenaeus vannamei","volume":"170","author":"Kniffin","year":"2014","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Fantini, C., Corinaldesi, C., Lenzi, A., Migliaccio, S., and Crescioli, C. (2023). Vitamin D as a Shield against Aging. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054546"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2289740","DOI":"10.1080\/13510002.2023.2289740","article-title":"Integrated Approach to Reducing Polypharmacy in Older People: Exploring the Role of Oxidative Stress and Antioxidant Potential Therapy","volume":"29","author":"Saso","year":"2024","journal-title":"Redox Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12983-021-00430-z","article-title":"Plasma Oxidative Stress in Reproduction of Two Eusocial African Mole-Rat Species, the Naked Mole-Rat and the Damaraland Mole-Rat","volume":"18","author":"Jacobs","year":"2021","journal-title":"Front. Zool."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1007\/s11033-022-08212-4","article-title":"Permissive Hypercapnia and Hypercapnic Hypoxia Inhibit Signaling Pathways of Neuronal Apoptosis in Ischemic\/Hypoxic Rats","volume":"50","author":"Tregub","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s10517-020-04972-w","article-title":"Hypercapnia and Hypoxia Stimulate Proliferation of Astrocytes and Neurons In Vitro","volume":"169","author":"Tregub","year":"2020","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Chen, L., Zeng, Z., Luo, H., Xiao, H., and Zeng, Y. (2024). The Effects of CypA on Apoptosis: Potential Target for the Treatment of Diseases. Appl. Microbiol. Biotechnol., 108.","DOI":"10.1007\/s00253-023-12860-2"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ibneur.2024.02.001","article-title":"Melatonin-Mediated Calcineurin Inactivation Attenuates Amyloid Beta-Induced Apoptosis","volume":"16","author":"Hong","year":"2024","journal-title":"IBRO Neurosci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1002\/mco2.161","article-title":"Heat Shock Proteins: Biological Functions, Pathological Roles, and Therapeutic Opportunities","volume":"3","author":"Hu","year":"2022","journal-title":"MedComm"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10522-008-9136-8","article-title":"Glycerol Stimulates Innate Chaperoning, Proteasomal and Stress-Resistance Functions: Implications for Geronto-Manipulation","volume":"9","author":"Deocaris","year":"2008","journal-title":"Biogerontology"},{"key":"ref_72","first-page":"56","article-title":"Geroprotection: A Promising Future","volume":"3","author":"Magon","year":"2012","journal-title":"J. Midlife Health"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lippi, A., and Krisko, A. (2022). CORE at the Boundary of Stress Resistance and Longevity. Int. J. Biochem. Cell Biol., 151.","DOI":"10.1016\/j.biocel.2022.106277"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-4933-10-15","article-title":"Stress Responses, Vitagenes and Hormesis as Critical Determinants in Aging and Longevity: Mitochondria as a \u201cChi\u201d","volume":"10","author":"Cornelius","year":"2013","journal-title":"Immun. Ageing"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12079-014-0253-7","article-title":"Sex Hormonal Regulation and Hormesis in Aging and Longevity: Role of Vitagenes","volume":"8","author":"Calabrese","year":"2014","journal-title":"J. Cell Commun. Signal."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s10517-016-3441-z","article-title":"Stress of the Endoplasmic Reticulum of Neurons in Stroke Can Be Maximally Limited by Combined Exposure to Hypercapnia and Hypoxia","volume":"161","author":"Tregub","year":"2016","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4614-7411-1_5","article-title":"Increased HIF-1\u03b1 and HIF-2\u03b1 Accumulation, but Decreased Microvascular Density, in Chronic Hyperoxia and Hypercapnia in the Mouse Cerebral Cortex","volume":"789","author":"Benderro","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Tregub, P.P., Malinovskaya, N.A., Morgun, A.V., Osipova, E.D., Kulikov, V.P., Kuzovkov, D.A., and Kovzelev, P.D. (2020). Hypercapnia Potentiates HIF-1\u03b1 Activation in the Brain of Rats Exposed to Intermittent Hypoxia. Respir. Physiol. Neurobiol., 278.","DOI":"10.1016\/j.resp.2020.103442"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.4103\/1673-5374.385845","article-title":"Microglial Response to Aging and Neuroinflammation in the Development of Neurodegenerative Diseases","volume":"19","author":"Han","year":"2024","journal-title":"Neural. Regen. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.4103\/1673-5374.390974","article-title":"How Do Neurons Age? A Focused Review on the Aging of the Microtubular Cytoskeleton","volume":"19","author":"Richardson","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e200271","DOI":"10.1212\/CPJ.0000000000200271","article-title":"Clinical Predictors of Postmortem Amyloid and Nonamyloid Cerebral Small Vessel Disease in Middle-Aged to Older Adults","volume":"14","author":"Smith","year":"2024","journal-title":"Neurol. Clin. Pract."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101343","DOI":"10.1016\/j.arr.2021.101343","article-title":"Hypoxia and Brain Aging: Neurodegeneration or Neuroprotection?","volume":"68","author":"Burtscher","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-Aging. An Evolutionary Perspective on Immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"618395","DOI":"10.3389\/fnins.2020.618395","article-title":"Inflamm-Aging and Brain Insulin Resistance: New Insights and Role of Life-Style Strategies on Cognitive and Social Determinants in Aging and Neurodegeneration","volume":"14","author":"Komleva","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/MCP.0000000000000099","article-title":"The Impact of Sleep and Hypoxia on the Brain: Potential Mechanisms for the Effects of Obstructive Sleep Apnea","volume":"20","author":"Rosenzweig","year":"2014","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.expneurol.2014.10.007","article-title":"Defining the Critical Hypoxic Threshold That Promotes Vascular Remodeling in the Brain","volume":"263","author":"Boroujerdi","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e13258","DOI":"10.14814\/phy2.13258","article-title":"Chronic Intermittent Hypoxia Induces Oxidative Stress and Inflammation in Brain Regions Associated with Early-Stage Neurodegeneration","volume":"5","author":"Snyder","year":"2017","journal-title":"Physiol. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijdevneu.2015.03.010","article-title":"Hypoxic Preconditioning Can Reduce Injury-Induced Inflammatory Processes in the Neonatal Rat Brain","volume":"43","author":"Parmar","year":"2015","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s11325-017-1486-5","article-title":"Hypoxia and Inflammation Indicate Significant Differences in the Severity of Obstructive Sleep Apnea within Similar Apnea-Hypopnea Index Groups","volume":"21","author":"Avci","year":"2017","journal-title":"Sleep Breath."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1162\/netn_a_00352","article-title":"Elevating Understanding: Linking High-Altitude Hypoxia to Brain Aging through EEG Functional Connectivity and Spectral Analyses","volume":"8","author":"Medel","year":"2024","journal-title":"Netw. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"604","DOI":"10.14336\/AD.2016.0215","article-title":"Oxidative Stress-Induced Telomere Length Shortening of Circulating Leukocyte in Patients with Obstructive Sleep Apnea","volume":"7","author":"Kim","year":"2016","journal-title":"Aging Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2174\/1871527322666230418114446","article-title":"SARS-CoV-2 Infection to Premature Neuronal Aging and Neurodegenerative Diseases: Is There Any Connection with Hypoxia?","volume":"23","author":"Sivagurunathan","year":"2024","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"304","DOI":"10.18632\/aging.100292","article-title":"Regulation of Life Span by Mitochondrial Respiration: The HIF-1 and ROS Connection","volume":"3","author":"Hwang","year":"2011","journal-title":"Aging"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.freeradbiomed.2011.05.010","article-title":"Extending Life Span by Increasing Oxidative Stress","volume":"51","author":"Ristow","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.resp.2005.01.006","article-title":"Oxygen and Life Span: Chronic Hypoxia as a Model for Studying HIF-1alpha, VEGF and NOS during Aging","volume":"147","author":"Bianchi","year":"2005","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1134\/S2079057019040052","article-title":"Adaptation to Dosed Hypoxia-Hyperoxia as a Factor in the Improvement of Quality of Life for Elderly Patients with Cardiac Pathology","volume":"9","author":"Glazachev","year":"2019","journal-title":"Adv. Gerontol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1533317519896725","DOI":"10.1177\/1533317519896725","article-title":"Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study","volume":"35","author":"Wang","year":"2020","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/MBP.0000000000000033","article-title":"Cerebrovascular and Systemic Hemodynamic Response to Carbon Dioxide in Humans","volume":"19","author":"Kuznetsova","year":"2014","journal-title":"Blood Press. Monit."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1136\/jnnp.51.12.1600-b","article-title":"The hyperventilation syndrome-research and clinical treatment","volume":"51","author":"Fried","year":"1988","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1590\/S0100-879X2004000200013","article-title":"Clinical features of panic patients sensitive to hyperventilation or breath-holding methods for inducing panic attacks","volume":"37","author":"Nardi","year":"2004","journal-title":"Braz. J. Med Biol. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1164\/rccm.200406-807OC","article-title":"Cerebrovascular response to carbon dioxide in patientswith congestive heart failure","volume":"172","author":"Xie","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1378\/chest.09-1329","article-title":"Exacerbation of obstructive sleep apnea by oral indomethacin","volume":"137","author":"Burgess","year":"2010","journal-title":"Chest"},{"key":"ref_103","first-page":"433","article-title":"Role of Cerebrovascular and Cardiovascular CO2-Reactivity in the Pathogenesis of Arterial Hypertension","volume":"23","author":"Kulikov","year":"2017","journal-title":"Arter. Hypertens."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"H515","DOI":"10.1152\/ajpheart.00177.2014","article-title":"Age, aerobic fitness, and cerebral perfusion during exercise: Role of carbon dioxide","volume":"307","author":"Braz","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"112595","DOI":"10.1016\/j.bbr.2020.112595","article-title":"Hypobaric Hypoxia Induced Fear and Extinction Memory Impairment and Effect of Ginkgo Biloba in Its Amelioration: Behavioral, Neurochemical and Molecular Correlates","volume":"387","author":"Kumari","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e01513","DOI":"10.1002\/brb3.1513","article-title":"Intermittent hypoxia improves cognition and reduces anxiety-related behavior in APP\/PS1 mice","volume":"10","author":"Meng","year":"2020","journal-title":"Brain Behav."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1152\/ajpregu.00208.2014","article-title":"Therapeutic Potential of Intermittent Hypoxia: A Matter of Dose","volume":"307","author":"Mitchell","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1152\/japplphysiol.00274.2020","article-title":"Intermittent Hypoxia Enhances Shear-Mediated Dilation of the Internal Carotid Artery in Young Adults","volume":"129","author":"Iwamoto","year":"2020","journal-title":"J. Appl. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/9780470942390.mo140195","article-title":"Aging Research Using Mouse Models","volume":"5","author":"Anderson","year":"2015","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/emmm.201200245","article-title":"Telomerase Gene Therapy in Adult and Old Mice Delays Aging and Increases Longevity without Increasing Cancer","volume":"4","author":"Vera","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin Fed Late in Life Extends Lifespan in Genetically Heterogeneous Mice","volume":"460","author":"Harrison","year":"2009","journal-title":"Nature"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.279.5349.349","article-title":"Extension of Life-Span by Introduction of Telomerase into Normal Human Cells","volume":"279","author":"Bodnar","year":"1998","journal-title":"Science"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-1-59745-361-5_17","article-title":"Methods of Evaluating the Effect of Pharmacological Drugs on Aging and Life Span in Mice","volume":"371","author":"Anisimov","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tree.2011.01.002","article-title":"Peto\u2019s Paradox: Evolution\u2019s Prescription for Cancer Prevention","volume":"26","author":"Caulin","year":"2011","journal-title":"Trends Ecol. Evol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/978-3-030-65943-1_15","article-title":"Spontaneous Disease and Pathology of Naked Mole-Rats","volume":"1319","author":"Delaney","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000215589","article-title":"Update on Slow Aging and Negligible Senescence\u2014A Mini-Review","volume":"55","author":"Finch","year":"2009","journal-title":"Gerontology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1089\/rej.2015.1774","article-title":"Healthspan Pharmacology","volume":"18","author":"Jafari","year":"2015","journal-title":"Rejuvenation Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/12\/6512\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:57:49Z","timestamp":1760108269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/12\/6512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":117,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ijms25126512"],"URL":"https:\/\/doi.org\/10.3390\/ijms25126512","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,13]]}}}